Gene Symbol: Lamp1
Description: Lamp1
Alias: CG3305, Dmel\CG3305, LAMP, LAMP1, Lamp, Lamp-1, dLAMP, dLamp, lamp1, Lamp1, CG3305-PA, Lamp1-PA, lysosomal-associated membrane protein 1, lysosome-associated membrane protein
Species: fruit fly

Top Publications

  1. Han Y, Kwok B, Kernan M. Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm. Curr Biol. 2003;13:1679-86 pubmed
    ..NOMPB, the Drosophila homolog of IFT88, is required for the assembly of sensory cilia but not for the extension or function of the sperm flagellum. Assembly of this extremely long axoneme is therefore independent of IFT. ..
  2. Hofmann I, Munro S. An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. J Cell Sci. 2006;119:1494-503 pubmed
    ..Live cell imaging shows that lysosomes move more frequently both toward and away from the cell periphery, suggesting a role for Arl8a and Arl8b as positive regulators of lysosomal transport. ..
  3. Takáts S, Nagy P, Varga Ã, Pircs K, Kárpáti M, Varga K, et al. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013;201:531-9 pubmed publisher
    ..Our findings reveal the molecular mechanism underlying autophagosomal fusion events and show that lysosomal degradation and recycling of sequestered autophagosome content is crucial to maintain proper functioning of the nervous system. ..
  4. Rusten T, Rodahl L, Pattni K, Englund C, Samakovlis C, Dove S, et al. Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell. 2006;17:3989-4001 pubmed
    ..This is consistent with the possibility that Fab1 functions at a late stage in endocytic receptor trafficking, at a point when signal termination has occurred. ..
  5. Cai W, Wei Y, Jarnik M, Reich J, Lilly M. The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function. PLoS Genet. 2016;12:e1006036 pubmed publisher
    ..Taken together our data support the model that Wdr24 is a key effector of the GATOR2 complex, required for both TORC1 activation and the TORC1 independent regulation of lysosomes. ..
  6. Rhiner C, López Gay J, Soldini D, Casas Tinto S, Martín F, Lombardia L, et al. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell. 2010;18:985-98 pubmed publisher
    ..Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells. ..
  7. Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T. Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Autophagy. 2016;12:499-514 pubmed publisher
    ..Our data suggest that lysosomal-associated functions regulated by the TFEB-V-ATPase axis might play a conserved role in shaping cell fate. ..
  8. Burgess J, Del Bel L, Ma C, Barylko B, Polevoy G, Rollins J, et al. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012;139:3040-50 pubmed publisher
    ..Our genetic analysis of PI4KII in flies thus reveals a novel role for PI4KII in regulating the fidelity of granule protein trafficking in secretory tissues. ..
  9. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, et al. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. EMBO J. 2016;35:121-42 pubmed publisher
    ..Taken together, our data indicate that impaired mTORC1 signaling and influenced ALP may contribute to TDP-43-mediated neurodegeneration. ..

More Information


  1. Parchure A, Vyas N, Ferguson C, Parton R, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Mol Biol Cell. 2015;26:4700-17 pubmed publisher
    ..These results provide evidence that nanoscale organization of Hh regulates the secretion of Hh on ESCRT-derived exovesicles, which in turn act as a vehicle for long-range signaling. ..
  2. Gomez Lamarca M, Snowdon L, Seib E, Klein T, Bray S. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol. 2015;210:303-18 pubmed publisher
    ..Together, these results highlight the importance of Rme-8 in coordinating normal endocytic recycling route and reveal that its absence predisposes toward conditions in which pathological Notch signaling can occur. ..
  3. Han C, Song Y, Xiao H, Wang D, Franc N, Jan L, et al. Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila. Neuron. 2014;81:544-560 pubmed publisher
    ..Our finding reveals the physiological importance of coordination between neurons and their surrounding epidermis, for both dendrite fragmentation and clearance. ..
  4. Stempfle D, Kanwar R, Loewer A, Fortini M, Merdes G. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol. 2010;30:3165-75 pubmed publisher
  5. Lone M, Kungl T, Koper A, Bottenberg W, KAMMERER R, Klein M, et al. The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila. J Cell Sci. 2010;123:2369-74 pubmed publisher
    ..This finding suggests the existence of a relationship between nuclear functions and endolysosomal trafficking. Future studies of Wah function will give us insights into this interesting phenomenon. ..
  6. Buchon N, Broderick N, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 2010;8:152 pubmed publisher
    ..We show that one signaling pathway, the EGFR pathway, is central to all these stages, and its activation at multiple steps could synchronize the complex cellular events leading to gut repair and homeostasis. ..
  7. Peltan A, Briggs L, Matthews G, Sweeney S, Smith D. Identification of Drosophila gene products required for phagocytosis of Leishmania donovani. PLoS ONE. 2012;7:e51831 pubmed publisher
    ..These observations suggest that this experimental approach has the potential to identify a large number of host effectors required for efficient parasite uptake and maintenance. ..
  8. Tuxworth R, Vivancos V, O Hare M, Tear G. Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways. Hum Mol Genet. 2009;18:667-78 pubmed publisher
    ..We have identified previously unknown interactions between CLN3 and the Notch and Jun N-terminal kinase signalling pathways and have uncovered a potential role for the RNA splicing and localization machinery in regulating CLN3 function. ..
  9. Vaccari T, Duchi S, Cortese K, Tacchetti C, Bilder D. The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development. 2010;137:1825-32 pubmed publisher
    ..The results also suggest that the ionic properties of the endosomal lumen might regulate Notch cleavage, providing a rationale for physiological as well as pathological endocytic control of Notch activity. ..
  10. Takáts S, Pircs K, Nagy P, Varga Ã, Kárpáti M, Hegedűs K, et al. Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell. 2014;25:1338-54 pubmed publisher
    ..Our results establish the role of HOPS and its likely mechanism of action during autophagy in metazoans. ..
  11. Dodson M, Leung L, Lone M, Lizzio M, Guo M. Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo. Dis Model Mech. 2014;7:1351-63 pubmed publisher
    ..Collectively, our data provides compelling evidence of a vital role for lrrk in lysosomal function and endolysosomal membrane transport in vivo, and suggests a link between lrrk and retromer-mediated endosomal recycling. ..
  12. Burlin A, Tillib S. A method to test a chromosomal regulatory element in vivo by its substitutive address insertion into the basic transgenic construct preliminarily integrated into the genome. Dokl Biochem Biophys. 2013;450:167-70 pubmed publisher
  13. Sanchez Garcia J, Arbelaez D, Jensen K, Rincon Limas D, Fernandez Funez P. Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking. Hum Mol Genet. 2013;22:4253-66 pubmed publisher
  14. Günesdogan U, Jackle H, Herzig A. A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. EMBO Rep. 2010;11:772-6 pubmed publisher
  15. Fang X, Zhou J, Liu W, Duan X, Gala U, Sandoval H, et al. Dynamin Regulates Autophagy by Modulating Lysosomal Function. J Genet Genomics. 2016;43:77-86 pubmed publisher
    ..Here, we provide evidence that dynamin also regulates autophagy indirectly by regulating lysosomal function. ..
  16. Feng X, Huang Y, Lu Y, Xiong J, Wong C, Yang P, et al. Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem. 2014;289:4262-72 pubmed publisher
    ..These features resemble more closely to mammalian TRPML1 than TRPML2 and TRPML3, but with some obvious differences. Together, our data support the use of Drosophila for assessing functional significance of TRPML1 in cell physiology. ..