Gene Symbol: Ide
Description: Insulin degrading metalloproteinase
Alias: CG5517, Dmel\CG5517, IDE, dIDE, dIde, dide, dlde, ide, insulin degrading metalloproteinase, CG5517-PB, Ide-PB, insulin degrading enzyme, insulin-degrading enzyme
Species: fruit fly

Top Publications

  1. Garcia J, Fenton B, Rosner M. Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster. Biochemistry. 1988;27:4237-44 pubmed
    An insulin-degrading enzyme (IDE) from the cytoplasm of Drosophila Kc cells has been purified and characterized. The purified enzyme is a monomer with an s value of 7...
  2. Tsuda M, Kobayashi T, Matsuo T, Aigaki T. Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. FEBS Lett. 2010;584:2916-20 pubmed publisher
    ..Here we provide genetic evidence that Drosophila Ide (dIde) antagonizes the insulin signaling pathway and human Abeta-induced neurotoxicity in Drosophila...
  3. Duckworth W, Garcia J, Liepnieks J, Hamel F, Hermodson M, Frank B, et al. Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites. Biochemistry. 1989;28:2471-7 pubmed
    ..Drosophila, which has insulin-like hormones and insulin receptor homologues, also expresses an insulin degrading enzyme with properties that are very similar to those of mammalian insulin protease...
  4. Becker A, Roth R. Identification of glutamate-169 as the third zinc-binding residue in proteinase III, a member of the family of insulin-degrading enzymes. Biochem J. 1993;292 ( Pt 1):137-42 pubmed
    ..3 mol of zinc/mol of enzyme. These findings are consistent with glutamate-169 being the third zinc-binding residue in proteinase III. ..
  5. Leips J, Mackay T. Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density. Genetics. 2000;155:1773-88 pubmed
    ..Further fine-scale mapping is necessary to determine whether candidate genes within the regions to which the QTL map are actually responsible for the observed variation in life span. ..
  6. Hyun J, Hashimoto C. Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila. Fly (Austin). 2011;5:53-7 pubmed
    Insulin-degrading enzyme (IDE) degrades insulin and other peptides, including the A? peptide of Alzheimer's disease...
  7. Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, et al. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A?42-induced Alzheimer's disease-like symptoms. Neurobiol Aging. 2013;34:2604-12 pubmed publisher was accompanied by a trend of decreased expression of amyloid-? degradation proteases (including NEP1-3 and IDE) with age and reduced Cu-A? interaction-induced oxidative stress in Ctr1C RNAi flies...
  8. Galagovsky D, Katz M, Acevedo J, Sorianello E, Glavic A, Wappner P. The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner. Mol Biol Cell. 2014;25:916-24 pubmed publisher
    ..We find that either loss or gain of function of Drosophila IDE (dIDE) can restrict growth in a cell-autonomous manner by affecting both cell size and cell number...
  9. Kuo W, Gehm B, Rosner M. Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme. Mol Endocrinol. 1990;4:1580-91 pubmed
    ..We now report the cloning and sequencing of the cDNA coding for the Drosophila IDE (dIDE). Northern blot analysis indicates that the dIDE is translated from a 3...

More Information


  1. Hamel F, Gehm B, Rosner M, Duckworth W. Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes. Biochim Biophys Acta. 1997;1338:207-14 pubmed
    Insulin-degrading enzyme (IDE) is a sulfhydryl-dependent metalloproteinase with a zinc binding site unique to a new class of proteinases...
  2. Finelli A, Kelkar A, Song H, Yang H, Konsolaki M. A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci. 2004;26:365-75 pubmed
    ..We propose that our Drosophila model is suitable for the study and elucidation of Abeta metabolism and toxicity at the genetic level. ..
  3. Pendse J, Ramachandran P, Na J, Narisu N, Fink J, Cagan R, et al. A Drosophila functional evaluation of candidates from human genome-wide association studies of type?2?diabetes and related metabolic traits identifies tissue-specific roles for dHHEX. BMC Genomics. 2013;14:136 pubmed publisher
    ..To our knowledge, this is the first large-scale effort to study the functional interaction between GWAS-identified candidate genes and an environmental risk factor such as diet in a model organism system. ..