Gene Symbol: Jra
Description: Jun-related antigen
Alias: AP-1, AP1, CG2275, D-Jun, D-jun, D-jun/Jra, DJUN, DJun, DM14, Djun, Dmel\CG2275, JRA, JUN, Jun, c-Jun, cJun, d-JRA, d-Jun, d-jun, dAP-1, dJRA, dJUN, dJra, dJun, djun, dm-Jun, jra, jun, l(2)46Ef, l(2)IA109, l(2R)IA109, Jun-related antigen, CG2275-PA, CG2275-PB, CG2275-PC, Jra-PA, Jra-PB, Jra-PC, Jun oncogene, Jun related antigen, activator protein 1, complementation group V, lethal(2)1A109, lethal(2)IA109
Species: fruit fly
Products:     Jra

Top Publications

  1. Weber U, Paricio N, Mlodzik M. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development. 2000;127:3619-29 pubmed
    b>Jun acts as a signal-regulated transcription factor in many cellular decisions, ranging from stress response to proliferation control and cell fate induction...
  2. Zeitlinger J, Bohmann D. Thorax closure in Drosophila: involvement of Fos and the JNK pathway. Development. 1999;126:3947-56 pubmed
  3. Patterson R, Juarez M, Hermann A, Sasik R, Hardiman G, McGinnis W. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. PLoS ONE. 2013;8:e61773 pubmed publisher
    ..These include puncture-induced activation only in epidermal cells in the immediate vicinity of wounds, or in all epidermal cells, or specifically in the fat body, or in multiple tissues...
  4. Collins C, Wairkar Y, Johnson S, DiAntonio A. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron. 2006;51:57-69 pubmed
    ..In addition to controlling synaptic growth, Highwire promotes synaptic function through a separate pathway that does not require wallenda. ..
  5. Sanyal S, Narayanan R, Consoulas C, Ramaswami M. Evidence for cell autonomous AP1 function in regulation of Drosophila motor-neuron plasticity. BMC Neurosci. 2003;4:20 pubmed
    The transcription factor AP1 mediates long-term plasticity in vertebrate and invertebrate central nervous systems...
  6. Jemc J, Milutinovich A, Weyers J, Takeda Y, Van Doren M. raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis. Dev Biol. 2012;367:114-25 pubmed publisher
    ..In particular, Raw functions upstream of the Drosophila Jun-related transcription factor to regulate its subcellular localization...
  7. Udomsinprasert R, Bogoyevitch M, Ketterman A. Reciprocal regulation of glutathione S-transferase spliceforms and the Drosophila c-Jun N-terminal kinase pathway components. Biochem J. 2004;383:483-90 pubmed
    In mammalian systems, detoxification enzymes of the GST (glutathione S-transferase) family regulate JNK (c-Jun N-terminal kinase) signal transduction by interaction with JNK itself or other proteins upstream in the JNK pathway...
  8. Biswas R, Stein D, Stanley E. Drosophila Dok is required for embryonic dorsal closure. Development. 2006;133:217-27 pubmed
    ..The Syk family tyrosine kinase Shark plays a crucial role in this Jun amino-terminal kinase (JNK)-dependent process, where it acts upstream of JNK in LE cells...
  9. Hou X, Goldstein E, Perrimon N. Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev. 1997;11:1728-37 pubmed
    We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun)...

More Information


  1. Chang K, Shi Y, MIN K. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A. 2003;100:15794-9 pubmed
  2. Stramer B, Martin P. Cell biology: master regulators of sealing and healing. Curr Biol. 2005;15:R425-7 pubmed
    ..Yet new evidence suggests a conserved transcription factor, Grainyhead, controls both their development and the means by which both structures repair themselves. ..
  3. Peverali F, Isaksson A, Papavassiliou A, Plastina P, Staszewski L, Mlodzik M, et al. Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. EMBO J. 1996;15:3943-50 pubmed
    Drosophila Jun (D-Jun) is a nuclear component of the receptor tyrosine kinase/Ras signal transduction pathway which triggers photoreceptor differentiation during eye development...
  4. Stronach B, Perrimon N. Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev. 2002;16:377-87 pubmed
    The Jun kinase (JNK) pathway has been characterized for its role in stimulating AP-1 activity and for modulating the balance between cell growth and death during development, inflammation, and cancer...
  5. Sekyrova P, Bohmann D, Jindra M, Uhlirova M. Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. Development. 2010;137:141-50 pubmed publisher
    ..All of these processes require the basic region-leucine zipper (bZIP) transcription factors Jun and Fos...
  6. Mace K, Pearson J, McGinnis W. An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head. Science. 2005;308:381-5 pubmed publisher
    ..The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier...
  7. Sluss H, Han Z, Barrett T, Goberdhan D, Wilson C, Davis R, et al. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 1996;10:2745-58 pubmed
    ..Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes...
  8. Polaski S, Whitney L, Barker B, Stronach B. Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development. Genetics. 2006;174:719-33 pubmed
    Mixed lineage kinases (MLKs) function as Jun-N-terminal kinase (JNK) kinase kinases to transduce extracellular signals during development and homeostasis in adults...
  9. Ciapponi L, Jackson D, Mlodzik M, Bohmann D. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev. 2001;15:1540-53 pubmed
    ..These results indicate that the distinction between ERK and JNK signals can be made at the level of D-Fos, and that different pathway-specific phosphorylated forms of the protein can elicit different responses. ..
  10. Perkins K, Dailey G, Tjian R. Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1. EMBO J. 1988;7:4265-73 pubmed
    ..cross-reactivity experiments suggest that these proteins are Drosophila homologs of proto-oncogene products, Jun and Fos...
  11. Lesch C, Jo J, Wu Y, Fish G, Galko M. A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes. Genetics. 2010;186:943-57 pubmed publisher
    ..redundancy among the upstream activating kinases and distinct roles for the downstream transcription factors DJun and DFos...
  12. Igaki T, Kanda H, Yamamoto Goto Y, Kanuka H, Kuranaga E, Aigaki T, et al. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 2002;21:3009-18 pubmed
    ..We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling. ..
  13. Reed B, Wilk R, Lipshitz H. Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo. Curr Biol. 2001;11:1098-108 pubmed
    ..in the dorsal-most (leading edge) cells of the epidermis activates the AP-1 transcription factor comprised of DJUN and DFOS that, in turn, upregulates the expression of the dpp gene...
  14. Leyssen M, Ayaz D, Hébert S, Reeve S, De Strooper B, Hassan B. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J. 2005;24:2944-55 pubmed
    ..Finally, we also found interactions between APP and the JNK stress kinase cascade. Our findings suggest a role for APP in axonal outgrowth after traumatic brain injury. ..
  15. Pearson J, Juarez M, Kim M, Drivenes Ø, McGinnis W. Multiple transcription factor codes activate epidermal wound-response genes in Drosophila. Proc Natl Acad Sci U S A. 2009;106:2224-9 pubmed publisher
    ..These epidermal wound enhancers all contain evolutionarily conserved sequences matching binding sites for JUN/FOS and GRH transcription factors, but vary widely in trans- and cis-requirements for these inputs and their ..
  16. Sanyal S, Sandstrom D, Hoeffer C, Ramaswami M. AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila. Nature. 2002;416:870-4 pubmed
    ..best known immediate early transcription factor, AP-1; a heterodimer of the basic leucine zipper proteins Fos and Jun. We observe that AP-1 positively regulates both synaptic strength and synapse number, thus showing a greater range ..
  17. Massaro C, Pielage J, Davis G. Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton. J Cell Biol. 2009;187:101-17 pubmed publisher
  18. Riesgo Escovar J, Hafen E. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. Genes Dev. 1997;11:1717-27 pubmed
    ..We have identified mutations in DJun and show that DJNK controls dorsal closure by activating DJun and inactivating the ETS repressor Aop/Yan by ..
  19. Su Y, Treisman J, Skolnik E. The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway. Genes Dev. 1998;12:2371-80 pubmed
    ..Drosophila JNK (DJNK) functions by phosphorylating and activating DJun, which in turn induces the transcription of decapentaplegic (dpp)...
  20. Riesgo Escovar J, Hafen E. Common and distinct roles of DFos and DJun during Drosophila development. Science. 1997;278:669-72 pubmed
    ..Here, mutations in the DFos gene are described. In dorsal closure, DFos cooperates with DJun by regulating the expression of dpp; Dpp acts as a relay signal that triggers cell shape changes and DFos ..
  21. Galko M, Krasnow M. Cellular and genetic analysis of wound healing in Drosophila larvae. PLoS Biol. 2004;2:E239 pubmed
    ..Subsequently, more-peripheral cells orient toward and fuse with the central syncytium. During this time, the Jun N-terminal kinase (JNK) pathway is activated in a gradient emanating out from the wound, and the epidermal cells ..
  22. Suganuma T, Mushegian A, Swanson S, Abmayr S, Florens L, Washburn M, et al. The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Cell. 2010;142:726-36 pubmed publisher
    In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes...
  23. Chatterjee N, Bohmann D. A versatile ?C31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture. PLoS ONE. 2012;7:e34063 pubmed publisher
    ..To complement the transgenic reporter fly lines, tissue culture assays were developed in which the same synthetic ARE and TRE elements control the expression of firefly luciferase. ..
  24. Noselli S. JNK signaling and morphogenesis in Drosophila. Trends Genet. 1998;14:33-8 pubmed
  25. Chen H, Marinissen M, Oh S, Chen X, Melnick M, Perrimon N, et al. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002;22:1792-803 pubmed
    ..We have also investigated how CKA acts. This unique molecule forms a complex with HEP (DJNKK), BSK (DJNK), DJUN, and DFOS. Complex formation activates BSK kinase, which in turn phosphorylates and activates DJUN and DFOS...
  26. Jindra M, Gaziova I, Uhlirova M, Okabe M, Hiromi Y, Hirose S. Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila. EMBO J. 2004;23:3538-47 pubmed
    Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses...
  27. Kockel L, Zeitlinger J, Staszewski L, Mlodzik M, Bohmann D. Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev. 1997;11:1748-58 pubmed
    Drosophila Jun is shown to be involved in different signal transduction pathways and developmental decisions...
  28. Treier M, Bohmann D, Mlodzik M. JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell. 1995;83:753-60 pubmed
    ..We show that expression of a constitutively activated JUN isoform in ommatidial precursor cells is sufficient to induce R7 fate independent of upstream signals normally ..
  29. Bates K, Higley M, Letsou A. Raw mediates antagonism of AP-1 activity in Drosophila. Genetics. 2008;178:1989-2002 pubmed publisher
    ..Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by ..
  30. Weber U, Pataki C, Mihaly J, Mlodzik M. Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. Dev Biol. 2008;316:110-23 pubmed publisher
    ..factors integrate input from Fz/PCP and Egfr-signaling and that the ETS factors Pnt and Yan cooperate with Fos (and Jun) in the PCP-specific R3/R4 determination...
  31. Harden N. Cell biology. Of grainy heads and broken skins. Science. 2005;308:364-5 pubmed
  32. Riesgo Escovar J, Jenni M, Fritz A, Hafen E. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 1996;10:2759-68 pubmed
    ..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that ..
  33. Dobens L, Martin Blanco E, Martinez Arias A, Kafatos F, Raftery L. Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis. Development. 2001;128:1845-56 pubmed
    puckered (puc) encodes a VH1-like phosphatase that down-regulates Jun kinase (JNK) activity during dorsal closure of the Drosophila embryo. We report a role for puc in follicle cell morphogenesis during oogenesis...
  34. Homsy J, Jasper H, Peralta X, Wu H, Kiehart D, Bohmann D. JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Dev Dyn. 2006;235:427-34 pubmed
    ..during embryonic development using confocal time-lapse microscopy, we have investigated how signaling through the Jun-N-terminal kinase (JNK) pathway governs the tissue sheet movements that result in dorsal closure (DC)...
  35. Singh A, Shi X, Choi K. Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development. 2006;133:4771-81 pubmed
    ..Blocking Jun-N-terminal kinase (JNK) signaling, which can induce caspase-independent cell death, significantly rescued ventral ..
  36. Eresh S, Riese J, Jackson D, Bohmann D, Bienz M. A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction. EMBO J. 1997;16:2014-22 pubmed
    ..Therefore, a CREB protein may act as a nuclear target, or as a partner of a nuclear target, for Dpp signalling in the embryonic midgut. ..
  37. Perkins K, Admon A, Patel N, Tjian R. The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor. Genes Dev. 1990;4:822-34 pubmed
    Drosophila AP-1 consists of two proteins (dFRA and dJRA) that have functional and structural properties in common with mammalian Fos and Jun proto-oncogene products...
  38. Han Z, Enslen H, Hu X, Meng X, Wu I, Barrett T, et al. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol. 1998;18:3527-39 pubmed
    ..The results revealed that one of the functions of D-p38 is to attenuate antimicrobial peptide gene expression following exposure to lipopolysaccharide. ..
  39. Delaney J, Stoven S, Uvell H, Anderson K, Engstrom Y, Mlodzik M. Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO J. 2006;25:3068-77 pubmed
    b>Jun N-terminal kinase (JNK) signaling is a highly conserved pathway that controls both cytoskeletal remodeling and transcriptional regulation in response to a wide variety of signals...
  40. Staehling Hampton K, Laughon A, Hoffmann F. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling. Development. 1995;121:3393-403 pubmed
    ..We conclude that shn function is critical for cells to respond properly to dpp and propose that shn protein is the first identified downstream component of the signal transduction pathway used by dpp and its receptors. ..
  41. Fernandez R, Takahashi F, Liu Z, Steward R, Stein D, Stanley E. The Drosophila shark tyrosine kinase is required for embryonic dorsal closure. Genes Dev. 2000;14:604-14 pubmed
    ..In response to activation of a conserved c-Jun amino-terminal kinase (JNK) signaling module, the dorsal-most layer of cells, which constitute the LE of the ..
  42. Llense F, Martin Blanco E. JNK signaling controls border cell cluster integrity and collective cell migration. Curr Biol. 2008;18:538-44 pubmed publisher
    ..We anticipate a role for the JNK pathway in controlling collective cell movements in other morphogenetic and clinical models. ..
  43. Wang G, Goldstein E. Transcription of Djun from D. melanogaster is positively regulated by DTF-1, AP-1, and CREB binding sites. Exp Cell Res. 1994;214:389-99 pubmed
    b>Djun is the homolog of the mammalian proto-oncogene jun in D. melanogaster, where it encodes a component of an AP-1-like nuclear DNA binding protein, or transcription factor...
  44. Wang G, Goldstein E. An AP-1 binding site in the upstream region of Deb-A is part of a developmentally regulated negative element. Biochim Biophys Acta. 1993;1216:94-104 pubmed
    ..the AP-1 binding site were identified in gel retardation assays using partially purified bacterially expressed Djun protein or nuclear extracts from Drosophila embryos...
  45. Moussian B, Uv A. An ancient control of epithelial barrier formation and wound healing. Bioessays. 2005;27:987-90 pubmed
    ..A key role is carried out by Grainy head, a phylogenetically conserved transcription factor expressed in epidermal cells in nematodes, flies, frogs, mice and humans. ..
  46. Strutt D. Frizzled signalling and cell polarisation in Drosophila and vertebrates. Development. 2003;130:4501-13 pubmed
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation. ..
  47. Weitzman J. Quick guide. Jnk. Curr Biol. 2000;10:R290 pubmed
  48. Lee K, Choi J, Hong S, Son T, Yu K. Mobile phone electromagnetic radiation activates MAPK signaling and regulates viability in Drosophila. Bioelectromagnetics. 2008;29:371-9 pubmed publisher
    ..The EMF exposures also activated extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) signaling, but not p38 kinase signaling. Interestingly, SAR 1...
  49. Scholz H, Sadlowski E, Klaes A, Klämbt C. Control of midline glia development in the embryonic Drosophila CNS. Mech Dev. 1997;62:79-91 pubmed
    ..In the midline glia pointedP2 in turn activates the transcription of argos, which encodes a diffusible negative regulator of EGF-receptor signalling. ..
  50. Riese J, Tremml G, Bienz M. D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction. Development. 1997;124:3353-61 pubmed
  51. Botella J, Baines I, Williams D, Goberdhan D, Proud C, Wilson C. The Drosophila cell shape regulator c-Jun N-terminal kinase also functions as a stress-activated protein kinase. Insect Biochem Mol Biol. 2001;31:839-47 pubmed
    Mammalian c-Jun N-terminal kinases (JNKs) are members of a group of stress-activated intracellular signalling molecules within the MAP kinase family...
  52. Haghayeghi A, Sarac A, Czerniecki S, Grosshans J, Schock F. Pellino enhances innate immunity in Drosophila. Mech Dev. 2010;127:301-7 pubmed publisher
    ..Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila. ..
  53. Stielow B, Sapetschnig A, Krüger I, Kunert N, Brehm A, Boutros M, et al. Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Mol Cell. 2008;29:742-54 pubmed publisher
    ..Our results suggest that MEP-1, Mi-2, and Sfmbt are part of a common repression complex established by DNA-bound SUMO-modified transcription factors. ..
  54. Rallis A, Moore C, Ng J. Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. Dev Biol. 2010;339:65-77 pubmed publisher
    ..Here we show activity levels and timing mechanisms determine distinct aspects of Jun N-terminal kinase (JNK) pathway dependent axonal morphogenesis in Drosophila mushroom body (MB) neurons...
  55. Liu J, Ghanim M, Xue L, Brown C, Iossifov I, Angeletti C, et al. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science. 2009;323:1218-22 pubmed publisher
    ..Drosophila SPOP mediates degradation of the Jun kinase phosphatase Puckered, thereby inducing tumor necrosis factor (TNF)/Eiger-dependent apoptosis...
  56. Yin H, Morioka H, Towle C, Vidal M, Watanabe T, Weissbach L. Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein. Cytokine. 2001;15:122-37 pubmed
    ..HAX-1 may serve to retain the IL-1 NTP in the cytoplasm, and complex formation between the IL-1 NTP and HAX-1 may play a role in motility and/or adhesion of cells. ..
  57. Vonhoff F, Kuehn C, Blumenstock S, Sanyal S, Duch C. Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development. Development. 2013;140:606-16 pubmed publisher
    ..factors, such as CREB, Crest or Mef2, as well as activity-regulated immediate-early genes, such as fos and jun. This study investigates the role of the transcriptional regulator AP-1, a Fos-Jun heterodimer, in activity-..
  58. Wong H, Shaukat Z, Wang J, Saint R, Gregory S. JNK signaling is needed to tolerate chromosomal instability. Cell Cycle. 2014;13:622-31 pubmed publisher
    ..Our findings suggest that chromosomal instability represents a significant stress to dividing cells, and that without JNK signaling, cells undergo apoptosis because they lack a timely and effective response to DNA damage. ..
  59. Tran D, Berg C. bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis. Development. 2003;130:6273-82 pubmed
    ..Candidate testing implicates Src42A in a similar role, suggesting conservation with a vertebrate signaling pathway involving non-receptor tyrosine kinases. ..
  60. Pickup A, Lamka M, Sun Q, Yip M, Lipshitz H. Control of photoreceptor cell morphology, planar polarity and epithelial integrity during Drosophila eye development. Development. 2002;129:2247-58 pubmed
    ..act as dominant suppressors of the hnt planar polarity phenotype, suggesting that HNT functions to downregulate JUN kinase (JNK) signaling during the establishment of ommatidial planar polarity...
  61. Perkins K, Dailey G, Tjian R. In vitro analysis of the Antennapedia P2 promoter: identification of a new Drosophila transcription factor. Genes Dev. 1988;2:1615-26 pubmed
    ..DTF-1 was purified by sequence-specific DNA affinity chromatography and identified as a doublet of approximately 50 kD. Purified DTF-1 enhances transcription from the Antp P2 promoter 7- to 15-fold in a binding site-dependent manner. ..
  62. Jungreis I, Lin M, Spokony R, Chan C, Negre N, Victorsen A, et al. Evidence of abundant stop codon readthrough in Drosophila and other metazoa. Genome Res. 2011;21:2096-113 pubmed publisher
  63. Kim L, Choi U, Cho H, Lee J, Lee W, Kim J, et al. Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol. 2007;5:e238 pubmed
    ..We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved. ..
  64. Muralikrishna B, Parnaik V. SP3 and AP-1 mediate transcriptional activation of the lamin A proximal promoter. Eur J Biochem. 2001;268:3736-43 pubmed
    ..promoter contains two essential motifs, a GC box that can bind to Sp1 and Sp3, and an AP-1 motif that can bind to c-Jun and c-Fos. In this study we have investigated the role of Sp1 and Sp3 in transactivation of the promoter...
  65. Gavin Smyth J, Wang Y, Butler I, Ferguson E. A genetic network conferring canalization to a bistable patterning system in Drosophila. Curr Biol. 2013;23:2296-2302 pubmed publisher
    ..These data both detail a new mechanism that generates developmental canalization and identify an example of a species with noncanalized axial patterning. ..