Gene Symbol: Hsp70Bbb
Description: Hsp70Bbb
Alias: CG31354, CG5834, Dm-hsp70, Dmel\CG5834, HSP70, HSP70Bbb, Hsp-70, Hsp70, Hsp70B, Hsp70Bb, dHsp70, hsp70, hsp70B, hsp70Bb-prime, Hsp70Bbb, CG5834-PA, Hsp70Bbb-PA, heat shock protein 70, heat-shock protein 70
Species: fruit fly
Products:     Hsp70Bbb

Top Publications

  1. Bettencourt B, Hogan C, Nimali M, Drohan B. Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance in Hsp70 null flies. BMC Biol. 2008;6:5 pubmed publisher
    The heat shock protein Hsp70 promotes inducible thermotolerance in nearly every organism examined to date...
  2. Zeitlinger J, Stark A, Kellis M, Hong J, Nechaev S, Adelman K, et al. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet. 2007;39:1512-6 pubmed
    ..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development. ..
  3. Buszczak M, Spradling A. The Drosophila P68 RNA helicase regulates transcriptional deactivation by promoting RNA release from chromatin. Genes Dev. 2006;20:977-89 pubmed
    ..Full-length hsp70 mRNA accumulates in the nucleus near its sites of transcription following heat shock of p68 homozygotes, and hsp70 ..
  4. Lebedeva L, Nabirochkina E, Kurshakova M, Robert F, Krasnov A, Evgen ev M, et al. Occupancy of the Drosophila hsp70 promoter by a subset of basal transcription factors diminishes upon transcriptional activation. Proc Natl Acad Sci U S A. 2005;102:18087-92 pubmed
    The presence of general transcription factors and other coactivators at the Drosophila hsp70 gene promoter in vivo has been examined by polytene chromosome immunofluorescence and chromatin immunoprecipitation at endogenous heat-shock ..
  5. Sørensen J, Loeschcke V. Larval crowding in Drosophila melanogaster induces Hsp70 expression, and leads to increased adult longevity and adult thermal stress resistance. J Insect Physiol. 2001;47:1301-1307 pubmed
    In this study we show for the first time that moderate high larval density induces Hsp70 expression in Drosophila melanogaster larvae. Larval crowding led to both increased mean and maximal longevity in adults of both sexes...
  6. Gong W, Golic K. Loss of Hsp70 in Drosophila is pleiotropic, with effects on thermotolerance, recovery from heat shock and neurodegeneration. Genetics. 2006;172:275-86 pubmed
    ..In Drosophila melanogaster the Hsp70 chaperone dominates the profile of protein synthesis during the heat-shock response...
  7. Zatsepina O, Velikodvorskaia V, Molodtsov V, Garbuz D, Lerman D, Bettencourt B, et al. A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression. J Exp Biol. 2001;204:1869-81 pubmed
    ..of high temperatures, which in Drosophila melanogaster is due in part to the inducible molecular chaperone Hsp70, is only modest in this strain...
  8. Takahashi K, Rako L, Takano Shimizu T, Hoffmann A, Lee S. Effects of small Hsp genes on developmental stability and microenvironmental canalization. BMC Evol Biol. 2010;10:284 pubmed publisher
    ..This novel finding may lead to a better understanding of non-Hsp90 molecular mechanisms controlling variability in morphological traits. ..
  9. Kopytova D, Orlova A, Krasnov A, Gurskiy D, Nikolenko J, Nabirochkina E, et al. Multifunctional factor ENY2 is associated with the THO complex and promotes its recruitment onto nascent mRNA. Genes Dev. 2010;24:86-96 pubmed publisher
    ..ENY2 and THO arrive on the transcribed region of the hsp70 gene after its activation, and ENY2 plays an important role in THO recruitment...

More Information


  1. Haney R, Feder M. Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters. PLoS ONE. 2009;4:e8486 pubmed publisher
    ..melanogaster natural populations. Hsp70 promoters exhibit more TE insertions per promoter than all other genesets in the 12 species, similarly to in ..
  2. Folk D, Zwollo P, Rand D, Gilchrist G. Selection on knockdown performance in Drosophila melanogaster impacts thermotolerance and heat-shock response differently in females and males. J Exp Biol. 2006;209:3964-73 pubmed
    ..Finally, we compared temporal profiles of the combined expression of two major heat-shock proteins, HSC70 and HSP70, during heat stress among the females and males from the selected T(KD) lines...
  3. Papaconstantinou M, Wu Y, Pretorius H, Singh N, Gianfelice G, Tanguay R, et al. Menin is a regulator of the stress response in Drosophila melanogaster. Mol Cell Biol. 2005;25:9960-72 pubmed
    ..The overexpression of menin enhanced the expression of HSP70 in embryos and interfered with its down-regulation during recovery at the normal temperature...
  4. Zhao Y, Sun H, Lu J, Li X, Chen X, Tao D, et al. Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors. J Exp Biol. 2005;208:697-705 pubmed
    ..To further determine if hsp22 and hsp70 expression is correlated with lifespan, and if histone acetylation participates in this process, RNA levels for ..
  5. Smith S, Petruk S, Sedkov Y, Cho E, Tillib S, Canaani E, et al. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex. Nat Cell Biol. 2004;6:162-7 pubmed
    Rapid induction of the Drosophila melanogaster heat shock gene hsp70 is achieved through the binding of heat shock factor (HSF) to heat shock elements (HSEs) located upstream of the transcription start site (reviewed in ref. 3)...
  6. Maside X, Bartolomé C, Charlesworth B. S-element insertions are associated with the evolution of the Hsp70 genes in Drosophila melanogaster. Curr Biol. 2002;12:1686-91 pubmed
    ..of three members of a heat shock gene family, Hsp70 (Hsp70Aa and Hsp70Ab in polytene chromosome band 87A, and Hsp70Bb in 87C). A PCR-based analysis suggests that the insertions are fixed or at high frequencies in the entire species...
  7. Chen B, Shilova V, Zatsepina O, Evgen ev M, Feder M. Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster. Cell Stress Chaperones. 2008;13:11-7 pubmed publisher
    ..to cluster-specific quantitative RT-PCR, expression of the Hsp70A cluster genes was typically greater than that of the Hsp70B gene cluster genes, although the latter are more numerous and, in this case, free of P element insertions.
  8. Auluck P, Meulener M, Bonini N. Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. J Biol Chem. 2005;280:2873-8 pubmed
    ..The molecular chaperone Hsp70 protects cells from the deleterious effects of alpha-synuclein, indicating a potential therapeutic approach to ..
  9. Saunders A, Werner J, Andrulis E, Nakayama T, Hirose S, Reinberg D, et al. Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science. 2003;301:1094-6 pubmed
    ..Our observations are consistent with FACT being restricted to transcription that involves nucleosome disassembly mechanisms. ..
  10. Shilova V, Garbuz D, Myasyankina E, Chen B, Evgen ev M, Feder M, et al. Remarkable site specificity of local transposition into the Hsp70 promoter of Drosophila melanogaster. Genetics. 2006;173:809-20 pubmed
    ..have exploited a local transposition technique and Drosophila melanogaster strains with EPgy2 insertions near the Hsp70 gene cluster at 87A7 to produce numerous novel EPgy2 insertions into these Hsp70 genes...
  11. Azad P, Ryu J, Haddad G. Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia. Free Radic Biol Med. 2011;51:530-8 pubmed publisher
    ..In this study, we employed the UAS-Gal4 system to dissect the protective role of Hsp70 in specific tissues in vivo under severe hypoxia...
  12. Landis G, Abdueva D, Skvortsov D, Yang J, Rabin B, Carrick J, et al. Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2004;101:7663-8 pubmed
    ..Immune reporter expression in young flies was partially predictive of remaining life span, suggesting their potential as biomonitors of aging. ..
  13. Smith E, Lee M, Winter B, Droz N, Eissenberg J, Shiekhattar R, et al. Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol. 2008;28:1041-6 pubmed
    ..Furthermore, heat shock induction results in the recruitment of dUTX to the hsp70 gene, like that of several other Pol II elongation factors...
  14. Gupta S, Siddique H, Saxena D, Chowdhuri D. Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase. Biochim Biophys Acta. 2005;1725:81-92 pubmed
    ..Third instar larvae of Drosophila melanogaster transgenic for hsp70 were exposed to 0.1 to 100.0 ppb dichlorvos and 5...
  15. Kurshakova M, Krasnov A, Kopytova D, Shidlovskii Y, Nikolenko J, Nabirochkina E, et al. SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC. EMBO J. 2007;26:4956-65 pubmed
    ..Importantly, E(y)2 and Xmas-2 knockdown decreases the contact between the heat-shock protein 70 (hsp70) gene loci and the nuclear envelope before and after activation and interferes with transcription...
  16. Zobeck K, Buckley M, Zipfel W, Lis J. Recruitment timing and dynamics of transcription factors at the Hsp70 loci in living cells. Mol Cell. 2010;40:965-75 pubmed publisher
    ..to examine at high temporal resolution the recruitment and dynamics of transcription factors to the inducible Hsp70 loci in individual Drosophila salivary gland nuclei...
  17. Azad P, Zhou D, Russo E, Haddad G. Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. PLoS ONE. 2009;4:e5371 pubmed publisher
    ..Heat shock proteins up-regulation (specifically Hsp23 and Hsp70) led to a significant increase in adult survival (as compared to controls) of P-element lines during CH...
  18. Eissenberg J, Shilatifard A, Dorokhov N, Michener D. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Mol Genet Genomics. 2007;277:101-14 pubmed
    ..b>Hsp 70 mRNA induction by heat shock was attenuated in Cdk9 knockdown larvae...
  19. Gong W, Golic K. Genomic deletions of the Drosophila melanogaster Hsp70 genes. Genetics. 2004;168:1467-76 pubmed
    ..melanogaster we set out to delete the Hsp70 genes...
  20. Fujikake N, Nagai Y, Popiel H, Okamoto Y, Yamaguchi M, Toda T. Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones. J Biol Chem. 2008;283:26188-97 pubmed publisher
    ..3% rescue), indicating that 17-AAG is widely effective against various polyQ diseases. 17-AAG induced Hsp70, Hsp40, and Hsp90 expression in a dose-dependent manner, and the expression levels correlated with its therapeutic ..
  21. Tulin A, Spradling A. Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science. 2003;299:560-2 pubmed
    Steroid response and stress-activated genes such as hsp70 undergo puffing in Drosophila larval salivary glands, a local loosening of polytene chromatin structure associated with gene induction...
  22. Newman A, Xiao C, Robertson R. Synaptic thermoprotection in a desert-dwelling Drosophila species. J Neurobiol. 2005;64:170-80 pubmed
    ..This induced thermoprotection has been ascribed to an up-regulation of the inducible heat-shock protein, Hsp70. However, the mechanisms mediating natural thermoprotection in the wild are unknown...
  23. Coléno Costes A, Jang S, de Vanssay A, Rougeot J, Bouceba T, Randsholt N, et al. New partners in regulation of gene expression: the enhancer of Trithorax and Polycomb Corto interacts with methylated ribosomal protein l12 via its chromodomain. PLoS Genet. 2012;8:e1003006 pubmed publisher
    ..Chromatin immunoprecipitation experiments show that Corto and RPL12 bind hsp70 and are similarly recruited on gene body after heat shock...
  24. Hanyu Nakamura K, Sonobe Nojima H, Tanigawa A, Lasko P, Nakamura A. Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells. Nature. 2008;451:730-3 pubmed publisher
    ..Thus, inhibition of P-TEFb is probably a common mechanism during germ cell specification in the disparate organisms C. elegans and Drosophila. ..
  25. Chopra V, Cande J, Hong J, Levine M. Stalled Hox promoters as chromosomal boundaries. Genes Dev. 2009;23:1505-9 pubmed publisher
    ..Thus, promoter-proximal stalling factors might help promote insulator-promoter interactions. We propose that stalled promoters help organize gene complexes within chromosomal loop domains. ..
  26. Sathyanarayanan S, Zheng X, Xiao R, Sehgal A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell. 2004;116:603-15 pubmed
    ..PP2A also affects PER phosphorylation in vitro and in vivo. We propose that the posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A. ..
  27. Tower J, Landis G, Gao R, Luan A, Lee J, Sun Y. Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes. J Gerontol A Biol Sci Med Sci. 2014;69:253-9 pubmed publisher
    The cytoplasmic chaperone gene Hsp70 and the mitochondrial chaperone gene Hsp22 are upregulated during normal aging in Drosophila in tissue-general patterns...
  28. Baker D, Russell S. Gene expression during Drosophila melanogaster egg development before and after reproductive diapause. BMC Genomics. 2009;10:242 pubmed publisher
    ..We believe that our dataset will facilitate further exploration of the developmental and evolutionary characteristics of oogenesis as well as the nature of reproductive arrest in Drosophila. ..
  29. Jin P, Zarnescu D, Zhang F, Pearson C, Lucchesi J, Moses K, et al. RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron. 2003;39:739-47 pubmed
    ..Although devoid of mutant protein, this neurodegeneration exhibits neuronal inclusion bodies that are Hsp70 and ubiquitin positive. Overexpression of Hsp70 could suppress the neurodegeneration...
  30. Zhang Y, Casas Tinto S, Rincon Limas D, Fernandez Funez P. Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila. PLoS ONE. 2014;9:e88522 pubmed publisher
    ..progressive locomotor dysfunction and accumulation of pathogenic PrP conformations, while co-expression of human Hsp70 delayed these changes...
  31. Fuda N, Buckley M, Wei W, Core L, Waters C, Reinberg D, et al. Fcp1 dephosphorylation of the RNA polymerase II C-terminal domain is required for efficient transcription of heat shock genes. Mol Cell Biol. 2012;32:3428-37 pubmed publisher
    ..Previously, we identified Drosophila Fcp1 as an important factor in optimal Hsp70 mRNA accumulation after heat shock. Here, we examine the role of Fcp1 in transcription of heat shock genes in vivo...
  32. Shaw P, Franken P. Perchance to dream: solving the mystery of sleep through genetic analysis. J Neurobiol. 2003;54:179-202 pubmed
    ..In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse. ..
  33. Juge F, Fernando C, Fic W, Tazi J. The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown. PLoS Genet. 2010;6:e1001124 pubmed publisher
    ..Our data show that B52 delivers Topo I to RNA polymerase II-active chromatin loci and provide the first evidence that DNA topology and mRNA release can be coordinated to control gene expression. ..
  34. Liévens J, Iché M, Laval M, Faivre Sarrailh C, Birman S. AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. Hum Mol Genet. 2008;17:882-94 pubmed
    ..kinases in the retina as well as in neurons and glia of the fly brain, compared with the rescuing effects of the HSP70 chaperone. We found that both AKT and HSP70 alleviated mHtt-induced toxicity in the retina...
  35. Lakhotia S, Prasanth K. Tissue- and development-specific induction and turnover of hsp70 transcripts from loci 87A and 87C after heat shock and during recovery in Drosophila melanogaster. J Exp Biol. 2002;205:345-58 pubmed
    ..genome of Drosophila melanogaster normally carries at least five nearly identical copies of heat-shock-inducible hsp70 genes, two copies at the 87A7 and three copies at the 87C1 chromosome sites...
  36. Cai W, Bao X, Deng H, Jin Y, Girton J, Johansen J, et al. RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila. Development. 2008;135:2917-25 pubmed publisher
    ..mRNA from the six genes that encode the major heat shock protein in Drosophila, Hsp70, is transcribed at robust levels in JIL-1 null mutants, as directly demonstrated by qRT-PCR...
  37. Poels J, Martinez A, Suner M, De Loof A, Dunbar S, Vanden Broeck J. Glucocorticoid-inducible gene expression vectors for use in Drosophila melanogaster Schneider 2 cells. Insect Mol Biol. 2004;13:205-11 pubmed
    ..The implications of the observations made are discussed in the context of promoter properties and of induction of genes that may be studied in Drosophila. ..
  38. Tian S, Haney R, Feder M. Phylogeny disambiguates the evolution of heat-shock cis-regulatory elements in Drosophila. PLoS ONE. 2010;5:e10669 pubmed publisher
    ..In contrast, in the multi-copy gene Hsp70, the number of HSEs is nearly constant across species...
  39. Behm Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. EMBO J. 2007;26:1591-601 pubmed
    ..These findings reveal a conserved role for PABPC1 in mRNA surveillance. ..
  40. Duncan R. Inhibition of Hsp90 function delays and impairs recovery from heat shock. FEBS J. 2005;272:5244-56 pubmed
    ..The cessation of heat shock protein synthesis did not occur until the levels of Hsp70 were substantially elevated relative to its standard threshold for autoregulation...
  41. Mosqueira M, Willmann G, Ruohola Baker H, Khurana T. Chronic hypoxia impairs muscle function in the Drosophila model of Duchenne's muscular dystrophy (DMD). PLoS ONE. 2010;5:e13450 pubmed publisher
    ..We hypothesize that targeting/correcting the disparate molecular response(s) to hypoxia may offer a novel therapeutic strategy in DMD. ..
  42. Li X, Heinrich J, Scott M. piggyBac-mediated transposition in Drosophila melanogaster: an evaluation of the use of constitutive promoters to control transposase gene expression. Insect Mol Biol. 2001;10:447-55 pubmed
    ..However, the success rate is often low. Previous piggyBac helper plasmids have used either the piggyBac or the hsp70 promoter from Drosophila melanogaster to control expression of the transposase gene...
  43. Posgai R, Ahamed M, Hussain S, Rowe J, Nielsen M. Inhalation method for delivery of nanoparticles to the Drosophila respiratory system for toxicity testing. Sci Total Environ. 2009;408:439-43 pubmed publisher
    ..Silver coated and uncoated nanoparticles were delivered in a toxicity test, and induced Hsp70 expression in flies, confirming the utility of this model in toxicity testing...
  44. Rutherford S. Between genotype and phenotype: protein chaperones and evolvability. Nat Rev Genet. 2003;4:263-74 pubmed
    ..Environmentally sensitive chaperone functions in protein folding and signal transduction have different potential consequences for the evolution of populations and lineages under selection in changing environments. ..
  45. Helfand S, Rogina B. Genetics of aging in the fruit fly, Drosophila melanogaster. Annu Rev Genet. 2003;37:329-48 pubmed
  46. Boeke J, Bag I, Ramaiah M, Vetter I, Kremmer E, Pal Bhadra M, et al. The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. PLoS ONE. 2011;6:e20761 pubmed publisher
  47. Ahamed M, Posgai R, Gorey T, Nielsen M, Hussain S, Rowe J. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol. 2010;242:263-9 pubmed publisher
    ..Ag NPs up-regulated the expression of heat shock protein 70 and induced oxidative stress in D. melanogaster...
  48. Halfon M, Arnosti D. New tools, resources for gene regulatory analysis in Drosophila. Fly (Austin). 2007;1:123-4 pubmed
  49. Canamasas I, Debes A, Natali P, Kurzik Dumke U. Understanding human cancer using Drosophila: Tid47, a cytosolic product of the DnaJ-like tumor suppressor gene l2Tid, is a novel molecular partner of patched related to skin cancer. J Biol Chem. 2003;278:30952-60 pubmed
    ..We demonstrate that in BCCs loss of htid expression correlates with loss of differentiation capacity of the neoplastic cells similar to that found in the Drosophila tumor model. ..
  50. Teves S, Henikoff S. Heat shock reduces stalled RNA polymerase II and nucleosome turnover genome-wide. Genes Dev. 2011;25:2387-97 pubmed publisher
    ..Our ability to precisely map both nucleosomal and subnucleosomal particles directly from low-salt-soluble chromatin extracts to assay changes in the chromatin landscape provides a simple general strategy for epigenome characterization. ..
  51. Rajendra T, Prasanth K, Lakhotia S. Male sterility associated with overexpression of the noncoding hsromega gene in cyst cells of testis of Drosophila melanogaster. J Genet. 2001;80:97-110 pubmed
  52. Mito Y, Henikoff J, Henikoff S. Histone replacement marks the boundaries of cis-regulatory domains. Science. 2007;315:1408-11 pubmed
    ..Our results suggest the existence of a continuous process that disrupts nucleosomes and maintains accessibility of cis-regulatory elements. ..
  53. Vazquez Pianzola P, Hernandez G, Suter B, Rivera Pomar R. Different modes of translation for hid, grim and sickle mRNAs in Drosophila. Cell Death Differ. 2007;14:286-95 pubmed
    ..Our results show that IRES-dependent initiation may play a role in the translation of Drosophila proapoptotic genes and suggest a variety of regulatory pathways. ..
  54. Marr S, Lis J, Treisman J, Marr M. The metazoan-specific mediator subunit 26 (Med26) is essential for viability and is found at both active genes and pericentric heterochromatin in Drosophila melanogaster. Mol Cell Biol. 2014;34:2710-20 pubmed
    ..This work is the first characterization of the metazoan-specific Mediator subunit in an animal model. ..
  55. Calabria G, Dolgova O, Rego C, Castañeda L, Rezende E, Balanya J, et al. Hsp70 protein levels and thermotolerance in Drosophila subobscura: a reassessment of the thermal co-adaptation hypothesis. J Evol Biol. 2012;25:691-700 pubmed publisher
    ..we show that flies carrying the warm-climate chromosome arrangement O(3+4) have higher basal protein levels of Hsp70 than their cold-climate O(st) counterparts, but this difference disappears after heat hardening...
  56. Iijima Ando K, Wu P, Drier E, Iijima K, Yin J. cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila. Proc Natl Acad Sci U S A. 2005;102:10261-6 pubmed
    ..As reported previously, overexpression of heat-shock protein 70 (Hsp70) rescues polyglutamine-dependent lethality. However, it does not rescue CREB-mediated transcription...
  57. Bell O, Wirbelauer C, Hild M, Scharf A, Schwaiger M, MacAlpine D, et al. Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J. 2007;26:4974-84 pubmed
    ..Thus di- and trimethylation of H3K36 have opposite effects on H4K16 acetylation, which we propose enable dynamic changes in chromatin compaction during transcript elongation. ..
  58. Siddique H, Gupta S, Mitra K, Bajpai V, Mathur N, Murthy R, et al. Adverse effect of tannery waste leachates in transgenic Drosophila melanogaster: role of ROS in modulation of Hsp70, oxidative stress and apoptosis. J Appl Toxicol. 2008;28:734-48 pubmed publisher
    ..The present study evaluated the role of ROS in tannery leachates induced Hsp70 expression, antioxidant enzymes and apoptosis in Drosophila. Different concentrations (0.05-2...
  59. Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell. 2010;143:813-25 pubmed publisher
    ..These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging. ..
  60. Bhargav D, Pratap Singh M, Murthy R, Mathur N, Misra D, Saxena D, et al. Toxic potential of municipal solid waste leachates in transgenic Drosophila melanogaster (hsp70-lacZ): hsp70 as a marker of cellular damage. Ecotoxicol Environ Saf. 2008;69:233-45 pubmed
    ..carried out to determine the possible toxic effects of leachates from MSW in transgenic Drosophila melanogaster (hsp70-lacZ). Third instar larvae exposed to 1.0-3...
  61. Wang H, Kazemi Esfarjani P, Benzer S. Multiple-stress analysis for isolation of Drosophila longevity genes. Proc Natl Acad Sci U S A. 2004;101:12610-5 pubmed
    ..Overexpression of either hsp26 or hsp27 extended the mean lifespan by 30%, and the flies also displayed increased stress resistance. The results demonstrate that multiple-stress screening can be used to identify new longevity genes. ..
  62. Krebs R. A comparison of Hsp70 expression and thermotolerance in adults and larvae of three Drosophila species. Cell Stress Chaperones. 1999;4:243-9 pubmed
    ..One is to facilitate, in part, organismal thermotolerance, of which the functional consequences depend on Hsp70 concentration and developmental stage in Drosophila melanogaster...
  63. Cakouros D, Daish T, Kumar S. Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues. J Cell Biol. 2004;165:631-40 pubmed
    ..These results indicate that direct binding of EcR-Usp is crucial for controlling the timing of dronc expression in specific tissues. ..
  64. Gurskiy D, Orlova A, Vorobyeva N, Nabirochkina E, Krasnov A, Shidlovskii Y, et al. The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila. Nucleic Acids Res. 2012;40:10689-700 pubmed publisher
    ..messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus...
  65. Adelman K, Marr M, Werner J, Saunders A, Ni Z, Andrulis E, et al. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol Cell. 2005;17:103-12 pubmed
    ..we report that Pol II is susceptible to transcription arrest within the promoter-proximal region of Drosophila hsp70 and that transcript cleavage factor TFIIS is essential for rapid induction of hsp70 RNA...
  66. Murawska M, Hassler M, Renkawitz Pohl R, Ladurner A, Brehm A. Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression. PLoS Genet. 2011;7:e1002206 pubmed publisher
    ..We suggest that stress-induced chromatin PARylation serves to rapidly attract factors that are required for an efficient and timely transcriptional response. ..
  67. Sakaguchi A, Karachentsev D, Seth Pasricha M, Druzhinina M, Steward R. Functional characterization of the Drosophila Hmt4-20/Suv4-20 histone methyltransferase. Genetics. 2008;179:317-22 pubmed publisher
    ..We find that even with this biochemical function, Suv4-20 is not required for survival and does not control position-effect variegation (PEV). ..
  68. Hurt J, Obar R, Zhai B, Farny N, Gygi S, Silver P. A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol. 2009;185:265-77 pubmed publisher
    ..Our data suggest a model wherein ZC3H3 interfaces between the polyadenylation machinery, newly poly(A) mRNAs, and factors for transcript export. ..
  69. Pankotai T, Ujfaludi Z, Vámos E, Suri K, Boros I. The dissociable RPB4 subunit of RNA Pol II has vital functions in Drosophila. Mol Genet Genomics. 2010;283:89-97 pubmed publisher
  70. Gerber M, Tenney K, Conaway J, Conaway R, Eissenberg J, Shilatifard A. Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A. J Biol Chem. 2005;280:4017-20 pubmed
    ..use of RNA interference in vivo, we show that dEloA is required for the proper expression of one of these genes, HSP70, and that its requirement for heat shock gene expression is exerted after the initiation of transcription at heat ..
  71. Grover D, Yang J, Tavare S, Tower J. Simultaneous tracking of fly movement and gene expression using GFP. BMC Biotechnol. 2008;8:93 pubmed publisher
    ..eyeless/Pax6 reporter expression had a 12 hr period that correlated with fly activity levels. hsp70 and hsp22 gene reporters were induced during fly aging in circadian patterns (24 hr and 18 hr periods, ..
  72. Hernández G, Vazquez Pianzola P, Sierra J, Rivera Pomar R. Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos. RNA. 2004;10:1783-97 pubmed
    ..The 5'UTR of reaper exhibits a high degree of similarity with that of Drosophila heat shock protein 70 mRNA, and both display IRES activity...
  73. Todd P, Oh S, Krans A, He F, Sellier C, Frazer M, et al. CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. Neuron. 2013;78:440-55 pubmed publisher
    ..These studies expand the growing list of nucleotide repeat disorders in which RAN translation occurs and provide evidence that RAN translation contributes to neurodegeneration. ..
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