Gene Symbol: koi
Description: klaroid
Alias: BEST:LD11166, CG18584, CG3287, CG44154, Dmel\CG44154, Dmel_CG18584, Dmel_CG3287, Koi, n(2)09967, klaroid, CG44154-PA, CG44154-PB, CG44154-PC, CG44154-PD, CG44154-PE, CG44154-PF, koi-PA, koi-PB, koi-PC, koi-PD, koi-PE, koi-PF
Species: fruit fly

Top Publications

  1. Starr D, Fischer J. KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins. Bioessays. 2005;27:1136-46 pubmed
  2. Kracklauer M, Banks S, Xie X, Wu Y, Fischer J. Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye. Fly (Austin). 2007;1:75-85 pubmed
    ..is it like Klarsicht, obviously essential for nuclear positioning only in the eye? Here, we identify Drosophila Klaroid, a SUN protein that tethers Klarsicht...
  3. Technau M, Roth S. The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis. Fly (Austin). 2008;2:82-91 pubmed
    ..Germ line nuclear envelope localization of both KASH domain proteins depends on klaroid, the only Drosophila SUN domain homolog expressed in females...
  4. Dialynas G, Speese S, Budnik V, Geyer P, Wallrath L. The role of Drosophila Lamin C in muscle function and gene expression. Development. 2010;137:3067-77 pubmed publisher
    ..These data demonstrate connections among the Drosophila A-type lamin, hormone-induced gene expression and muscle function. ..
  5. Elhanany Tamir H, Yu Y, Shnayder M, Jain A, WELTE M, Volk T. Organelle positioning in muscles requires cooperation between two KASH proteins and microtubules. J Cell Biol. 2012;198:833-46 pubmed publisher
    ..Thus, our results describe a novel mechanism of nuclear spacing in striated muscles controlled by the cooperative activity of MSP-300, Klar, and astral MTs, and demonstrate its physiological significance. ..
  6. Yadlapalli S, Yamashita Y. Chromosome-specific nonrandom sister chromatid segregation during stem-cell division. Nature. 2013;498:251-4 pubmed publisher
    ..We propose that nonrandom sister chromatid segregation may serve to transmit distinct information carried on two sister chromatids to the daughters of asymmetrically dividing stem cells. ..
  7. Huelsmann S, Ylanne J, Brown N. Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells. Dev Cell. 2013;26:604-15 pubmed publisher
    ..We provide a revised model for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery. ..
  8. Ramdas N, Shivashankar G. Cytoskeletal control of nuclear morphology and chromatin organization. J Mol Biol. 2015;427:695-706 pubmed publisher
    ..Taken together, we suggest that perinuclear actin and basolateral microtubule organization exerts mechanical control on nuclear morphology and chromatin dynamics. ..
  9. Myat M, Rashmi R, Manna D, Xu N, Patel U, Galiano M, et al. Drosophila KASH-domain protein Klarsicht regulates microtubule stability and integrin receptor localization during collective cell migration. Dev Biol. 2015;407:103-14 pubmed publisher
    ..In muscles and photoreceptors, KASH isoforms of Klar work together with Klaroid (Koi), a SUN domain protein, to position nuclei; however, loss of Koi had no effect on salivary gland migration, ..

More Information


  1. Christophorou N, Rubin T, Bonnet I, Piolot T, Arnaud M, Huynh J. Microtubule-driven nuclear rotations promote meiotic chromosome dynamics. Nat Cell Biol. 2015;17:1388-400 pubmed publisher
    ..We further found that Klaroid (SUN) and Klarsicht (KASH) co-localize with centromeres at the nuclear envelope and are required for proper ..
  2. Starr D, Han M. ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci. 2003;116:211-6 pubmed
    ..Syne/ANC-1 anchors nuclei by directly tethering the nuclear envelope to the actin cytoskeleton, and UNC-84/SUN functions at the nuclear envelope to recruit Syne/ANC-1. ..
  3. Commisso C, Boulianne G. The neuralized homology repeat 1 domain of Drosophila neuralized mediates nuclear envelope association and delta-dependent inhibition of nuclear import. J Mol Biol. 2008;375:1125-40 pubmed
    ..Altogether, our data demonstrate that Neur localizes to the nuclear envelope and that this localization can be negatively regulated by Dl, suggesting a possible nuclear function for Neur in Drosophila. ..
  4. Hampoelz B, Azou Gros Y, Fabre R, Markova O, Puech P, Lecuit T. Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos. Development. 2011;138:3377-86 pubmed publisher
    ..Thus, the NE is a dynamic organelle, fluctuations of which increase chromatin dynamics. We propose that such mechanical regulation of chromatin dynamics by MTs might be important for gene regulation...
  5. Dialynas G, Flannery K, Zirbel L, Nagy P, Mathews K, Moore S, et al. LMNA variants cause cytoplasmic distribution of nuclear pore proteins in Drosophila and human muscle. Hum Mol Genet. 2012;21:1544-56 pubmed publisher
    ..of larval body wall muscle revealed that the mutant A-type lamin, B-type lamins, the Sad1p, UNC-84 domain protein Klaroid and nuclear pore complex proteins were mislocalized to the cytoplasm...
  6. Wesolowska N, Amariei F, Rong Y. Clustering and protein dynamics of Drosophila melanogaster telomeres. Genetics. 2013;195:381-91 pubmed publisher
    ..Based on these results, we propose that clustering is independent of sequence and is likely maintained by an as yet undetermined factor. ..
  7. Ryu T, Spatola B, Delabaere L, Bowlin K, Hopp H, Kunitake R, et al. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nat Cell Biol. 2015;17:1401-11 pubmed publisher