Gene Symbol: l(2)37Cd
Description: lethal (2) 37Cd
Alias: CG10563, Dmel\CG10563, lethal (2) 37Cd, CG10563-PA, l(2)37Cd-PA
Species: fruit fly

Top Publications

  1. Gilbert D, Hirsh J, Wright T. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Genetics. 1984;106:679-94 pubmed
    ..Six of these complementation groups are within 23 kb of DNA, and all ten complementation groups, including Ddc, lie within 78-82 kb of DNA. The potential significance of this unusually high gene density is discussed. ..
  2. Wright T, Beermann W, Marsh J, Bishop C, Steward R, Black B, et al. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region. Chromosoma. 1981;83:45-58 pubmed
    ..It eliminates Ddc+ and 1(2)37Ca+ function and at 30 degrees C reduces 1(2)37Ce+ function. It is not a deficiency but could be a polar mutant. ..
  3. Fujiyama Nakamura S, Ito S, Sawatsubashi S, Yamauchi Y, Suzuki E, Tanabe M, et al. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Genes Cells. 2009;14:965-73 pubmed publisher
    ..These findings suggest that dKLHL18 is an adaptor for a dCul3 E3 ubiquitin ligase to accommodate CG10324, CG5808 and l(2)37Cb proteins for ubiquitination. ..
  4. Marsh J, Gibbs P, Timmons P. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Mol Gen Genet. 1985;198:393-403 pubmed
    ..Possible reasons for the differences between the regulation of transduced genes in Drosophila and the regulation of transformed genes in mammalian systems are discussed. ..
  5. Pentz E, Wright T. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Genetics. 1986;112:843-59 pubmed
    ..The Dox-A2 locus is within 3.4 to 4.4 kb of the Df(2L)OD15 breakpoint, placing four of the vital loci within a maximum of 15.5 kb. The location of Dox-A2 in a cluster of genes affecting cuticle formation is discussed. ..
  6. Stathakis D, Pentz E, Freeman M, Kullman J, Hankins G, Pearlson N, et al. The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. Genetics. 1995;141:629-55 pubmed
  7. Wright T. The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster. J Hered. 1996;87:175-90 pubmed
    ..Thus, the Ddc gene cluster represents in higher eukaryotes an unusual example of a large cluster of functionally related genes involved in a common physiological process. ..
  8. McCrady E, Tolin D. Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in Drosophila. J Exp Zool. 1994;268:469-76 pubmed
    ..Heteroallelic heterozygotes of Bd7 x Bd4 also produced fully fertile ovaries, but no other heteroallelic combinations did so.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  9. Stone E, Ayroles J. Modulated modularity clustering as an exploratory tool for functional genomic inference. PLoS Genet. 2009;5:e1000479 pubmed publisher
    ..We show MMC to be effective and suitable to applications of large scale. In light of these features, we advocate MMC as a standard tool for exploration and hypothesis generation. ..