Genomes and Genes
Gene Symbol: HnRNP-K
Description: Heterogeneous nuclear ribonucleoprotein K
Alias: CG13425, Dmel\CG13425, Hrb57A, Q18, dhnRNP K, hnRNP K, hnRNP-A1L, l(2)k08305, heterogeneous nuclear ribonucleoprotein K, CG13425-PA, CG13425-PB, CG13425-PC, CG13425-PD, CG13425-PE, CG13425-PF, HnRNP-K-PA, HnRNP-K-PB, HnRNP-K-PC, HnRNP-K-PD, HnRNP-K-PE, HnRNP-K-PF, bancal, bancal hnRNP, heterogeneous nuclear ribonucleoprotein at 57A
Species: fruit fly
- Gortchakov A, Eggert H, Gan M, Mattow J, Zhimulev I, Saumweber H. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Chromosoma. 2005;114:54-66 pubmed publisher..Reducing Z4 protein does not affect Chriz binding to polytene chromosomes and vice versa. Z4 is still chromosomally bound when Chriz protein is depleted by RNA interference...
- Fukami Kobayashi K, Tomoda S, Go M. Evolutionary clustering and functional similarity of RNA-binding proteins. FEBS Lett. 1993;335:289-93 pubmed..In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA-binding domain(s) and domain organization, as compared with other RNPs. ..
- Bayer C, Halsell S, Fristrom J, Kiehart D, von Kalm L. Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. Genetics. 2003;165:1417-32 pubmed..Our results provide evidence that the type II transmembrane serine proteases, a class of proteins linked to human developmental abnormalities and pathology, may be associated with intracellular signaling required for normal development. ..
- Li X, Carthew R. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell. 2005;123:1267-77 pubmed..Expression is switched when EGFR signaling transiently triggers Yan degradation. This two-tiered mechanism explains how signal transduction activity can robustly generate a stable change in gene-expression patterns. ..
- Mallik M, Lakhotia S. Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models. Genetics. 2010;184:927-45 pubmed publisher..Our data suggest that CBP and hnRNPs like Hrb57A and Hrb87F physically interact with each other...
- Marhold J, Zbylut M, Lankenau D, Li M, Gerlich D, Ballestar E, et al. Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation. Chromosoma. 2002;111:13-21 pubmed..Our results indicate that dMBD2/3 forms specialized nuclear compartments to keep certain genes epigenetically silenced during genome activation. ..
- Mallik M, Lakhotia S. The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila. Genetics. 2009;183:831-52 pubmed publisher..Our results suggest that the hsromega transcripts regulate cellular levels of DIAP1 via the hnRNP Hrb57A, which physically interacts with DIAP1, and any alteration in levels of the hsromega transcripts in eye disc cells ..
- Charroux B, Angelats C, Fasano L, Kerridge S, Vola C. The levels of the bancal product, a Drosophila homologue of vertebrate hnRNP K protein, affect cell proliferation and apoptosis in imaginal disc cells. Mol Cell Biol. 1999;19:7846-56 pubmedWe have characterized the Drosophila bancal gene, which encodes a Drosophila homologue of the vertebrate hnRNP K protein. The bancal gene is essential for the correct size of adult appendages...
- Jolly C, Lakhotia S. Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells. Nucleic Acids Res. 2006;34:5508-14 pubmed
- Gasser S. Visualizing chromatin dynamics in interphase nuclei. Science. 2002;296:1412-6 pubmed..Determining the distribution and regulation of mobile domains in interphase chromosomes, and characterizing sites of anchorage, will undoubtedly shed new light on the function of nuclear order. ..
- Aboobaker A, Tomancak P, Patel N, Rubin G, Lai E. Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A. 2005;102:18017-22 pubmed..We also describe an intronic miRNA (miR-7) whose expression pattern is distinct from that of its host mRNA (bancal), which demonstrates that intronic miRNAs can be subject to independent cis-regulatory control...
- Pek J, Lim A, Kai T. Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7. Dev Cell. 2009;17:417-24 pubmed publisher..We propose that Mael ensures proper differentiation in the GSC lineage by repressing miR-7. ..
- Venken K, He Y, Hoskins R, Bellen H. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006;314:1747-51 pubmed..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
- Oas S, Bryantsev A, Cripps R. Arrest is a regulator of fiber-specific alternative splicing in the indirect flight muscles of Drosophila. J Cell Biol. 2014;206:895-908 pubmed publisher..Our observations provide insight into a transcriptional and splicing regulatory network for muscle fiber specification. ..
- Singh A, Lakhotia S. The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster. J Biosci. 2012;37:659-78 pubmed..Therefore, in spite of the functional redundancy provided by Hrp38, Hrp36 is essential for normal development and for survival under conditions of stress. ..
- He X, Duque T, Sinha S. Evolutionary origins of transcription factor binding site clusters. Mol Biol Evol. 2012;29:1059-70 pubmed publisher..The quantitative framework we develop here can be used more generally to understand how mechanisms of enhancer action influence their composition and evolution. ..
- Buchenau P, Hodgson J, Strutt H, Arndt Jovin D. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. J Cell Biol. 1998;141:469-81 pubmed..These observations have important implications for models of the mechanism and maintenance of PcG- mediated gene repression. ..
- Ochoa Espinosa A, Yucel G, Kaplan L, Pare A, Pura N, Oberstein A, et al. The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila. Proc Natl Acad Sci U S A. 2005;102:4960-5 pubmed..We propose that the key design principle in AP patterning is the differential integration of positive and negative transcriptional information at the level of individual CRMs for each target gene. ..
- Gates J, Lam G, Ortiz J, Losson R, Thummel C. rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development. Development. 2004;131:25-36 pubmed..Furthermore, the dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development. ..