Genomes and Genes
Gene Symbol: lark
Alias: CG8597, Dmel\CG8597, LARK, Lark, dLARK, lark, CG8597-PA, CG8597-PB, CG8597-PC, CG8597-PD, CG8597-PE, lark-PA, lark-PB, lark-PC, lark-PD, lark-PE
Species: fruit fly
- Huang Y, Howlett E, Stern M, Jackson F. Altered LARK expression perturbs development and physiology of the Drosophila PDF clock neurons. Mol Cell Neurosci. 2009;41:196-205 pubmed publisherThe LARK RNA-binding protein (RBP) has well documented roles in the circadian systems of Drosophila and mammals...
- Schroeder A, Genova G, Roberts M, Kleyner Y, Suh J, Jackson F. Cell-specific expression of the lark RNA-binding protein in Drosophila results in morphological and circadian behavioral phenotypes. J Neurogenet. 2003;17:139-69 pubmedPast studies have implicated the Drosophila LARK protein in the circadian control of adult eclosion behavior. LARK has a broad tissue pattern of distribution, and is pan-neuronal in the differentiated brain...
- Stanewsky R. Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J Neurobiol. 2003;54:111-47 pubmed..This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks. ..
- Lim C, Allada R. ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila. Science. 2013;340:875-9 pubmed publisher..Thus, ATX2 coordinates an active translation complex important for PER expression and circadian rhythms. ..
- Schroeder A, Jackson F. Phenotypic and molecular characterization of GAL4/UAS-mediated LARK expression. Genesis. 2002;34:91-4 pubmed
- Jackson F, Banfi S, Guffanti A, Rossi E. A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans. Genomics. 1997;41:444-52 pubmedThe Drosophila lark gene encodes an essential RNA-binding protein of the RNA recognition motif (RRM) class that is required during embryonic development...
- McNeil G, Zhang X, Roberts M, Jackson F. Maternal function of a retroviral-type zinc-finger protein is essential for Drosophila development. Dev Genet. 1999;25:387-96 pubmedPrevious studies have shown that zygotic expression of the Drosophila lark gene, which encodes an RNA-binding protein, is essential for embryogenesis...
- McNeil G, Smith F, Galioto R. The Drosophila RNA-binding protein Lark is required for the organization of the actin cytoskeleton and Hu-li tai shao localization during oogenesis. Genesis. 2004;40:90-100 pubmedElimination of maternal expression of the Drosophila RNA-binding protein Lark results in female sterility. Here we show that this is due to a requirement during oogenesis...
- Lu C, Chen T, Wu J, Chen H, Yu H, Tarn W. Phylogenetic and molecular characterization of the splicing factor RBM4. PLoS ONE. 2013;8:e59092 pubmed publisher..This study offers a first clue to functional evolution of a splicing factor...
- Rosato E, Kyriacou C. Flies, clocks and evolution. Philos Trans R Soc Lond B Biol Sci. 2001;356:1769-78 pubmed publisher..Variation in clock gene sequences between and within fly species is examined and the role of co-evolution between and within clock molecules is described, particularly with reference to adaptive functions of the circadian phenotype...
- Martin M, Ahern Djamali S, Hoffmann F, Saxton W. Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1. Mol Biol Cell. 2005;16:4225-30 pubmed..A concomitant reduction in ena dosage rescued those defects. These results suggest that Ena/VASP, when not inhibited by the Abl pathway, can bind Khc and reduce its transport activity in axons. ..
- Levine J. Sharing time on the fly. Curr Opin Cell Biol. 2004;16:210-6 pubmed..The identification of inter-organismal components of the circadian system in Drosophila suggests new perspectives as the progression continues from the systems level to the social level and onwards to the level of ecosystems. ..
- Hendricks J. Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms. J Appl Physiol (1985). 2003;94:1660-72; discussion 1673 pubmed..Nonetheless, studies have already established that two transcription factors alter rest and rest homeostasis. The implications of these advances for the future of sleep research are summarized. ..
- Stoiber M, Olson S, May G, Duff M, Manent J, Obar R, et al. Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila. Genome Res. 2015;25:1692-702 pubmed publisher..From the simultaneous acquisition and integrative analysis of protein and RNA constituents of RNPs, we identify extensive cross-regulatory and hierarchical interactions in post-transcriptional control. ..
- Santos A, Kanellopoulos A, Bagni C. Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us. Learn Mem. 2014;21:543-55 pubmed publisher..Additionally, we discuss several potential treatments under study in animal models that are able to partially revert some of the FXS abnormalities. ..
- Brown S, Schibler U. The ins and outs of circadian timekeeping. Curr Opin Genet Dev. 1999;9:588-94 pubmed..Taken together, these observations are reshaping thinking about inputs and outputs of metazoan circadian clocks. ..
- Hall J. Tripping along the trail to the molecular mechanisms of biological clocks. Trends Neurosci. 1995;18:230-40 pubmed
- Pflugfelder G. Genetic lesions in Drosophila behavioural mutants. Behav Brain Res. 1998;95:3-15 pubmed..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations. ..
- Huang Y, McNeil G, Jackson F. Translational regulation of the DOUBLETIME/CKIÎ´/Îµ kinase by LARK contributes to circadian period modulation. PLoS Genet. 2014;10:e1004536 pubmed publisher..we show that translation of dbt transcripts are directly regulated by a rhythmic RNA-binding protein (RBP) called LARK (known as RBM4 in mammals)...
- Sehgal A. Molecular genetic analysis of circadian rhythms in vertebrates and invertebrates. Curr Opin Neurobiol. 1995;5:824-31 pubmed..A combination of genetic, molecular and biochemical approaches is leading to an emerging picture of how molecular events enable organisms to keep time. ..
- Rosato E, Piccin A, Kyriacou C. Circadian rhythms: from behaviour to molecules. Bioessays. 1997;19:1075-82 pubmed..More recently, the cloning of mouse clock genes, including putative per homologues, opens up exciting possibilities for mammalian molecular chronobiology. ..
- Swain A, Misulovin Z, Pherson M, Gause M, Mihindukulasuriya K, Rickels R, et al. Drosophila TDP-43 RNA-Binding Protein Facilitates Association of Sister Chromatid Cohesion Proteins with Genes, Enhancers and Polycomb Response Elements. PLoS Genet. 2016;12:e1006331 pubmed publisher..It is unknown why some active genes bind high levels of cohesin and some do not. Here we show that the TBPH and Lark RNA-binding proteins influence association of Nipped-B and cohesin with genes and gene regulatory sequences...
- Wilsbacher L, Takahashi J. Circadian rhythms: molecular basis of the clock. Curr Opin Genet Dev. 1998;8:595-602 pubmed..In addition, the discovery of brain-independent clocks promises to revolutionize the study of circadian biology. ..
- McNeil G, Kaur M, Purrier S, Kang R. The Drosophila RNA-binding protein Lark is required for localization of Dmoesin to the oocyte cortex during oogenesis. Dev Genes Evol. 2009;219:11-9 pubmed publisherThe RNA-binding protein Lark has an essential maternal role during Drosophila oogenesis. Elimination of maternal expression results in defects in cytoplasmic dumping and actin cytoskeletal organization in nurse cells...
- Sofola O, Sundram V, Ng F, Kleyner Y, Morales J, Botas J, et al. The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior. J Neurosci. 2008;28:10200-5 pubmed publisher..study, we present biochemical and genetic evidence that dFMRP interacts with a known clock output component, the LARK RNA-binding protein...
- Dunlap J. Molecular bases for circadian clocks. Cell. 1999;96:271-90 pubmed
- Stanewsky R. Clock mechanisms in Drosophila. Cell Tissue Res. 2002;309:11-26 pubmed..Although their regulation depends on the major clock genes, the majority of the clock-controlled genes are not direct targets of clock factors. ..
- Panda S, Hogenesch J, Kay S. Circadian rhythms from flies to human. Nature. 2002;417:329-35 pubmed..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila. ..