LanA

Summary

Gene Symbol: LanA
Description: Laminin A
Alias: CG10236, CT28769, Dmel\CG10236, FBgn0002526, FBtr0077014, LM-A/alpha1, Lam, Lam-A, LamA, Lan, alpha3/5, alpha[[3, hdln, lamA, laminin alpha3/5, lanA, laminin A, CG10236-PA, LanA-PA, alpha3,5 laminin, headline, laminin, laminin A chain, laminin A subunit, laminin A5, laminin alpha, laminin alpha-chain, laminin alpha3,5, laminin alpha[[3,5]], lamininA
Species: fruit fly
Products:     LanA

Top Publications

  1. Bunt S, Hooley C, Hu N, Scahill C, Weavers H, Skaer H. Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila. Dev Cell. 2010;19:296-306 pubmed publisher
    ..Such regulated interplay between cell-cell and cell-matrix interactions is likely to have wide relevance in organogenesis and congenital disease. ..
  2. Tanentzapf G, Devenport D, Godt D, Brown N. Integrin-dependent anchoring of a stem-cell niche. Nat Cell Biol. 2007;9:1413-8 pubmed
    ..On the basis of our data, we propose that integrins are required for the attachment of the hub cells to the ECM, which is essential for maintaining the stem-cell niche. ..
  3. Stevens A, Jacobs J. Integrins regulate responsiveness to slit repellent signals. J Neurosci. 2002;22:4448-55 pubmed
    ..Drosophila doubly heterozygous for slit and the genes encoding the integrin ligands Laminin A and Tiggrin reveal similar errors in midline axon guidance...
  4. Christoforou C, Greer C, Challoner B, Charizanos D, Ray R. The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins. Dev Biol. 2008;313:519-32 pubmed
  5. Gotwals P, Fessler L, Wehrli M, Hynes R. Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Proc Natl Acad Sci U S A. 1994;91:11447-51 pubmed
    ..We report that PS1 integrin is a laminin receptor and that PS1 and PS2 integrins promote cell spreading on two different Drosophila extracellular matrix ..
  6. Garrison K, MacKrell A, Fessler J. Drosophila laminin A chain sequence, interspecies comparison, and domain structure of a major carboxyl portion. J Biol Chem. 1991;266:22899-904 pubmed
    ..1-kilobase pair nucleotide cDNA sequence encoding 1951 amino acids and the carboxyl end of a Drosophila laminin A chain. It corresponds to the mouse laminin A domains G, I, II, and III, but may represent a different type of ..
  7. Wolfstetter G, Holz A. The role of LamininB2 (LanB2) during mesoderm differentiation in Drosophila. Cell Mol Life Sci. 2012;69:267-82 pubmed publisher
    In Drosophila, four genes encode for laminin subunits and the formation of two laminin heterotrimers has been postulated...
  8. Stark K, Yee G, Roote C, Williams E, Zusman S, Hynes R. A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development. 1997;124:4583-94 pubmed
    ..Phenotypic similarities suggest that laminin A is a potential ligand for this integrin, at least in some tissues.
  9. Brown N. Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 2000;19:191-201 pubmed
    ..to Drosophila alphaPS2betaPS and vertebrate alpha5beta1, alphaVbeta1 and alpha8beta1, and one putative laminin binding integrin alphaina-1betapat-3, corresponding to Drosophila alphaPS1betaPS and vertebrate alpha3beta1, ..

More Information

Publications74

  1. Araujo H, Negreiros E, Bier E. Integrins modulate Sog activity in the Drosophila wing. Development. 2003;130:3851-64 pubmed
    ..We propose that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism. ..
  2. MacMullin A, Jacobs J. Slit coordinates cardiac morphogenesis in Drosophila. Dev Biol. 2006;293:154-64 pubmed
    ..However, there is a strong phenotypic interaction with Integrin genes and their ligands, including Laminin and Collagen, and intracellular messengers, including Talin and ILK...
  3. Kusche Gullberg M, Garrison K, MacKrell A, Fessler L, Fessler J. Laminin A chain: expression during Drosophila development and genomic sequence. EMBO J. 1992;11:4519-27 pubmed
    A Drosophila laminin A chain gene was characterized as a 14 kb genomic nucleotide sequence which encodes an open reading frame of 3712 amino acids in 15 exons...
  4. Devenport D, Brown N. Morphogenesis in the absence of integrins: mutation of both Drosophila beta subunits prevents midgut migration. Development. 2004;131:5405-15 pubmed
    ..Having generated the tools to eliminate integrin function completely, we confirm that Drosophila integrins do not control proliferation as they do in mammals, and have identified alphaPS3 as a heterodimeric partner for betanu. ..
  5. Tsai P, Wang M, Kao H, Cheng Y, Lin Y, Chen R, et al. Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. Proc Natl Acad Sci U S A. 2012;109:17699-704 pubmed publisher
    ..Here we report that laminin A (LanA) functions as a retrograde signal to suppress synapse growth at Drosophila neuromuscular junctions (NMJs)...
  6. Narasimha M, Brown N. Novel functions for integrins in epithelial morphogenesis. Curr Biol. 2004;14:381-5 pubmed
    ..Thus, dorsal closure shares mechanistic similarities with vertebrate epithelial morphogenetic events, including epiboly, that also employ an underlying substrate. ..
  7. Gutzeit H, Eberhardt W, Gratwohl E. Laminin and basement membrane-associated microfilaments in wild-type and mutant Drosophila ovarian follicles. J Cell Sci. 1991;100 ( Pt 4):781-8 pubmed
    The localization of the extracellular matrix glycoprotein laminin was studied using polyclonal anti-laminin antibodies...
  8. Pagliarini R, Xu T. A genetic screen in Drosophila for metastatic behavior. Science. 2003;302:1227-31 pubmed
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development. ..
  9. Urbano J, Torgler C, Molnar C, Tepass U, López Varea A, Brown N, et al. Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis. Development. 2009;136:4165-76 pubmed publisher
    ..The Drosophila genome encodes two laminin alpha chains, one beta and one Gamma, which form two distinct laminin trimers...
  10. Murakami S, Umetsu D, Maeyama Y, Sato M, Yoshida S, Tabata T. Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. Development. 2007;134:1539-48 pubmed
    ..Hence the optic stalk is a simple monolayered structure that can serve as an ideal system for studying glial cell morphogenesis and the developmental role(s) of focal adhesion signaling. ..
  11. Fessler L, Campbell A, Duncan K, Fessler J. Drosophila laminin: characterization and localization. J Cell Biol. 1987;105:2383-91 pubmed
    Drosophila laminin was isolated from the medium of Drosophila Kc cell cultures. It was purified by velocity sedimentation, gel filtration, and chromatography...
  12. Martinek N, Shahab J, Saathoff M, Ringuette M. Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryos. J Cell Sci. 2008;121:1671-80 pubmed publisher
    ..Drosophila embryos, high levels of SPARC and other basal lamina components (such as network-forming collagen IV, laminin and perlecan) are synthesized and secreted by haemocytes, and assembled into basal laminae...
  13. Deng W, Schneider M, Frock R, Castillejo Lopez C, Gaman E, Baumgartner S, et al. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development. 2003;130:173-84 pubmed
    ..Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton; however, how these ..
  14. Medioni C, Noselli S. Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. Development. 2005;132:3069-77 pubmed
    ..apical capping with major basement membrane proteins, including the two Drosophila Collagen IV alpha chains, Laminin A and Perlecan...
  15. Henchcliffe C, Garcia Alonso L, Tang J, Goodman C. Genetic analysis of laminin A reveals diverse functions during morphogenesis in Drosophila. Development. 1993;118:325-37 pubmed
    ..the functions of laminin A in vivo, we have undertaken a molecular and genetic characterization of the laminin A subunit (lamA) gene in Drosophila. Sequence analysis predicts a multidomain structure similar to mammalian homologs...
  16. Tsai P, Kao H, Grabbe C, Lee Y, Ghose A, Lai T, et al. Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev. 2008;3:26 pubmed publisher
    ..Unlike its conventional role in activating MAPK/ERK, Fak56 suppresses ERK activation in this process. These results suggest that Fak56 mediates a specific neuronal signaling pathway distinct from that in other cellular processes. ..
  17. Prokop A, Martin Bermudo M, Bate M, Brown N. Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos. Dev Biol. 1998;196:58-76 pubmed
    ..PS1 integrin (alphaPS1betaPS), PS2 integrin (alphaPS2betaPS), and/or their potential extracellular ligand laminin A. At the muscle attachments PS integrins are essential for the adhesion of hemiadherens junctions (HAJs) to ..
  18. Friedrich M, Schneider M, Timpl R, Baumgartner S. Perlecan domain V of Drosophila melanogaster. Sequence, recombinant analysis and tissue expression. Eur J Biochem. 2000;267:3149-59 pubmed
    ..It consists of three laminin G-type (LG) and epidermal growth factor-like (EG) modules but lacks the EG3 module and a link region found in ..
  19. Dobie K, Kennedy C, Velasco V, McGrath T, Weko J, Patterson R, et al. Identification of chromosome inheritance modifiers in Drosophila melanogaster. Genetics. 2001;157:1623-37 pubmed
  20. Frydman H, Spradling A. The receptor-like tyrosine phosphatase lar is required for epithelial planar polarity and for axis determination within drosophila ovarian follicles. Development. 2001;128:3209-20 pubmed
    ..by these cells within the extracellular matrix (ECM), possibly in the distribution of the candidate Lar ligand Laminin A, and read out at the time Oskar is localized in a Lar-dependent manner...
  21. Schock F, Perrimon N. Retraction of the Drosophila germ band requires cell-matrix interaction. Genes Dev. 2003;17:597-602 pubmed
    ..We demonstrate that alpha1, 2 laminin and alphaPS3betaPS integrin are required for the spreading of a small group of cells of the amnioserosa ..
  22. Montell D, Goodman C. Drosophila substrate adhesion molecule: sequence of laminin B1 chain reveals domains of homology with mouse. Cell. 1988;53:463-73 pubmed
    b>Laminin, a substrate adhesion molecule in vertebrates, is a large glycoprotein complex in basement membranes that promotes cell adhesion, cell migration, and neurite outgrowth...
  23. Urbano J, Domínguez Giménez P, Estrada B, Martin Bermudo M. PS integrins and laminins: key regulators of cell migration during Drosophila embryogenesis. PLoS ONE. 2011;6:e23893 pubmed publisher
    ..In addition, we have identified the Laminin ?1,2 trimer, as the key extracellular matrix (ECM) component regulating CVM migration...
  24. Montell D, Goodman C. Drosophila laminin: sequence of B2 subunit and expression of all three subunits during embryogenesis. J Cell Biol. 1989;109:2441-53 pubmed
    In a previous study, we described the cloning of the genes encoding the three subunits of Drosophila laminin, a substrate adhesion molecule, and the cDNA sequence of the B1 subunit (Montell and Goodman, 1988)...
  25. Schneider M, Khalil A, Poulton J, Castillejo Lopez C, Egger Adam D, Wodarz A, et al. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development. 2006;133:3805-15 pubmed
    ..Furthermore, Dg depends on Pcan but not on Laminin A for its localization in the basal-cell membrane, and the two proteins bind in vitro...
  26. Knox J, Moyer K, Yacoub N, Soldaat C, Komosa M, Vassilieva K, et al. Syndecan contributes to heart cell specification and lumen formation during Drosophila cardiogenesis. Dev Biol. 2011;356:279-90 pubmed publisher
    ..Phenotypic interactions of syndecan with slit and Integrin mutants suggest intersecting function, consistent with Syndecan acting as a co-receptor for Slit in the Drosophila heart. ..
  27. Gotwals P, Paine Saunders S, Stark K, Hynes R. Drosophila integrins and their ligands. Curr Opin Cell Biol. 1994;6:734-9 pubmed
  28. Yarnitzky T, Volk T. Laminin is required for heart, somatic muscles, and gut development in the Drosophila embryo. Dev Biol. 1995;169:609-18 pubmed
    ..of laminin during mesoderm development and morphogenesis was dissected by analyzing embryos deficient in laminin A chain alone or in both laminin A and B2 chains...
  29. Pastor Pareja J, Xu T. Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev Cell. 2011;21:245-56 pubmed publisher
    ..Our results uncover incorporation of Collagen IV and Perlecan into BMs as a major determinant of organ shape and animal form. ..
  30. Fessler L, Nelson R, Fessler J. Drosophila extracellular matrix. Methods Enzymol. 1994;245:271-94 pubmed
  31. Martin D, Zusman S, Li X, Williams E, Khare N, DaRocha S, et al. wing blister, a new Drosophila laminin alpha chain required for cell adhesion and migration during embryonic and imaginal development. J Cell Biol. 1999;145:191-201 pubmed
    ..Mutation analysis in the eye demonstrates a function in rhabdomere organization. In summary, this new laminin alpha chain is essential for embryonic viability and is involved in processes requiring cell migration and cell ..
  32. Haag T, Haag N, Lekven A, Hartenstein V. The role of cell adhesion molecules in Drosophila heart morphogenesis: faint sausage, shotgun/DE-cadherin, and laminin A are required for discrete stages in heart development. Dev Biol. 1999;208:56-69 pubmed
    ..In this paper we focus on three adhesion molecules, faint sausage (fas), shotgun/DE-cadherin (shg/DE-Cad), and laminin A (lam A), that are essential for heart development...
  33. Bogdanik L, Framery B, Frölich A, Franco B, Mornet D, Bockaert J, et al. Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction. PLoS ONE. 2008;3:e2084 pubmed publisher
    ..postsynaptically at the glutamatergic NMJ, where, like in vertebrates, it controls the concentration of synaptic Laminin and Dystrophin homologues. We also found that synaptic Dg controlled the amount of postsynaptic 4...
  34. Zhang L, Zhang Y, Hagen K. A mucin-type O-glycosyltransferase modulates cell adhesion during Drosophila development. J Biol Chem. 2008;283:34076-86 pubmed publisher
    ..This study provides the first evidence for the role of O-glycosylation in a developmentally regulated, integrin-mediated, cell adhesion event and reveals a novel player in wing blade formation during Drosophila development. ..
  35. Szafranski P, Goode S. Basolateral junctions are sufficient to suppress epithelial invasion during Drosophila oogenesis. Dev Dyn. 2007;236:364-73 pubmed
    ..Our results demonstrate that spatiotemporal patterns of basolateral junction activity directly suppress epithelial invasion by organizing the cooperative activity of distinct polarity and motility pathways. ..
  36. Patel U, Myat M. Receptor guanylyl cyclase Gyc76C is required for invagination, collective migration and lumen shape in the Drosophila embryonic salivary gland. Biol Open. 2013;2:711-7 pubmed publisher
    ..The extracellular matrix protein, laminin, also failed to accumulate around the migrating salivary gland of gyc76C mutant embryos, and gyc76C and laminin ..
  37. López Ceballos P, Herrera Reyes A, Coombs D, Tanentzapf G. In vivo regulation of integrin turnover by outside-in activation. J Cell Sci. 2016;129:2912-24 pubmed publisher
    ..This data identifies a new in vivo role for outside-in activation and sheds light on the key transition between tissue morphogenesis and maintenance. ..
  38. Fristrom D, Wilcox M, Fristrom J. The distribution of PS integrins, laminin A and F-actin during key stages in Drosophila wing development. Development. 1993;117:509-23 pubmed
    ..Disc ultrastructure is correlated with the distribution of the beta chain of integrin, laminin A, and filamentous actin for each key stage of pupal development...
  39. Gullberg D, Ekblom P. Extracellular matrix and its receptors during development. Int J Dev Biol. 1995;39:845-54 pubmed
    ..It will be an interesting task to study the signal transduction pathways elicited by the interactions between ECM and the two receptor systems during muscle and epithelial morphogenesis. ..
  40. Salminen T, Vesala L, Laiho A, Merisalo M, Hoikkala A, Kankare M. Seasonal gene expression kinetics between diapause phases in Drosophila virilis group species and overwintering differences between diapausing and non-diapausing females. Sci Rep. 2015;5:11197 pubmed publisher
    ..littoralis and D. ezoana. The present study helps to achieve a better understanding of the genetic regulation of diapause and of the plasticity of seasonal responses in general. ..
  41. Takagi Y, Nomizu M, Ui Tei K, Tokushige N, Hirohashi S. Active sites in the carboxyl-terminal region of the laminin alpha chain in Drosophila neuronal cell spreading. Arch Insect Biochem Physiol. 2004;56:162-9 pubmed
    An established Drosophila neuronal cell line (BG2-c6) proved to be useful to analyze laminin-mediated cell spreading and signal transduction [Takagi et al. (2000) Biochem Biophys Res Commun 270:482-487]...
  42. Horne Badovinac S. The Drosophila egg chamber-a new spin on how tissues elongate. Integr Comp Biol. 2014;54:667-76 pubmed publisher
  43. Yurchenco P, O Rear J. Basal lamina assembly. Curr Opin Cell Biol. 1994;6:674-81 pubmed
    ..In particular, the evidence supports the concept of enmeshed collagen and laminin polymers, in which nidogen/entactin acts as a bridge between these molecules and provides anchorage for diverse ..
  44. Yamamoto A, Zwarts L, Callaerts P, Norga K, Mackay T, Anholt R. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2008;105:12393-8 pubmed publisher
    ..We find that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks. ..
  45. Volk T, Fessler L, Fessler J. A role for integrin in the formation of sarcomeric cytoarchitecture. Cell. 1990;63:525-36 pubmed
    ..alpha PS2 beta PS accumulated at contact regions of Drosophila embryo cells cultured in D-22 medium on Drosophila laminin. Myotubes formed, but subsequent addition of serum or fibronectin was needed for sarcomere formation: integrin ..
  46. Koper A, Schenck A, Prokop A. Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ. PLoS ONE. 2012;7:e36339 pubmed publisher
    ..show strong partial detachment of the junction when BM-to-cell surface attachment is impaired by removing Laminin A, or when BMs lose their structural integrity upon loss of type IV collagens...
  47. MacKrell A, Kusche Gullberg M, Garrison K, Fessler J. Novel Drosophila laminin A chain reveals structural relationships between laminin subunits. FASEB J. 1993;7:375-81 pubmed
    ..The amino-terminal two-thirds of the newly characterized Drosophila laminin A chain appears to encode a novel structure, but the analysis presented here shows that substantial portions of its ..
  48. Lo P, Frasch M. A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech Dev. 2001;104:49-60 pubmed
    ..We also describe the tinman cis sequences that mediate tinman repression by seven-up and examine whether Seven-up can bind these sequences to directly inhibit tinman. ..
  49. Yamamoto A, Anholt R, Mackay T. Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster. Genet Res (Camb). 2009;91:373-82 pubmed publisher
  50. Andersen D, Horne Badovinac S. Influence of ovarian muscle contraction and oocyte growth on egg chamber elongation in Drosophila. Development. 2016;143:1375-87 pubmed publisher
    ..These findings highlight how physical contributions from several cell types are integrated to shape an organ. ..
  51. Petley Ragan L, Ardiel E, Rankin C, Auld V. Accumulation of Laminin Monomers in Drosophila Glia Leads to Glial Endoplasmic Reticulum Stress and Disrupted Larval Locomotion. J Neurosci. 2016;36:1151-64 pubmed publisher
    ..Glial cells in many organisms secrete laminin, a large heterotrimeric protein consisting of an α, β, and γ subunit...
  52. Begun D, Holloway A, Stevens K, Hillier L, Poh Y, Hahn M, et al. Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans. PLoS Biol. 2007;5:e310 pubmed
    ..simulans. ..
  53. Baena Lopez L, Rodriguez I, Baonza A. The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like. Proc Natl Acad Sci U S A. 2008;105:9645-50 pubmed publisher
  54. Han C, Wang D, Soba P, Zhu S, Lin X, Jan L, et al. Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron. 2012;73:64-78 pubmed publisher
    ..Removing neuronal integrins or blocking epidermal laminin production causes dendrites to grow into the epidermis, suggesting that integrin-laminin interaction attaches ..
  55. Smith D, Wohlgemuth J, Calvi B, Franklin I, Gelbart W. hobo enhancer trapping mutagenesis in Drosophila reveals an insertion specificity different from P elements. Genetics. 1993;135:1063-76 pubmed
    ..Hence, hobo insertion may facilitate access to genes resistant to P element insertion. ..
  56. Garcia Alonso L, Fetter R, Goodman C. Genetic analysis of Laminin A in Drosophila: extracellular matrix containing laminin A is required for ocellar axon pathfinding. Development. 1996;122:2611-21 pubmed
    Genetic analysis of the Laminin A (LamA) gene in Drosophila reveals that distinct classes of sensory axons have different requirements for extracellular matrix (ECM) containing laminin A versus epithelial cell surfaces...
  57. Vandenborre G, Van Damme E, Ghesquière B, Menschaert G, Hamshou M, Rao R, et al. Glycosylation signatures in Drosophila: fishing with lectins. J Proteome Res. 2010;9:3235-42 pubmed publisher
    ..Furthermore, it was demonstrated that a specific glycosylation signature can be associated with a functionally related group of glycoproteins in Drosophila, both in terms of biological process and molecular function. ..
  58. Zwarts L, Magwire M, Carbone M, Versteven M, Herteleer L, Anholt R, et al. Complex genetic architecture of Drosophila aggressive behavior. Proc Natl Acad Sci U S A. 2011;108:17070-5 pubmed publisher
  59. Gullberg D, Fessler L, Fessler J. Differentiation, extracellular matrix synthesis, and integrin assembly by Drosophila embryo cells cultured on vitronectin and laminin substrates. Dev Dyn. 1994;199:116-28 pubmed
    Two contrasting substrates, Drosophila laminin and human vitronectin, caused determined primary Drosophila embryo cells to follow alternate intermediate differentiation steps without affecting the final outcome of differentiation...
  60. Mirth C, Akam M. Joint development in the Drosophila leg: cell movements and cell populations. Dev Biol. 2002;246:391-406 pubmed
    ..These markers also define a number of more localised territories within the pupal joint. ..
  61. Wei J, Hortsch M, Goode S. Neuroglian stabilizes epithelial structure during Drosophila oogenesis. Dev Dyn. 2004;230:800-8 pubmed
    ..Our data also suggest that Ig superfamily members have significant functional redundancy in maintaining epithelial polarity, with individual members playing subtle, unique roles during epithelial morphogenesis. ..
  62. Taylor M. A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNA. Dev Biol. 2000;220:37-52 pubmed
    ..The tin-independent and Dmef2-independent expression of Dmeso18E indicates that it either occupies a link between twi and genes like tin and Dmef2 or it lies in a parallel pathway of gene activation. ..
  63. Poulton J, Deng W. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc Natl Acad Sci U S A. 2006;103:12775-80 pubmed
    ..disrupts apicobasal polarity in the PFC, which includes mislocalization of the extracellular matrix component Laminin. Our data indicate that Dystroglycan links EGFR-induced repression of the anterior follicle cell fate and ..
  64. Schneider M, Baumgartner S. Differential expression of Dystroglycan-spliceforms with and without the mucin-like domain during Drosophila embryogenesis. Fly (Austin). 2008;2:29-35 pubmed
    ..of O-linked glycosylation in the mucin-like domain of DG, which is required for binding of the ECM molecules Laminin and Perlecan...
  65. Gellon G, Harding K, McGinnis N, Martin M, McGinnis W. A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. Development. 1997;124:3321-31 pubmed
    ..We propose that apt acts in parallel to, or as a cofactor with, HOX proteins to regulate homeotic targets in the ventral gnathal region. ..