kat-60L1

Summary

Gene Symbol: kat-60L1
Description: katanin p60-like 1
Alias: CG1193, DmCG1193, Dmel\CG1193, katanin p60-like 1, CG1193-PA, CG1193-PB, CG1193-PC, CG1193-PD, CG1193-PE, CG1193-PF, CG1193-PG, CG1193-PH, Katanin-p60L1, kat-60L1-PA, kat-60L1-PB, kat-60L1-PC, kat-60L1-PD, kat-60L1-PE, kat-60L1-PF, kat-60L1-PG, kat-60L1-PH
Species: fruit fly

Top Publications

  1. Lee H, Jan L, Jan Y. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci U S A. 2009;106:6363-8 pubmed publisher
    ..Our study thus implicates Ik2 and Kat-60L1 in dendrite severing that involves local microtubule disassembly. ..
  2. Stewart A, Tsubouchi A, Rolls M, Tracey W, Sherwood N. Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. J Neurosci. 2012;32:11631-42 pubmed publisher
  3. Chen L, Stone M, Tao J, Rolls M. Axon injury and stress trigger a microtubule-based neuroprotective pathway. Proc Natl Acad Sci U S A. 2012;109:11842-7 pubmed publisher
    ..We conclude that axon injury or stress triggers a microtubule-based neuroprotective pathway that stabilizes neurons against degeneration. ..
  4. Zhang D, Rogers G, Buster D, Sharp D. Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. J Cell Biol. 2007;177:231-42 pubmed
    ..Collectively, these findings reveal novel and significant roles for microtubule severing within the spindle and broaden our understanding of the molecular machinery used to move chromosomes. ..
  5. Baxter S, Allard D, Crowl C, Sherwood N. Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). Dis Model Mech. 2014;7:1005-12 pubmed publisher
    ..Mild hypothermia, a common neuroprotective technique in clinical treatment of acute anoxia, might thus hold additional promise as a therapeutic approach for AD-HSP and, potentially, for other neurodegenerative diseases. ..
  6. Tao J, Rolls M. Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. J Neurosci. 2011;31:5398-405 pubmed publisher
    ..Thus, dendrites do have a rapid program of degeneration, as do axons, but this program does not require the machinery used during developmental pruning. ..
  7. Katzenberger R, Rach E, Anderson A, Ohler U, Wassarman D. The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. PLoS ONE. 2012;7:e45009 pubmed publisher
    ..These findings set the stage for determining the mechanism by which the TCE regulates testis-specific transcription and understanding the dual role of the TCE in translational and transcriptional regulation. ..