Gene Symbol: His2A:CG31618
Description: histone H2A
Alias: BEST:CK01438, CG31618, Dmel\CG31618, histone H2A, CG31618-PA, His2A:CG31618-PA
Species: fruit fly

Top Publications

  1. Bulger M, Ito T, Kamakaka R, Kadonaga J. Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein. Proc Natl Acad Sci U S A. 1995;92:11726-30 pubmed
    ..The dCAF-4 activity copurified with a 56-kDa core-histone-binding protein that was purified to > 90% homogeneity. ..
  2. Tie F, Stratton C, Kurzhals R, Harte P. The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27. Mol Cell Biol. 2007;27:2014-26 pubmed
    ..Our data suggest that one of the roles of ESC (and ESCL and EED) in PRC2 complexes is to enable E(Z) to utilize histone H3 as a substrate by physically linking enzyme and substrate. ..
  3. Zhou B, Feng H, Kato H, Dai L, Yang Y, Zhou Y, et al. Structural insights into the histone H1-nucleosome complex. Proc Natl Acad Sci U S A. 2013;110:19390-5 pubmed publisher
  4. Ito T, Bulger M, Kobayashi R, Kadonaga J. Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays. Mol Cell Biol. 1996;16:3112-24 pubmed
    ..Thus, NAP-1 appears to be one component of a multifactor chromatin assembly machinery that mediates the ATP-facilitated assembly of regularly spaced nucleosomal arrays. ..
  5. Ito T, Tyler J, Bulger M, Kobayashi R, Kadonaga J. ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster. J Biol Chem. 1996;271:25041-8 pubmed
    ..These and other data collectively suggest that dNLP may participate in parallel with other histone-binding proteins such as dNAP-1 in the assembly of chromatin. ..
  6. Smith E, Pannuti A, Gu W, Steurnagel A, Cook R, Allis C, et al. The drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol Cell Biol. 2000;20:312-8 pubmed
    ..These results demonstrate that the MSL complex is responsible for the specific chromatin modification characteristic of the X chromosome in Drosophila males. ..
  7. Wang H, Wang L, Erdjument Bromage H, Vidal M, Tempst P, Jones R, et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature. 2004;431:873-8 pubmed
    ..report the purification and functional characterization of an E3 ubiquitin ligase complex that is specific for histone H2A. The complex, termed hPRC1L (human Polycomb repressive complex 1-like), is composed of several Polycomb-group ..
  8. Eberharter A, Vetter I, Ferreira R, Becker P. ACF1 improves the effectiveness of nucleosome mobilization by ISWI through PHD-histone contacts. EMBO J. 2004;23:4029-39 pubmed
    ..Connecting ACF to histones may be prerequisite for efficient conversion of ATP-dependent conformational changes of ISWI into translocation of DNA relative to the histones during nucleosome mobilization. ..
  9. Kusch T, Florens L, Macdonald W, Swanson S, Glaser R, Yates J, et al. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science. 2004;306:2084-7 pubmed
    ..Thus, these data reveal a previously unknown mechanism for selective histone exchange that uses the concerted action of two distinct chromatin-remodeling enzymes within the same multiprotein complex. ..

More Information


  1. Clapier C, Chakravarthy S, Petosa C, Fernández Tornero C, Luger K, Müller C. Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer. Proteins. 2008;71:1-7 pubmed
    ..This highlights the tight evolutionary constraints exerted on histones since the vertebrate and invertebrate lineages diverged. ..
  2. Kusch T, Mei A, Nguyen C. Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression. Proc Natl Acad Sci U S A. 2014;111:4850-5 pubmed publisher
    ..Furthermore, this mechanism prevents the accumulation of epigenetic noise caused by random complex-nucleosome collisions. ..
  3. Klinker H, Haas C, Harrer N, Becker P, Mueller Planitz F. Rapid purification of recombinant histones. PLoS ONE. 2014;9:e104029 pubmed publisher
    ..We expect that the RHP protocol can be readily applied to the purification of canonical histones from other species as well as the numerous histone variants. ..
  4. Emelyanov A, Rabbani J, Mehta M, Vershilova E, Keogh M, Fyodorov D. Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization. Genes Dev. 2014;28:2027-40 pubmed publisher
  5. Carrier F, Georgel P, Pourquier P, Blake M, Kontny H, Antinore M, et al. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol. 1999;19:1673-85 pubmed
    ..Both histone acetylation and UV radiation are thought to destabilize the nucleosomal structure. Hence, these results imply that Gadd45 can recognize an altered chromatin state and modulate DNA accessibility to cellular proteins. ..
  6. Lagarou A, Mohd Sarip A, Moshkin Y, Chalkley G, Bezstarosti K, Demmers J, et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev. 2008;22:2799-810 pubmed publisher
    ..Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2)...
  7. Zhou B, Feng H, Ghirlando R, Li S, Schwieters C, Bai Y. A Small Number of Residues Can Determine if Linker Histones Are Bound On or Off Dyad in the Chromatosome. J Mol Biol. 2016;428:3948-3959 pubmed publisher
    ..Taken together, our results suggest that a small number of residues in the globular domain of a linker histone can control its binding location on the nucleosome and higher-order chromatin structure. ..