Gene Symbol: Kmn1
Description: kinetochore Mis12-Ndc80 network component 1
Alias: CG1558, CT4038, Dmel\CG1558, Nsl1, anon-WO03040301.201, dmNsl1R, l(1)G0237, nsl1, kinetochore Mis12-Ndc80 network component 1, CG1558-PA, CG1558-PB, Kmn1-PA, Kmn1-PB, Nsl1-related protein, l(1)G0237, lethal (1) G0237
Species: fruit fly

Top Publications

  1. Schittenhelm R, Heeger S, Althoff F, Walter A, Heidmann S, Mechtler K, et al. Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes. Chromosoma. 2007;116:385-402 pubmed
    ..The N terminus of Cenp-C is further out, clustered with Mis12 and the Spc25 end of the rod-like Ndc80 complex, which is known to bind to microtubules at its other more distal Ndc80/Nuf2 end. ..
  2. González J, Lenkov K, Lipatov M, Macpherson J, Petrov D. High rate of recent transposable element-induced adaptation in Drosophila melanogaster. PLoS Biol. 2008;6:e251 pubmed publisher
    ..Such a high rate of TE-induced adaptation is inconsistent with the number of fixed TEs in the D. melanogaster genome, and we discuss possible explanations for this discrepancy. ..
  3. Schittenhelm R, Chaleckis R, Lehner C. Intrakinetochore localization and essential functional domains of Drosophila Spc105. EMBO J. 2009;28:2374-86 pubmed publisher
    ..Spc105 seems to provide a platform within the outer kinetochore allowing independent assembly of various kinetochore components. ..
  4. González J, Karasov T, Messer P, Petrov D. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. PLoS Genet. 2010;6:e1000905 pubmed publisher
    ..We argue that reverse population genomic analyses, as the one described in this work, are necessary to arrive at a comprehensive picture of adaptation. ..
  5. Venkei Z, Przewloka M, Glover D. Drosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. Genetics. 2011;187:131-40 pubmed publisher
    ..We show that despite the sequential kinetochore recruitment of Mis12 complex subunits Mis12 and Nsl1, the complex acts as a single functional unit...
  6. Przewloka M, Venkei Z, Bolanos Garcia V, Debski J, Dadlez M, Glover D. CENP-C is a structural platform for kinetochore assembly. Curr Biol. 2011;21:399-405 pubmed publisher
    ..Thus, the N-terminal part of Drosophila CENP-C is sufficient to recruit core kinetochore components and acts as the principal linkage between centromere and kinetochore during mitosis. ..
  7. Meller V, Rattner B. The roX genes encode redundant male-specific lethal transcripts required for targeting of the MSL complex. EMBO J. 2002;21:1084-91 pubmed
    ..Therefore, the roX1 and roX2 genes produce redundant, male-specific lethal transcripts required for targeting the MSL complex. ..
  8. Williams B, Leung G, Maiato H, Wong A, Li Z, Williams E, et al. Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila. J Cell Sci. 2007;120:3522-33 pubmed
    ..Despite the crucial role of Mitch in cell division, the mitch gene has evolved very rapidly among species in the genus Drosophila. ..
  9. Schittenhelm R, Althoff F, Heidmann S, Lehner C. Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1. J Cell Sci. 2010;123:3768-79 pubmed publisher
    ..We demonstrate that the low amount of endogenous Cal1 prevents centromere expansion and mitotic kinetochore failure when Cenp-A/Cid and Cenp-C are present in excess. ..

More Information


  1. Venkei Z, Przewloka M, Ladak Y, Albadri S, Sossick A, Juhasz G, et al. Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore. Open Biol. 2012;2:110032 pubmed publisher
    ..Our study thus indicates that physical accessibility of kinetochore components plays a crucial role in the regulation of Drosophila kinetochore assembly and leads us to a model in which Spc105 is a licensing factor for its onset. ..
  2. Morais da Silva S, Moutinho Santos T, Sunkel C. A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. J Cell Biol. 2013;201:385-93 pubmed publisher
    ..Our data suggest that Bub3 has a nonkinetochore-dependent function that is consistent with its role as a tumor suppressor. ..
  3. Mateo L, Ullastres A, González J. A transposable element insertion confers xenobiotic resistance in Drosophila. PLoS Genet. 2014;10:e1004560 pubmed publisher
    ..We showed that other than being incorporated into Kmn1 transcript, FBti0019627 insertion also affects the polyadenylation signal choice of CG11699 gene...
  4. Lipinszki Z, Lefevre S, Savoian M, Singleton M, Glover D, Przewloka M. Centromeric binding and activity of Protein Phosphatase 4. Nat Commun. 2015;6:5894 pubmed publisher
    ..We also show that binding of Flfl to CENP-C is required to bring PP4 activity to centromeres to maintain CENP-C and attached core kinetochore proteins at chromosomes during mitosis. ..
  5. Richter M, Poznanski J, Zdziarska A, Czarnocki Cieciura M, Lipinszki Z, Dadlez M, et al. Network of protein interactions within the Drosophila inner kinetochore. Open Biol. 2016;6:150238 pubmed publisher
    ..Adjacent to these interacting CCs is a carboxy-terminal domain that also interacts with Nsl1. The amino-terminal parts of Mis12 and Nnf1 form a CENP-C-binding surface, which docks the complex and thus the ..
  6. Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, et al. Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Open Biol. 2016;6:150236 pubmed publisher
    ..Our studies shed light on the structural and functional organization of a highly divergent kinetochore particle. ..
  7. Clemente Ruiz M, Muzzopappa M, Milan M. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Cell Cycle. 2014;13:1450-5 pubmed publisher
    ..Here we re-examined this proposal. In contrast to the previous report, we observed that depletion of CENP-E or Nsl1-the latter mediating kinetochore targeting of Bub3-in epithelial tissues unable to activate the apoptotic program ..