ItgaPS4

Summary

Gene Symbol: ItgaPS4
Description: Integrin alphaPS4 subunit
Alias: CG16827, CT37393, Dmel\CG16827, ItgalphaPS4, alpha-PS4, alpha-ps4, alphaPS4, integrin alphaPS4 subunit, CG16827-PA, ItgaPS4-PA, alphaPS4, alphaPS4 integrin
Species: fruit fly

Top Publications

  1. Brown N. Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 2000;19:191-201 pubmed
  2. Crozatier M, Ubeda J, Vincent A, Meister M. Cellular immune response to parasitization in Drosophila requires the EBF orthologue collier. PLoS Biol. 2004;2:E196 pubmed
    ..Further investigations on Col/EBF expression and function in other phyla should provide fresh insight into the evolutionary origin of lymphoid cells. ..
  3. Krzemien J, Dubois L, Makki R, Meister M, Vincent A, Crozatier M. Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature. 2007;446:325-8 pubmed
  4. Schock F, Perrimon N. Retraction of the Drosophila germ band requires cell-matrix interaction. Genes Dev. 2003;17:597-602 pubmed
    ..We further implicate a role for this spreading in the process of germ-band retraction...
  5. Brower D. Platelets with wings: the maturation of Drosophila integrin biology. Curr Opin Cell Biol. 2003;15:607-13 pubmed
    ..Drosophila also is beginning to yield some insights into integrin heterodimer structure and function. ..
  6. Nonaka S, Nagaosa K, Mori T, Shiratsuchi A, Nakanishi Y. Integrin ?PS3/??-mediated phagocytosis of apoptotic cells and bacteria in Drosophila. J Biol Chem. 2013;288:10374-80 pubmed publisher
    ..These results collectively indicated that integrin ?PS3/?? serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes. ..
  7. Delon I, Brown N. The integrin adhesion complex changes its composition and function during morphogenesis of an epithelium. J Cell Sci. 2009;122:4363-74 pubmed publisher
    ..Molecular variation of the integrin complex is thus a key component of developmentally programmed morphogenesis. ..
  8. Makki R, Meister M, Pennetier D, Ubeda J, Braun A, Daburon V, et al. A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response. PLoS Biol. 2010;8:e1000441 pubmed publisher
  9. Shulman J, Imboywa S, Giagtzoglou N, Powers M, Hu Y, Devenport D, et al. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet. 2014;23:870-7 pubmed publisher
    ..Our results highlight cell adhesion pathways as important in Tau toxicity and AD susceptibility and demonstrate the power of model organism genetic screens for the functional follow-up of human GWAS. ..

More Information

Publications16

  1. Hughes A. Evolution of the integrin alpha and beta protein families. J Mol Evol. 2001;52:63-72 pubmed
  2. Tanentzapf G, Devenport D, Godt D, Brown N. Integrin-dependent anchoring of a stem-cell niche. Nat Cell Biol. 2007;9:1413-8 pubmed
    ..On the basis of our data, we propose that integrins are required for the attachment of the hub cells to the ECM, which is essential for maintaining the stem-cell niche. ..
  3. Dinkins M, Fratto V, LeMosy E. Integrin alpha chains exhibit distinct temporal and spatial localization patterns in epithelial cells of the Drosophila ovary. Dev Dyn. 2008;237:3927-39 pubmed publisher
    ..on apical, lateral, and basal membranes with the betaPS chain, whereas alphaPS3-family integrins (alphaPS3, alphaPS4, alphaPS5) are expressed in anterior cells late in oogenesis...
  4. Stofanko M, Kwon S, Badenhorst P. Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS ONE. 2010;5:e14051 pubmed publisher
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge. ..
  5. Thimgan M, Gottschalk L, Toedebusch C, McLeland J, Rechtschaffen A, Gilliland Roberts M, et al. Cross-translational studies in human and Drosophila identify markers of sleep loss. PLoS ONE. 2013;8:e61016 pubmed publisher
    ..These cross-translational data indicate that fly and human discovery experiments are mutually reinforcing and can be used interchangeably to identify candidate biomarkers of sleep loss. ..
  6. Bökel C, Brown N. Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev Cell. 2002;3:311-21 pubmed
    ..Integrins also participate in signaling events that govern tissue differentiation and organogenesis. Finally, adhesion by integrin-mediated junctions allows tissues to withstand mechanical load and is essential for tissue integrity. ..
  7. Lo S. Focal adhesions: what's new inside. Dev Biol. 2006;294:280-91 pubmed
    ..Recent studies using genetic approaches in invertebrate and vertebrate systems have begun to reveal the structure and function of these complexes in vivo. ..