Gene Symbol: kdn
Description: knockdown
Alias: BEST:GM01832, CG 3861, CG3861, Csyn, Dmel\CG3861, l (1) G0030, l(1)G0030, l(1)G0033, l(1)G0159, knockdown, CG3861-PA, CG3861-PB, citrate synthase, kdn-PA, kdn-PB, lethal (1) G0030
Species: fruit fly

Top Publications

  1. Burnell A, Reaper C, Doherty J. The effect of acclimation temperature on enzyme activity in Drosophila melanogaster. Comp Biochem Physiol B. 1991;98:609-14 pubmed
    ..6. The results presented here extend the data on the range of D. melanogaster enzymes which show compensation upon thermal acclimation and on the type of acclimation response which occurs. ..
  2. de Castro I, Costa A, Celardo I, Tufi R, Dinsdale D, Loh S, et al. Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis. 2013;4:e873 pubmed publisher
    ..We conclude that Ref(2)P is a crucial downstream effector of a pathway involving Pink1 and Parkin and is responsible for the maintenance of a viable pool of cellular mitochondria by promoting their aggregation and autophagic clearance. ..
  3. Lee J, Wu C. Electroconvulsive seizure behavior in Drosophila: analysis of the physiological repertoire underlying a stereotyped action pattern in bang-sensitive mutants. J Neurosci. 2002;22:11065-79 pubmed
  4. Rera M, Bahadorani S, Cho J, Koehler C, Ulgherait M, Hur J, et al. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 2011;14:623-34 pubmed publisher
    ..Our findings point to the possibility that alterations in PGC-1 activity in high-turnover tissues, such as the intestine, may be an important determinant of longevity in mammals. ..
  5. Schwarze S, Weindruch R, Aiken J. Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med. 1998;25:740-7 pubmed
    ..No statistically significant influences of age on activities of complexes I and II or citrate synthase were observed...
  6. Anderson P, Kirby K, Hilliker A, Phillips J. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. Hum Mol Genet. 2005;14:3397-405 pubmed
  7. Fergestad T, Olson L, Patel K, Miller R, Palladino M, Ganetzky B. Neuropathology in Drosophila mutants with increased seizure susceptibility. Genetics. 2008;178:947-56 pubmed publisher
    ..These results emphasize the importance of proper cellular metabolism in maintaining both the activity and viability of neurons. ..
  8. Liu W, Gnanasambandam R, Benjamin J, Kaur G, Getman P, Siegel A, et al. Mutations in cytochrome c oxidase subunit VIa cause neurodegeneration and motor dysfunction in Drosophila. Genetics. 2007;176:937-46 pubmed
    ..The levy mutants provide a genetic model to understand the mechanisms underlying COX-mediated mitochondrial encephalomyopathies and to explore possible therapeutic interventions. ..
  9. Slaninova V, Krafcikova M, Perez Gomez R, Steffal P, Trantirek L, Bray S, et al. Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle. Open Biol. 2016;6:150155 pubmed publisher
    ..Notch is active in situations that involve metabolic reprogramming, and the direct regulation of metabolic genes may be a common mechanism that helps Notch to exert its effects in target tissues. ..

More Information


  1. Wang B, Goode J, Best J, Meltzer J, Schilman P, Chen J, et al. The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila. Cell Metab. 2008;7:434-44 pubmed publisher
    ..As disruption of insulin signaling also augmented TORC activity in adult flies, our results illustrate the importance of an insulin-regulated pathway that functions in the brain to maintain energy balance. ..
  2. Adán C, Matsushima Y, Hernández Sierra R, Marco Ferreres R, Fernández Moreno M, Gonzalez Vioque E, et al. Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development. J Biol Chem. 2008;283:12333-42 pubmed publisher
    ..We have silenced the expression of TFB2M by RNA interference in Drosophila melanogaster. RNA interference knockdown of TF2BM causes lethality by arrest of larval development...
  3. Rao R, Yuan C, Allegood J, Rawat S, Edwards M, Wang X, et al. Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. Proc Natl Acad Sci U S A. 2007;104:11364-9 pubmed
  4. Ferguson M, Mockett R, Shen Y, Orr W, Sohal R. Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem J. 2005;390:501-11 pubmed
    ..Collectively, these results support the hypothesis that impairment of mitochondrial respiration may be a causal factor in the aging process, and that such impairment may result from and contribute to increased H2O2 production in vivo. ..
  5. Ganetzky B, Wu C. Indirect Suppression Involving Behavioral Mutants with Altered Nerve Excitability in DROSOPHILA MELANOGASTER. Genetics. 1982;100:597-614 pubmed
    ..Genetic interactions of this type help reveal functional relationships between different behavioral mutants and suggest ways of isolating new mutants with altered excitable membranes. ..
  6. Song J, Tanouye M. Seizure suppression by shakB2, a gap junction mutation in Drosophila. J Neurophysiol. 2006;95:627-35 pubmed
    ..In double mutant combinations, shakB2 completely suppresses seizures caused by slamdance (sda), knockdown (kdn), and jitterbug (jbug) mutations...
  7. Pavlidis P, Tanouye M. Seizures and failures in the giant fiber pathway of Drosophila bang-sensitive paralytic mutants. J Neurosci. 1995;15:5810-9 pubmed
    ..This hypothesis is supported by the finding that, in double mutant combination with mlenapts, which suppresses behavioral bang sensitivity, DLM failures, but not seizures, were reduced. ..
  8. Fergestad T, Bostwick B, Ganetzky B. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Genetics. 2006;173:1357-64 pubmed
    ..We mapped the bang-sensitive seizure mutation knockdown (kdn) to cytological position 5F3 and identified citrate synthase as the affected gene...
  9. Lindsay H, Baines R, ffrench Constant R, Lilley K, Jacobs H, O Dell K. The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Genetics. 2008;180:873-84 pubmed publisher
    ..Therefore, in the absence of suitable vertebrate models, Ocd provides a system in which genetic, molecular, physiological, and behavioral tools can be exploited to determine mechanisms underlying sodium channel periodic paralyses...
  10. Toivonen J, O Dell K, Petit N, Irvine S, Knight G, Lehtonen M, et al. Technical knockout, a Drosophila model of mitochondrial deafness. Genetics. 2001;159:241-54 pubmed
    ..We infer that the tko(25t) mutant provides a model of mitochondrial hearing impairment resulting from a quantitative deficiency of mitochondrial translational capacity. ..
  11. Prasad S, Muralidhara -. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. J Insect Physiol. 2014;60:7-16 pubmed publisher
    ..Interestingly, ACR induced mitochondrial dysfunctions (MTT reduction, activities of SDH and citrate synthase enzymes) were alleviated by both phytoconstituents...