Gene Symbol: jvl
Alias: CG33330, CG3563, CG43162, Dmel\CG43162, Dmel_CG33330, Dmel_CG3563, Jvl, anon-WO0153538.4, anon-WO0153538.5, javelin-like, CG43162-PA, CG43162-PB, CG43162-PC, CG43162-PD, CG43162-PE, CG43162-PF, CG43162-PG, Javelin-Like, javelinlike, jvl-PA, jvl-PB, jvl-PC, jvl-PD, jvl-PE, jvl-PF, jvl-PG
Species: fruit fly
Anderson K, Nusslein Volhard C. Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature. 1984;311:223-7 pubmed
..Injection of RNA isolated from wild-type embryos into mutants at six loci partially restores dorsal-ventral polarity. For the mutant snake, injection of poly(A)+ RNA restores a complete dorsal-ventral pattern. ..
Amsalem S, Bakrhat A, Otani T, Hayashi S, Goldstein B, Abdu U. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Mol Cell Biol. 2013;33:4371-80 pubmed publisher
The Drosophila melanogaster Spn-F, Ik2, and Javelin-like (Jvl) proteins interact to regulate oocyte mRNA localization and cytoskeleton organization. However, the mechanism by which these proteins interact remains unclear...
Otani T, Oshima K, Kimpara A, Takeda M, Abdu U, Hayashi S. A transport and retention mechanism for the sustained distal localization of Spn-F-IKKÎµ during Drosophila bristle elongation. Development. 2015;142:2338-51 pubmed publisher
..We found that Javelin-like (Jvl) is a key regulator of Spn-F retention...
Tilney L, Connelly P, Ruggiero L, Vranich K, Guild G. Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. Mol Biol Cell. 2003;14:3953-66 pubmed
..As a result, filament turnover plays an important role in regulating cytoskeleton assembly and consequently cell shape. ..
Nelson C, Szauter P. Cytogenetic analysis of chromosome region 89A of Drosophila melanogaster: isolation of deficiencies and mapping of Po, Aldox-1 and transposon insertions. Mol Gen Genet. 1992;235:11-21 pubmed
..in the enzyme loci Po and Aldox-1, the indirect flight muscle genes Tm2 and act88F, the morphological mutations jvl, sbd2 and Sb, the vital loci srp, pnr and mor, and a newly described vital locus l(3)89Aa...
Green L, Wolf N, McDonald K, Fuller M. Two types of genetic interaction implicate the whirligig gene of Drosophila melanogaster in microtubule organization in the flagellar axoneme. Genetics. 1990;126:961-73 pubmed
..However, in post-meiotic stages, flagellar axonemes show loss of the accessory microtubule on the B-subfiber of outer doublet microtubules, outer triplet instead of outer doublet microtubules, and missing central pair microtubules. ..
Dickinson W, Thatcher J. Morphogenesis of denticles and hairs in Drosophila embryos: involvement of actin-associated proteins that also affect adult structures. Cell Motil Cytoskeleton. 1997;38:9-21 pubmed
..We suggest that interactions between these and other actin-associated proteins are important in generating the diverse shapes of the cuticular specializations seen in both larvae and adults. ..
Kulkarni M, Booker M, Silver S, Friedman A, Hong P, Perrimon N, et al
. Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods. 2006;3:833-8 pubmed
..Although a full appreciation of all causes of false positive errors remains to be determined, we suggest simple guidelines to help ensure high-quality information from RNAi high-throughput screens. ..
Dubin Bar D, Bitan A, Bakhrat A, Amsalem S, Abdu U. Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis. Development. 2011;138:4661-71 pubmed publisher
..In this study, we have identified a novel gene, CG43162, that regulates mRNA localization during oogenesis and also affects bristle development...