Hsp60A

Summary

Gene Symbol: Hsp60A
Description: Heat shock protein 60A
Alias: BP5, CG12101, Cpn60, Dm10A, DmHsp60, Dmel\CG12101, Dmhsp60, G62, HSP60, HSP60A, Hsp 60, Hsp60, Hsp64, IEF16, Mmp-P1, SSP 7506, cpn60, d-hsp60, hsp60, hsp60A, l(1)10Ac, l(1)BP5, l(1)G8, l(1)HM21, l(1)L12, l(1)dp025, heat shock protein 60A, 60-kDa heat shock protein, mitochondrial, CG12101-PA, CG12101-PB, Hsp 60, Hsp60A-PA, Hsp60A-PB, heat shock protein 60, heat shock protein 60 kDa, lethal(1)10Ac, mitochondrial matrix protein P1
Species: fruit fly
Products:     Hsp60A

Top Publications

  1. Shaw P, Tononi G, Greenspan R, Robinson D. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature. 2002;417:287-91 pubmed
    ..These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat. ..
  2. Baena Lopez L, Alonso J, Rodriguez J, Santarén J. The expression of heat shock protein HSP60A reveals a dynamic mitochondrial pattern in Drosophila melanogaster embryos. J Proteome Res. 2008;7:2780-8 pubmed publisher
    ..we have used two-dimensional gel electrophoresis followed by MALDI-TOF to identify and purify heat shock protein HSP60A of Drosophila melanoagaster...
  3. Bayat V, Thiffault I, Jaiswal M, Tetreault M, Donti T, Sasarman F, et al. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol. 2012;10:e1001288 pubmed publisher
    ..Patient cells also exhibited reduced Complex I activity, increased ROS, and a slower cell proliferation rate, similar to Drosophila Aats-met mutants...
  4. Falke E, Wright T. Cold-sensitive mutants of Drosophila melanogaster defective in ribosome assembly. Genetics. 1975;81:655-82 pubmed
    ..The same is true for the RNA in their ribosomal particles. Sucrose gradient analysis of ribosomes from cold-sensitive lethal, female-sterile mutants appears to be an effective method for finding mutants that affect ribosome assembly. ..
  5. Singh M, Reddy M, Mathur N, Saxena D, Chowdhuri D. Induction of hsp70, hsp60, hsp83 and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation. Toxicol Appl Pharmacol. 2009;235:226-43 pubmed publisher
    ..RT-PCR amplification studies in Oregon R(+) larvae revealed a similar induction pattern of these genes along with hsp60 in the order of hsp70>hsp60>hsp26>or=hsp83...
  6. Arya R, Mallik M, Lakhotia S. Heat shock genes - integrating cell survival and death. J Biosci. 2007;32:595-610 pubmed
    ..Hsp70 also modulates JNK,NF-kappa B and Akt signaling pathways in the apoptotic cascade. In contrast, Hsp60 has both anti-and pro-apoptotic roles...
  7. Laayouni H, García Franco F, Chávez Sandoval B, Trotta V, Beltran S, Corominas M, et al. Thermal evolution of gene expression profiles in Drosophila subobscura. BMC Evol Biol. 2007;7:42 pubmed
    ..Furthermore, some clustering of genes within inverted chromosomal sections was detected. Disentangling the effects of inversions will be obviously required in any future approach if we want to identify the relevant candidate genes. ..
  8. Górska Andrzejak J, Stowers R, Borycz J, Kostyleva R, Schwarz T, Meinertzhagen I. Mitochondria are redistributed in Drosophila photoreceptors lacking milton, a kinesin-associated protein. J Comp Neurol. 2003;463:372-88 pubmed
    ..Our findings indicate the direct and compensatory responses in a population of neurons when mitochondria are not correctly targeted to their synaptic terminals. ..
  9. Zhang K, Li Z, Jaiswal M, Bayat V, Xiong B, Sandoval H, et al. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit. J Cell Biol. 2013;200:807-20 pubmed publisher
    ..Our data indicate that cytosolic chaperones are required for the subcellular transport of ND42. ..

More Information

Publications51

  1. Kuo Y, Ren S, Lao U, Edgar B, Wang T. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. Cell Death Dis. 2013;4:e833 pubmed publisher
    ..Our data provide a functional link between HSP40 and HSP110 in suppressing the cytotoxicity of aggregation-prone proteins, and suggest that HSP40 and HSP110 function together in protein homeostasis control. ..
  2. Lefevre G. Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster. Genetics. 1971;67:497-513 pubmed
  3. Zhimulev I, Pokholkova G, Bgatov A, Semeshin V, Belyaeva E. Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis. Chromosoma. 1981;82:25-40 pubmed
    ..About 70% of the band's DNA was found to be silent. - Using the set of chromosome rearrangements removing different parts of the band it was shown that these five sequences may function independently from each other. ..
  4. Lakhotia S, Srivastava P, Prasanth K. Regulation of heat shock proteins, Hsp70 and Hsp64, in heat-shocked Malpighian tubules of Drosophila melanogaster larvae. Cell Stress Chaperones. 2002;7:347-56 pubmed
    ..larvae is different from that in other tissues because instead of the Hsp70 and other common heat shock proteins, Hsp64 and certain other new proteins are induced immediately after HS...
  5. Breloy I, Schwientek T, Althoff D, Holz M, Koppen T, Krupa A, et al. Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen. Biomolecules. 2016;6:8 pubmed publisher
  6. Lakhotia S, Singh B. Synthesis of a ubiquitously present new HSP60 family protein is enhanced by heat shock only in the Malpighian tubules of Drosophila. Experientia. 1996;52:751-6 pubmed
    A homologue of the chaperonin protein of the HSP60 family has not been shown so far in Drosophila...
  7. Bettencourt B, Hogan C, Nimali M, Drohan B. Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance in Hsp70 null flies. BMC Biol. 2008;6:5 pubmed publisher
  8. Frydman H, Li J, Robson D, Wieschaus E. Somatic stem cell niche tropism in Wolbachia. Nature. 2006;441:509-12 pubmed
    ..This is, to our knowledge, the first report of an intracellular parasite displaying tropism for a stem cell niche. ..
  9. Nakahara K, Kim K, Sciulli C, Dowd S, Minden J, Carthew R. Targets of microRNA regulation in the Drosophila oocyte proteome. Proc Natl Acad Sci U S A. 2005;102:12023-8 pubmed
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization. ..
  10. Singh M, Ram K, Mishra M, Shrivastava M, Saxena D, Chowdhuri D. Effects of co-exposure of benzene, toluene and xylene to Drosophila melanogaster: alteration in hsp70, hsp60, hsp83, hsp26, ROS generation and oxidative stress markers. Chemosphere. 2010;79:577-87 pubmed publisher
    ..Further, our study supports the use of Drosophila as an alternative animal model for first tier screening of adverse effects of chemical mixtures. ..
  11. Sarkar S, Lakhotia S. The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility. J Genet. 2005;84:265-81 pubmed
    Earlier studies have shown that of the four genes (Hsp60A, Hsp60B, Hsp60C, Hsp60D genes) predicted to encode the conserved Hsp60 family chaperones in Drosophila melanogaster, the Hsp60A gene (at the 10A polytene region) is expressed in ..
  12. Colinet H, Lee S, Hoffmann A. Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster. FEBS J. 2010;277:174-85 pubmed publisher
    ..On the basis of their response, we consider that Hsp60, Hsp67Ba and Hsc70-1 are not cold-inducible, whereas Hsp22, Hsp23, Hsp26, Hsp27, Hsp40, Hsp68, Hsp70Aa and Hsp83 ..
  13. Robertson S, Ni W, Dhadialla T, Nisbet A, McCusker C, Ley S, et al. Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells. Arch Insect Biochem Physiol. 2007;64:200-8 pubmed
    ..Identification of the members of this complex by Peptide Mass Fingerprinting (PMF) and N-terminal sequencing identified heat shock protein 60 (hsp60) as one of its components.
  14. Rera M, Bahadorani S, Cho J, Koehler C, Ulgherait M, Hur J, et al. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 2011;14:623-34 pubmed publisher
    ..Our findings point to the possibility that alterations in PGC-1 activity in high-turnover tissues, such as the intestine, may be an important determinant of longevity in mammals. ..
  15. Morrow G, Le Pécheur M, Tanguay R. Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response. Biogerontology. 2016;17:61-70 pubmed publisher
    ..The induction of mitochondrial chaperones expression, particularly of Hsp60 and Hsp70, is a hallmark of this pathway...
  16. Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet. 2014;10:e1004391 pubmed publisher
  17. Adán C, Matsushima Y, Hernández Sierra R, Marco Ferreres R, Fernández Moreno M, Gonzalez Vioque E, et al. Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development. J Biol Chem. 2008;283:12333-42 pubmed publisher
  18. Perezgasga L, Segovia L, Zurita M. Molecular characterization of the 5' control region and of two lethal alleles affecting the hsp60 gene in Drosophila melanogaster. FEBS Lett. 1999;456:269-73 pubmed
    ..We present here the molecular analysis of the hsp60 gene promoter region and of two Drosophila hsp60 ethyl methane sulfonate embryonic lethal alleles that have an ..
  19. Kulbaba M, Worley A. Selection on Polemonium brandegeei (Polemoniaceae) flowers under hummingbird pollination: in opposition, parallel, or independent of selection by hawkmoths?. Evolution. 2013;67:2194-206 pubmed publisher
  20. Gillardon F. Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro. Neuroscience. 2009;163:533-9 pubmed publisher
    ..These findings suggest that the interaction between LRRK2 and EF1A may reciprocally modulate their physiological function...
  21. Martin C, Flores A, Cuezva J. Cpn60 is exclusively localized into mitochondria of rat liver and embryonic Drosophila cells. J Cell Biochem. 1995;59:235-45 pubmed
    Several reports have claimed that the mitochondrial chaperonin cpn60, or a close homolog, is also present in some other subcellular compartments of the eukaryotic cell...
  22. Shirasaki D, Greiner E, Al Ramahi I, Gray M, Boontheung P, Geschwind D, et al. Network organization of the huntingtin proteomic interactome in mammalian brain. Neuron. 2012;75:41-57 pubmed publisher
  23. Grant J, Saldanha J, Gould A. A Drosophila model for primary coenzyme Q deficiency and dietary rescue in the developing nervous system. Dis Model Mech. 2010;3:799-806 pubmed publisher
    ..Together, these findings show that Drosophila qless provides a useful model for studying the neural effects of CoQ deficiency and dietary supplementation. ..
  24. Backes S, Hess S, Boos F, Woellhaf M, Gödel S, Jung M, et al. Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences. J Cell Biol. 2018;217:1369-1382 pubmed publisher
  25. Norry F, Larsen P, Liu Y, Loeschcke V. Combined expression patterns of QTL-linked candidate genes best predict thermotolerance in Drosophila melanogaster. J Insect Physiol. 2009;55:1050-7 pubmed publisher
    ..b>hsp60 and hsc70-3 map within an X-linked QTL, while CG10383, catsup, ddc, trap1, and cyp6a13 are linked in a KRHT-QTL on ..
  26. Morrow G, Battistini S, Zhang P, Tanguay R. Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila. J Biol Chem. 2004;279:43382-5 pubmed
    ..The absence of Hsp22 also sensitizes flies to mild stress. These data support a key role of sHsps in aging and underline the importance of mitochondrial sHsps in this process. ..
  27. Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, et al. Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database. Mol Gen Genet. 1999;261:64-70 pubmed
    ..Our experimental strategy represents an efficient approach to the identification and interspecies comparison of genes encoding products targeted to the mitochondrion. ..
  28. Pokholkova G, Solov eva I. [Characteristics of inserted mutations obtained in the P-M hybrid dysgenesis system in the 9F12-10A7 region of the Drosophila melanogaster X-chromosome]. Genetika. 1989;25:1776-85 pubmed
    ..As a result of complementation analysis, all these mutations were localized at previously known loci: l(1)BP1, l(1)BP5, l(1)BP8, l(1)BP7. No insertion mutations were found at the vermilion locus...
  29. Moussian B, Söding J, Schwarz H, NUSSLEIN VOLHARD C. Retroactive, a membrane-anchored extracellular protein related to vertebrate snake neurotoxin-like proteins, is required for cuticle organization in the larva of Drosophila melanogaster. Dev Dyn. 2005;233:1056-63 pubmed
    ..We propose that this binding function of Rtv may assist the organization of chitin fibers at the epidermal cell surface during cuticle assembly. ..
  30. Karunanithi S, Barclay J, Robertson R, Brown I, Atwood H. Neuroprotection at Drosophila synapses conferred by prior heat shock. J Neurosci. 1999;19:4360-9 pubmed
    ..The time course of these physiological changes is similar to that of elevated hsp70. Thus, stress-induced neuroprotective mechanisms maintain function at synapses by modifying their properties. ..
  31. Pandey A, Vimal D, Chandra S, Saini S, Narayan G, Kar Chowdhuri D. Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster. Age (Dordr). 2014;36:9628 pubmed publisher
  32. Santaren J, Van Damme J, Puype M, Vandekerckhove J, Garcia Bellido A. Identification of Drosophila wing imaginal disc proteins by two-dimensional gel analysis and microsequencing. Exp Cell Res. 1993;206:220-6 pubmed
    ..As an illustration we present 12 of them: 8 corresponding to proteins already known in Drosophila and the 4 showing homologies with proteins of other organisms. ..
  33. Wang L, Zhou L, Zhu Z, Ma W, Lei C. Differential temporal expression profiles of heat shock protein genes in Drosophila melanogaster (Diptera: Drosophilidae) under ultraviolet A radiation stress. Environ Entomol. 2014;43:1427-34 pubmed publisher
    ..So DmHsps might act in a coordinated and cooperative manner at the transcriptional level to counteract UV-A radiation-based stress. ..
  34. Doganlar O, Doganlar Z. Effects of a mixture of volatile organic compounds on total DNA and gene expression of heat shock proteins in Drosophila melanogaster. Arch Environ Contam Toxicol. 2015;68:395-404 pubmed publisher
    ..13 volatile organic compounds (VOCs) on total DNA profiles and the expression of heat shock proteins (HSPs) HSP26, HSP60, HSP70, and HSP83 in fruit fly tissues were examined...
  35. Sarkar S, Lakhotia S. Hsp60C is required in follicle as well as germline cells during oogenesis in Drosophila melanogaster. Dev Dyn. 2008;237:1334-47 pubmed publisher
    ..melanogaster shows a dynamic spatiotemporal expression during oogenesis and seems to contribute bulk of the Hsp60 family proteins in ovarioles...
  36. Kozlova T, Semeshin V, Tretyakova I, Kokoza E, Pirrotta V, Grafodatskaya V, et al. Molecular and cytogenetical characterization of the 10A1-2 band and adjoining region in the Drosophila melanogaster polytene X chromosome. Genetics. 1994;136:1063-73 pubmed
    ..In contrast, the 10A1-2 band contains three genes and at least six transcribed DNA fragments. (3) Comparison of genetic and physical maps shows that in this region 0.01 centiMorgan corresponds to 3.3 kb of DNA. ..
  37. Stowers R, Megeath L, Górska Andrzejak J, Meinertzhagen I, Schwarz T. Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein. Neuron. 2002;36:1063-77 pubmed
    ..Transfected into HEK293T cells, Milton induces a redistribution of mitochondria within the cell. We propose that Milton is a mitochondria-associated protein required for kinesin-mediated transport of mitochondria to nerve terminals. ..
  38. Li Z, Thiel K, Thul P, Beller M, Kühnlein R, Welte M. Lipid droplets control the maternal histone supply of Drosophila embryos. Curr Biol. 2012;22:2104-13 pubmed publisher
    ..This work reveals a novel aspect of histone metabolism and establishes lipid droplets as functional storage sites for unstable or detrimental proteins. ..
  39. Baqri R, Pietron A, Gokhale R, Turner B, Kaguni L, Shingleton A, et al. Mitochondrial chaperone TRAP1 activates the mitochondrial UPR and extends healthspan in Drosophila. Mech Ageing Dev. 2014;141-142:35-45 pubmed publisher
    ..Together these studies suggest that TRAP1 regulates healthspan, potentially through activation of the UPR(mt). ..
  40. Singh A, Lakhotia S. Expression of hsrω-RNAi transgene prior to heat shock specifically compromises accumulation of heat shock-induced Hsp70 in Drosophila melanogaster. Cell Stress Chaperones. 2016;21:105-20 pubmed publisher
  41. Perrimon N, Engstrom L, Mahowald A. The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol. 1984;105:404-14 pubmed
    ..Three loci were found which, in germ-line clones, produced embryonic phenotypes that resemble maternal effect mutations. The implications of this study for the genetic analysis of early development are discussed. ..
  42. Gillardon F. Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?. J Neurochem. 2009;110:1514-22 pubmed publisher
    ..These findings suggest that LRRK2(G2019S)-induced neurodegeneration in Parkinsonian brains may be partly mediated by increased phosphorylation of tubulin-beta and constraining of microtubule dynamics...