hpo

Summary

Gene Symbol: hpo
Description: hippo
Alias: CG11228, Dmel\CG11228, Hippo, Hpo, MST, MST2, dMST, hipo, hippo, CG11228-PA, CG11228-PB, MST, hippo kinase, hpo-PA, hpo-PB
Species: fruit fly

Top Publications

  1. Sun S, Zhao S, Wang Z. Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila. Dev Dyn. 2008;237:270-5 pubmed
    b>Hippo pathway and its related genes are required for growth control in various somatic tissues. The mutations of Hippo pathway components lead to tissue overgrowth cell-autonomously...
  2. Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19:491-505 pubmed publisher
    ..These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal ..
  3. Fernández B, Gaspar P, Bras Pereira C, Jezowska B, Rebelo S, Janody F. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 2011;138:2337-46 pubmed publisher
    The conserved Hippo tumor suppressor pathway is a key kinase cascade that controls tissue growth by regulating the nuclear import and activity of the transcription co-activator Yorkie...
  4. Jukam D, Xie B, Rister J, TERRELL D, Charlton Perkins M, Pistillo D, et al. Opposite feedbacks in the Hippo pathway for growth control and neural fate. Science. 2013;342:1238016 pubmed publisher
    Signaling pathways are reused for multiple purposes in plant and animal development. The Hippo pathway in mammals and Drosophila coordinates proliferation and apoptosis via the coactivator and oncoprotein YAP/Yorkie (Yki), which is ..
  5. Willecke M, Hamaratoglu F, Sansores Garcia L, Tao C, Halder G. Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci U S A. 2008;105:14897-902 pubmed publisher
    The conserved Hippo tumor suppressor pathway is a key signaling pathway that controls organ size in Drosophila. To date a signal transduction cascade from the Cadherin Fat at the plasma membrane into the nucleus has been discovered...
  6. Poernbacher I, Baumgartner R, Marada S, Edwards K, Stocker H. Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation. Curr Biol. 2012;22:389-96 pubmed publisher
    The conserved Hippo signaling pathway acts in growth control and is fundamental to animal development and oncogenesis. Hippo signaling has also been implicated in adult midgut homeostasis in Drosophila...
  7. Oh H, Irvine K. In vivo analysis of Yorkie phosphorylation sites. Oncogene. 2009;28:1916-27 pubmed publisher
    The co-activator Yorkie (Yki) mediates transcriptional regulation effected by the Drosophila Fat-Warts (Wts)-Hippo (Hpo) pathways...
  8. Herranz H, Hong X, Cohen S. Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr Biol. 2012;22:651-7 pubmed publisher
    The epidermal growth factor receptor (EGFR) and Hippo signaling pathways control cell proliferation and apoptosis to promote tissue growth during development. Misregulation of these pathways is implicated in cancer...
  9. Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol. 2003;5:921-7 pubmed
    ..Here we identify Hippo (Hpo), the Drosophila orthologue of the mammalian MST1 and MST2 serine/threonine kinases, as a partner of Sav...

More Information

Publications79

  1. Zhang X, Milton C, Poon C, Hong W, Harvey K. Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. Cell Death Differ. 2011;18:1346-55 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is a key controller of tissue growth in both flies and mammals, and deregulation of pathway activity contributes to tumour formation...
  2. Neto Silva R, de Beco S, Johnston L. Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell. 2010;19:507-20 pubmed publisher
    ..that the activities of the conserved growth-promoting transcription factor Myc and the tumor-suppressing Hippo pathway are codependent during growth of Drosophila imaginal discs...
  3. Yin F, Yu J, Zheng Y, Chen Q, Zhang N, Pan D. Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell. 2013;154:1342-55 pubmed publisher
    ..Recent studies in Drosophila revealed a potential link between Merlin and the Hippo pathway by placing Merlin genetically upstream of the kinase Hpo/Mst...
  4. Yu J, Poulton J, Huang Y, Deng W. The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS ONE. 2008;3:e1761 pubmed publisher
    ..Here we show that the newly identified Hippo tumor-suppressor pathway plays a crucial role in the posterior follicle cells in the regulation of oocyte polarity...
  5. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell. 2008;14:377-87 pubmed publisher
    The Hippo (Hpo) signaling pathway governs cell growth, proliferation, and apoptosis by controlling key regulatory genes that execute these processes; however, the transcription factor of the pathway has remained elusive...
  6. Yu J, Zheng Y, Dong J, Klusza S, Deng W, Pan D. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell. 2010;18:288-99 pubmed publisher
    ..protein complex localized to the apical domain of epithelial cells, and that this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav...
  7. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-9 pubmed
    ..Cell growth and cell death are coordinately regulated during development by the Hippo signaling pathway...
  8. Grzeschik N, Parsons L, Allott M, Harvey K, Richardson H. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol. 2010;20:573-81 pubmed publisher
    ..in eye epithelial tissue, where polarity is maintained, results in upregulation of targets of the Salvador/Warts/Hippo (SWH) tumor suppressor pathway...
  9. Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development. 2010;137:4135-45 pubmed publisher
    ..In addition, the Hippo pathway has been recently implicated in the regulation of Upd production from the ECs...
  10. Deng Y, Matsui Y, Zhang Y, Lai Z. Hippo activation through homodimerization and membrane association for growth inhibition and organ size control. Dev Biol. 2013;375:152-9 pubmed publisher
    b>Hippo (Hpo) signaling plays a critical role in restricting tissue growth and organ size in both invertebrate and vertebrate animals. However, how the Hpo kinase is regulated during development has not been clearly understood...
  11. Zecca M, Struhl G. A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol. 2010;8:e1000386 pubmed publisher
    ..Here, we identify the protocadherins Fat (Ft) and Dachsous (Ds), the Warts-Hippo tumor suppressor pathway, and the transcriptional co-activator Yorkie (Yki, a YES associated protein, or YAP) as ..
  12. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    Several developmental pathways contribute to processes that regulate tissue growth and organ size. The Hippo pathway has emerged as one such critical regulator...
  13. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..Here we demonstrate that the Hippo (Hpo) signaling pathway, an evolutionarily conserved pathway implicated in organ size control and tumorigenesis, ..
  14. Ohsawa S, Sato Y, Enomoto M, Nakamura M, Betsumiya A, Igaki T. Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila. Nature. 2012;490:547-51 pubmed publisher
    ..JNK cooperates with oncogenic Ras to inactivate the Hippo pathway, leading to upregulation of its targets Unpaired (an interleukin-6 homologue) and Wingless (a Wnt ..
  15. Zhang J, Ji J, Yu M, Overholtzer M, Smolen G, Wang R, et al. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009;11:1444-50 pubmed publisher
    The Hippo signalling pathway regulates cellular proliferation and survival, thus has profound effects on normal cell fate and tumorigenesis...
  16. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    The Salvador Warts Hippo (SWH) network limits tissue size in Drosophila and vertebrates [1]. Decreased SWH pathway activity gives rise to excess proliferation and reduced apoptosis...
  17. Bennett F, Harvey K. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol. 2006;16:2101-10 pubmed
    ..A newly emerging signaling pathway that controls organ size during development is the Salvador/Warts/Hippo pathway. Here we demonstrate that Fat limits organ size by modulating activity of the Salvador/Warts/Hippo pathway...
  18. Ryoo H, Steller H. Hippo and its mission for growth control. Nat Cell Biol. 2003;5:853-5 pubmed
  19. Matakatsu H, Blair S. Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous. Development. 2012;139:1498-508 pubmed publisher
    ..Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki)...
  20. Salah Z, Aqeilan R. WW domain interactions regulate the Hippo tumor suppressor pathway. Cell Death Dis. 2011;2:e172 pubmed publisher
    The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis in Drosophila and mammalians...
  21. Polesello C, Huelsmann S, Brown N, Tapon N. The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol. 2006;16:2459-65 pubmed
    ..Perturbation of this delicate balance leads to cancer formation . Hippo (Hpo), the Drosophila ortholog of MST1 and MST2 (Mammalian Sterile 20-like 1 and 2) is a key regulator of a ..
  22. Wu S, Huang J, Dong J, Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell. 2003;114:445-56 pubmed
    ..Here, we report the identification of hippo (hpo) as a gene that regulates both cell proliferation and cell death in Drosophila...
  23. Ziosi M, Baena Lopez L, Grifoni D, Froldi F, Pession A, Garoia F, et al. dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells. PLoS Genet. 2010;6:e1001140 pubmed publisher
    ..The evolutionarily conserved Hippo (Hpo) signaling pathway regulates organ size and prevents hyperplastic disease from flies to humans by restricting ..
  24. Rauskolb C, Pan G, Reddy B, Oh H, Irvine K. Zyxin links fat signaling to the hippo pathway. PLoS Biol. 2011;9:e1000624 pubmed publisher
    The Hippo signaling pathway has a conserved role in growth control and is of fundamental importance during both normal development and oncogenesis...
  25. Wehr M, Holder M, Gailite I, Saunders R, Maile T, Ciirdaeva E, et al. Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Nat Cell Biol. 2013;15:61-71 pubmed
    ..The conserved Hippo (Hpo) pathway, which promotes both cell-cycle exit and apoptosis, is a major determinant of size control...
  26. Zhang J, Smolen G, Haber D. Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res. 2008;68:2789-94 pubmed publisher
    The Hippo pathway defines a novel signaling cascade regulating cell proliferation and survival in Drosophila, which involves the negative regulation of the transcriptional coactivator Yorkie by the kinases Hippo and Warts...
  27. Emoto K, Parrish J, Jan L, Jan Y. The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature. 2006;443:210-3 pubmed
    ..We further provide biochemical and genetic evidence for the tumour suppressor kinase Hippo (Hpo) as an upstream regulator of Wts and Trc for dendrite maintenance and tiling, respectively, thereby revealing ..
  28. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine K. Delineation of a Fat tumor suppressor pathway. Nat Genet. 2006;38:1142-50 pubmed
    ..The tumor suppressors Merlin, expanded, hippo, salvador and mob as tumor suppressor also share multiple Fat pathway phenotypes but regulate Warts activity ..
  29. Hamaratoglu F, Gajewski K, Sansores Garcia L, Morrison C, Tao C, Halder G. The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci. 2009;122:2351-9 pubmed publisher
    ..indicated that Merlin (Mer) and Expanded (Ex) are members of the Hippo pathway and act upstream of the Hippo kinase. In contrast to this model, it was suggested that Mer and Ex primarily regulate membrane dynamics and receptor ..
  30. Willecke M, Hamaratoglu F, Kango Singh M, Udan R, Chen C, Tao C, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol. 2006;16:2090-100 pubmed
    The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila...
  31. Straßburger K, Tiebe M, Pinna F, Breuhahn K, Teleman A. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. Dev Biol. 2012;367:187-96 pubmed publisher
    ..The mechanism by which this occurs, however, is not completely understood. The Hippo signaling pathway regulates cell proliferation via the transcriptional co-activator Yorkie/YAP, however the ..
  32. Udan R, Kango Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol. 2003;5:914-20 pubmed
    ..Here we show that Hippo (Hpo), the Drosophila homologue of the mammalian Ste20-like kinases, MST1/2, promotes proper termination of cell ..
  33. Zhao B, Wei X, Li W, Udan R, Yang Q, Kim J, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 2007;21:2747-61 pubmed
    The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila...
  34. Oh H, Irvine K. In vivo regulation of Yorkie phosphorylation and localization. Development. 2008;135:1081-8 pubmed publisher
    Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase...
  35. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford S, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130:1120-33 pubmed
    ..In Drosophila, these two processes are orchestrated by the Hippo kinase cascade, a growth-suppressive pathway that ultimately antagonizes the transcriptional coactivator Yorkie (Yki)...
  36. Hariharan I. Growth regulation: a beginning for the hippo pathway. Curr Biol. 2006;16:R1037-9 pubmed
    A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways.
  37. Shaw R, Kohlmaier A, Polesello C, Veelken C, Edgar B, Tapon N. The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration. Development. 2010;137:4147-58 pubmed publisher
    ..We have investigated the role of the Hippo (Hpo) pathway in the Drosophila intestine (midgut)...
  38. Wu S, Liu Y, Zheng Y, Dong J, Pan D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell. 2008;14:388-98 pubmed publisher
    The Hippo (Hpo) kinase cascade restricts tissue growth by inactivating the transcriptional coactivator Yorkie (Yki), which regulates the expression of target genes such as the cell death inhibitor diap1 by unknown mechanisms...
  39. Pellock B, Buff E, White K, Hariharan I. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol. 2007;304:102-15 pubmed
    ..ex double mutants, they are proposed to function together in at least a partially redundant manner upstream of the Hippo (Hpo) and Warts (Wts) proteins to regulate cell growth and division...
  40. Thompson B, Cohen S. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell. 2006;126:767-74 pubmed
    The Hippo signaling pathway acts upon the Yorkie transcriptional activator to control tissue growth in Drosophila...
  41. Goulev Y, Fauny J, Gonzalez Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol. 2008;18:435-41 pubmed publisher
    ..Recently, YORKIE (YKI) was identified as a transcriptional coactivator that is the downstream effector of the Hippo signaling pathway, which controls cell proliferation and apoptosis in Drosophila[8]...
  42. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 2007;177:1667-77 pubmed
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control. ..
  43. Zhai B, Villen J, Beausoleil S, Mintseris J, Gygi S. Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res. 2008;7:1675-82 pubmed publisher
    ..63% at the peptide level. Because of the large size of the data set, both novel and known phosphorylation motifs were extracted using the Motif-X algorithm, including those representative of potential ordered phosphorylation events. ..
  44. Sansores Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 2011;30:2325-35 pubmed publisher
    The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size...
  45. Marcinkevicius E, Zallen J. Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat. Development. 2013;140:433-43 pubmed publisher
    ..an upstream regulator of the conserved Hippo pathway, and mutations in Hippo and Warts, two kinases in the Hippo kinase cascade...
  46. Hamaratoglu F, Willecke M, Kango Singh M, Nolo R, Hyun E, Tao C, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006;8:27-36 pubmed
    ..Here, we show that Drosophila Merlin and Expanded are components of the Hippo signalling pathway, an emerging tumour-suppressor pathway...
  47. Tyler D, Baker N. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol. 2007;305:187-201 pubmed
    ..During disc growth, ex was largely epistatic to ft, and the Warts pathway mutation hippo largely epistatic to ex. Our data suggest that ft and ex act partially through the Warts pathway.
  48. Nolo R, Morrison C, Tao C, Zhang X, Halder G. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol. 2006;16:1895-904 pubmed
    The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila...
  49. Reddy B, Irvine K. Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. Development. 2011;138:5201-12 pubmed publisher
    ..Here, we identify and characterize a requirement for the Hippo pathway and its transcriptional co-activator Yorkie in controlling Drosophila glial proliferation...
  50. Colombani J, Polesello C, Josué F, Tapon N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr Biol. 2006;16:1453-8 pubmed
    ..The Hippo (Hpo) pathway comprises the kinases Hpo and Warts/Lats (Wts), the adaptors Salvador (Sav) and Mob1 as a tumor ..
  51. Meignin C, Alvarez Garcia I, Davis I, Palacios I. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol. 2007;17:1871-8 pubmed
    ..We show that the Salvador Warts Hippo (SWH) tumor-suppressor pathway is required in the follicle cells in order to induce their Gurken- and Notch-..
  52. Huang J, Wu S, Barrera J, Matthews K, Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122:421-34 pubmed
    ..In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats)...
  53. Ho L, Wei X, Shimizu T, Lai Z. Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. Dev Biol. 2010;337:274-83 pubmed publisher
    Growth inhibition mediated by Hippo (Hpo) signaling is essential for tissue growth and organ size control in Drosophila...
  54. Das Thakur M, Feng Y, Jagannathan R, Seppa M, Skeath J, Longmore G. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol. 2010;20:657-62 pubmed publisher
    ..an essential gene for development and a novel regulator of epithelial organ size as a component of the conserved Hippo (Hpo) pathway, which has been implicated in both tissue size control and cancer development...
  55. Jin Y, Dong L, Lu Y, Wu W, Hao Q, Zhou Z, et al. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. J Biol Chem. 2012;287:5784-96 pubmed publisher
    The Hippo (Hpo) signaling pathway controls organ size by regulating the balance between cell proliferation and apoptosis. Although the Hpo function is conserved, little is known about the mechanism of how its kinase activity is regulated...
  56. Genevet A, Wehr M, Brain R, Thompson B, Tapon N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell. 2010;18:300-8 pubmed publisher
    The Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) network controls tissue growth by inhibiting cell proliferation and promoting apoptosis...
  57. Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, et al. Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP. Oncogene. 2012;31:238-50 pubmed publisher
    The Salvador/Warts/Hippo (Hippo) signaling pathway defines a novel signaling cascade regulating cell contact inhibition, organ size control, cell growth, proliferation, apoptosis and cancer development in mammals...
  58. Ribeiro P, Josué F, Wepf A, Wehr M, Rinner O, Kelly G, et al. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Mol Cell. 2010;39:521-34 pubmed publisher
    The Hippo (Hpo) pathway is a central determinant of tissue size in both Drosophila and higher organisms...
  59. Wei X, Shimizu T, Lai Z. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 2007;26:1772-81 pubmed
    ..Recent studies have demonstrated that Hippo (Hpo) signaling plays a crucial role in coordinating these processes by restricting cell proliferation and ..
  60. Genevet A, Tapon N. The Hippo pathway and apico-basal cell polarity. Biochem J. 2011;436:213-24 pubmed publisher
    ..Studies in Drosophila have uncovered complex interactions between the conserved Hpo (Hippo) tumour suppressor pathway and apico-basal polarity determinants...
  61. Dutta S, Baehrecke E. Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr Biol. 2008;18:1466-75 pubmed publisher
    ..Our data indicate that the Wts-pathway components Yki, Sd, and bantam fail to function in salivary glands and that Wts regulates salivary gland cell death in a PI3K-dependent manner. ..
  62. Verghese S, Bedi S, Kango Singh M. Hippo signalling controls Dronc activity to regulate organ size in Drosophila. Cell Death Differ. 2012;19:1664-76 pubmed publisher
    The Hippo pathway controls organ size by multiple mechanisms that ultimately regulate the transcriptional co-activator Yorkie (Yki)...
  63. Genevet A, Polesello C, Blight K, Robertson F, Collinson L, Pichaud F, et al. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci. 2009;122:2360-70 pubmed publisher
    The Hippo pathway, identified in Drosophila and conserved in vertebrates, regulates tissue growth by promoting cell cycle exit and apoptosis...
  64. Chen C, Gajewski K, Hamaratoglu F, Bossuyt W, Sansores Garcia L, Tao C, et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci U S A. 2010;107:15810-5 pubmed publisher
    ..Crb gain and loss of function caused defects in Hippo signaling, a key signaling pathway that controls tissue growth in Drosophila and mammals...
  65. Baumgartner R, Poernbacher I, Buser N, Hafen E, Stocker H. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell. 2010;18:309-16 pubmed publisher
    The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis...
  66. Boggiano J, Vanderzalm P, Fehon R. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell. 2011;21:888-95 pubmed publisher
    Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth-suppressive signals are transduced upstream of Hippo remains unclear...
  67. Sarikaya D, Belay A, Ahuja A, Dorta A, Green D, Extavour C. The roles of cell size and cell number in determining ovariole number in Drosophila. Dev Biol. 2012;363:279-89 pubmed publisher
    ..This work provides for the first time specific and quantitative developmental tools to investigate the evolution of a highly conserved reproductive structure. ..
  68. Sun G, Irvine K. Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol. 2011;350:139-51 pubmed publisher
    ..The Hippo signaling pathway has emerged as an important regulator of growth during normal development and oncogenesis from ..
  69. Nicolay B, Frolov M. Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet. 2008;4:e1000205 pubmed publisher
    The Hippo pathway negatively regulates the cell number in epithelial tissue. Upon its inactivation, an excess of cells is produced...
  70. Poon C, Lin J, Zhang X, Harvey K. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 2011;21:896-906 pubmed publisher
    The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth...