Gene Symbol: HtrA2
Description: HTRA2-related serine protease
Alias: CG8464, DmHtrA2, Dmel\CG8464, HtrA2/Omi, Omi, dOmi, domi, htrA2, htrA2/omi, omi, HTRA2-related serine protease, CG8464-PA, CG8464-PB, HtrA2-PA, HtrA2-PB, serine protease HTRA2
Species: fruit fly
Products:     HtrA2

Top Publications

  1. Khan F, Fujioka M, Datta P, Fernandes Alnemri T, Jaynes J, Alnemri E. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. Cell Death Differ. 2008;15:1073-83 pubmed publisher
    Mitochondrial proteins such as cytochrome c, Smac/DIABLO and Omi/HtrA2 play important roles in the cell death pathways of mammalian cells. In Drosophila, the role of mitochondria in cell death is less clear...
  2. Igaki T, Suzuki Y, Tokushige N, Aonuma H, Takahashi R, Miura M. Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem Biophys Res Commun. 2007;356:993-7 pubmed
    ..To address this, we cloned and characterized DmHtrA2, a Drosophila homolog of a mitochondrial serine protease HtrA2/Omi. We show that DmHtrA2 normally resides in mitochondria and is up-regulated by UV-irradiation...
  3. Whitworth A, Lee J, Ho V, Flick R, Chowdhury R, McQuibban G. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Dis Model Mech. 2008;1:168-74; discussion 173 pubmed publisher
    ..cause, particularly with the identification of mutations in the PTEN-induced putative kinase (pink1), parkin and htrA2 (also known as omi) genes that are linked to PD...
  4. Challa M, Malladi S, Pellock B, Dresnek D, Varadarajan S, Yin Y, et al. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 2007;26:3144-56 pubmed
    ..Herein, we demonstrate that Drosophila Omi (dOmi), a fly homologue of the serine protease Omi/HtrA2, is a developmentally regulated mitochondrial intermembrane space protein that undergoes processive cleavage, in ..
  5. Yun J, Cao J, Dodson M, Clark I, Kapahi P, Chowdhury R, et al. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. J Neurosci. 2008;28:14500-10 pubmed publisher
    Recently, a mutation in the mitochondrial protease Omi/HtrA2, G399S, was found in sporadic Parkinson's disease (PD) patients, leading to the designation of Omi/HtrA2 as PD locus 13 (PARK13)...
  6. Tain L, Chowdhury R, Tao R, Plun Favreau H, Moisoi N, Martins L, et al. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ. 2009;16:1118-25 pubmed publisher
    High temperature requirement A2 (HtrA2/Omi) is a mitochondrial protease that exhibits proapoptotic and cell-protective properties and has been linked to Parkinson's disease (PD)...
  7. Banerjee S, Chinthapalli B. A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis. Int J Biochem Cell Biol. 2014;54:36-48 pubmed publisher
    ..we delineated bonafide interactors like dMitofilin, Marf, Serine protease High temperature requirement protein A2 (HTRA2), Rhomboid-7 (Rho-7) along with novel interactors such as Mortalin ortholog (Hsc70-5) from Drosophila ..
  8. Freeman M. The rhomboid-like superfamily: molecular mechanisms and biological roles. Annu Rev Cell Dev Biol. 2014;30:235-54 pubmed publisher
    ..Their potential medical significance is now becoming apparent in several areas. ..
  9. Holland C, Lipsett D, Clark D. A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster. Genetics. 2011;188:359-67 pubmed publisher
    ..Among the upregulated genes was HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine ..

More Information


  1. Qi Y, Liu H, Daniels M, Zhang G, Xu H. Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration. Cell Death Differ. 2016;23:291-302 pubmed publisher
    ..Furthermore, inhibiting apoptosis by targeting dOmi (Drosophila Htra2/Omi) or DIAP1, or reducing ROS accumulation suppressed retinal degeneration...
  2. Xu D, Woodfield S, Lee T, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3:78-90 pubmed
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes. ..
  3. Yacobi Sharon K, Namdar Y, Arama E. Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart. Dev Cell. 2013;25:29-42 pubmed publisher
    ..We then identified, in a screen, the Parkinson's disease-associated mitochondrial protease, HtrA2/Omi, as an important mediator of GCD, acting mainly through its catalytic activity rather than by antagonizing ..