Gene Symbol: kuk
Description: kugelkern
Alias: CG5175, Dmel\CG5175, Kuk, char, kuk/char, kugelkern, CG5175-PA, CG5175-PB, CG5175-PC, Kugelkern/Charleston, charleston, kugelkem, kuk-PA, kuk-PB, kuk-PC
Species: fruit fly

Top Publications

  1. Brandt A, Papagiannouli F, Wagner N, Wilsch Bräuninger M, Braun M, Furlong E, et al. Developmental control of nuclear size and shape by Kugelkern and Kurzkern. Curr Biol. 2006;16:543-52 pubmed
    ..5-fold increase in nuclear length during cellularization. We identified two genes, kugelkern and kurzkern, required for nuclear elongation...
  2. Brandt A, Krohne G, Grosshans J. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Aging Cell. 2008;7:541-51 pubmed publisher
    ..these age-related changes are laminDelta50 specific or whether proteins that affect nuclear shape such as KUGELKERN or LAMIN B in general play a causative role in senescence...
  3. Melcer S, Gruenbaum Y. Nuclear morphology: when round kernels do the Charleston. Curr Biol. 2006;16:R195-7 pubmed
    New studies in Drosophila have identified a novel nuclear envelope protein with a farnesyl moiety, termed Kugelkern/Charleston, that helps regulate the size, shape and position of cellular blastoderm nuclei.
  4. Polychronidou M, Hellwig A, Grosshans J. Farnesylated nuclear proteins Kugelkern and lamin Dm0 affect nuclear morphology by directly interacting with the nuclear membrane. Mol Biol Cell. 2010;21:3409-20 pubmed publisher
    ..the molecular mechanism behind nuclear shape changes, we analyzed how the farnesylated nuclear envelope proteins Kugelkern and lamin Dm0 affect the structure of the nuclear membrane...
  5. Polychronidou M, Grobhans J. Determining nuclear shape: the role of farnesylated nuclear membrane proteins. Nucleus. 2011;2:17-23 pubmed publisher
    ..Based on recent work with the two farnesylated nuclear membrane Drosophila proteins, kugelkern and lamin Dm0, we propose that the direct interaction of farnesylated nuclear membrane proteins with the ..
  6. Hampoelz B, Azou Gros Y, Fabre R, Markova O, Puech P, Lecuit T. Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos. Development. 2011;138:3377-86 pubmed publisher
    ..However, MT bundles cannot produce grooves when the farnesylated inner nuclear membrane protein Kugelkern (Kuk) is absent...
  7. Demontis F, Piccirillo R, Goldberg A, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013;6:1339-52 pubmed publisher
  8. Pirone L, Xolalpa W, Sigurðsson J, Ramirez J, Pérez C, Gonzalez M, et al. A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation. Sci Rep. 2017;7:40756 pubmed publisher
    ..Ease of use and the flexibility to modify existing vectors will make the bioUbL system a powerful complement to existing strategies for studying this important mode of protein regulation. ..
  9. Sung H, Spangenberg S, Vogt N, Großhans J. Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription. Curr Biol. 2013;23:133-8 pubmed publisher
    ..We propose that activation of zygotic gene expression is the trigger that determines the timely and concerted cell-cycle pause and cellularization. ..

More Information


  1. Iampietro C, Bergalet J, Wang X, Cody N, Chin A, Lefebvre F, et al. Developmentally regulated elimination of damaged nuclei involves a Chk2-dependent mechanism of mRNA nuclear retention. Dev Cell. 2014;29:468-81 pubmed publisher
    ..These results reveal a layer of regulation within the DNA damage surveillance systems that safeguard genome integrity in eukaryotes. ..
  2. Amcheslavsky A, Nie Y, Li Q, He F, Tsuda L, Markstein M, et al. Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila. Development. 2014;141:2621-32 pubmed publisher
    ..The results together suggest that Charlatan does not simply act as an anti-differentiation factor but instead functions to maintain a chromatin structure that is compatible with stem cell properties, including proliferation. ..