Gene Symbol: Irp-1A
Description: Iron regulatory protein 1A
Alias: C-Acon, CG4900, Dmel\CG4900, IRF, IRP, IRP-1, IRP-1A, IRP1, c-Acon, cACON, cAcon, dIRP, irp1A, iron regulatory protein 1A, CG4900-PA, Irp-1A-PA, c-aconitase, cytoplasmic aconitase, cytosolic aconitase, iron regulatory factor, iron regulatory protein
Species: fruit fly

Top Publications

  1. Missirlis F, Hu J, Kirby K, Hilliker A, Rouault T, Phillips J. Compartment-specific protection of iron-sulfur proteins by superoxide dismutase. J Biol Chem. 2003;278:47365-9 pubmed
    ..We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iron and oxidative stress through its labile iron sulfur cluster by ..
  2. Anderson P, Kirby K, Hilliker A, Phillips J. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. Hum Mol Genet. 2005;14:3397-405 pubmed
  3. Lind M, Missirlis F, Melefors O, Uhrigshardt H, Kirby K, Phillips J, et al. Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein. J Biol Chem. 2006;281:18707-14 pubmed
    ..normoxia, but IRP1 is the more ancient protein in evolutionary terms and has an additional function as a cytosolic aconitase. The Caenorhabditis elegans genome does not contain an IRP2 homolog or identifiable IREs; its IRP1 homolog ..
  4. Surdej P, Richman L, Kühn L. Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant. Insect Biochem Mol Biol. 2008;38:891-4 pubmed publisher
    ..We have investigated the effect of wild-type human IRP1 (hIRP1) and the constitutively active mutant hIRP1-S437 in transgenic Drosophila melanogaster...
  5. Metzendorf C, Wu W, Lind M. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Biochem J. 2009;421:463-71 pubmed publisher
    ..of dmfrn in the Drosophila l(2)mbn cell line (mbn-dmfrn) resulted in decreased binding between IRP-1A (iron regulatory protein 1A) and stem-loop RNA structures referred to as IREs (iron responsive elements)...
  6. Katsuyama T, Sugawara T, Tatsumi M, Oshima Y, Gehring W, Aigaki T, et al. Involvement of winged eye encoding a chromatin-associated bromo-adjacent homology domain protein in disc specification. Proc Natl Acad Sci U S A. 2005;102:15918-23 pubmed
    ..These findings suggest that wge functions in the determination of disc-specific identity, downstream of Hox genes. ..
  7. Rothenberger S, Mullner E, Kuhn L. The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution. Nucleic Acids Res. 1990;18:1175-9 pubmed
    A post-transcriptional regulatory protein, termed iron regulatory factor (IRF), that binds specifically to the iron-responsive elements of ferritin and transferrin receptor mRNA, has recently been identified in the cytoplasm of human and ..
  8. Wicks S, Bain N, Duttaroy A, Hilliker A, Phillips J. Hypoxia rescues early mortality conferred by superoxide dismutase deficiency. Free Radic Biol Med. 2009;46:176-81 pubmed publisher
    ..Elucidating these pathways should provide novel insights into how aerobic cells manage oxidative stress in health, aging, and disease. ..
  9. Kirby K, Jensen L, Binnington J, Hilliker A, Ulloa J, Culotta V, et al. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem. 2008;283:35393-401 pubmed publisher
    ..SOD1-null mutants in terms of reduced adult life span, hypersensitivity to oxidative stress, and loss of cytosolic aconitase activity...

More Information


  1. Soriano S, Calap Quintana P, Llorens J, Al Ramahi I, Gutierrez L, Martínez Sebastián M, et al. Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS ONE. 2016;11:e0159209 pubmed publisher
    ..Taken together, these results demonstrate that the metal dysregulation in FRDA includes other metals besides iron, therefore providing a new set of potential therapeutic targets. ..
  2. Tian L, Chen J, Chen M, Gui C, Zhong C, Hong L, et al. The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU. J Biol Chem. 2014;289:31856-65 pubmed publisher
    ..These results imply a new mechanistic connection between the p38 pathway and mitochondria iron-sulfur clusters. ..
  3. Uhrigshardt H, Rouault T, Missirlis F. Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. J Biol Inorg Chem. 2013;18:441-9 pubmed publisher the iron cells where ferritin is constitutively expressed and apparently translated independently of iron regulatory protein 1A...
  4. Muckenthaler M, Gunkel N, Frishman D, Cyrklaff A, Tomancak P, Hentze M. Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans. Eur J Biochem. 1998;254:230-7 pubmed
    Iron-regulatory protein-1 (IRP-1) plays a dual role as a regulatory RNA-binding protein and as a cytoplasmic aconitase. When bound to iron-responsive elements (IRE), IRP-1 post-transcriptionally regulates the expression of mRNAs involved ..
  5. Gray N, Pantopoulos K, Dandekar T, Ackrell B, Hentze M. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements. Proc Natl Acad Sci U S A. 1996;93:4925-30 pubmed
    ..Drosophila melanogaster IRP binds to an IRE in the 5' untranslated region of the mRNA encoding the iron-sulfur protein (Ip) subunit of ..
  6. Sun X, Komatsu T, Lim J, Laslo M, Yolitz J, Wang C, et al. Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging Cell. 2012;11:783-93 pubmed publisher
  7. Wang C, Yolitz J, Alberico T, Laslo M, Sun Y, Wheeler C, et al. Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila. J Gerontol A Biol Sci Med Sci. 2014;69:945-54 pubmed publisher
    ..Our study reveals an interaction of cranberry with dietary macronutrients and stresses the importance of considering diet composition in designing interventions for promoting healthy aging. ..
  8. Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher