Gene Symbol: HipHop
Description: HP1-HOAP-interacting protein
Alias: BcDNA:RE10558, CG6874, Dmel\CG6874, HIPHOP, Hiphop, hiphop, l(3)neo26, HP1-HOAP-interacting protein, CG6874-PA, CG6874-PB, HP1 and HOAP-interacting protein, HP1-HOAP interacting protein, HipHop-PA, HipHop-PB, l(3)neo26, lethal (3) neo26
Species: fruit fly

Top Publications

  1. Gao G, Walser J, Beaucher M, Morciano P, Wesolowska N, Chen J, et al. HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J. 2010;29:819-29 pubmed publisher
    ..we isolated proteins that interact with the HP1/ORC-associated protein (HOAP) capping protein, and identified HipHop as a subunit of the complex...
  2. Gao G, Cheng Y, Wesolowska N, Rong Y. Paternal imprint essential for the inheritance of telomere identity in Drosophila. Proc Natl Acad Sci U S A. 2011;108:4932-7 pubmed publisher
    ..The ms(3)k81 (k81) gene is a duplication of hiphop that encodes a telomeric protein...
  3. Loppin B, Lepetit D, Dorus S, Couble P, Karr T. Origin and neofunctionalization of a Drosophila paternal effect gene essential for zygote viability. Curr Biol. 2005;15:87-93 pubmed publisher
    ..We present a detailed case history of the origin and evolution of a new essential gene and, in so doing, provide the first molecular identification of a Drosophila paternal effect gene, ms(3)K81 (K81)...
  4. Dubruille R, Orsi G, Delabaere L, Cortier E, Couble P, Marais G, et al. Specialization of a Drosophila capping protein essential for the protection of sperm telomeres. Curr Biol. 2010;20:2090-9 pubmed publisher
    ..capping complex at telomeres notably involves the recruitment of HOAP, HP1, and their recently identified partner, HipHop. We previously showed that the hiphop gene was duplicated before the radiation of the melanogaster subgroup of ..
  5. Raffa G, Ciapponi L, Cenci G, Gatti M. Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres. Nucleus. 2011;2:383-91 pubmed publisher
    ..Recent work has shown that Drosophila telomeres are capped by a complex, we call terminin, which includes HOAP, HipHop, Moi and Ver; these are fast-evolving proteins that prevent telomere fusion, directly interact with each other, ..
  6. Mathew V, Pauleau A, Steffen N, Bergner A, Becker P, Erhardt S. The histone-fold protein CHRAC14 influences chromatin composition in response to DNA damage. Cell Rep. 2014;7:321-30 pubmed publisher
    ..CENP-A and CHRAC14 are able to interact upon damage. Our data suggest that CHRAC14 modulates chromatin composition in response to DNA damage, which is required for efficient DNA damage repair in Drosophila. ..
  7. Pröschel M, Zhang Z, Parsch J. Widespread adaptive evolution of Drosophila genes with sex-biased expression. Genetics. 2006;174:893-900 pubmed
    ..melanogaster and D. simulans. This suggests that sexual selection and intersexual coevolution are the major forces driving genetic differentiation between species. ..
  8. Morciano P, Zhang Y, Cenci G, Rong Y. A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila. G3 (Bethesda). 2013;3:1043-8 pubmed publisher
    ..In contrast, there is a prominent reduction of the level of HipHop, an essential member of the Drosophila capping complex...
  9. Dubruille R, Loppin B. Protection of Drosophila chromosome ends through minimal telomere capping. J Cell Sci. 2015;128:1969-81 pubmed publisher
    ..We propose that these complexes prevent fusions by acting at the very extremity of chromosomes, reminiscent of the protection conferred by extremely short telomeric arrays in yeast or mammalian systems. ..

More Information


  1. Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa G, et al. A role for Separase in telomere protection. Nat Commun. 2016;7:10405 pubmed publisher
    ..Finally, we find that siRNA-induced depletion of ESPL1, the Sse human orthologue, causes telomere dysfunction and HP1 level reduction in primary fibroblasts, highlighting a conserved role of Separase in telomere protection. ..
  2. Dubruille R, Marais G, Loppin B. Repeated evolution of testis-specific new genes: the case of telomere-capping genes in Drosophila. Int J Evol Biol. 2012;2012:708980 pubmed publisher
    ..Here we review the case of such a new gene, which involves a telomere-capping gene family in Drosophila. hiphop and its testis-specific paralog K81 are critical for the protection of chromosome ends in somatic cells and male ..
  3. Raffa G, Cenci G, Ciapponi L, Gatti M. Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Front Oncol. 2013;3:112 pubmed publisher
    ..that Drosophila telomeres are capped by the terminin complex, which includes the fast-evolving proteins HOAP, HipHop, Moi, and Ver...
  4. Vedelek B, Blastyák A, Boros I. Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins. PLoS ONE. 2015;10:e0142771 pubmed publisher
    ..melanogaster Drosophila Telomere Loss and D. yakuba Verrocchio proteins does not preclude their stable interaction. ..
  5. Kurzhals R, Fanti L, Ebsen A, Rong Y, Pimpinelli S, Golic K. Chromosome Healing Is Promoted by the Telomere Cap Component Hiphop in Drosophila. Genetics. 2017;207:949-959 pubmed publisher
    ..In addition, overexpression of the telomere cap component Hiphop increased the survival of somatic cells with broken chromosomes, while the cap component HP1 did not, and ..