Gene Symbol: Lam
Description: Lamin
Alias: 2459, 74/76, CG6944, DM[[O]], D[[m0]], Dm(0), Dm0, Dm1, Dm2, DmLamin, DmO, Dm[[0]], Dm[[1]], Dm[[2]], Dm[[mit]], Dm[[o]], Dmel\CG6944, Dmo, LAM, Lam Dm[[0]], Lam(Dm0), LamDm, LamDm0, LamDm[[0]], LamDm[[o]], Lam[[Dm0]], Lamin B, Lamin Dm[[0]], jf27, l(2)04643, l(2)25Ec, l(2)gdh-7, l(2)gdh7, l(2)jf27, lam, lamDm0, lamDm[[0]], lamin, lamin B, lamin Dm0, lamin Dm[[0]], lamin-B, misg, nlam, lamin, B-type lamin, CG6944-PA, CG6944-PB, CG6944-PC, CG6944-PD, Lam-PA, Lam-PB, Lam-PC, Lam-PD, Lamin-B, LaminDm, LaminDm0, alpha-Lamin, intermediate filament-like lamina, lamin A, lamin B, lamin D, lamin D[[0]], lamin D[[m0]], lamin D[[m]]0, lamin D[[o]], lamin Dm, lamin Dm0, lamin Dm[[0]], lamin Dmo, lethal(2)25Ec, misguided, misrouted, n-lamin, nuclear lamin
Species: fruit fly
Products:     Lam

Top Publications

  1. Klapper M, Exner K, Kempf A, Gehrig C, Stuurman N, Fisher P, et al. Assembly of A- and B-type lamins studied in vivo with the baculovirus system. J Cell Sci. 1997;110 ( Pt 20):2519-32 pubmed
    ..Xenopus lamin A), a probable A-type lamin (Drosophila lamin C), two B-type lamins (Xenopus lamin LI, Drosophila lamin Dmo), and two mutants of Xenopus lamin A in Sf9 cells...
  2. Muñoz Alarcón A, Pavlovic M, Wismar J, Schmitt B, Eriksson M, Kylsten P, et al. Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. PLoS ONE. 2007;2:e532 pubmed
    ..It is therefore of interest to examine the effects of mutations in lamin genes. Mutations in the mammalian lamin A/C gene cause a range of diseases, collectively called laminopathies, that include muscular dystrophies and ..
  3. Schulze S, Curio Penny B, Speese S, Dialynas G, Cryderman D, McDonough C, et al. A comparative study of Drosophila and human A-type lamins. PLoS ONE. 2009;4:e7564 pubmed publisher
    ..The Drosophila genome possesses two genes encoding lamins, Lamin C and lamin Dm(0), which have been designated A- and B-type, respectively, based on their expression profile and structural ..
  4. Capelson M, Corces V. The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Mol Cell. 2005;20:105-16 pubmed
    ..dTopors associates with the nuclear lamina, and mutations in lamin disrupt dTopors localization as well as nuclear organization and activity of the gypsy insulator...
  5. Martin D, Baehrecke E. Caspases function in autophagic programmed cell death in Drosophila. Development. 2004;131:275-84 pubmed
    ..salivary gland destruction, and coincide with increased levels of active Caspase 3 and a cleaved form of nuclear Lamin. Mutations in the steroid-regulated genes beta FTZ-F1, E93, BR-C and E74A that prevent salivary gland cell ..
  6. Bossie C, Sanders M. A cDNA from Drosophila melanogaster encodes a lamin C-like intermediate filament protein. J Cell Sci. 1993;104 ( Pt 4):1263-72 pubmed
    ..Of these, one has been identified as the previously characterized Drosophila nuclear lamin cDNA, Dm0, and a second, pG-IF, demonstrates homology to Dm0 by cross hybridization on Southern blots...
  7. Baricheva E, Berrios M, Bogachev S, Borisevich I, Lapik E, Sharakhov I, et al. DNA from Drosophila melanogaster beta-heterochromatin binds specifically to nuclear lamins in vitro and the nuclear envelope in situ. Gene. 1996;171:171-6 pubmed
    A DNA fragment designated lambda 20p1.4 binds in vitro to polymerized Drosophila melanogaster lamin. In situ hybridization of lambda 20p1...
  8. Walker D, Wang D, Jin Y, Rath U, Wang Y, Johansen J, et al. Skeletor, a novel chromosomal protein that redistributes during mitosis provides evidence for the formation of a spindle matrix. J Cell Biol. 2000;151:1401-12 pubmed
    ..Thus, the identification and characterization of skeletor represents the first direct molecular evidence for the existence of a complete spindle matrix that forms within the nucleus before microtubule spindle formation. ..
  9. Taniue K, Nishida A, Hamada F, Sugie A, Oda T, Ui Tei K, et al. Sunspot, a link between Wingless signaling and endoreplication in Drosophila. Development. 2010;137:1755-64 pubmed publisher
    ..In addition, Ssp was found not to be involved in the signaling pathway mediated by Arm associated with dTCF. Our findings indicate that Arm controls development in part by regulating the function of Ssp. ..

More Information


  1. Abdu U, Brodsky M, Schupbach T. Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk. Curr Biol. 2002;12:1645-51 pubmed
    ..DmChk2 is a transducer of the meiotic checkpoint in flies that is activated by unrepaired double-strand DNA breaks. Activation of DmChk2 in this specific checkpoint affects a cell cycle regulator as well as mRNA translation. ..
  2. Padiath Q, Saigoh K, Schiffmann R, Asahara H, Yamada T, Koeppen A, et al. Lamin B1 duplications cause autosomal dominant leukodystrophy. Nat Genet. 2006;38:1114-23 pubmed
    ..This is the first human disease attributable to mutations in the gene encoding lamin B1. Antibodies to lamin B are found in individuals with autoimmune diseases, and it is also an antigen recognized by a monoclonal antibody ..
  3. Pinto B, Wilmington S, Hornick E, Wallrath L, Geyer P. Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein. Genetics. 2008;180:133-45 pubmed publisher
    ..The tissue-specific, age-enhanced dMAN1 mutant phenotypes are reminiscent of human laminopathies, suggesting that studies in Drosophila will provide insights into lamina dysfunction associated with disease. ..
  4. Wagner N, Weber D, Seitz S, Krohne G. The lamin B receptor of Drosophila melanogaster. J Cell Sci. 2004;117:2015-28 pubmed
    ..Third, dLBR can be shown by co-immunoprecipitations and in vitro binding assays to bind to the Drosophila B-type lamin Dm0. Fourth, the N-terminal domain of dLBR is sufficient for in vitro binding to sperm chromatin and lamin Dm0...
  5. Lancaster O, Breuer M, Cullen C, Ito T, Ohkura H. The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila. PLoS Genet. 2010;6:e1001179 pubmed publisher
    ..Therefore we propose that NHK-1 is a crucial regulator of meiosis and that the meiotic checkpoint suppresses NHK-1 activity to prevent oocyte nuclear reorganisation until DNA breaks are repaired. ..
  6. Goldberg M, Harel A, Brandeis M, Rechsteiner T, Richmond T, Weiss A, et al. The tail domain of lamin Dm0 binds histones H2A and H2B. Proc Natl Acad Sci U S A. 1999;96:2852-7 pubmed
    ..Deletion mutants of Drosophila lamin Dm0 were expressed to map regions of the protein that are required for its binding to chromosomes...
  7. Berry D, Baehrecke E. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell. 2007;131:1137-48 pubmed
  8. Smith D, Gruenbaum Y, Berrios M, Fisher P. Biosynthesis and interconversion of Drosophila nuclear lamin isoforms during normal growth and in response to heat shock. J Cell Biol. 1987;105:771-90 pubmed
    ..Both lamins are apparently derived posttranslationally from a single, primary translation product, lamin Dm0. A pathway has been established whereby lamin Dm0 is processed almost immediately upon synthesis in the ..
  9. Schulze S, Curio Penny B, Li Y, Imani R, Rydberg L, Geyer P, et al. Molecular genetic analysis of the nested Drosophila melanogaster lamin C gene. Genetics. 2005;171:185-96 pubmed
    ..These transgenic animals display a nuclear lamin aggregation phenotype remarkably similar to that observed when human mutant A-type lamins are expressed in ..
  10. Arama E, Agapite J, Steller H. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev Cell. 2003;4:687-97 pubmed
    ..These observations suggest that an apoptosis-like mechanism is required for spermatid differentiation in Drosophila. ..
  11. Ulitzur N, Harel A, Feinstein N, Gruenbaum Y. Lamin activity is essential for nuclear envelope assembly in a Drosophila embryo cell-free extract. J Cell Biol. 1992;119:17-25 pubmed
    The role of the Drosophila lamin protein in nuclear envelope assembly was studied using a Drosophila in vitro assembly system that reconstitutes nuclei from added sperm chromatin or naked DNA...
  12. Civelekoglu Scholey G, Tao L, Brust Mascher I, Wollman R, Scholey J. Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope. J Cell Biol. 2010;188:49-68 pubmed publisher
    ..Functional perturbation and modeling suggest that this range can be extended significantly by a disassembling lamin-B envelope that surrounds the prometaphase spindle and augments the finely tuned, antagonistic kinesin force ..
  13. Patterson K, Molofsky A, Robinson C, Acosta S, Cater C, Fischer J. The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye. Mol Biol Cell. 2004;15:600-10 pubmed
    ..In addition, in a genetic screen for klarsicht-interacting genes, we identified Lam Dm(0), which encodes nuclear lamin. We find that, like Klarsicht, lamin is required for photoreceptor nuclear migration and for nuclear ..
  14. Gemkow M, Verveer P, Arndt Jovin D. Homologous association of the Bithorax-Complex during embryogenesis: consequences for transvection in Drosophila melanogaster. Development. 1998;125:4541-52 pubmed
    ..We examined the onset of pairing of the chromosome 4 as well as of loci near the centromere of chromosome 3 and near the telomere of 3R in order to test models for the mechanism of homologue pairing. ..
  15. Fung J, Marshall W, Dernburg A, Agard D, Sedat J. Homologous chromosome pairing in Drosophila melanogaster proceeds through multiple independent initiations. J Cell Biol. 1998;141:5-20 pubmed
    ..Thus, we conclude that simple random contacts through diffusion could suffice to allow pairing of homologous sites. ..
  16. Zaremba Czogalla M, Gagat P, Kozioł K, Dubińska Magiera M, Sikora J, Dadlez M, et al. Identification of new in vivo phosphosites on lamin Dm - the evidence of heterogeneity of phosphorylation sites in different Drosophila tissues. Nucleus. 2011;2:478-88 pubmed publisher
    ..Here, we report the identification of new in vivo phosphorylation sites on Drosophila melanogater lamin Dm using immunoisolation and mass spectrometry with collision-induced peptide fragmentation (Electrospray-Linear ..
  17. Marshall W, Dernburg A, Harmon B, Agard D, Sedat J. Specific interactions of chromatin with the nuclear envelope: positional determination within the nucleus in Drosophila melanogaster. Mol Biol Cell. 1996;7:825-42 pubmed
  18. Fraser A, McCarthy N, Evan G. drICE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J. 1997;16:6192-9 pubmed
    ..expression or cycloheximide treatment contain a caspase activity with DEVD specificity which can cleave p35, lamin DmO, drICE and DCP-1 in vitro, and which can trigger chromatin condensation in isolated nuclei...
  19. Pickersgill H, Kalverda B, de Wit E, Talhout W, Fornerod M, van Steensel B. Characterization of the Drosophila melanogaster genome at the nuclear lamina. Nat Genet. 2006;38:1005-14 pubmed
    ..Using an in vivo approach, we identified approximately 500 Drosophila melanogaster genes that interact with B-type lamin (Lam)...
  20. Furukawa K, Ishida K, Tsunoyama T, Toda S, Osoda S, Horigome T, et al. A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells. Exp Cell Res. 2009;315:1181-9 pubmed publisher
    ..nuclear lamina re-assembly in vivo, Drosophila A-type and B-type lamins were artificially expressed in Drosophila lamin Dm(0)null mutant brain cells...
  21. Byrd K, Corces V. Visualization of chromatin domains created by the gypsy insulator of Drosophila. J Cell Biol. 2003;162:565-74 pubmed
    ..These results suggest that the gypsy insulator might establish higher-order domains of chromatin structure and regulate nuclear organization by tethering the DNA to the nuclear matrix and creating chromatin loops. ..
  22. van Bemmel J, Pagie L, Braunschweig U, Brugman W, Meuleman W, Kerkhoven R, et al. The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome. PLoS ONE. 2010;5:e15013 pubmed publisher
    ..Our results provide insights into the evolution of LAD organization and identify SU(HW) as a fine-tuner of genome - NL interactions...
  23. Brandt A, Krohne G, Grosshans J. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Aging Cell. 2008;7:541-51 pubmed publisher
    ..The expression of laminDelta50, a constitutively active lamin A splicing variant in Hutchinson-Gilford progeria syndrome patients, leads to the lobulation of the nuclear ..
  24. Daish T, Mills K, Kumar S. Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell. 2004;7:909-15 pubmed
    ..Our results indicate that DRONC is involved in specific developmental cell death pathways and that in some tissues, effector caspase activation and cell death can occur independently of DRONC. ..
  25. Paddy M, Belmont A, Saumweber H, Agard D, Sedat J. Interphase nuclear envelope lamins form a discontinuous network that interacts with only a fraction of the chromatin in the nuclear periphery. Cell. 1990;62:89-106 pubmed
    Antibodies directed against nuclear envelope lamin proteins have been used in conjunction with three-dimensional light and electron microscope methodologies to determine the spatial organization of lamins in diploid interphase nuclei and ..
  26. Mattout A, Goldberg M, Tzur Y, Margalit A, Gruenbaum Y. Specific and conserved sequences in D. melanogaster and C. elegans lamins and histone H2A mediate the attachment of lamins to chromosomes. J Cell Sci. 2007;120:77-85 pubmed
    ..have mapped a region between the rod domain and the Ig fold in the tail domain of Drosophila melanogaster lamin Dm0, which binds chromatin in vitro via the histone H2A/H2B dimer...
  27. Wagner N, Schmitt J, Krohne G. Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel). Eur J Cell Biol. 2004;82:605-16 pubmed
    ..By RNA interference we have down-regulated the expression of Bocksbeutel, BAF, otefin, and lamin DmO in Drosophila Kc167 cells...
  28. Rzepecki R, Bogachev S, Kokoza E, Stuurman N, Fisher P. In vivo association of lamins with nucleic acids in Drosophila melanogaster. J Cell Sci. 1998;111 ( Pt 1):121-9 pubmed
    ..Interactions with DNA as well as RNA were detected. In contrast, interaction of nucleic acids with mitotic lamin was not observed...
  29. Rzepecki R, Fisher P. During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain. J Cell Sci. 2000;113 ( Pt 9):1635-47 pubmed
    ..Our observations suggest that cell cycle-dependent changes in the distribution, nucleic acid interactions and enzymatic activity of topo II are regulated, at least in part, by phosphorylation/dephosphorylation. ..
  30. Ashery Padan R, Ulitzur N, Arbel A, Goldberg M, Weiss A, Maus N, et al. Localization and posttranslational modifications of otefin, a protein required for vesicle attachment to chromatin, during Drosophila melanogaster development. Mol Cell Biol. 1997;17:4114-23 pubmed
    ..With the exception of sperm cells, otefin colocalizes with lamin Dm0 derivatives in situ and presumably in vivo and is present in all somatic cells examined during the different ..
  31. Hadjieconomou D, Rotkopf S, Alexandre C, Bell D, Dickson B, Salecker I. Flybow: genetic multicolor cell labeling for neural circuit analysis in Drosophila melanogaster. Nat Methods. 2011;8:260-6 pubmed publisher
  32. Smith D, Fisher P. Interconversion of Drosophila nuclear lamin isoforms during oogenesis, early embryogenesis, and upon entry of cultured cells into mitosis. J Cell Biol. 1989;108:255-65 pubmed
    Two isoforms of a single nuclear lamin, distinguishable on one-dimensional SDS-polyacrylamide gels, have previously been identified in Drosophila nuclei during interphase...
  33. Lancaster O, Cullen C, Ohkura H. NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus. J Cell Biol. 2007;179:817-24 pubmed
    ..We propose that BAF phosphorylation by NHK-1 disrupts anchorage of chromosomes to the nuclear envelope, allowing karyosome formation in oocytes. These data provide the first mechanistic insight into how the karyosome forms. ..
  34. Riemer D, Stuurman N, Berrios M, Hunter C, Fisher P, Weber K. Expression of Drosophila lamin C is developmentally regulated: analogies with vertebrate A-type lamins. J Cell Sci. 1995;108 ( Pt 10):3189-98 pubmed
    ..the pG-IF encoded protein is expressed and whether it encodes a cytoplasmic intermediate filament protein or a nuclear lamin we raised antibodies against the recombinant pG-IF protein...
  35. Schneider U, Mini T, Jeno P, Fisher P, Stuurman N. Phosphorylation of the major Drosophila lamin in vivo: site identification during both M-phase (meiosis) and interphase by electrospray ionization tandem mass spectrometry. Biochemistry. 1999;38:4620-32 pubmed
    ..tandem mass spectrometry, we determined the phosphorylation sites of both interphase and M-phase isoforms of nuclear lamin Dm from Drosophila melanogaster...
  36. Lince Faria M, Maffini S, Orr B, Ding Y, Cláudia Florindo -, Sunkel C, et al. Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator. J Cell Biol. 2009;184:647-57 pubmed publisher
  37. Melcer S, Gruenbaum Y, Krohne G. Invertebrate lamins. Exp Cell Res. 2007;313:2157-66 pubmed
    ..Studying lamins in invertebrate species has unique advantages including the smaller number of lamin genes in the invertebrate genomes and powerful genetic analyses in Caenorhabditis elegans and Drosophila ..
  38. Furukawa K, Sugiyama S, Osouda S, Goto H, Inagaki M, Horigome T, et al. Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila. J Cell Sci. 2003;116:3811-23 pubmed
    ..At the light microscopic level, grossly aberrant nuclear lamina structure and B-type lamin distribution correlated well with the loss of detectable amounts of BAF protein from nuclei...
  39. Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, et al. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Dev Biol. 2005;284:219-32 pubmed
    ..Although in all these mutants, lamin Dm(0) protein was undetectable in neuroblasts and imaginal disc cells from the second instar larval stage onward, ..
  40. Nabel Rosen H, Dorevitch N, Reuveny A, Volk T. The balance between two isoforms of the Drosophila RNA-binding protein how controls tendon cell differentiation. Mol Cell. 1999;4:573-84 pubmed
    ..This inhibition is likely to be counteracted by the short How(S) protein, present in both nucleus and cytoplasm, which is upregulated in the muscle-bound tendon cell following EGF receptor activation. ..
  41. Stuurman N, Delbecque J, Callaerts P, Aebi U. Ectopic overexpression of Drosophila lamin C is stage-specific lethal. Exp Cell Res. 1999;248:350-7 pubmed
    ..we transformed Drosophila melanogaster with a construct containing the hsp70 promoter followed by the Drosophila lamin C (an analog of vertebrate A-type lamins) cDNA...
  42. Brandt A, Papagiannouli F, Wagner N, Wilsch Bräuninger M, Braun M, Furlong E, et al. Developmental control of nuclear size and shape by Kugelkern and Kurzkern. Curr Biol. 2006;16:543-52 pubmed
    ..We propose that association of farnesylated Kugelkern with the inner nuclear membrane induces expansion of nuclear surface area, allowing nuclear growth. ..
  43. Prüfert K, Vogel A, Krohne G. The lamin CxxM motif promotes nuclear membrane growth. J Cell Sci. 2004;117:6105-16 pubmed
    ..the influence of lamins on nuclear envelope growth in cultured Xenopus A6 cells by the overexpression of human lamin A, Xenopus and zebrafish lamins B2 and Drosophila lamins Dm0 and C as GFP fusion proteins...
  44. Guillemin K, Williams T, Krasnow M. A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila. Nat Cell Biol. 2001;3:848-51 pubmed
    ..Here we present evidence that a nuclear lamin is also required for cytoplasmic organization in two highly polarized cell types...
  45. Filson A, Lewis A, Blobel G, Fisher P. Monoclonal antibodies prepared against the major Drosophila nuclear Matrix-pore complex-lamina glycoprotein bind specifically to the nuclear envelope in situ. J Biol Chem. 1985;260:3164-72 pubmed
    ..Ottaviano, Y., and Kondor-Koch, C. (1982) J. Cell Biol. 95, 826-837). ..
  46. Starr D, Fischer J. KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins. Bioessays. 2005;27:1136-46 pubmed
  47. Osman M, Paz M, Landesman Y, Fainsod A, Gruenbaum Y. Molecular analysis of the Drosophila nuclear lamin gene. Genomics. 1990;8:217-24 pubmed
    A complete nucleotide sequence of a 4.2-kb genomic fragment containing the Drosophila lamin gene and flanking sequences is presented...
  48. Dialynas G, Speese S, Budnik V, Geyer P, Wallrath L. The role of Drosophila Lamin C in muscle function and gene expression. Development. 2010;137:3067-77 pubmed publisher
    ..The GAL4-UAS system was used to express wild-type and mutant forms of Lamin C (the presumed Drosophila A-type lamin), in an otherwise wild-type background...
  49. Zhao K, Harel A, Stuurman N, Guedalia D, Gruenbaum Y. Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state. FEBS Lett. 1996;380:161-4 pubmed
    ..M/SARs bind in vitro to lamin polymers. We show that the polymerized alpha-helical rod domain of lamin Dm0 provides by itself the specific binding to the ftz M/SAR...
  50. Prokopenko S, Brumby A, O KEEFE L, Prior L, He Y, Saint R, et al. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 1999;13:2301-14 pubmed
    ..Our results identify Pbl as a RhoGEF specifically required for cytokinesis and linked through Rho1 activity to the reorganization of the actin cytoskeleton at the cleavage furrow. ..
  51. Paddy M, Saumweber H, Agard D, Sedat J. Time-resolved, in vivo studies of mitotic spindle formation and nuclear lamina breakdown in Drosophila early embryos. J Cell Sci. 1996;109 ( Pt 3):591-607 pubmed
    ..The process of lamin delocalization and dispersal, typical of 'open' forms of mitosis, does not begin until about the time the final, ..
  52. Kracklauer M, Banks S, Xie X, Wu Y, Fischer J. Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye. Fly (Austin). 2007;1:75-85 pubmed
    ..Finally, while perinuclear Klaroid is ubiquitous in the eye, Klarsicht expression is limited to differentiating cells and may be part of the trigger for apical nuclear migration. ..
  53. Beard G, Bridger J, Kill I, Tree D. Towards a Drosophila model of Hutchinson-Gilford progeria syndrome. Biochem Soc Trans. 2008;36:1389-92 pubmed publisher
    The laminopathy Hutchinson-Gilford progeria syndrome (HGPS) is caused by the mutant lamin A protein progerin and leads to premature aging of affected children...
  54. Kumar S, Doumanis J. The fly caspases. Cell Death Differ. 2000;7:1039-44 pubmed
    ..The presence of multiple caspases in Drosophila indicates that apoptotic pathways in insects are likely to be as complex as in vertebrates. ..
  55. Lenz Böhme B, Wismar J, Fuchs S, Reifegerste R, Buchner E, Betz H, et al. Insertional mutation of the Drosophila nuclear lamin Dm0 gene results in defective nuclear envelopes, clustering of nuclear pore complexes, and accumulation of annulate lamellae. J Cell Biol. 1997;137:1001-16 pubmed
    ..Here, we describe a Drosophila lamin Dm0 mutant resulting from a P element insertion into the first intron of the Dm0 gene...
  56. Stuurman N. Identification of a conserved phosphorylation site modulating nuclear lamin polymerization. FEBS Lett. 1997;401:171-4 pubmed
    ..A co-immunoprecipitation assay, employing Drosophila nuclear lamin Dm0 fragments was used to study the effect of phosphorylation on head-to-tail binding...
  57. Gruenbaum Y, Landesman Y, Drees B, Bare J, Saumweber H, Paddy M, et al. Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. J Cell Biol. 1988;106:585-96 pubmed
    ..Southern blot analyses of genomic DNA are consistent with the notion that a single or only a few highly similar genes encoding Drosophila nuclear lamin Dm0 exist in the genome.
  58. Xylourgidis N, Roth P, Sabri N, Tsarouhas V, Samakovlis C. The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in Drosophila. J Cell Sci. 2006;119:4409-19 pubmed
    ..We hypothesize that variation in levels of the Nup214-Nup88 complex at the pore changes the amount of NPC-bound CRM1 and influences the relative strength and duration of NFkappaB signaling responses. ..
  59. Lin L, Fisher P. Immunoaffinity purification and functional characterization of interphase and meiotic Drosophila nuclear lamin isoforms. J Biol Chem. 1990;265:12596-601 pubmed
    Three isoforms of a single nuclear lamin have been identified in Drosophila. Two, lamins Dm1 and Dm2, are present during interphase and are apparently in equilibrium with each other in vivo...
  60. Sasse B, Lustig A, Aebi U, Stuurman N. In vitro assembly of Drosophila lamin Dm0--lamin polymerization properties are conserved. Eur J Biochem. 1997;250:30-8 pubmed
    ..conditions where vertebrate cytoplasmic IF proteins form tetramers consisting of laterally associated dimers, nuclear lamin dimers associate longitudinally into head-to-tail polymers...
  61. Stuurman N, Maus N, Fisher P. Interphase phosphorylation of the Drosophila nuclear lamin: site-mapping using a monoclonal antibody. J Cell Sci. 1995;108 ( Pt 9):3137-44 pubmed
    The Drosophila nuclear lamin is highly phosphorylated during interphase. Two interphase isoforms, differing in degree of phosphorylation, can be distinguished by one-dimensional SDS-polyacrylamide gel electrophoresis...
  62. Pindyurin A, Moorman C, de Wit E, Belyakin S, Belyaeva E, Christophides G, et al. SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila. J Cell Sci. 2007;120:2344-51 pubmed
    ..PcG proteins (Pc and Esc; Polycomb and Extra sexcombs), heterochromatic proteins [HP1 and SU(VAR)3-9] and B-type lamin. The SUUR binding profile negatively correlates with the DNA polytenization levels of salivary gland polytene ..
  63. Uv A, Roth P, Xylourgidis N, Wickberg A, Cantera R, Samakovlis C. members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Genes Dev. 2000;14:1945-57 pubmed
    ..Our results demonstrate that distinct nuclear import events require different nucleoporins in vivo and suggest a regulatory role for mbo in signal transduction. ..
  64. Herrmann H, Strelkov S. History and phylogeny of intermediate filaments: now in insects. BMC Biol. 2011;9:16 pubmed publisher
    ..Here we briefly review the history of research on intermediate filaments, and discuss the implications of this latest finding in the context of what is known of their structure and functions. ..