Gene Symbol: kis
Description: kismet
Alias: 136/31, 2532, 5841, BEST:GM02209, CG18326, CG3660, CG3696, DmelPex20, Dmel\CG3696, EC2-7, EK2-4, EP(2)0474, EP474, FBtr0078144, GM02209, KIS, KIS-L, Kis, Pex20, Su(Pc)21AB, anon-WO0172774.164, anon-WO0257455.5, kiss, l(2)07812, l(2)k08827, l(2)k11324, l(2)k13631, l(2)k14112, l(2)k16510, l(2)s3527, l(2)s4771, l(2)s4793, kismet, CG3696-PA, CG3696-PB, CG3696-PC, CG3696-PD, CG3696-PE, CG3696-PF, EP474, kis-PA, kis-PB, kis-PC, kis-PD, kis-PE, kis-PF, lethal (2) k11324, lethal (2) k16510, peroxin 20
Species: fruit fly

Top Publications

  1. Melicharek D, Ramirez L, Singh S, Thompson R, Marenda D. Kismet/CHD7 regulates axon morphology, memory and locomotion in a Drosophila model of CHARGE syndrome. Hum Mol Genet. 2010;19:4253-64 pubmed publisher
    ..Here, we show that the Drosophila homolog of Chd7, kismet, is required for proper axonal pruning, guidance and extension in the developing fly's central nervous system...
  2. Oh S, Kingsley T, Shin H, Zheng Z, Chen H, Chen X, et al. A P-element insertion screen identified mutations in 455 novel essential genes in Drosophila. Genetics. 2003;163:195-201 pubmed
    ..Our mutation collection represents approximately 56% of the second chromosome vital genes and approximately 24% of the total vital Drosophila genes. ..
  3. Lopez A, Higuet D, Rosset R, Deutsch J, Peronnet F. corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae. Mol Genet Genomics. 2001;266:572-83 pubmed
    ..corto also genetically interacts with a number of trx-G genes (ash1, kismet, kohtalo, moira, osa, Trithorax-like and Vha55)...
  4. Srinivasan S, Armstrong J, Deuring R, Dahlsveen I, McNeill H, Tamkun J. The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II. Development. 2005;132:1623-35 pubmed
    The Drosophila trithorax group gene kismet (kis) was identified in a screen for extragenic suppressors of Polycomb (Pc) and subsequently shown to play important roles in both segmentation and the determination of body segment identities...
  5. Srinivasan S, Dorighi K, Tamkun J. Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II. PLoS Genet. 2008;4:e1000217 pubmed publisher
    ..The trithorax group protein Kismet-L (KIS-L) is a member of the CHD subfamily of chromatin-remodeling factors that plays a global role in ..
  6. Terriente Félix A, Molnar C, Gomez Skarmeta J, de Celis J. A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression. Dev Biol. 2011;350:382-92 pubmed publisher
    ..In this work we identified Kismet, a chromodomain-containing protein of the SNF2-like family of ATPases, as a novel component of the hedgehog ..
  7. Daubresse G, Deuring R, Moore L, Papoulas O, Zakrajsek I, Waldrip W, et al. The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. Development. 1999;126:1175-87 pubmed
    The Drosophila kismet gene was identified in a screen for dominant suppressors of Polycomb, a repressor of homeotic genes...
  8. Melicharek D, Shah A, DiStefano G, Gangemi A, Orapallo A, Vrailas Mortimer A, et al. Identification of novel regulators of atonal expression in the developing Drosophila retina. Genetics. 2008;180:2095-110 pubmed publisher
    ..We characterize the role of the daughterless, kismet, and roughened eye genes on atonal transcriptional regulation in the developing retina and show that each gene ..
  9. Papp B, Muller J. Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev. 2006;20:2041-54 pubmed

More Information


  1. Therrien M, Morrison D, Wong A, Rubin G. A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in Drosophila. Genetics. 2000;156:1231-42 pubmed
    ..In addition, we have identified 4 additional complementation groups. One of them corresponds to the kismet locus, which encodes a putative chromatin remodeling factor...
  2. Dorighi K, Tamkun J. The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila. Development. 2013;140:4182-92 pubmed publisher
    ..The trithorax group protein Kismet (KIS) is related to the SWI/SNF and CHD families of chromatin remodeling factors...
  3. Ivaldi M, Karam C, Corces V. Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila. Genes Dev. 2007;21:2818-31 pubmed
    ..Taken together, the results introduce H3S10 phosphorylation by JIL-1 as a hallmark of early transcription elongation in Drosophila. ..
  4. Kennison J, Tamkun J. Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc Natl Acad Sci U S A. 1988;85:8136-40 pubmed
    ..e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes. ..
  5. Ghosh R, Vegesna S, Safi R, Bao H, Zhang B, Marenda D, et al. Kismet positively regulates glutamate receptor localization and synaptic transmission at the Drosophila neuromuscular junction. PLoS ONE. 2014;9:e113494 pubmed publisher
    ..The chromodomain helicase DNA binding (CHD) protein, Kismet (Kis), is expressed in both motor neuron nuclei and postsynaptic muscle nuclei of the Drosophila larvae...
  6. Vazquez M, Moore L, Kennison J. The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. Development. 1999;126:733-42 pubmed
    ..The OSA protein contains an ARID domain, a DNA-binding domain also present in the yeast SWI1 and Drosophila DRI proteins. We propose that the OSA protein may target the BRM complex to Antennapedia and other regulated genes. ..
  7. Gellon G, Harding K, McGinnis N, Martin M, McGinnis W. A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. Development. 1997;124:3321-31 pubmed
    ..We propose that apt acts in parallel to, or as a cofactor with, HOX proteins to regulate homeotic targets in the ventral gnathal region. ..
  8. Kennison J. Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet. 1993;9:75-9 pubmed
    ..Some of the trans-acting proteins may facilitate interactions between cis-regulatory elements and the promoter by bringing together distant chromosomal elements. ..
  9. Singer A, Gall J. An inducible nuclear body in the Drosophila germinal vesicle. Nucleus. 2011;2:403-9 pubmed publisher
    ..We suggest that their behavior serves as a useful model for self-assembly of nuclear bodies in general, and we discuss the possibility that similar bodies may occur normally in cells of other organisms. ..
  10. Mills A. Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer. 2010;10:669-82 pubmed publisher
    ..Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis. ..
  11. Verma P, Cohen S. miR-965 controls cell proliferation and migration during tissue morphogenesis in the Drosophila abdomen. elife. 2015;4: pubmed publisher
    ..By regulating both cell proliferation and cell migration, miR-965 contributes to the robustness of this morphogenetic system. ..
  12. Rougeot J, Renard M, Randsholt N, Peronnet F, Mouchel Vielh E. The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings. PLoS ONE. 2013;8:e77592 pubmed publisher
    ..We propose that Corto and the Elongin complex participate together in vein vs intervein fate, possibly through tissue-specific transcriptional regulation of rhomboid. ..
  13. Horvath M, Mihajlovic Z, Slaninova V, Perez Gomez R, Moshkin Y, Krejci A. The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila. Biochem J. 2016;473:4129-4143 pubmed
    ..The role of Sirt1 in Notch signalling is, therefore, more complex than previously recognized, and its diverse effects may be explained by a plethora of Sirt1 substrates involved in the regulation of Notch signalling. ..
  14. Kassis J. Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region. Genetics. 1994;136:1025-38 pubmed
    ..I propose that engrailed PS sites normally act to promote interactions between distantly located engrailed regulatory sites and the engrailed promoter. ..
  15. van Swinderen B, Greenspan R. Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics. 2005;169:2151-63 pubmed
    ..The pattern of epistatic interactions that occurs within this set of variants is dramatically altered in the two different genetic contexts. The results imply considerable flexibility in the network interactions of genes. ..
  16. Qian J, Tu R, Yuan L, Xie W. Intronic miR-932 targets the coding region of its host gene, Drosophila neuroligin2. Exp Cell Res. 2016;344:183-93 pubmed publisher
    ..This study would be valuable in elucidating the regulation of intronic miRNA on host gene, and provide new information about the biological context of their genomic arrangements and functions. ..
  17. Nakayama T, Shimojima T, Hirose S. The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. Development. 2012;139:4582-90 pubmed publisher
    ..3 replacement to execute boundary functions. Our results provide new insight into the function of the trithorax group during development. ..
  18. Murawska M, Kunert N, van Vugt J, L ngst G, Kremmer E, Logie C, et al. dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol Cell Biol. 2008;28:2745-57 pubmed publisher
    ..Three CHD proteins, dMi-2, dChd1, and Kismet, have been described for Drosophila melanogaster. Here, we study dCHD3, a novel member of the CHD family...
  19. Bloyer S, Cavalli G, Brock H, Dura J. Identification and characterization of polyhomeotic PREs and TREs. Dev Biol. 2003;261:426-42 pubmed
    ..Our data suggest that ph PRE/TREs are cis-acting DNA elements that modulate rather than silence Pc-G- and trx-G-mediated regulation, enlarging the role of these two groups of genes in transcriptional regulation. ..
  20. Gutierrez L, Zurita M, Kennison J, Vázquez M. The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Development. 2003;130:343-54 pubmed
    ..subunits of the Brm complex, with mutations in subunits of the Mediator complex, and with mutations of the SWI2/SNF2 family ATPase gene kismet. We propose that Tna is involved in postranslational modification of transcription complexes.
  21. Bhatia S, Pawar H, Dasari V, Mishra R, Chandrashekaran S, Brahmachari V. Chromatin remodeling protein INO80 has a role in regulation of homeotic gene expression in Drosophila. Genes Cells. 2010;15:725-35 pubmed publisher
    ..Concurrently, the localization of dINO80 to sequences upstream of misexpressed genes in vivo shows that dINO80 is involved in homeotic gene regulation and probably through its interactions with PcG-trxG complexes. ..
  22. Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon G, et al. Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res. 2007;17:1865-79 pubmed
    ..For mir-10 in particular, both arms show abundant processing, and both show highly conserved target sites in Hox genes, suggesting a possible cooperation of the two arms, and their role as a master Hox regulator. ..
  23. Sollars V, Lu X, Xiao L, Wang X, Garfinkel M, Ruden D. Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution. Nat Genet. 2003;33:70-4 pubmed
    ..These findings suggest that Hsp90 acts as a capacitor for morphological evolution through epigenetic and genetic mechanisms. ..
  24. Tie F, Banerjee R, Conrad P, Scacheri P, Harte P. Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol. 2012;32:2323-34 pubmed publisher
    ..We propose that direct binding of UTX and BRM to CBP and their modulation of H3K27ac play an important role in antagonizing Polycomb silencing. ..
  25. Clyne P, Brotman J, Sweeney S, Davis G. Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Genetics. 2003;165:1433-41 pubmed
    ..This technology allows the generation of GFP-tagged reagents on a genome-wide scale with diverse potential applications. ..
  26. Schneiderman J, Sakai A, Goldstein S, Ahmad K. The XNP remodeler targets dynamic chromatin in Drosophila. Proc Natl Acad Sci U S A. 2009;106:14472-7 pubmed publisher
    ..Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus. ..
  27. Robin C, Daborn P, Hoffmann A. Fighting fly genes. Trends Genet. 2007;23:51-4 pubmed
    ..Here, we describe the study of aggressive behaviour in flies and explore the possibility that cytochrome P450 is involved in aggression. ..
  28. Go M, Artavanis Tsakonas S. A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development. Genetics. 1998;150:211-20 pubmed
  29. Thompson B, Tremblay V, Lin G, Bochar D. CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. Mol Cell Biol. 2008;28:3894-904 pubmed publisher
    ..This regulation is also conserved through evolution; RNA interference against kismet, the apparent Drosophila ortholog of CHD8, results in a similar activation of beta-catenin target genes...
  30. McDaniel I, Lee J, Berger M, Hanagami C, Armstrong J. Investigations of CHD1 function in transcription and development of Drosophila melanogaster. Genetics. 2008;178:583-7 pubmed publisher
    ..These results clarify the roles of chromatin remodelers in transcription and provide novel insights into CHD1 function. ..
  31. Anderson A, Galko M. Rapid clearance of epigenetic protein reporters from wound edge cells in Drosophila larvae does not depend on the JNK or PDGFR/VEGFR signaling pathways. Regeneration (Oxf). 2014;1:11-25 pubmed
    ..Three downregulated proteins, Osa, Kismet, and Spt6, are generally associated with active chromatin, while four others, Sin3A, Sap130, Mi-2, and Mip120, are ..
  32. Hagstrom K, Muller M, Schedl P. A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. Genetics. 1997;146:1365-80 pubmed
    ..The iab-7 PRE silencer is contained within a 0.8-kb fragment that spans a nuclease hypersensitive site, and silencing appears to depend on the chromatin remodeling protein, the GAGA factor. ..
  33. Marfella C, Imbalzano A. The Chd family of chromatin remodelers. Mutat Res. 2007;618:30-40 pubmed
    ..Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease. ..
  34. Fasulo B, Deuring R, Murawska M, Gause M, Dorighi K, Schaaf C, et al. The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet. 2012;8:e1002878 pubmed publisher
    ..These findings demonstrate that dMi-2 is an important regulator of both chromosome condensation and cohesin binding in interphase cells. ..
  35. Wiellette E, Harding K, Mace K, Ronshaugen M, Wang F, McGinnis W. spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk. Development. 1999;126:5373-85 pubmed
    ..This raises the intriguing possibility that the Spen RNP protein might integrate signals from both the Raf and Hox pathways. ..
  36. Bejarano F, Busturia A. Function of the Trithorax-like gene during Drosophila development. Dev Biol. 2004;268:327-41 pubmed
    ..We also suggest that GAGA factor may not have a dual activator/repressor function. Rather, Trithorax-like mutations may produce dual loss of activation and loss of repression effects. ..
  37. Yamaguchi M, Yoshida H, Hirose F, Inoue Y, Hayashi Y, Yamagishi M, et al. Ectopic expression of BEAF32A in the Drosophila eye imaginal disc inhibits differentiation of photoreceptor cells and induces apoptosis. Chromosoma. 2001;110:313-21 pubmed
    ..The transgenic flies established in this study should be useful to identify targets of BEAF32A and its positive or negative regulators in Drosophila. ..
  38. Karam C, Kellner W, Takenaka N, Clemmons A, Corces V. 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila. PLoS Genet. 2010;6:e1000975 pubmed publisher
    ..These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation. ..
  39. Mathieu J, Sung H, Pugieux C, Soetaert J, Rorth P. A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila. Genetics. 2007;176:1579-90 pubmed
    ..Mutations in genes not previously described to be required in border cells were also uncovered: hrp48, vir, rme-8, kismet, and puckered. puckered was unique in that the migration defects were observed only when PVR signaling was reduced...
  40. Li F, Zheng Q, Ryvkin P, Dragomir I, Desai Y, Aiyer S, et al. Global analysis of RNA secondary structure in two metazoans. Cell Rep. 2012;1:69-82 pubmed publisher
    ..Overall, our findings provide a global assessment of RNA folding in animals. ..
  41. Paik D, Jang Y, Lee Y, Lee Y, Yamamoto R, Gee H, et al. Misexpression screen delineates novel genes controlling Drosophila lifespan. Mech Ageing Dev. 2012;133:234-45 pubmed publisher
  42. Petruk S, Smith S, Sedkov Y, Mazo A. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity. Development. 2008;135:2383-90 pubmed publisher
    ..There is, however, no overall synergism or antagonism between and within the trxG and PcG proteins and, instead, only subsets of trxG proteins act synergistically. ..