Hph

Summary

Gene Symbol: Hph
Description: HIF prolyl hydroxylase
Alias: 0303/04, 31543, CG1114, CG14665, CG2676, CG31543, CG44015, CR31541, Dm.egl-9, Dmel\CG44015, Dmel_CG31543, Dmel_CR31541, PHD, anon-EST:Posey69, dHPH, dPHD2, dmHPH, fga, hph, l(3)02255, l(3)82Fe, l(3)S030304, CG44015-PA, CG44015-PB, CG44015-PC, HIF prolyl 4-hydroxylase, HIF-1a prolyl hyroxylase, Hph-PA, Hph-PB, Hph-PC, fatiga, lethal (3) 82Fe, lethal (3) S030304, lopped, prolyl-4-hydroxylase
Species: fruit fly

Top Publications

  1. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
  2. ncbi Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Dev Cell 6:241-51. 2004
  3. ncbi Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar
    Sofía Lavista-Llanos
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires 1405, Argentina
    Mol Cell Biol 22:6842-53. 2002
  4. ncbi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
  5. ncbi Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima
    Lazaro Centanin
    Instituto Leloir and IIB, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    EMBO Rep 6:1070-5. 2005
  6. ncbi Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export
    Maximiliano Irisarri
    Instituto Leloir and FCEyN, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1405 Buenos Aires, Argentina
    Mol Biol Cell 20:3878-87. 2009
  7. ncbi Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis
    Leigh Cuttell
    Medical Research Council Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Cell and Developmental Biology Department, University College London, Gower Street, London WC1E 6BT, UK
    Cell 135:524-34. 2008
  8. ncbi The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 24:623-34. 2005
  9. ncbi Characterization and comparative analysis of the EGLN gene family
    M S Taylor
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Gene 275:125-32. 2001
  10. ncbi A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph
    Robert J Duronio
    Department of Biology, Program in Molecular Biology and Biotechnology, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Cell 6:163-4. 2004

Scientific Experts

  • Christian Frei
  • J Myllyharju
  • M S Taylor
  • Lazaro Centanin
  • Pablo Wappner
  • Maximiliano Irisarri
  • Andres Dekanty
  • Sofía Lavista-Llanos
  • Julieta M Acevedo
  • Leigh Cuttell
  • Robert J Duronio
  • Peter J Ratcliffe
  • Rachael L French
  • R K Bruick
  • Nuria M Romero
  • Nuria Romero
  • Magali Quirin
  • Jean Pierre Eid
  • Emeline Van Goethem
  • Elizabeth Silva
  • Mark Lavine
  • Claire J Escaron
  • Andrew Vaughan
  • Thomas A Gorr
  • Nathalie C Franc
  • K Amber Cosand
  • Celeste A Berg
  • Jonathan M Gleadle
  • Silvia N Bocca
  • Daniela M Russo
  • Mariana Muzzopappa
  • S L McKnight

Detail Information

Publications13

  1. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..We identified a conserved family of HIF prolyl hydoxylase (HPH) enzymes that appear to be responsible for this posttranslational modification...
  2. ncbi Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Dev Cell 6:241-51. 2004
    ..Loss-of-function mutations in Hif-1 prolyl hydroxylase (Hph), an enzyme involved in the cellular response to hypoxic stress, dominantly suppress the growth but not the ..
  3. ncbi Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar
    Sofía Lavista-Llanos
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires 1405, Argentina
    Mol Cell Biol 22:6842-53. 2002
    ..Abrogation of the Drosophila Egl-9 prolyl hydroxylase homologue, CG1114, caused both stabilization and nuclear localization of Sima, indicating a central involvement in both processes...
  4. ncbi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
    ..extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on the HIF-prolyl hydroxylase Fatiga that operates as an oxygen sensor...
  5. ncbi Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima
    Lazaro Centanin
    Instituto Leloir and IIB, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    EMBO Rep 6:1070-5. 2005
    ..Here, we describe novel loss-of-function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality...
  6. ncbi Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export
    Maximiliano Irisarri
    Instituto Leloir and FCEyN, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1405 Buenos Aires, Argentina
    Mol Biol Cell 20:3878-87. 2009
    ..HIFalpha/Sima nucleo-cytoplasmic localization is the result of a dynamic equilibrium between nuclear import and nuclear export, and nuclear export is modulated by oxygen tension...
  7. ncbi Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis
    Leigh Cuttell
    Medical Research Council Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Cell and Developmental Biology Department, University College London, Gower Street, London WC1E 6BT, UK
    Cell 135:524-34. 2008
    ..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway...
  8. ncbi The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 24:623-34. 2005
    ..CycD/Cdk4 stimulates mitochondrial activity, and this is mRpL12 dependent. Hif-1 prolyl hydroxylase (Hph), another effector of CycD/Cdk4, regulates growth and is required for inhibition of the hypoxia-inducible ..
  9. ncbi Characterization and comparative analysis of the EGLN gene family
    M S Taylor
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Gene 275:125-32. 2001
    ..These results provide new insights into host-pathogen interactions and a basis for further functional characterization of the gene family and resolve discrepancies in annotation between gene family members...
  10. ncbi A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph
    Robert J Duronio
    Department of Biology, Program in Molecular Biology and Biotechnology, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Cell 6:163-4. 2004
    ..In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a prolyl hydroxylase that is a key component of a cell's ability to respond to hypoxia.
  11. ncbi Collagens, modifying enzymes and their mutations in humans, flies and worms
    Johanna Myllyharju
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
    Trends Genet 20:33-43. 2004
    ..elegans mutants are also available to analyse the collagen gene family and their modifying enzymes...
  12. ncbi The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis
    Rachael L French
    Program in Genetics, Department of Genome Sciences, University of Washington, Box 357730, Seattle, Washington, 98195 7730, USA
    Dev Biol 253:18-35. 2003
    ..We hypothesize that loss of Ttk69 in all follicle cells disrupts chorion gene expression and lack of function in dorsal anterior follicle cells inhibits morphogenetic changes required for elongating the dorsal appendages...
  13. ncbi Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/Sima
    Julieta M Acevedo
    Instituto Leloir, Buenos Aires, Argentina
    PLoS ONE 5:e12390. 2010
    ..PHD2, the longest PHD isoform includes a MYND domain, whose biochemical function is unclear...