Gene Symbol: HP1b
Description: Heterochromatin Protein 1b
Alias: CG7041, Dmel\CG7041, HP1, HP1B, Hp1b, heterochromatin protein 1b, CG7041-PA, CG7041-PB, CG7041-PC, HP1b-PA, HP1b-PB, HP1b-PC, heterochromatin protein 1B
Species: fruit fly
Products:     HP1b

Top Publications

  1. Minervini C, Marsano R, Casieri P, Fanti L, Caizzi R, Pimpinelli S, et al. Heterochromatin protein 1 interacts with 5'UTR of transposable element ZAM in a sequence-specific fashion. Gene. 2007;393:1-10 pubmed
    ..Here we provide evidence that a similar interaction should occur between ZAM, a gypsy-like element, and HP1, one of the most extensively studied chromatin proteins...
  2. Smothers J, Henikoff S. The hinge and chromo shadow domain impart distinct targeting of HP1-like proteins. Mol Cell Biol. 2001;21:2555-69 pubmed
    ..We have characterized the subnuclear localization patterns of two newly discovered Drosophila HP1-like proteins (HP1b and HP1c), comparing them with that of the originally described fly HP1 protein (here designated HP1a)...
  3. Li Y, Kirschmann D, Wallrath L. Does heterochromatin protein 1 always follow code?. Proc Natl Acad Sci U S A. 2002;99 Suppl 4:16462-9 pubmed
    Heterochromatin protein 1 (HP1) is a conserved chromosomal protein that participates in chromatin packaging and gene silencing. A loss of HP1 leads to lethality in Drosophila and correlates with metastasis in human breast cancer cells...
  4. Brower Toland B, Findley S, Jiang L, Liu L, Yin H, Dus M, et al. Drosophila PIWI associates with chromatin and interacts directly with HP1a. Genes Dev. 2007;21:2300-11 pubmed
    ..These findings implicate a direct interaction between the PIWI-mediated small RNA mechanism and heterochromatin-forming pathways in determining the epigenetic state of the fly genome. ..
  5. Badugu R, Shareef M, Kellum R. Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. J Biol Chem. 2003;278:34491-8 pubmed
    ..Two additional HP1-like proteins (HP1b and HP1c) were recently identified in Drosophila, and the unique chromosomal distribution of each isoform is ..
  6. Levine M, McCoy C, Vermaak D, Lee Y, Hiatt M, Matsen F, et al. Phylogenomic analysis reveals dynamic evolutionary history of the Drosophila heterochromatin protein 1 (HP1) gene family. PLoS Genet. 2012;8:e1002729 pubmed publisher
    ..introduce unprecedented structural diversity, lineage-restriction, and germline-biased expression patterns into the HP1 family...
  7. Lomberk G, Wallrath L, Urrutia R. The Heterochromatin Protein 1 family. Genome Biol. 2006;7:228 pubmed
    Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin...
  8. Vermaak D, Henikoff S, Malik H. Positive selection drives the evolution of rhino, a member of the heterochromatin protein 1 family in Drosophila. PLoS Genet. 2005;1:96-108 pubmed publisher
    ..One of the best markers for heterochromatin is the heterochromatin protein 1 (HP1), which is an essential, nonhistone chromosomal protein...
  9. Lin C, Li B, Swanson S, Zhang Y, Florens L, Washburn M, et al. Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell. 2008;32:696-706 pubmed publisher
    ..We found that the chromo shadow domain of HP1a and a HP1-interacting motif of dKDM4A are responsible for this interaction...

More Information


  1. Wood J, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, et al. Chromatin remodeling in the aging genome of Drosophila. Aging Cell. 2010;9:971-8 pubmed publisher
    ..We found dramatic reorganization of chromosomal regions with age. Mapping of H3K9me3 and HP1 signals to fly chromosomes reveals in young flies the expected high enrichment in the pericentric regions, the 4th ..
  2. Silver Morse L, Li W. JAK-STAT in heterochromatin and genome stability. JAKSTAT. 2013;2:e26090 pubmed publisher
    ..These higher heterochromatin levels result in suppression of hematopoietic tumor-like masses, increased resistance to DNA damage, and longer lifespan. ..
  3. Abel J, Eskeland R, Raffa G, Kremmer E, Imhof A. Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc. PLoS ONE. 2009;4:e5089 pubmed publisher
    b>HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture...
  4. Schulze S, Curio Penny B, Speese S, Dialynas G, Cryderman D, McDonough C, et al. A comparative study of Drosophila and human A-type lamins. PLoS ONE. 2009;4:e7564 pubmed publisher
    ..These studies provide new insights on the role of lamins in nuclear biology and support Drosophila as a model for studies of human laminopathies involving muscle dysfunction. ..
  5. Kwon S, Florens L, Swanson S, Washburn M, Abmayr S, Workman J. Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. Genes Dev. 2010;24:2133-45 pubmed publisher
    Heterochromatin protein 1 (HP1) is well known as a silencing protein found at pericentric heterochromatin. Most eukaryotes have at least three isoforms of HP1 that play differential roles in heterochromatin and euchromatin...
  6. Mendez D, Mandt R, Elgin S. Heterochromatin Protein 1a (HP1a) partner specificity is determined by critical amino acids in the chromo shadow domain and C-terminal extension. J Biol Chem. 2013;288:22315-23 pubmed publisher
    ..in homodimerization and the impact of the C-terminal extension (CTE) by contrasting HP1a to its paralogue, HP1b. HP1a and HP1b differ in the dimerization interface, with HP1a having an Arg at position 188 rather than Glu...
  7. Koryakov D, Reuter G, Dimitri P, Zhimulev I. The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster. Chromosoma. 2006;115:296-310 pubmed
    ..distribution of three heterochromatic proteins [SUppressor of UnderReplication (SUUR), heterochromatin protein 1 (HP1), and SU(VAR)3-9] in chromosomes of nurse cells (NCs) and have compared the data obtained with the distribution of ..
  8. Lee D, Li Y, Shin D, Yi S, Bang S, Park E, et al. DNA microarray profiling of genes differentially regulated by three heterochromatin protein 1 (HP1) homologs in Drosophila. Biochem Biophys Res Commun. 2013;434:820-8 pubmed publisher
    Heterochromatin protein 1 (HP1) is an epigenetic gene silencing protein that is regulated by lysine 9 methylation of histone H3...
  9. Dietz K, Di Stefano L, Maher R, Zhu H, MacDonald M, Gusella J, et al. The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development. Hum Mol Genet. 2015;24:330-45 pubmed publisher
    ..These findings suggest that a fundamental aspect of huntingtin function in heterochromatin/euchromatin organization is evolutionarily conserved across phyla. ..
  10. Kemkemer C, Long M. New genes important for development. EMBO Rep. 2014;15:460-1 pubmed publisher
  11. Branco A, Hartl D, Lemos B. Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis. Genetics. 2013;194:609-18 pubmed publisher
    ..expression levels of mod(mdg4) as well as Su(var)205; the latter gene codes for heterochromatin protein 1 (HP1) in Drosophila...
  12. Zhang D, Wang D, Sun F. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Chromosoma. 2011;120:97-108 pubmed publisher
    ..Here, we investigate the function of heterochromatin protein HP1b, a member of the HP1 family in Drosophila melanogaster, in transcription and development...
  13. Demakov S, Vatolina T, Babenko V, Semeshin V, Belyaeva E, Zhimulev I. Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. BMC Genomics. 2011;12:566 pubmed publisher
    ..Our observations suggest strikingly similar organization of interband chromatin in polytene chromosomes and in chromosomes from cell lines thereby reflecting the existence of a universal principle of interphase chromosome organization. ..
  14. Linder B, Gerlach N, Jackle H. The Drosophila homolog of the human AF10 is an HP1-interacting suppressor of position effect variegation. EMBO Rep. 2001;2:211-6 pubmed
    ..We also demonstrate that dAF10 can associate with the heterochromatin protein 1 (HP1) in vitro and in vivo...
  15. Alfieri C, Gambetta M, Matos R, Glatt S, Sehr P, Fraterman S, et al. Structural basis for targeting the chromatin repressor Sfmbt to Polycomb response elements. Genes Dev. 2013;27:2367-79 pubmed publisher
    ..Our results support a model where DNA tethering of Sfmbt by Pho and multivalent interactions of Sfmbt with histone modifications and other PcG proteins create a hub for PcG protein complex assembly at PREs. ..
  16. Levine M, Malik H. A rapidly evolving genomic toolkit for Drosophila heterochromatin. Fly (Austin). 2013;7:137-41 pubmed publisher
    ..reported over 20 new members of what was traditionally believed to be a small and static Heterochromatin Protein 1 (HP1) gene family...
  17. Ross B, Rosin L, Thomae A, Hiatt M, Vermaak D, de la Cruz A, et al. Stepwise evolution of essential centromere function in a Drosophila neogene. Science. 2013;340:1211-4 pubmed publisher
    ..Our evolutionary cell biology approach provides temporal and mechanistic detail about how young genes gain essential function. Such innovations may constantly alter the repertoire of centromeric proteins in eukaryotes...
  18. Li H, Rodriguez J, Yoo Y, Shareef M, Badugu R, Horabin J, et al. Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision. PLoS Genet. 2011;7:e1002122 pubmed publisher
    ..RNAi knockdown of the highly conserved heterochromatin protein HP1 in Drosophila was previously shown to preferentially reduce male viability...
  19. Ryu H, Lee D, Florens L, Swanson S, Washburn M, Kwon S. Analysis of the heterochromatin protein 1 (HP1) interactome in Drosophila. J Proteomics. 2014;102:137-47 pubmed publisher
    ..In addition, little is known about the overall interaction network of the three Drosophila HP1 homologs, HP1a, HP1b, and HP1c...
  20. Delattre M, Spierer A, Tonka C, Spierer P. The genomic silencing of position-effect variegation in Drosophila melanogaster: interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1. J Cell Sci. 2000;113 Pt 23:4253-61 pubmed
    ..An increase in the amounts of the heterochromatin-associated Su(var)3-7 and HP1 proteins augments silencing...
  21. Beck E, Llopart A. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup. Sci Rep. 2015;5:17197 pubmed publisher