Gene Symbol: Hop
Description: Hsp70/Hsp90 organizing protein
Alias: CG2720, Dmel\CG2720, EP(2)0418, HOP, Sti1, dHop, dSTI1, dhop, dmSTI1, hop, l(2)k00616, Hsp70/Hsp90 organizing protein, CG2720-PA, Hop-PA, Hsp70(Hsp90) organizing protein, Hsp70-Hsp90 organizing protein, Hsp70/Hsp90 organizing protein homolog, stress inducible protein 1
Species: fruit fly

Top Publications

  1. Carrigan P, Riggs D, Chinkers M, Smith D. Functional comparison of human and Drosophila Hop reveals novel role in steroid receptor maturation. J Biol Chem. 2005;280:8906-11 pubmed
    ..structure/function relationships, we have extended comparisons to the Hop ortholog from Drosophila melanogaster (dHop), which lacks DP1...
  2. Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell. 2010;143:813-25 pubmed publisher
    ..These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging. ..
  3. Gangaraju V, Yin H, Weiner M, Wang J, Huang X, Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nat Genet. 2011;43:153-8 pubmed publisher
    ..Furthermore, we isolated a protein complex composed of Hsp90, Piwi and Hop, the Hsp70/Hsp90 organizing protein homolog, and we demonstrated the function of this complex in canalization...
  4. Igaki T, Suzuki Y, Tokushige N, Aonuma H, Takahashi R, Miura M. Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Biochem Biophys Res Commun. 2007;356:993-7 pubmed
    ..Our observations suggest that DmHtrA2 promotes cell death through a cleavage of DIAP1 in the vicinity of mitochondria, which may represent a prototype of mitochondrial cell death pathway in evolution. ..
  5. Yi F, Doudevski I, Regan L. HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP. Protein Sci. 2010;19:19-25 pubmed publisher
    The co-chaperone Hsp70-Hsp90 organizing protein (HOP) plays a central role in protein folding in vivo, binding to both Hsp70 and Hsp90 and bringing them together in a functional complex...
  6. Demontis F, Piccirillo R, Goldberg A, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013;6:1339-52 pubmed publisher
  7. Wang L, Ryoo H, Qi Y, Jasper H. PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress. PLoS Genet. 2015;11:e1005220 pubmed publisher
    ..Our studies highlight the significance of the PERK branch of the unfolded protein response of the ER (UPRER) in intestinal homeostasis and provide a viable strategy to improve organismal health- and lifespan. ..
  8. Lee M, Toh L, Yaw L, Luo Y. Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes. J Biol Chem. 2010;285:9041-53 pubmed publisher
    ..Finally, dmOCA-S is recruited to the Drosophila histone locus bodies in the S-phase, marking S-phase-specific transcription activation of core histone genes. ..
  9. Iwasaki S, Kobayashi M, Yoda M, Sakaguchi Y, Katsuma S, Suzuki T, et al. Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes. Mol Cell. 2010;39:292-9 pubmed publisher
    ..Our data suggest that the chaperone machinery may serve as the driving force for the RISC assembly pathway. ..

More Information


  1. Gomes A, Nolasco S, Soares H. Non-coding RNAs: multi-tasking molecules in the cell. Int J Mol Sci. 2013;14:16010-39 pubmed publisher
    ..We also highlighted the implications of biogenesis and gene expression deregulation of sncRNAs and lncRNAs in human diseases like cancer. ..
  2. Weinkove D, Neufeld T, Twardzik T, Waterfield M, Leevers S. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr Biol. 1999;9:1019-29 pubmed
    ..Our results indicate that Dp110 and p60 signalling can affect growth in multiple ways, which has important implications for the function of signalling through class I(A) PI 3-kinases. ..
  3. Belozerov V, Ratkovic S, McNeill H, Hilliker A, McDermott J. In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle. Mol Cell Biol. 2014;34:474-84 pubmed publisher
    ..Biochemical analyses of Rack1 in aging and stressed muscle suggest a model whereby p38 MAPK signaling causes a redistribution of Rack1 between a ribosome-bound pool and a putative translational repressor complex. ..
  4. Bozoky Z, Alexa A, Dancsok J, Gogl G, Klement E, Medzihradszky K, et al. Identifying calpain substrates in intact S2 cells of Drosophila. Arch Biochem Biophys. 2009;481:219-25 pubmed publisher
    ..In a typical run, 11 candidate substrates were recognized; out of these, four were randomly selected: all four were verified to be calpain substrates, by digestion of the recombinant protein with recombinant calpain. ..
  5. Kankare M, Salminen T, Laiho A, Vesala L, Hoikkala A. Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study. BMC Ecol. 2010;10:3 pubmed publisher
    ..montana is worth of studying in more details. Also, further studies using the candidate gene microarray with more specific experimental designs and target tissues may reveal additional genes with more restricted expression patterns. ..
  6. Iwasaki S, Sasaki H, Sakaguchi Y, Suzuki T, Tadakuma H, Tomari Y. Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex. Nature. 2015;521:533-6 pubmed publisher
    ..Here we reconstitute RISC assembly using only Ago2, Dicer-2, R2D2, Hsc70, Hsp90, Hop, Droj2 (an Hsp40 homologue) and p23...