JIL 1

Summary

Gene Symbol: JIL 1
Description: JIL-1 kinase
Alias: 2Ab17, CG6297, Dmel\CG6297, IL-1, JIL, JIL1, Jil-1, Jil1, MSK, MSK1, Su(var)3-1, Su(var)3-103, Su-var(3)1, Su-var(3)103, anon-WO0118547.379, mAb2A, JIL-1 kinase, CG6297-PA, CG6297-PB, CG6297-PC, JIL-1 histone H3S10 kinase, JIL-1 histone kinase, JIL-1-PA, JIL-1-PB, JIL-1-PC, suppressor of variegation 3-1
Species: fruit fly
Products:     JIL 1

Top Publications

  1. Jin Y, Wang Y, Walker D, Dong H, Conley C, Johansen J, et al. JIL-1: a novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Mol Cell. 1999;4:129-35 pubmed
    We have cloned and characterized JIL-1, a novel tandem kinase in Drosophila that associates with the chromosomes throughout the cell cycle...
  2. Nowak S, Corces V. Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. 2004;20:214-20 pubmed
    ..3 variant, which has a conserved N-terminal tail, can replace histone H3 at sites of active transcription, adds a new layer of complexity and possibilities to the regulation of transcription through changes in chromatin structure. ..
  3. Wang C, Yao C, Li Y, Cai W, Bao X, Girton J, et al. Evidence against a role for the JIL-1 kinase in H3S28 phosphorylation and 14-3-3 recruitment to active genes in Drosophila. PLoS ONE. 2013;8:e62484 pubmed publisher
    b>JIL-1 is the major kinase controlling phosphorylation of histone H3S10 and has been demonstrated to function to counteract heterochromatization and gene silencing...
  4. Karam C, Kellner W, Takenaka N, Clemmons A, Corces V. 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila. PLoS Genet. 2010;6:e1000975 pubmed publisher
    ..Studies in Drosophila have shown that the phosphorylation of histone H3 at Ser10 (H3S10ph) by JIL-1 is required specifically during early transcription elongation...
  5. Phalke S, Nickel O, Walluscheck D, Hortig F, Onorati M, Reuter G. Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet. 2009;41:696-702 pubmed publisher
    ..Together, these results demonstrate a previously unappreciated role of DNA methylation in retrotransposon silencing and telomere integrity in Drosophila. ..
  6. Wang C, Cai W, Li Y, Deng H, Bao X, Girton J, et al. The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in Drosophila melanogaster. J Cell Sci. 2011;124:4309-17 pubmed publisher
    The JIL-1 kinase localizes specifically to euchromatin interband regions of polytene chromosomes and is the kinase responsible for histone H3S10 phosphorylation at interphase...
  7. Boeke J, Regnard C, Cai W, Johansen J, Johansen K, Becker P, et al. Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1. PLoS ONE. 2010;5:e10042 pubmed publisher
    ..Among several other proteins known to bind Su(VAR)3-9 we isolated the chromosomal kinase JIL-1 as a strong interactor...
  8. Ciurciu A, Tombácz I, Popescu C, Boros I. GAL4 induces transcriptionally active puff in the absence of dSAGA- and ATAC-specific chromatin acetylation in the Drosophila melanogaster polytene chromosome. Chromosoma. 2009;118:513-26 pubmed publisher
    ..Moreover, the reduced level of JIL-1-specific H3 serine 10 phosphorylation did not abolish puff formation in ATAC mutants...
  9. Kellner W, Ramos E, Van Bortle K, Takenaka N, Corces V. Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters. Genome Res. 2012;22:1081-8 pubmed publisher
    ..Here, we show that the JIL-1 kinase is present at both enhancers and promoters of ecdysone-induced Drosophila genes, where it phosphorylates ..

More Information

Publications74

  1. Rath U, Ding Y, Deng H, Qi H, Bao X, Zhang W, et al. The chromodomain protein, Chromator, interacts with JIL-1 kinase and regulates the structure of Drosophila polytene chromosomes. J Cell Sci. 2006;119:2332-41 pubmed
    ..Furthermore, we demonstrate that Chromator co-localizes with the JIL-1 kinase at polytene interband regions and that the two proteins interact within the same protein complex...
  2. Deng H, Bao X, Zhang W, Girton J, Johansen J, Johansen K. Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase. Genetics. 2007;177:79-87 pubmed
    It has recently been demonstrated that activity of the essential JIL-1 histone H3S10 kinase is a major regulator of chromatin structure and that it functions to maintain euchromatic domains while counteracting heterochromatization and ..
  3. Bao X, Zhang W, Krencik R, Deng H, Wang Y, Girton J, et al. The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. J Cell Sci. 2005;118:5079-87 pubmed
    We have used a yeast two-hybrid screen to identify lamin Dm0 as an interaction partner for the nuclear JIL-1 kinase...
  4. Lerach S, Zhang W, Bao X, Deng H, Girton J, Johansen J, et al. Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila. Genetics. 2006;173:2403-6 pubmed
    In this article we show that hypomorphic loss-of-function alleles of the JIL-1 histone H3S10 kinase are strong suppressors of position effect variegation (PEV) of the wm4 allele and that lack of JIL-1 activity can counteract the effect ..
  5. Ivaldi M, Karam C, Corces V. Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila. Genes Dev. 2007;21:2818-31 pubmed
    The Drosophila JIL-1 kinase is known to phosphorylate histone H3 at Ser10 (H3S10) during interphase. This modification is associated with transcriptional activation, but its function is not well understood...
  6. Ding Y, Yao C, Lince Faria M, Rath U, Cai W, Maiato H, et al. Chromator is required for proper microtubule spindle formation and mitosis in Drosophila. Dev Biol. 2009;334:253-63 pubmed publisher
  7. Deng H, Bao X, Cai W, Blacketer M, Belmont A, Girton J, et al. Ectopic histone H3S10 phosphorylation causes chromatin structure remodeling in Drosophila. Development. 2008;135:699-705 pubmed publisher
    ..In Drosophila phosphorylation of histone H3S10 in euchromatic chromatin regions by the JIL-1 tandem kinase has been implicated in counteracting heterochromatization and gene silencing...
  8. Andreyeva E, Belyaeva E, Semeshin V, Pokholkova G, Zhimulev I. Three distinct chromatin domains in telomere ends of polytene chromosomes in Drosophila melanogaster Tel mutants. J Cell Sci. 2005;118:5465-77 pubmed
    ..is associated with proteins characteristic for both heterochromatin (H3Me3K9) and euchromatin (H3Me3K4, JIL-1, Z4). The TAS region is enriched for H3Me3K27...
  9. Wang Y, Zhang W, Jin Y, Johansen J, Johansen K. The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell. 2001;105:433-43 pubmed
    To analyze the function of the chromosomal kinase JIL-1, we generated an allelic series of hypomorphic and null mutations...
  10. Zhang W, Jin Y, Ji Y, Girton J, Johansen J, Johansen K. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Genetics. 2003;165:1341-54 pubmed
    In this study we provide a cytological and genetic characterization of the JIL-1 locus in Drosophila. JIL-1 is an essential chromosomal tandem kinase and in JIL-1 null animals chromatin structure is severely perturbed...
  11. Yao C, Ding Y, Cai W, Wang C, Girton J, Johansen K, et al. The chromodomain-containing NH(2)-terminus of Chromator interacts with histone H1 and is required for correct targeting to chromatin. Chromosoma. 2012;121:209-20 pubmed publisher
    ..Taken together these findings suggest that Chromator's chromatin functions are largely governed by the NH(2)-terminal domain whereas functions related to mitosis are mediated mainly by COOH-terminal sequences. ..
  12. Deng H, Zhang W, Bao X, Martin J, Girton J, Johansen J, et al. The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes. Chromosoma. 2005;114:173-82 pubmed
    The JIL-1 kinase localizes to interband regions of Drosophila polytene chromosomes and phosphorylates histone H3 Ser10...
  13. Silva Sousa R, López Panadès E, Piñeyro D, Casacuberta E. The chromosomal proteins JIL-1 and Z4/Putzig regulate the telomeric chromatin in Drosophila melanogaster. PLoS Genet. 2012;8:e1003153 pubmed publisher
    ..Here we describe two chromosomal proteins, JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription ..
  14. Ciurciu A, Komonyi O, Boros I. Loss of ATAC-specific acetylation of histone H4 at Lys12 reduces binding of JIL-1 to chromatin and phosphorylation of histone H3 at Ser10. J Cell Sci. 2008;121:3366-72 pubmed publisher
    ..at Lys12 by the ATAC-HAT complex leads to a decrease in the histone H3 phosphorylation at Ser10 by the kinase JIL-1...
  15. Gan M, Moebus S, Eggert H, Saumweber H. The Chriz-Z4 complex recruits JIL-1 to polytene chromosomes, a requirement for interband-specific phosphorylation of H3S10. J Biosci. 2011;36:425-38 pubmed
    ..Here we show that both proteins form a complex that recruits the JIL-1 kinase to polytene chromosomes, enabling local H3S10 phosphorylation of interband nucleosomal histones...
  16. Straub T, Becker P. Dosage compensation: the beginning and end of generalization. Nat Rev Genet. 2007;8:47-57 pubmed
  17. Deng H, Cai W, Wang C, Lerach S, Delattre M, Girton J, et al. JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila. Genetics. 2010;185:1183-92 pubmed publisher
    The essential JIL-1 histone H3S10 kinase is a key regulator of chromatin structure that functions to maintain euchromatic domains while counteracting heterochromatization and gene silencing...
  18. Johansen K, Johansen J. Regulation of chromatin structure by histone H3S10 phosphorylation. Chromosome Res. 2006;14:393-404 pubmed
  19. Bao X, Deng H, Johansen J, Girton J, Johansen K. Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin. Genetics. 2007;176:1355-8 pubmed
    In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor ..
  20. Wang C, Cai W, Li Y, Girton J, Johansen J, Johansen K. H3S10 phosphorylation by the JIL-1 kinase regulates H3K9 dimethylation and gene expression at the white locus in Drosophila. Fly (Austin). 2012;6:93-7 pubmed publisher
    The JIL-1 kinase is a multidomain protein that localizes specifically to euchromatin interband regions of polytene chromosomes and is the kinase responsible for histone H3S10 phosphorylation at interphase...
  21. Jin Y, Wang Y, Johansen J, Johansen K. JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex. J Cell Biol. 2000;149:1005-10 pubmed
    b>JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila...
  22. Cai W, Bao X, Deng H, Jin Y, Girton J, Johansen J, et al. RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila. Development. 2008;135:2917-25 pubmed publisher
    b>JIL-1 is the major kinase controlling the phosphorylation state of histone H3S10 at interphase in Drosophila...
  23. Zhang W, Deng H, Bao X, Lerach S, Girton J, Johansen J, et al. The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. Development. 2006;133:229-35 pubmed
    In this study, we show that a reduction in the levels of the JIL-1 histone H3S10 kinase results in the spreading of the major heterochromatin markers dimethyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most ..
  24. Ebert A, Schotta G, Lein S, Kubicek S, Krauss V, Jenuwein T, et al. Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev. 2004;18:2973-83 pubmed
    ..Su(var)3-1 was identified as "antimorphic" mutants of the euchromatic H3-S10 kinase JIL-1...
  25. Wang C, Girton J, Johansen J, Johansen K. A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila. Genetics. 2011;188:745-8 pubmed publisher
    In this study, we show that the haplo-enhancer effect of JIL-1 has the ability to counterbalance the haplo-suppressor effect of both Su(var)3-9 and Su(var)2-5 on position-effect variegation, providing evidence that a finely tuned balance ..
  26. Bao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, et al. The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin. J Biol Chem. 2008;283:32741-50 pubmed publisher
    The JIL-1 histone H3S10 kinase in Drosophila localizes specifically to euchromatic interband regions of polytene chromosomes and is enriched 2-fold on the male X chromosome...
  27. Regnard C, Straub T, Mitterweger A, Dahlsveen I, Fabian V, Becker P. Global analysis of the relationship between JIL-1 kinase and transcription. PLoS Genet. 2011;7:e1001327 pubmed publisher
    The ubiquitous tandem kinase JIL-1 is essential for Drosophila development...
  28. Joanis V, Lloyd V. Genomic imprinting in Drosophila is maintained by the products of Suppressor of variegation and trithorax group, but not Polycomb group, genes. Mol Genet Genomics. 2002;268:103-12 pubmed
  29. Kelley R, Kuroda M. Noncoding RNA genes in dosage compensation and imprinting. Cell. 2000;103:9-12 pubmed
  30. Lerach S, Zhang W, Deng H, Bao X, Girton J, Johansen J, et al. JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila. Genesis. 2005;43:213-5 pubmed
    The upregulation of the JIL-1 kinase on the male X chromosome and its association with the male-specific lethal (MSL) complex suggest that JIL-1 may play a role in regulating dosage compensation...
  31. Mihailovic M, Mihailovich M, Wurth L, Zambelli F, Abaza I, Militti C, et al. Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNR. RNA. 2012;18:53-64 pubmed publisher
    ..These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner. ..
  32. Fauvarque M, Dura J. polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes Dev. 1993;7:1508-20 pubmed
    ..We suggest that a multimeric complex containing PH and PC proteins, at a minimum, causes a local and clonally inherited heterochromatinization, which maintains the repressed state of transcription of the homeotic genes. ..
  33. Girton J, Wang C, Johansen J, Johansen K. The effect of JIL-1 on position-effect variegation is proportional to the total amount of heterochromatin in the genome. Fly (Austin). 2013;7:129-33 pubmed publisher
    ..In Drosophila heterochromatic spreading and gene silencing is counteracted by H3S10 phosphorylation by the JIL-1 kinase, and we further demonstrate that the haplo-enhancer effect of JIL-1 is proportional to the amount of total ..
  34. Cai W, Wang C, Li Y, Yao C, Shen L, Liu S, et al. Genome-wide analysis of regulation of gene expression and H3K9me2 distribution by JIL-1 kinase mediated histone H3S10 phosphorylation in Drosophila. Nucleic Acids Res. 2014;42:5456-67 pubmed publisher
    In this study we have determined the genome-wide relationship of JIL-1 kinase mediated H3S10 phosphorylation with gene expression and the distribution of the epigenetic H3K9me2 mark...
  35. Abramov Y, Kibanov M, Gvozdev V, Lavrov S. Genetic and molecular analysis of gene trans-inactivation caused by homologous eu-heterochromatic chromosome rearrangement in Drosophila melanogaster. Dokl Biochem Biophys. 2011;437:72-6 pubmed publisher
  36. Silva Sousa R, Casacuberta E. The JIL-1 kinase affects telomere expression in the different telomere domains of Drosophila. PLoS ONE. 2013;8:e81543 pubmed publisher
    ..We have recently shown that the essential kinase JIL-1 is the first positive regulator of the telomere retrotransposons...
  37. Zhimulev I, Belyaeva E, Makunin I, Pirrotta V, Semeshin V, Alekseyenko A, et al. Intercalary heterochromatin in Drosophila melanogaster polytene chromosomes and the problem of genetic silencing. Genetica. 2003;117:259-70 pubmed
    ..IH and PH as well as regions subject to PEV have in common the condensed chromatin appearance, the localization of specific proteins, late replication, underreplication in polytene chromosomes, and ectopic pairing. ..
  38. Takács S, Biessmann H, Reddy H, Mason J, Torok T. Protein interactions on telomeric retrotransposons in Drosophila. Int J Biol Sci. 2012;8:1055-61 pubmed publisher
    ..The TRF2/DREF complex may promote the open structure of HTT chromatin. The protein interactions controlling HTT chromatin structure and telomere length may be modulated by sumoylation. ..
  39. Nusinow D, Panning B. Recognition and modification of seX chromosomes. Curr Opin Genet Dev. 2005;15:206-13 pubmed
    ..Finally, evidence from mammals suggests that the chromatin modifications that mediate dosage compensation are very dynamic, because they are established, reversed and re-established early in development. ..
  40. Li Y, Cai W, Wang C, Yao C, Bao X, Deng H, et al. Domain requirements of the JIL-1 tandem kinase for histone H3 serine 10 phosphorylation and chromatin remodeling in vivo. J Biol Chem. 2013;288:19441-9 pubmed publisher
    The JIL-1 kinase localizes to Drosophila polytene chromosome interbands and phosphorylates histone H3 at interphase, counteracting histone H3 lysine 9 dimethylation and gene silencing...
  41. Li G, Zhou L. Genome-wide identification of chromatin transitional regions reveals diverse mechanisms defining the boundary of facultative heterochromatin. PLoS ONE. 2013;8:e67156 pubmed publisher
    ..However, boundary-associated insulator binding sites are distinctively flanked by nucleosome destabilizing sequences, which correlates with significantly decreased nucleosome density and increased binding of co-factors. ..
  42. Figueiredo M, Kim M, Philip P, Allgardsson A, Stenberg P, Larsson J. Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions. PLoS Genet. 2014;10:e1004865 pubmed publisher
    ..We hypothesize that roX mutants reveal the ancient targeting of the MSL-complex and propose that the role of roX RNAs is to prevent the binding of the MSL-complex to heterochromatin. ..
  43. Lucchesi J, Kuroda M. Dosage compensation in Drosophila. Cold Spring Harb Perspect Biol. 2015;7: pubmed publisher
    ..Interestingly, two noncoding RNAs are key for MSL assembly and spreading to active genes along the length of the X chromosome. ..
  44. Zee B, Alekseyenko A, McElroy K, Kuroda M. Streamlined discovery of cross-linked chromatin complexes and associated histone modifications by mass spectrometry. Proc Natl Acad Sci U S A. 2016;113:1784-9 pubmed publisher
    ..In summary, we greatly extend the practicality of BioTAP-XL to enable comprehensive identification of protein complexes and their local chromatin environment. ..
  45. Alekseyenko A, Ho J, Peng S, Gelbart M, Tolstorukov M, Plachetka A, et al. Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. PLoS Genet. 2012;8:e1002646 pubmed publisher
    ..targeting of the male X chromosome include increase in nucleosome lability, enrichment for H4K16 acetylation and JIL-1 kinase, and depletion of linker histone H1 on active X-linked genes...
  46. Raffa G, Cenci G, Ciapponi L, Gatti M. Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Front Oncol. 2013;3:112 pubmed publisher
    ..The identification of additional Drosophila genes encoding non-terminin proteins involved in telomere protection might lead to the discovery of novel components of human telomeres. ..
  47. Öst A, Lempradl A, Casas E, Weigert M, Tiko T, Deniz M, et al. Paternal diet defines offspring chromatin state and intergenerational obesity. Cell. 2014;159:1352-64 pubmed publisher
    ..The findings provide insight into the mechanisms underlying intergenerational metabolic reprogramming and carry profound implications for our understanding of phenotypic variation and evolution. ..
  48. Wutz A. RNAs templating chromatin structure for dosage compensation in animals. Bioessays. 2003;25:434-42 pubmed
    ..They do not appear to act in a sequence-specific manner but might provide scaffolds for co-operative binding of chromatin-associated complexes that enable spreading of chromatin modifications. ..
  49. Johansen K, Johansen J, Jin Y, Walker D, Wang D, Wang Y. Chromatin structure and nuclear remodeling. Crit Rev Eukaryot Gene Expr. 1999;9:267-77 pubmed
    ..Using the monoclonal antibody mAb2A, we have identified two proteins that appear to play important roles in these processes: JIL-1 is a tandem serine-..
  50. Huang H, Yu Z, Zhang S, Liang X, Chen J, Li C, et al. Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. J Cell Sci. 2010;123:2853-61 pubmed publisher
    ..Together, these findings suggest that Drosophila CAF-1 p180 is an essential factor in the epigenetic control of heterochromatin formation and/or maintenance. ..
  51. Grewal S, Elgin S. Transcription and RNA interference in the formation of heterochromatin. Nature. 2007;447:399-406 pubmed
    ..Silencing of chromatin might involve trans-acting sources of the crucial small RNAs that carry out RNA interference, but in some cases, transcription of the region to be silenced seems to be required--an apparent contradiction. ..
  52. Soruco M, Larschan E. A new player in X identification: the CLAMP protein is a key factor in Drosophila dosage compensation. Chromosome Res. 2014;22:505-15 pubmed publisher
    ..Understanding how the newly identified CLAMP protein is involved in X targeting in the fly could provide key insights into how the X chromosome is initially identified across species. ..
  53. Gilfillan G, Dahlsveen I, Becker P. Lifting a chromosome: dosage compensation in Drosophila melanogaster. FEBS Lett. 2004;567:8-14 pubmed
    ..Deciphering the principles of X chromosome recognition and the nature of the chromatin configuration, that allows fine-tuning of transcription, remain the most interesting challenges. ..
  54. Erhardt S, Lyko F, Ainscough J, Surani M, Paro R. Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila. Dev Genes Evol. 2003;213:336-44 pubmed
    ..Polycomb group proteins are essential for gene silencing during development. Our results indicate that Polycomb group proteins may also be involved in the regulation of mammalian imprinted genes. ..
  55. Prabhakaran M, Kelley R. Mutations in the transcription elongation factor SPT5 disrupt a reporter for dosage compensation in Drosophila. PLoS Genet. 2012;8:e1003073 pubmed publisher
    ..We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation. ..
  56. Thomas C, Kotova E, Andrake M, Adolf Bryfogle J, Glaser R, Regnard C, et al. Kinase-mediated changes in nucleosome conformation trigger chromatin decondensation via poly(ADP-ribosyl)ation. Mol Cell. 2014;53:831-42 pubmed publisher
    ..We report that a nuclear tandem kinase, JIL-1, controls gene expression by activating poly(ADP-ribose) polymerase-1 (PARP-1)...
  57. Wang C, Li Y, Cai W, Bao X, Girton J, Johansen J, et al. Histone H3S10 phosphorylation by the JIL-1 kinase in pericentric heterochromatin and on the fourth chromosome creates a composite H3S10phK9me2 epigenetic mark. Chromosoma. 2014;123:273-80 pubmed publisher
    The JIL-1 kinase mainly localizes to euchromatic interband regions of polytene chromosomes and is the kinase responsible for histone H3S10 phosphorylation at interphase in Drosophila...
  58. Fagegaltier D, Baker B. X chromosome sites autonomously recruit the dosage compensation complex in Drosophila males. PLoS Biol. 2004;2:e341 pubmed
    ..We propose a new model in which the distribution of compensasomes along the X chromosome is achieved according to the hierarchical affinities of individual binding sites. ..
  59. Liu K, Ding L, Li Y, Yang H, Zhao C, Lei Y, et al. Neuronal necrosis is regulated by a conserved chromatin-modifying cascade. Proc Natl Acad Sci U S A. 2014;111:13960-5 pubmed publisher
    ..Using a Drosophila model of calcium overloading, we found JIL-1/mitogen- and stress-activated protein kinase 1/2 is a regulator of neuronal necrosis through phosphorylation of ..
  60. Westphal T, Reuter G. Recombinogenic effects of suppressors of position-effect variegation in Drosophila. Genetics. 2002;160:609-21 pubmed
    ..Our data suggest that crossing-over suppression by heterochromatin is controlled at chromatin structure as well as illustrate the possible effects of heterochromatin on total crossing-over frequencies in the genome. ..
  61. Lindehell H, Kim M, Larsson J. Proximity ligation assays of protein and RNA interactions in the male-specific lethal complex on Drosophila melanogaster polytene chromosomes. Chromosoma. 2015;124:385-95 pubmed publisher
    ..Our results also indicate that JIL1, a histone H3 Ser10 kinase enriched on the male X chromosome, interacts with MSL1 and MSL2, but not MSL3 of the MSL ..
  62. Johansen K. Dynamic remodeling of nuclear architecture during the cell cycle. J Cell Biochem. 1996;60:289-96 pubmed
    ..Using a monoclonal antibody (mAb2A) which specifically stains a novel nuclear meshwork which reorganizes during the cell cycle in Drosophila, we have ..
  63. Park J, Al Ramahi I, Tan Q, Mollema N, Diaz Garcia J, Gallego Flores T, et al. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature. 2013;498:325-331 pubmed publisher
    ..Our approach revealed that downregulation of several components of the RAS-MAPK-MSK1 pathway decreases ATXN1 levels and suppresses neurodegeneration in Drosophila and mice...
  64. Hohl A, Thompson M, Soshnev A, Wu J, Morris J, Hsieh T, et al. Restoration of topoisomerase 2 function by complementation of defective monomers in Drosophila. Genetics. 2012;192:843-56 pubmed publisher
    ..Our studies establish the first series of Top2 alleles in a multicellular organism. Future analyses of these alleles will enhance our knowledge about the contributions made by type II topoisomerases to development. ..
  65. Abramov Y, Shatskikh A, Maksimenko O, Bonaccorsi S, Gvozdev V, Lavrov S. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Genetics. 2016;202:93-106 pubmed publisher
    ..We demonstrate that trans-inactivation is followed by de novo HP1a accumulation in the affected transgene; trans-inactivation is specifically favored by the chromatin remodeler SAYP and prevented by Argonaute AGO2. ..