Gene Symbol: jet
Description: jetlag
Alias: CG8873, Dmel\CG8873, FBXL15, JET, jetlag, CG8873-PA, CG8873-PB, jet-PA, jet-PB
Species: fruit fly

Top Publications

  1. Peschel N, Veleri S, Stanewsky R. Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc Natl Acad Sci U S A. 2006;103:17313-8 pubmed
    ..which encodes a less-light-sensitive form of Timeless in combination with a mutant variant of the F-box protein Jetlag. However, neither the ls-tim nor the jetlag genetic variant alone is sufficient to disrupt light input into the ..
  2. Ozturk N, VanVickle Chavez S, Akileswaran L, Van Gelder R, Sancar A. Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex. Proc Natl Acad Sci U S A. 2013;110:4980-5 pubmed publisher
    ..Thus, this study identifies a light-activated E3 ligase complex essential for light-mediated CRY degradation in Drosophila cells. ..
  3. Ozturk N, Selby C, Annayev Y, Zhong D, Sancar A. Reaction mechanism of Drosophila cryptochrome. Proc Natl Acad Sci U S A. 2011;108:516-21 pubmed publisher
    ..conformation has a half-life of ?15 min in the dark at 25?°C and is characterized by increased affinity to Jetlag E3 ligase...
  4. Koh K, Zheng X, Sehgal A. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science. 2006;312:1809-12 pubmed
    ..We have identified mutations in jetlag-a gene coding for an F-box protein with leucine-rich repeats-that result in reduced light sensitivity of the ..
  5. Knowles A, Koh K, Wu J, Chien C, Chamovitz D, Blau J. The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci. 2009;29:1152-62 pubmed publisher
    ..Defects in TIM degradation and resetting of behavioral phases were rescued by overexpression of Jetlag (JET), the F-box protein required for light-mediated TIM degradation...
  6. Skaar J, Pagan J, Pagano M. SnapShot: F box proteins I. Cell. 2009;137:1160-1160.e1 pubmed publisher
  7. Ozturk N, Selby C, Zhong D, Sancar A. Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore. J Biol Chem. 2014;289:4634-42 pubmed publisher
    ..and reduced (FAD) forms of dCRY undergo light-induced conformational change in vitro that enable dCRY to bind JET and that Trp triad and Trp-536 mutations that block known or presumed intraprotein electron transfer reactions do ..
  8. Crane B, Young M. Interactive features of proteins composing eukaryotic circadian clocks. Annu Rev Biochem. 2014;83:191-219 pubmed publisher
  9. Fischer R, Helfrich Förster C, Peschel N. GSK-3 Beta Does Not Stabilize Cryptochrome in the Circadian Clock of Drosophila. PLoS ONE. 2016;11:e0146571 pubmed publisher
    ..This depends on the interaction of CRY with several proteins such as the E3 ubiquitin ligases Jetlag (JET) and Ramshackle (BRWD3)...

More Information


  1. Yang M, Lee J, Padgett R, Edery I. Circadian regulation of a limited set of conserved microRNAs in Drosophila. BMC Genomics. 2008;9:83 pubmed publisher
    ..Intriguingly, the mature forms of dme-miR-263a and -263b are very similar in sequence to several miRNAs recently shown to be under circadian regulation in the mouse retina, suggesting conserved functions. ..
  2. Peschel N, Chen K, Szabo G, Stanewsky R. Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless. Curr Biol. 2009;19:241-7 pubmed publisher
    ..Cry) mediates a rapid light-dependent degradation of the clock protein Timeless (Tim) via the F box protein Jetlag (Jet) and the proteasome, which initiates the resetting of the molecular clock [2, 3]...
  3. Tang C, Hinteregger E, Shang Y, Rosbash M. Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. Neuron. 2010;66:378-85 pubmed publisher
  4. Hara T, Koh K, Combs D, Sehgal A. Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant. J Neurosci. 2011;31:9982-90 pubmed publisher
    ..We also show that a stable form of PER is cytoplasmic in tim-null flies. These studies establish an essential role of TIM in the timed nuclear entry of PER. ..
  5. Vaidya A, Top D, Manahan C, Tokuda J, Zhang S, Pollack L, et al. Flavin reduction activates Drosophila cryptochrome. Proc Natl Acad Sci U S A. 2013;110:20455-60 pubmed publisher
    ..Thus, photoreduction to the ASQ releases the dCRY CTT and promotes binding to at least one region of TIM. Flavin reduction by either light or cellular reductants may be a general mechanism of CRY activation. ..
  6. Lamba P, Bilodeau Wentworth D, Emery P, Zhang Y. Morning and evening oscillators cooperate to reset circadian behavior in response to light input. Cell Rep. 2014;7:601-8 pubmed publisher
    ..autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM), and promotes its degradation, which is mediated by JETLAG (JET)...
  7. Dolezelova E, Dolezel D, Hall J. Rhythm defects caused by newly engineered null mutations in Drosophila's cryptochrome gene. Genetics. 2007;177:329-45 pubmed
    ..Because some norpAP24 cry0 individuals can resynchronize to novel photic regimes, an as-yet undetermined light-input route exists in Drosophila. ..
  8. Chen K, Peschel N, Zavodska R, Sehadova H, Stanewsky R. QUASIMODO, a Novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock. Curr Biol. 2011;21:719-29 pubmed publisher
    ..Even in the additional absence of visual photoreception, partial molecular and behavioral light synchronization persists. Therefore, other important clock-related photoreceptive and synchronization mechanisms must exist...