Gene Symbol: HnRNP-K
Description: Heterogeneous nuclear ribonucleoprotein K
Alias: CG13425, Dmel\CG13425, Hrb57A, Q18, dhnRNP K, hnRNP K, hnRNP-A1L, l(2)k08305, heterogeneous nuclear ribonucleoprotein K, CG13425-PA, CG13425-PB, CG13425-PC, CG13425-PD, CG13425-PE, CG13425-PF, HnRNP-K-PA, HnRNP-K-PB, HnRNP-K-PC, HnRNP-K-PD, HnRNP-K-PE, HnRNP-K-PF, bancal, bancal hnRNP, heterogeneous nuclear ribonucleoprotein at 57A
Species: fruit fly

Top Publications

  1. Zimowska G, Paddy M. Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure. Exp Cell Res. 2002;276:223-32 pubmed
  2. Buchenau P, Saumweber H, Arndt Jovin D. The dynamic nuclear redistribution of an hnRNP K-homologous protein during Drosophila embryo development and heat shock. Flexibility of transcription sites in vivo. J Cell Biol. 1997;137:291-303 pubmed
    ..loci in vivo during the recovery from heat shock could be followed by the rapid redistribution of the hnRNP K during stress recovery...
  3. Rajendra T, Prasanth K, Lakhotia S. Male sterility associated with overexpression of the noncoding hsromega gene in cyst cells of testis of Drosophila melanogaster. J Genet. 2001;80:97-110 pubmed
    ..Two of the hnRNPs, viz. HRB87F and Hrb57A, which are expressed in cyst cells, also formed large clusters in these cells in parallel with the hsromega-n ..
  4. Prasanth K, Rajendra T, Lal A, Lakhotia S. Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila. J Cell Sci. 2000;113 Pt 19:3485-97 pubmed
    ..staining using antibodies against heterogenous nuclear RNA binding proteins (hnRNPs) like HRB87F, Hrp40, Hrb57A and S5 revealed that, in all cell types, all the hnRNPs gave a diffuse staining of chromatin areas and in addition,..
  5. Hovemann B, Reim I, Werner S, Katz S, Saumweber H. The protein Hrb57A of Drosophila melanogaster closely related to hnRNP K from vertebrates is present at sites active in transcription and coprecipitates with four RNA-binding proteins. Gene. 2000;245:127-37 pubmed
    The hnRNP K protein is among the major hnRNA-binding proteins with a strong preference for cytidine-rich sequences. We have cloned a Drosophila hnRNP protein closely related to this vertebrate protein...
  6. Bomsztyk K, Denisenko O, Ostrowski J. hnRNP K: one protein multiple processes. Bioessays. 2004;26:629-38 pubmed
    ..The greater diversity of mammalian K protein interactions and function may reflect gain of novel docking sites and expansion evolutionary of gene expression networks. ..
  7. Gates J, Thummel C. An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Genetics. 2000;156:1765-76 pubmed
    ..screen we identified four mutations, one of which corresponds to bancal, which encodes the Drosophila homolog of hnRNP K. We also identified vulcan, which encodes a protein that shares sequence similarity with a family of rat SAPAP ..
  8. Lukacsovich T, Asztalos Z, Awano W, Baba K, Kondo S, Niwa S, et al. Dual-tagging gene trap of novel genes in Drosophila melanogaster. Genetics. 2001;157:727-42 pubmed
  9. Fernando C, Audibert A, Simon F, Tazi J, Juge F. A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in Drosophila. Genetics. 2015;199:1201-11 pubmed publisher
    ..Our results demonstrate a role of this SR protein in cell growth and identify candidate proteins that may overcome the effects of SR protein overexpression in mammals. ..

More Information


  1. Gortchakov A, Eggert H, Gan M, Mattow J, Zhimulev I, Saumweber H. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Chromosoma. 2005;114:54-66 pubmed publisher
    ..Reducing Z4 protein does not affect Chriz binding to polytene chromosomes and vice versa. Z4 is still chromosomally bound when Chriz protein is depleted by RNA interference...
  2. Fukami Kobayashi K, Tomoda S, Go M. Evolutionary clustering and functional similarity of RNA-binding proteins. FEBS Lett. 1993;335:289-93 pubmed
    ..In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA-binding domain(s) and domain organization, as compared with other RNPs. ..
  3. Bayer C, Halsell S, Fristrom J, Kiehart D, von Kalm L. Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. Genetics. 2003;165:1417-32 pubmed
    ..Our results provide evidence that the type II transmembrane serine proteases, a class of proteins linked to human developmental abnormalities and pathology, may be associated with intracellular signaling required for normal development. ..
  4. Li X, Carthew R. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell. 2005;123:1267-77 pubmed
    ..Expression is switched when EGFR signaling transiently triggers Yan degradation. This two-tiered mechanism explains how signal transduction activity can robustly generate a stable change in gene-expression patterns. ..
  5. Mallik M, Lakhotia S. Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models. Genetics. 2010;184:927-45 pubmed publisher
    ..Our data suggest that CBP and hnRNPs like Hrb57A and Hrb87F physically interact with each other...
  6. Marhold J, Zbylut M, Lankenau D, Li M, Gerlich D, Ballestar E, et al. Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation. Chromosoma. 2002;111:13-21 pubmed
    ..Our results indicate that dMBD2/3 forms specialized nuclear compartments to keep certain genes epigenetically silenced during genome activation. ..
  7. Mallik M, Lakhotia S. The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila. Genetics. 2009;183:831-52 pubmed publisher
    ..Our results suggest that the hsromega transcripts regulate cellular levels of DIAP1 via the hnRNP Hrb57A, which physically interacts with DIAP1, and any alteration in levels of the hsromega transcripts in eye disc cells ..
  8. Charroux B, Angelats C, Fasano L, Kerridge S, Vola C. The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells. Mol Cell Biol. 1999;19:7846-56 pubmed
    We have characterized the Drosophila bancal gene, which encodes a Drosophila homologue of the vertebrate hnRNP K protein. The bancal gene is essential for the correct size of adult appendages...
  9. Jolly C, Lakhotia S. Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells. Nucleic Acids Res. 2006;34:5508-14 pubmed
  10. Ochoa Espinosa A, Yu D, Tsirigos A, Struffi P, Small S. Anterior-posterior positional information in the absence of a strong Bicoid gradient. Proc Natl Acad Sci U S A. 2009;106:3823-8 pubmed publisher
  11. Gasser S. Visualizing chromatin dynamics in interphase nuclei. Science. 2002;296:1412-6 pubmed
    ..Determining the distribution and regulation of mobile domains in interphase chromosomes, and characterizing sites of anchorage, will undoubtedly shed new light on the function of nuclear order. ..
  12. Aboobaker A, Tomancak P, Patel N, Rubin G, Lai E. Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A. 2005;102:18017-22 pubmed
    ..We also describe an intronic miRNA (miR-7) whose expression pattern is distinct from that of its host mRNA (bancal), which demonstrates that intronic miRNAs can be subject to independent cis-regulatory control...
  13. Pek J, Lim A, Kai T. Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7. Dev Cell. 2009;17:417-24 pubmed publisher
    ..We propose that Mael ensures proper differentiation in the GSC lineage by repressing miR-7. ..
  14. Venken K, He Y, Hoskins R, Bellen H. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006;314:1747-51 pubmed
    ..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
  15. Oas S, Bryantsev A, Cripps R. Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila. J Cell Biol. 2014;206:895-908 pubmed publisher
    ..Our observations provide insight into a transcriptional and splicing regulatory network for muscle fiber specification. ..
  16. Singh A, Lakhotia S. The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster. J Biosci. 2012;37:659-78 pubmed
    ..Therefore, in spite of the functional redundancy provided by Hrp38, Hrp36 is essential for normal development and for survival under conditions of stress. ..
  17. He X, Duque T, Sinha S. Evolutionary origins of transcription factor binding site clusters. Mol Biol Evol. 2012;29:1059-70 pubmed publisher
    ..The quantitative framework we develop here can be used more generally to understand how mechanisms of enhancer action influence their composition and evolution. ..
  18. Buchenau P, Hodgson J, Strutt H, Arndt Jovin D. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. J Cell Biol. 1998;141:469-81 pubmed
    ..These observations have important implications for models of the mechanism and maintenance of PcG- mediated gene repression. ..
  19. Ochoa Espinosa A, Yucel G, Kaplan L, Pare A, Pura N, Oberstein A, et al. The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila. Proc Natl Acad Sci U S A. 2005;102:4960-5 pubmed
    ..We propose that the key design principle in AP patterning is the differential integration of positive and negative transcriptional information at the level of individual CRMs for each target gene. ..
  20. Gates J, Lam G, Ortiz J, Losson R, Thummel C. rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development. 2004;131:25-36 pubmed
    ..Furthermore, the dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development. ..