Gene Symbol: Ire1
Description: Inositol-requiring enzyme-1
Alias: CG4583, Dmel\CG4583, IRE-like, IRE1, Ire, Ire-1, dIRE1, dire-1, ire-1, ire1, Inositol-requiring enzyme-1, CG4583-PB, Ire, Ire1-PB, inositol required 1, ire-1
Species: fruit fly

Top Publications

  1. Kang M, Chung J, Ryoo H. CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol. 2012;14:409-15 pubmed publisher
    ..These findings establish a previously unrecognized branch of ER-stress response signalling involved in degenerative diseases. ..
  2. Gaddam D, Stevens N, Hollien J. Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells. Mol Biol Cell. 2013;24:14-20 pubmed publisher
    b>Ire1 is an endoplasmic reticulum (ER) transmembrane protein that senses disturbances in protein folding homeostasis and contributes to a multifaceted response to stress...
  3. Moore K, Plant J, Gaddam D, Craft J, Hollien J. Regulation of sumo mRNA during endoplasmic reticulum stress. PLoS ONE. 2013;8:e75723 pubmed publisher
    ..The UPR is mediated in part by Ire1, an ER transmembrane kinase and endoribonuclease that is activated when misfolded proteins accumulate in the ER...
  4. Plongthongkum N, Kullawong N, Panyim S, Tirasophon W. Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster. Biochem Biophys Res Commun. 2007;354:789-94 pubmed
    ..This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress. ..
  5. Ryoo H, Steller H. Unfolded protein response in Drosophila: why another model can make it fly. Cell Cycle. 2007;6:830-5 pubmed
    ..Here, we review the molecular components of the Drosophila UPR as well as the disease models that may be affected by this signaling pathway. ..
  6. Ryoo H, Domingos P, Kang M, Steller H. Unfolded protein response in a Drosophila model for retinal degeneration. EMBO J. 2007;26:242-52 pubmed
    ..The Drosophila xbp1 mRNA undergoes ire-1-mediated unconventional splicing in response to ER stress, and this property was used to develop a specific UPR ..
  7. Luis N, Wang L, Ortega M, Deng H, Katewa S, Li P, et al. Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction. Cell Rep. 2016;17:1207-1216 pubmed publisher
    ..Here, we show that the IRE1/XBP1 endoplasmic reticulum (ER) stress signaling module mediates metabolic adaptation upon DR in flies by promoting ..
  8. Lindström R, Lindholm P, Kallijärvi J, Palgi M, Saarma M, Heino T. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS ONE. 2016;11:e0151550 pubmed publisher
    ..Our data suggest a role for Manf in the regulation of Drosophila UPR. ..
  9. Sánchez Alvarez M, Zhang Q, Finger F, Wakelam M, Bakal C. Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. Open Biol. 2015;5:150093 pubmed publisher
    ..We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. ..

More Information


  1. Ryoo H. Drosophila as a model for unfolded protein response research. BMB Rep. 2015;48:445-53 pubmed
    ..The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. ..
  2. Coelho D, Gaspar C, Domingos P. Ire1 mediated mRNA splicing in a C-terminus deletion mutant of Drosophila Xbp1. PLoS ONE. 2014;9:e105588 pubmed publisher
    ..The more conserved branch of the UPR relies on an ER transmembrane enzyme, Ire1, which, upon ER stress, promotes the unconventional splicing of a small intron from the mRNA encoding the ..
  3. Coelho D, Domingos P. Physiological roles of regulated Ire1 dependent decay. Front Genet. 2014;5:76 pubmed publisher
    Inositol-requiring enzyme 1 (Ire1) is an important transducer of the unfolded protein response (UPR) that is activated by the accumulation of misfolded proteins in the endoplamic reticulum (ER stress)...
  4. Ryoo H, Li J, Kang M. Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load. PLoS ONE. 2013;8:e75774 pubmed publisher
    ..A major branch of the UPR pathway is mediated by IRE1, an ER-tethered endonuclease...
  5. Qin Q, Pei J, Ancona V, Shaw B, Ficht T, de Figueiredo P. RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication. PLoS Pathog. 2008;4:e1000110 pubmed publisher
    ..The most intriguing of these was inositol-requiring enzyme 1 (IRE1), a transmembrane kinase that regulates the eukaryotic unfolded protein response (UPR)...
  6. Park S, Ludwig M, Tamarina N, He B, Carl S, Dickerson D, et al. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014;196:539-55 pubmed publisher
    ..Mutant (but not wild-type) proinsulin expression in the eye imaginal disc induces IRE1-mediated XBP1 alternative splicing, a signal for endoplasmic reticulum stress response activation, and produces ..
  7. Rincon Limas D, Jensen K, Fernandez Funez P. Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des. 2012;18:1108-22 pubmed
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications. ..
  8. Wang L, Ryoo H, Qi Y, Jasper H. PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress. PLoS Genet. 2015;11:e1005220 pubmed publisher
    ..Our studies highlight the significance of the PERK branch of the unfolded protein response of the ER (UPRER) in intestinal homeostasis and provide a viable strategy to improve organismal health- and lifespan. ..
  9. Xu Z, Chikka M, Xia H, Ready D. Ire1 supports normal ER differentiation in developing Drosophila photoreceptors. J Cell Sci. 2016;129:921-9 pubmed publisher
    ..Inositol-requiring enzyme 1 (Ire1), a conserved core protein of the unfolded protein response (UPR), participates in ER remodeling and is ..
  10. Zacharogianni M, Kondylis V, Tang Y, Farhan H, Xanthakis D, Fuchs F, et al. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO J. 2011;30:3684-700 pubmed publisher
    ..These results reveal the existence of new signalling circuits participating in the complex regulation of cell growth. ..