Gene Symbol: Hr4
Description: Hormone receptor 4
Alias: CG16902, CG3600, CG42527, CG43692, CG43934, DHR4, Dmel\CG43934, Dmel_CG16902, Dmel_CG3600, Dmel_CG42527, EG:133E12.2, EG:BACH61I5.1, EP(X)1232, EP1232, GRF, NR6A2, null, hormone receptor 4, CG43934-PC, CG43934-PD, CG43934-PE, CG43934-PF, CG43934-PG, CG43934-PH, CG43934-PI, CG43934-PJ, CG43934-PK, Hr4-PC, Hr4-PD, Hr4-PE, Hr4-PF, Hr4-PG, Hr4-PH, Hr4-PI, Hr4-PJ, Hr4-PK
Species: fruit fly

Top Publications

  1. King Jones K, Thummel C. Nuclear receptors--a perspective from Drosophila. Nat Rev Genet. 2005;6:311-23 pubmed
    ..Here, we review recent breakthroughs in our understanding of D. melanogaster nuclear receptors, and interpret these results in light of findings from their evolutionarily conserved vertebrate homologues. ..
  2. King Jones K, Charles J, Lam G, Thummel C. The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila. Cell. 2005;121:773-84 pubmed
    ..We show here that mutations in the DHR4 orphan nuclear receptor result in larvae that precociously leave the food to form premature prepupae, resulting in ..
  3. Palanker L, Necakov A, Sampson H, Ni R, Hu C, Thummel C, et al. Dynamic regulation of Drosophila nuclear receptor activity in vivo. Development. 2006;133:3549-62 pubmed
  4. Fahrbach S, Smagghe G, Velarde R. Insect nuclear receptors. Annu Rev Entomol. 2012;57:83-106 pubmed publisher
    ..An exciting new technology allows EcR to be used in chimeric, ligand-inducible gene-switch systems with applications in pest management and medicine. ..
  5. Skalska L, Stojnic R, Li J, Fischer B, Cerda Moya G, Sakai H, et al. Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation. EMBO J. 2015;34:1889-904 pubmed publisher
    ..This intriguing example of a core histone modification increasing over short timescales may therefore underpin changes in chromatin accessibility needed to promote transcription following signalling activation. ..
  6. Wilk R, Hu J, Krause H. Spatial profiling of nuclear receptor transcription patterns over the course of Drosophila development. G3 (Bethesda). 2013;3:1177-89 pubmed publisher
    ..These patterns will serve as a useful reference for future studies on the tissue-specific roles and interactions of nuclear receptor proteins, partners, cofactors and ligands. ..
  7. de Rosny E, de Groot A, Jullian Binard C, Borel F, Suarez C, Le Pape L, et al. DHR51, the Drosophila melanogaster homologue of the human photoreceptor cell-specific nuclear receptor, is a thiolate heme-binding protein. Biochemistry. 2008;47:13252-60 pubmed publisher
    ..and screening for the heme-binding ability of 11 NR ligand-binding domains of Drosophila melanogaster (DHR3, DHR4, DHR39, DHR51, DHR78, DHR83, HNF4, TLL, ERR, FTZ-F1, and E78), of unknown structure...
  8. Ou Q, Magico A, King Jones K. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. PLoS Biol. 2011;9:e1001160 pubmed publisher
    ..Here, we demonstrate that Drosophila Hormone Receptor 4 (DHR4), a nuclear receptor, is a key target of the PTTH pathway and establishes temporal boundaries by ..
  9. Sobala L, Adler P. The Gene Expression Program for the Formation of Wing Cuticle in Drosophila. PLoS Genet. 2016;12:e1006100 pubmed publisher
    ..Alternatively, some of the genes expressed during the deposition of the envelope could form a platform that is essential for the deposition of all cuticle layers. ..

More Information


  1. Shlyueva D, Stelzer C, Gerlach D, Yáñez Cuna J, Rath M, Boryń Ł, et al. Hormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin. Mol Cell. 2014;54:180-192 pubmed publisher
    ..Our strategy is applicable to study signal-dependent enhancers for different pathways and across organisms. ..
  2. Kozlova T, Lam G, Thummel C. Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion. Dev Dyn. 2009;238:701-7 pubmed publisher
    ..Although an earlier study identified three point mutations in DHR38, none of these were shown to be a null allele for the locus, leaving it unclear whether a complete loss of DHR38 function might uncover novel roles for ..
  3. Stabell M, Larsson J, Aalen R, Lambertsson A. Drosophila dSet2 functions in H3-K36 methylation and is required for development. Biochem Biophys Res Commun. 2007;359:784-9 pubmed
    ..A transheterozygous EcR null mutation/dSet2 RNAi combination produces a complete (balloon) separation of the wing surfaces, revealing a genetic ..
  4. Manak J, Dike S, Sementchenko V, Kapranov P, Biemar F, Long J, et al. Biological function of unannotated transcription during the early development of Drosophila melanogaster. Nat Genet. 2006;38:1151-8 pubmed
    ..Collectively, these data indicate that at least 85% of the fly genome is transcribed and processed into mature transcripts representing at least 30% of the fly genome. ..
  5. Acharya S, Laupsien P, Wenzl C, Yan S, Großhans J. Function and dynamics of slam in furrow formation in early Drosophila embryo. Dev Biol. 2014;386:371-84 pubmed publisher
    ..Here we investigate the null phenotype of slam, the dynamics of Slam protein, and its control by the recycling endosome...
  6. Shingleton A. Body-size regulation: combining genetics and physiology. Curr Biol. 2005;15:R825-7 pubmed
    ..New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth. ..
  7. Dubrovsky E, Dubrovskaya V, Bernardo T, Otte V, Difilippo R, Bryan H. The Drosophila FTZ-F1 nuclear receptor mediates juvenile hormone activation of E75A gene expression through an intracellular pathway. J Biol Chem. 2011;286:33689-700 pubmed publisher
    ..We propose that FTZ-F1 functions as a competence factor by loading JH signaling components to the promoter, thus facilitating the direct regulation of E75A gene expression by JH. ..
  8. Gauhar Z, Sun L, Hua S, Mason C, Fuchs F, Li T, et al. Genomic mapping of binding regions for the Ecdysone receptor protein complex. Genome Res. 2009;19:1006-13 pubmed publisher
    ..Accordingly, we found that three direct targets of ECR/USP--hairy, vrille, and Hr4--are required for cellular differentiation in response to the hormone...
  9. Mazina M, Nikolenko J, Fursova N, Nedil ko P, Krasnov A, Vorobyeva N. Early-late genes of the ecdysone cascade as models for transcriptional studies. Cell Cycle. 2015;14:3593-601 pubmed publisher
    The DHR3 and Hr4 early-late genes of the ecdysone cascade are described as models for transcriptional studies in Drosophila cells...
  10. Maglich J, Sluder A, Guan X, Shi Y, McKee D, Carrick K, et al. Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol. 2001;2:RESEARCH0029 pubmed
    ..This work provides the basis for new insights into the evolution and functional relationships of NR superfamily members. ..