Gene Symbol: HP6
Description: Heterochromatin protein 6
Alias: CG15636, Dmel\CG15636, UMB, UMBREA, Umbrea, umbrea, heterochromatin protein 6, CG15636-PA, HP6-PA, umbrea
Species: fruit fly

Top Publications

  1. Greil F, de Wit E, Bussemaker H, van Steensel B. HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila. EMBO J. 2007;26:741-51 pubmed
    ..Three of these proteins (HP3, HP4 and HP5) interact directly with HP1, whereas HP6 in turn binds to each of these three proteins...
  2. Chen S, Zhang Y, Long M. New genes in Drosophila quickly become essential. Science. 2010;330:1682-5 pubmed publisher
    ..Lethality was attributed to diverse cellular and developmental defects, such as organ formation and patterning defects. These data suggest that new genes frequently and rapidly evolve essential functions and participate in development. ..
  3. Mukai M, Hayashi Y, Kitadate Y, Shigenobu S, Arita K, Kobayashi S. MAMO, a maternal BTB/POZ-Zn-finger protein enriched in germline progenitors is required for the production of functional eggs in Drosophila. Mech Dev. 2007;124:570-83 pubmed
    ..We propose that maternal MAMO activates downstream genes to promote specialized morphological changes of both female meiotic chromosomes and the sperm nucleus, which are critical in zygote formation. ..
  4. Joppich C, Scholz S, Korge G, Schwendemann A. Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP. Chromosome Res. 2009;17:19-36 pubmed publisher
    ..Here, we report the identification and characterization of the Hip-interacting protein Umbrea. We found that Umbrea interacts directly with Hip, HP1 and HOAP in vitro...
  5. Levine M, McCoy C, Vermaak D, Lee Y, Hiatt M, Matsen F, et al. Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family. PLoS Genet. 2012;8:e1002729 pubmed publisher
  6. Brideau N, Barbash D. Functional conservation of the Drosophila hybrid incompatibility gene Lhr. BMC Evol Biol. 2011;11:57 pubmed publisher
    ..We conclude that evolution of the hybrid lethality properties of Lhr between D. melanogaster and D. simulans did not involve extensive loss or gain of functions associated with protein interactions or localization to heterochromatin...
  7. Levine M, Malik H. A rapidly evolving genomic toolkit for Drosophila heterochromatin. Fly (Austin). 2013;7:137-41 pubmed publisher
    ..The birth and death of HP1 genes follows a "revolving door" pattern, where new HP1s appear to replace old HP1s. Here, we address alternative evolutionary models that drive this constant innovation. ..
  8. Sawamura K. Chromatin evolution and molecular drive in speciation. Int J Evol Biol. 2012;2012:301894 pubmed publisher
    ..As a result, chromatin binding proteins may not be able to interact with chromosomes from another species in a hybrid, causing hybrid sterility and inviability. ..
  9. Ross B, Rosin L, Thomae A, Hiatt M, Vermaak D, de la Cruz A, et al. Stepwise evolution of essential centromere function in a Drosophila neogene. Science. 2013;340:1211-4 pubmed publisher
    ..We traced the evolutionary steps by which the Drosophila gene Umbrea acquired an essential role in chromosome segregation in D...

More Information


  1. Kemkemer C, Long M. New genes important for development. EMBO Rep. 2014;15:460-1 pubmed publisher