Gene Symbol: IntS3
Description: Integrator 3
Alias: CG17665, Dmel\CG17665, IR23, Int3, NC19, NC28, l(2)IR23, l(2)NC19, l(2)NC28, l(2Rh)IR23, integrator 3, CG17665-PA, IntS3-PA, lethal (2) IR23, lethal (2) NC19, lethal (2) NC28
Species: fruit fly

Top Publications

  1. Chen J, Waltenspiel B, Warren W, Wagner E. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. J Biol Chem. 2013;288:4867-77 pubmed publisher
    ..Collectively, these results identify an unexpected interaction between the largest and smallest integrator subunits that is essential for the 3' end formation of Drosophila snRNA. ..
  2. Dimitri P, Arca B, Berghella L, Mei E. High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997;94:8052-7 pubmed
    ..Together, these data indicate that I factors transpose with high frequency into pericentric regions of chromosome 2 and may play a role in the evolution of constitutive heterochromatin. ..
  3. Wendler F, Gillingham A, Sinka R, Rosa Ferreira C, Gordon D, Franch Marro X, et al. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. EMBO J. 2010;29:304-14 pubmed publisher
    ..Given this coverage, the small number of novel components suggests that contrary to previous indications the number of essential core components of the secretory pathway is not much greater in metazoans than in yeasts. ..
  4. Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
    ..In total, we verified the existence of eight novel essential loci in 2Rh: CG17665, CG17683, CG17684, CG17883, CG40127, CG41265, CG42595, and Atf6...