Gene Symbol: Kat60
Description: Katanin 60
Alias: CG10229, Dm-Kat60, DmCG10229, Dmel\CG10229, Katanin-60, kat60, katanin-60, katanin60-dm, katanin 60, CG10229-PA, CG10229-PB, Kat60-PA, Kat60-PB, Katanin-60, katanin
Species: fruit fly

Top Publications

  1. Nicolaï M, Lasbleiz C, Dura J. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. J Neurobiol. 2003;57:291-302 pubmed
    ..Moreover, Src64 is shown here to act in a cell-autonomous fashion and is likely to interact with the previously-identified linotte/derailed receptor tyrosine kinase in MB development. ..
  2. Kammermeier L, Spring J, Stierwald M, Burgunder J, Reichert H. Identification of the Drosophila melanogaster homolog of the human spastin gene. Dev Genes Evol. 2003;213:412-5 pubmed
    ..Given this nervous system-specific expression, it will be important to determine if Drosophila spastin loss-of-function mutations also lead to neurodegeneration. ..
  3. Zhang D, Rogers G, Buster D, Sharp D. Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. J Cell Biol. 2007;177:231-42 pubmed
    ..melanogaster incorporates the activities of three different microtubule severing enzymes, Spastin, Fidgetin, and Katanin. Spastin and Fidgetin are utilized to stimulate microtubule minus-end depolymerization and flux...
  4. Zhang D, Grode K, Stewman S, Diaz Valencia J, Liebling E, Rath U, et al. Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration. Nat Cell Biol. 2011;13:361-70 pubmed publisher
    ..Here we show that the Drosophila katanin Dm-Kat60 functions to generate a dynamic cortical-microtubule interface in interphase cells...
  5. Diaz Valencia J, Morelli M, Bailey M, Zhang D, Sharp D, Ross J. Drosophila katanin-60 depolymerizes and severs at microtubule defects. Biophys J. 2011;100:2440-9 pubmed publisher
    ..In this work, we investigate how katanin (p60), believed to be the first discovered severing enzyme, binds and severs MTs via single molecule total ..
  6. Taniguchi K, Hozumi S, Maeda R, Okumura T, Matsuno K. Roles of type I myosins in Drosophila handedness. Fly (Austin). 2007;1:287-90 pubmed
    ..We propose that the actin-based functions of type I Myosins play critical roles in generating LR asymmetry in invertebrates. ..
  7. Taniguchi K, Kokuryo A, Imano T, Minami R, Nakagoshi H, Adachi Yamada T. Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophila male accessory gland cells. BMC Dev Biol. 2014;14:46 pubmed publisher
    ..We also propose that Mud(S) is a key regulator triggering cytokinesis skipping in binucleation processes. ..
  8. Chen L, Stone M, Tao J, Rolls M. Axon injury and stress trigger a microtubule-based neuroprotective pathway. Proc Natl Acad Sci U S A. 2012;109:11842-7 pubmed publisher
    ..We conclude that axon injury or stress triggers a microtubule-based neuroprotective pathway that stabilizes neurons against degeneration. ..
  9. Eckert T, Le D, Link S, Friedmann L, Woehlke G. Spastin's microtubule-binding properties and comparison to katanin. PLoS ONE. 2012;7:e50161 pubmed publisher
    Spastin and katanin are ring-shaped hexameric AAA ATPases that sever microtubules, and thus crucially depend on a physical interaction with microtubules...

More Information


  1. Mao C, Xiong Y, Xiong Z, Wang Q, Zhang Y, Jin S. Microtubule-severing protein Katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila. Development. 2014;141:1064-74 pubmed publisher
    ..Katanin consists of two subunits; the catalytic subunit katanin 60 contains an AAA (ATPases associated with a variety of cellular activities) domain and breaks MT fibers while ..
  2. Booth A, Blanchard G, Adams R, Röper K. A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation. Dev Cell. 2014;29:562-576 pubmed publisher
    ..The medial actomyosin network interacts with the minus ends of acentrosomal microtubule bundles through the cytolinker protein Shot, and disruption of Shot also impairs apical constriction. ..
  3. Cuttell L, Vaughan A, Silva E, Escaron C, Lavine M, Van Goethem E, et al. Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis. Cell. 2008;135:524-34 pubmed publisher
    ..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway. ..
  4. Widmann T, Dahmann C. Dpp signaling promotes the cuboidal-to-columnar shape transition of Drosophila wing disc epithelia by regulating Rho1. J Cell Sci. 2009;122:1362-73 pubmed publisher
    ..Our results identify a cell-autonomous role for Dpp signaling in promoting and maintaining the elongated columnar shape of wing disc cells and suggest that Dpp signaling acts by regulating Rho1 and MRLC. ..
  5. Grode K, Rogers S. The non-catalytic domains of Drosophila katanin regulate its abundance and microtubule-disassembly activity. PLoS ONE. 2015;10:e0123912 pubmed publisher
    ..b>Katanin is a conserved heterodimeric ATPase that severs and disassembles microtubules, but the molecular determinants for ..