Gene Symbol: Irk3
Description: Inwardly rectifying potassium channel 3
Alias: CG10369, Dmel\CG10369, dKirIII, irk3, inwardly rectifying potassium channel 3, CG10369-PA, CG10369-PC, CG10369-PD, Irk3-PA, Irk3-PC, Irk3-PD
Species: fruit fly

Top Publications

  1. Döring F, Wischmeyer E, Kühnlein R, Jackle H, Karschin A. Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function. J Biol Chem. 2002;277:25554-61 pubmed
    ..The protein sequences of Drosophila KirI (dKirI) and dKirII are moderately (<44%) and dKirIII sequence is weakly (<27%) identical to human Kir channel subunits...
  2. Evans J, Allan A, Davies S, Dow J. Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. J Exp Biol. 2005;208:3771-83 pubmed
    ..abundant and enriched K(+) channel genes encoding the three inward rectifier channels of Drosophila: ir, irk2 and irk3. Enriched expression of inward rectifier channels in tubule was verified by quantitative RT-PCR, and all three IRKs ..
  3. An S, Wang S, Gilbert L, Beerntsen B, Ellersieck M, Song Q. Global identification of bursicon-regulated genes in Drosophila melanogaster. BMC Genomics. 2008;9:424 pubmed publisher
    ..The data obtained here will form the basis for future studies aimed at elucidating the exact mechanisms upstream from the secretion of bursicon and its binding to target cells. ..
  4. Luan Z, Li H. Inwardly rectifying potassium channels in Drosophila. Sheng Li Xue Bao. 2012;64:515-9 pubmed
    ..The knowledge of Drosophila Kir channels may lead us to uncover novel functions and regulation mechanisms of human Kir channels and help on pathological studies of related diseases. ..
  5. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed
  6. Norry F, Larsen P, Liu Y, Loeschcke V. Combined expression patterns of QTL-linked candidate genes best predict thermotolerance in Drosophila melanogaster. J Insect Physiol. 2009;55:1050-7 pubmed publisher
    ..Network effects with other untested linked loci are apparent because, in spite of their associations with KRHT phenotypes, e-PCs were sometimes uncorrelated with their QTL genotype. ..
  7. Eleftherianos I, Won S, Chtarbanova S, Squiban B, Ocorr K, Bodmer R, et al. ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections. Proc Natl Acad Sci U S A. 2011;108:12024-9 pubmed publisher
    ..1 subunit of K(ATP) channels, than in controls. Together, our data suggest that K(ATP) channel deregulation can have a critical impact on innate antiviral immunity in the heart. ..
  8. Dahal G, Rawson J, Gassaway B, Kwok B, Tong Y, Ptacek L, et al. An inwardly rectifying K+ channel is required for patterning. Development. 2012;139:3653-64 pubmed publisher
    ..As Irk channels contribute to Dpp signaling in flies, a similar role for Kir2.1 in BMP signaling may explain the morphological defects of Andersen-Tawil Syndrome and the Kir2.1 knockout mouse. ..
  9. Wu Y, Baum M, Huang C, Rodan A. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Am J Physiol Regul Integr Comp Physiol. 2015;309:R747-56 pubmed publisher
    ..In Drosophila melanogaster, this includes transcripts of the Irk1, Irk2, and Irk3 genes. The role of each of these gene products in renal tubule function is unknown...

More Information


  1. Enell L, Kapan N, Söderberg J, Kahsai L, Nassel D. Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila. PLoS ONE. 2010;5:e15780 pubmed publisher
    ..Knockdown of irk3, possibly part of a G protein-activated inwardly rectifying K(+) channel that may link to GBRs, phenocopies GBR ..