Gene Symbol: jhamt
Description: juvenile hormone acid methyltransferase
Alias: BG:DS09218.5, CG17330, DmJHAMT, Dmel\CG17330, JAHMT, JHAMT, JHamt, Jhamt, juvenile hormone acid methyltransferase, CG17330-PA, CG17330-PB, jhamt-PA, jhamt-PB, juvenile hormone acid O-Methyl transferase, juvenile hormone acid O-methyltransferase, juvenile hormone acid methyl transferase
Species: fruit fly

Top Publications

  1. Shinoda T, Itoyama K. Juvenile hormone acid methyltransferase: a key regulatory enzyme for insect metamorphosis. Proc Natl Acad Sci U S A. 2003;100:11986-91 pubmed
    ..Putative orthologs, DmJHAMT and AgJHAMT, were identified from the genome sequence of the fruit fly Drosophila melanogaster, and a malaria ..
  2. Burtenshaw S, Su P, Zhang J, Tobe S, Dayton L, Bendena W. A putative farnesoic acid O-methyltransferase (FAMeT) orthologue in Drosophila melanogaster (CG10527): relationship to juvenile hormone biosynthesis?. Peptides. 2008;29:242-51 pubmed publisher
    ..Deficiency strains that reduce the level of FAMeT showed reduced longevity relative to wildtype but this result may be due to other genetic influences. ..
  3. Niwa R, Niimi T, Honda N, Yoshiyama M, Itoyama K, Kataoka H, et al. Juvenile hormone acid O-methyltransferase in Drosophila melanogaster. Insect Biochem Mol Biol. 2008;38:714-20 pubmed publisher
    ..Here we report on the functional characterization of the CG17330/DmJHAMT gene in the fruit fly Drosophila melanogaster...
  4. Defelipe L, Dolghih E, Roitberg A, Nouzova M, Mayoral J, Noriega F, et al. Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase. Insect Biochem Mol Biol. 2011;41:228-35 pubmed publisher
    ..In Lepidoptera, epoxidation by a P450 monooxygenase precedes esterification by a juvenile hormone acid methyltransferase (JHAMT). In Orthoptera, Dictyoptera, Coleoptera and Diptera epoxidation follows methylation...
  5. Bendena W, Zhang J, Burtenshaw S, Tobe S. Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. Gen Comp Endocrinol. 2011;172:56-61 pubmed publisher
    ..Finally, we have used the UAS-GAL4 system in Drosophila to express juvenile hormone acid methyltransferase (JHAMT) in vivo...
  6. Huang J, Tian L, Peng C, Abdou M, Wen D, Wang Y, et al. DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase. Development. 2011;138:2283-91 pubmed publisher
    ..of TGF? signaling in transferring brain signals into transcriptional changes of JH acid methyltransferase (jhamt), a key regulatory enzyme of JH biosynthesis...
  7. Wijesekera T, Saurabh S, Dauwalder B. Juvenile Hormone Is Required in Adult Males for Drosophila Courtship. PLoS ONE. 2016;11:e0151912 pubmed publisher
    ..in male reproductive behavior we created males with reduced levels of Juvenile Hormone Acid O-Methyl Transferase (JHAMT) and tested them for courtship...
  8. Sherkhanov S, Korman T, Clarke S, Bowie J. Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme. Sci Rep. 2016;6:24239 pubmed publisher
    ..alternative, broad spectrum methyltransferase, Drosophila melanogaster Juvenile Hormone Acid O-Methyltransferase (DmJHAMT). By introducing DmJHAMT in E...
  9. Prokupek A, Kachman S, Ladunga I, Harshman L. Transcriptional profiling of the sperm storage organs of Drosophila melanogaster. Insect Mol Biol. 2009;18:465-75 pubmed publisher
    ..Differences in functional gene categories indicate that these organs play unique roles in sperm storage. ..

More Information


  1. Halfon M, Zhu Q, Brennan E, Zhou Y. Erroneous attribution of relevant transcription factor binding sites despite successful prediction of cis-regulatory modules. BMC Genomics. 2011;12:578 pubmed publisher
    ..Our study underscores the importance of empirical validation of computational results even when these results are in line with expectation. ..
  2. Baumann A, Benoit J, Michalková V, Mireji P, Attardo G, Moulton J, et al. Juvenile hormone and insulin suppress lipolysis between periods of lactation during tsetse fly pregnancy. Mol Cell Endocrinol. 2013;372:30-41 pubmed publisher
  3. Yang Q, Gong Z, Zhou Y, Yuan J, Cheng J, Tian L, et al. Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity. Cell Mol Life Sci. 2010;67:1477-90 pubmed publisher
    ..Collectively, these results suggest that Dacer plays an important role in the Drosophila development and longevity by controlling the metabolism of ceramides. ..
  4. Liu C, Wang J, Zheng Y, Xiong E, Li J, Yuan L, et al. Wolbachia-induced paternal defect in Drosophila is likely by interaction with the juvenile hormone pathway. Insect Biochem Mol Biol. 2014;49:49-58 pubmed publisher
    ..Considering that Jhamt gene encodes JH acid methyltransferase, a key regulatory enzyme of JH biosynthesis, and that methoprene-tolerant (..
  5. Wen D, Rivera Pérez C, Abdou M, Jia Q, He Q, Liu X, et al. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. PLoS Genet. 2015;11:e1005038 pubmed publisher
    ..Knockout of JH acid methyl transferase (jhamt) did not result in lethality; it decreased biosynthesis of JHB3, but MF biosynthesis was not affected...
  6. Vallejo D, Juarez Carreño S, Bolivar J, Morante J, Dominguez M. A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. Science. 2015;350:aac6767 pubmed publisher
    ..This previously unrecognized circuit suggests how growth and maturation rate are matched and co-regulated according to Dilp8 signals to stabilize organismal size. ..