Gene Symbol: jnj
Description: java no jive
Alias: AAF56254, CG5524, Dmel\CG5524, Huc-95DE, SMC6, Smc6, huc95E, huc[95D-E], huc[95DE], huc[95E], smc6, java no jive, CG5524-PA, HU- and caffeine-dependent 95D-E, HU- or caffeine-sensitive 95E, hydroxyurea- and (or) caffeine-sensitive 95E, jnj-PA
Species: fruit fly
Silva E, Lee B, Caceres L, Renouf D, Vilay B, Yu O, et al
. A novel strategy for identifying mutations that sensitize Drosophila eye development to caffeine and hydroxyurea. Genome. 2006;49:1416-27 pubmed
..We have mapped the cytological positions of huc(29D) and huc(95E) as a first step toward molecularly characterizing the relevant genes. ..
Chiolo I, Minoda A, Colmenares S, Polyzos A, Costes S, Karpen G. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 2011;144:732-44 pubmed publisher
..We propose that the spatial and temporal control of DSB repair in heterochromatin safeguards genome stability by preventing aberrant exchanges between repeats. ..
Li X, Zhuo R, Tiong S, Di Cara F, King Jones K, Hughes S, et al
. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. PLoS ONE. 2013;8:e59866 pubmed publisher
..This approach identified inactivating mutations in CG5524 and MAGE, homologs of genes encoding Smc6 and Nse3 in yeasts...
Harvey S, Krien M, O Connell M. Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases. Genome Biol. 2002;3:REVIEWS3003 pubmed
..Recent studies are beginning to decipher molecular details of how these processes are carried out. ..
Haering C, Nasmyth K. Building and breaking bridges between sister chromatids. Bioessays. 2003;25:1178-91 pubmed
..New research suggests that these ancient regulators of chromosome structure might function as topological devices that trap chromosomal DNA between 50 nm long coiled coils. ..
Carter S, Sjögren C. The SMC complexes, DNA and chromosome topology: right or knot?. Crit Rev Biochem Mol Biol. 2012;47:1-16 pubmed publisher
..This review focuses on the details of the relationship between the SMC complexes and topology. It also discusses the possibility that the SMC complexes are united by a capability to sense the geometrical chirality of DNA crossings. ..
Hirano T. Condensins: universal organizers of chromosomes with diverse functions. Genes Dev. 2012;26:1659-78 pubmed publisher
..Future studies on condensins will not only enhance our understanding of chromosome architecture and dynamics, but also help address a previously underappreciated yet profound set of questions in chromosome biology. ..
Ryu T, Spatola B, Delabaere L, Bowlin K, Hopp H, Kunitake R, et al
. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nat Cell Biol. 2015;17:1401-11 pubmed publisher
Tran M, Tsarouhas V, Kegel A. Early development of Drosophila embryos requires Smc5/6 function during oogenesis. Biol Open. 2016;5:928-41 pubmed publisher
..To investigate Smc5/6 function during early embryogenesis we examined smc5 and smc6 mutants of the fruit fly Drosophila melanogaster using a combination of reverse genetics and microscopy approaches...