Ku80

Summary

Gene Symbol: Ku80
Description: Ku80
Alias: BG:DS09217.6, CG18801, DmKu80, Dmel\CG18801, KU80, ku80, Ku80, CG18801-PA, Ku80-PA
Species: fruit fly
Products:     Ku80

Top Publications

  1. Min B, Weinert B, Rio D. Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks. Proc Natl Acad Sci U S A. 2004;101:8906-11 pubmed
    ..RNA interference (RNAi) to knock down expression of DmBLM and one or both of the Drosophila Ku subunits, DmKu70 or DmKu80. Our results show that upon reduction of DmKu, an increase in small deletions (1-49 bp) and large deletions (>/=..
  2. Lee Y, Langley C. Long-term and short-term evolutionary impacts of transposable elements on Drosophila. Genetics. 2012;192:1411-32 pubmed publisher
  3. Mishra M, Sharma A, Shukla A, Pragya P, Murthy R, de Pomerai D, et al. Transcriptomic analysis provides insights on hexavalent chromium induced DNA double strand breaks and their possible repair in midgut cells of Drosophila melanogaster larvae. Mutat Res. 2013;747-748:28-39 pubmed publisher
    ..We selected two strains, one mutant (ligIV) and another ku80-RNAi (knockdown of ku80), whose functions are essentially linked to NHEJ-DSB repair pathway...
  4. Wesolowska N, Amariei F, Rong Y. Clustering and protein dynamics of Drosophila melanogaster telomeres. Genetics. 2013;195:381-91 pubmed publisher
    ..Based on these results, we propose that clustering is independent of sequence and is likely maintained by an as yet undetermined factor. ..
  5. Juraeva D, Treutlein J, Scholz H, Frank J, Degenhardt F, Cichon S, et al. XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Neuropsychopharmacology. 2015;40:361-71 pubmed publisher
    ..Drosophila mutants with reduced function of Ku80-the homolog of mammalian XRCC5-due to RNAi silencing showed reduced sensitivity to ethanol...
  6. Shaposhnikov M, Proshkina E, Shilova L, Zhavoronkov A, Moskalev A. Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes. Sci Rep. 2015;5:15299 pubmed publisher
    ..homologs of XPF, XPC and AP-endonuclease-1), and repair of double-stranded DNA breaks (homologs of BRCA2, XRCC3, KU80 and WRNexo)...
  7. Sekelsky J, Brodsky M, Burtis K. DNA repair in Drosophila: insights from the Drosophila genome sequence. J Cell Biol. 2000;150:F31-6 pubmed
  8. Sutcliffe J, Brehm A. Of flies and men; p53, a tumour suppressor. FEBS Lett. 2004;567:86-91 pubmed
    ..In addition, studying p53 in Drosophila provides an opportunity to learn about the evolution of tumour suppressors. Here, we will discuss what is known about Drosophila p53 in relation to human p53. ..
  9. Cenci G, Ciapponi L, Gatti M. The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma. 2005;114:135-45 pubmed
    ..We believe that the molecular characterization of these genes will lead to identification of many novel human genes with roles in telomere maintenance. ..

More Information

Publications14

  1. Boutanaev A, Mikhaylova L, Nurminsky D. Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells. FEBS Lett. 2007;581:1707-15 pubmed
    ..Abundance of Ku in the cyst cell cytoplasm suggests the role for Ku subunits in the regulation of sperm individualization. ..
  2. Zhang Y, Lin N, Carroll P, Chan G, Guan B, Xiao H, et al. Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos. Dev Cell. 2008;14:481-93 pubmed publisher
    ..Thus, direct epigenetic regulation of two proapoptotic genes controls cellular sensitivity to cytotoxic stimuli. ..
  3. Chiolo I, Minoda A, Colmenares S, Polyzos A, Costes S, Karpen G. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 2011;144:732-44 pubmed publisher
    ..We propose that the spatial and temporal control of DSB repair in heterochromatin safeguards genome stability by preventing aberrant exchanges between repeats. ..
  4. Zhang C, Hong Z, Ma W, Ma D, Qian Y, Xie W, et al. Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE. 2013;8:e78652 pubmed publisher
    ..an additional essential role of UTX in the DNA damage response, in which it upregulates the expression of ku80 in Drosophila, both in cultured cells and in third instar larvae...
  5. Melnikova L, Biessmann H, Georgiev P. The Ku protein complex is involved in length regulation of Drosophila telomeres. Genetics. 2005;170:221-35 pubmed
    ..Here we show that a decrease in Ku70 or Ku80 gene dosage causes a sharp increase in the frequency of HeT-A and TART attachments to a broken chromosome end and ..