KCNQ

Summary

Gene Symbol: KCNQ
Description: KCNQ potassium channel
Alias: CG12215, CG12915, CG33135, DKCNQ, Dmel\CG33135, KQT, KQT 1, dKCNQ, kcnq1, KCNQ potassium channel, CG33135-PC, CG33135-PD, CG33135-PE, CG33135-PF, CG33135-PG, CG33135-PH, CG33135-PI, CG33135-PJ, CG33135-PK, KCNQ-PC, KCNQ-PD, KCNQ-PE, KCNQ-PF, KCNQ-PG, KCNQ-PH, KCNQ-PI, KCNQ-PJ, KCNQ-PK, KCNQ-type K[+] channel
Species: fruit fly

Top Publications

  1. Wen H, Weiger T, Ferguson T, Shahidullah M, Scott S, Levitan I. A Drosophila KCNQ channel essential for early embryonic development. J Neurosci. 2005;25:10147-56 pubmed
    ..We cloned a novel Drosophila KCNQ channel (dKCNQ) based on its sequence homology to the mammalian genes...
  2. Ocorr K, Reeves N, Wessells R, Fink M, Chen H, Akasaka T, et al. KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. Proc Natl Acad Sci U S A. 2007;104:3943-8 pubmed
    ..in aging fruit fly hearts and a concomitant decrease in the expression of the Drosophila homolog of human KCNQ1-encoded K(+) channel alpha subunits...
  3. Cavaliere S, Hodge J. Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. PLoS ONE. 2011;6:e23898 pubmed publisher
    ..Drosophila contains a single KCNQ (dKCNQ) that appears to serve alone the functions of all the duplicated mammalian neuronal and cardiac KCNQ channels ..
  4. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed
    ..in Drosophila and Anopheles are present in a 1:1 ratio, Anopheles has more genes in three K+-channel types, namely KQT, Kv3, and inward rectifier channels...
  5. Gao L, Fei H, Connors N, Zhang J, Levitan I. Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels. J Neurophysiol. 2008;99:2736-40 pubmed publisher
    ..Direct interaction of CG11963 and dKCNQ was demonstrated by yeast two-hybrid screen and coimmunoprecipitation...
  6. Reddy B, Bajpe P, Bassett A, Moshkin Y, Kozhevnikova E, Bezstarosti K, et al. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Mol Cell Biol. 2010;30:5234-44 pubmed publisher
    ..Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment. ..
  7. Fabrizio J, Aqeel N, Cote J, Estevez J, Jongoy M, Mangal V, et al. Mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster. Fly (Austin). 2012;6:261-72 pubmed publisher
    ..alleles of mlt to two overlapping genes, CG12214 (the Drosophila tubulin-binding cofactor E-like homolog) and KCNQ (a large voltage-gated potassium channel)...
  8. Frolov R, Bagati A, Casino B, Singh S. Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives. J Neurogenet. 2012;26:275-90 pubmed
    ..These include signaling pathways involved in regulating and modulating ion channels, basic information on channels and currents where very little is currently known, and the role of ion channels in physiology and pathology. ..
  9. Huang Q, Wu Y, Wei X, He W, Liu X, Ye J. Evolutionary analysis of voltage-gated potassium channels by Bayes method. J Mol Neurosci. 2014;53:41-9 pubmed publisher

More Information

Publications12

  1. Ocorr K, Akasaka T, Bodmer R. Age-related cardiac disease model of Drosophila. Mech Ageing Dev. 2007;128:112-6 pubmed
    ..Compromised KCNQ and K(ATP) ion channel functions also seem to contribute to the decline in heart performance in aging flies, ..
  2. Cavaliere S, Gillespie J, Hodge J. KCNQ channels show conserved ethanol block and function in ethanol behaviour. PLoS ONE. 2012;7:e50279 pubmed publisher
    ..We show that dKCNQ is broadly expressed in the nervous system, with targeted reduction in neuronal KCNQ increasing neural ..
  3. Cavaliere S, Malik B, Hodge J. KCNQ channels regulate age-related memory impairment. PLoS ONE. 2013;8:e62445 pubmed publisher
    ..We show that the single KCNQ channel in Drosophila (dKCNQ) when mutated show decrements in associative short- and long-term memory, with KCNQ function in the mushroom body ?..