hh

Summary

Gene Symbol: hh
Description: hedgehog
Alias: CG4637, Dmel\CG4637, Mir, Mrt, anon-WO0134654.19, anon-WO0182946.19, bar, bar-3, bar3, l(3)hh, l(3)neo56, l(3)neo57, hedgehog, CG4637-PB, PKC, atypical, bar-on-3, hedghog, hh-PB, mirabile, moonrat
Species: fruit fly
Products:     hh

Top Publications

  1. Casso D, Liu S, Iwaki D, Ogden S, Kornberg T. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008;178:1399-413 pubmed publisher
    Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases...
  2. Suh J, Gao X, McKay J, McKay R, Salo Z, Graff J. Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab. 2006;3:25-34 pubmed
    b>Hedgehog (Hh) signals regulate invertebrate and vertebrate development, yet the role of the cascade in adipose development was undefined. To analyze a potential function, we turned to Drosophila and mammalian models...
  3. Chu T, Chiu M, Zhang E, Kunes S. A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain. Dev Cell. 2006;10:635-46 pubmed
    The developmental signal Hedgehog is distributed to two receptive fields by the photoreceptor neurons of the developing Drosophila retina. Delivery to the retina propagates ommatidial development across a precursor field...
  4. Glise B, Miller C, Crozatier M, Halbisen M, Wise S, Olson D, et al. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell. 2005;8:255-66 pubmed
    We here identify and characterize an extracellular modulator of Hedgehog signaling in Drosophila, Shifted. Shifted is required for high levels of long-range signaling in the developing wing imaginal disc...
  5. Callejo A, Bilioni A, Mollica E, Gorfinkiel N, Andres G, Ibañez C, et al. Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc Natl Acad Sci U S A. 2011;108:12591-8 pubmed publisher
    b>Hedgehog (Hh) moves from the producing cells to regulate the growth and development of distant cells in a variety of tissues...
  6. Torroja C, Gorfinkiel N, Guerrero I. Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development. 2004;131:2395-408 pubmed
    The Hedgehog (Hh) morphogenetic gradient controls multiple developmental patterning events in Drosophila and vertebrates. Patched (Ptc), the Hh receptor, restrains both Hh spreading and Hh signaling...
  7. Christiansen A, Ding T, Fan Y, Graves H, Herz H, Lindblad J, et al. Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila. Cell Death Differ. 2013;20:302-11 pubmed publisher
    b>Hedgehog (Hh) signaling is important for development and homeostasis in vertebrates and invertebrates...
  8. Bilioni A, Sanchez Hernandez D, Callejo A, Gradilla A, Ibañez C, Mollica E, et al. Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif. Dev Biol. 2013;376:198-212 pubmed publisher
    b>Hedgehog can signal both at a short and long-range, and acts as a morphogen during development in various systems...
  9. Han C, Belenkaya T, Khodoun M, Tauchi M, Lin X, Lin X. Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development. 2004;131:1563-75 pubmed
    ..been implicated in regulating the signalling activities of secreted morphogen molecules including Wingless (Wg), Hedgehog (Hh) and Decapentaplegic (Dpp)...
  10. CARROLL C, Marada S, Stewart D, Ouyang J, Ogden S. The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation. Development. 2012;139:612-21 pubmed publisher
    The Hedgehog (Hh) signaling pathway plays an instructional role during development, and is frequently activated in cancer...

Detail Information

Publications98

  1. Casso D, Liu S, Iwaki D, Ogden S, Kornberg T. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008;178:1399-413 pubmed publisher
    Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases...
  2. Suh J, Gao X, McKay J, McKay R, Salo Z, Graff J. Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab. 2006;3:25-34 pubmed
    b>Hedgehog (Hh) signals regulate invertebrate and vertebrate development, yet the role of the cascade in adipose development was undefined. To analyze a potential function, we turned to Drosophila and mammalian models...
  3. Chu T, Chiu M, Zhang E, Kunes S. A C-terminal motif targets Hedgehog to axons, coordinating assembly of the Drosophila eye and brain. Dev Cell. 2006;10:635-46 pubmed
    The developmental signal Hedgehog is distributed to two receptive fields by the photoreceptor neurons of the developing Drosophila retina. Delivery to the retina propagates ommatidial development across a precursor field...
  4. Glise B, Miller C, Crozatier M, Halbisen M, Wise S, Olson D, et al. Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog. Dev Cell. 2005;8:255-66 pubmed
    We here identify and characterize an extracellular modulator of Hedgehog signaling in Drosophila, Shifted. Shifted is required for high levels of long-range signaling in the developing wing imaginal disc...
  5. Callejo A, Bilioni A, Mollica E, Gorfinkiel N, Andres G, Ibañez C, et al. Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium. Proc Natl Acad Sci U S A. 2011;108:12591-8 pubmed publisher
    b>Hedgehog (Hh) moves from the producing cells to regulate the growth and development of distant cells in a variety of tissues...
  6. Torroja C, Gorfinkiel N, Guerrero I. Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development. 2004;131:2395-408 pubmed
    The Hedgehog (Hh) morphogenetic gradient controls multiple developmental patterning events in Drosophila and vertebrates. Patched (Ptc), the Hh receptor, restrains both Hh spreading and Hh signaling...
  7. Christiansen A, Ding T, Fan Y, Graves H, Herz H, Lindblad J, et al. Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila. Cell Death Differ. 2013;20:302-11 pubmed publisher
    b>Hedgehog (Hh) signaling is important for development and homeostasis in vertebrates and invertebrates...
  8. Bilioni A, Sanchez Hernandez D, Callejo A, Gradilla A, Ibañez C, Mollica E, et al. Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif. Dev Biol. 2013;376:198-212 pubmed publisher
    b>Hedgehog can signal both at a short and long-range, and acts as a morphogen during development in various systems...
  9. Han C, Belenkaya T, Khodoun M, Tauchi M, Lin X, Lin X. Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development. 2004;131:1563-75 pubmed
    ..been implicated in regulating the signalling activities of secreted morphogen molecules including Wingless (Wg), Hedgehog (Hh) and Decapentaplegic (Dpp)...
  10. CARROLL C, Marada S, Stewart D, Ouyang J, Ogden S. The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation. Development. 2012;139:612-21 pubmed publisher
    The Hedgehog (Hh) signaling pathway plays an instructional role during development, and is frequently activated in cancer...
  11. Zhang Y, Mao F, Lu Y, Wu W, Zhang L, Zhao Y. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res. 2011;21:1436-51 pubmed publisher
    The Hedgehog (Hh) family of secreted proteins is essential for development in both vertebrates and invertebrates...
  12. Kim M, Saunders A, Hamaoka B, Beachy P, Leahy D. Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A. 2011;108:13112-7 pubmed publisher
    ..The Dlp core protein is required for normal responsiveness to Hedgehog (Hh) signals, and we identify a localized region on the Dlp surface important for mediating its function in Hh ..
  13. Li S, Chen Y, Shi Q, Yue T, Wang B, Jiang J. Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol. 2012;10:e1001239 pubmed publisher
    b>Hedgehog transduces signal by promoting cell surface expression of the seven-transmembrane protein Smoothened (Smo) in Drosophila, but the underlying mechanism remains unknown...
  14. Ou C, Wang C, Jiang J, Chien C. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol. 2007;308:106-19 pubmed
    ..Here we show that cullin3 (Cul3) suppresses Hedgehog (Hh) signaling through downregulating the level of the signaling pathway effector cubitus interruptus (Ci)...
  15. Chen Y, Jiang J. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res. 2013;23:186-200 pubmed publisher
    b>Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis, and its deregulation leads to numerous human disorders including cancer...
  16. Liu Y, Cao X, Jiang J, Jia J. Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev. 2007;21:1949-63 pubmed
    The seven-transmembrane protein Smoothened (Smo) acts as a signal transducer in the Hedgehog (Hh) pathway that mediates many key developmental processes...
  17. Liu M, Lim T, Cai Y. The Drosophila female germline stem cell lineage acts to spatially restrict DPP function within the niche. Sci Signal. 2010;3:ra57 pubmed publisher
    ..Thus, our data reveal that the reciprocal crosstalk between the GSCs and the somatic cells defines the spatial limits of DPP action and therefore the extent of the GSC niche. ..
  18. Zhao Y, Tong C, Jiang J. Hedgehog regulates smoothened activity by inducing a conformational switch. Nature. 2007;450:252-8 pubmed
    b>Hedgehog (HH) morphogen is essential for metazoan development. The seven-transmembrane protein smoothened (SMO) transduces the HH signal across the plasma membrane, but how SMO is activated remains poorly understood...
  19. Zhang C, Williams E, Guo Y, Lum L, Beachy P. Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A. 2004;101:17900-7 pubmed
    The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell...
  20. Zheng X, Mann R, Sever N, Beachy P. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010;24:57-71 pubmed publisher
    Although the transporter-like protein Patched (Ptc) is genetically implicated in reception of the extracellular Hedgehog (Hh) protein signal, a clear definition of the Hh receptor is complicated by the existence of additional Hh-binding ..
  21. Su V, Jones K, Brodsky M, The I. Quantitative analysis of Hedgehog gradient formation using an inducible expression system. BMC Dev Biol. 2007;7:43 pubmed
    The Hedgehog (Hh) family of secreted growth factors are morphogens that act in development to direct growth and patterning. Mutations in human Hh and other Hh pathway components have been linked to human diseases...
  22. Hsiung F, Ramirez Weber F, Iwaki D, Kornberg T. Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic. Nature. 2005;437:560-3 pubmed
    ..We also show that the Dpp receptor, Thickveins (Tkv), is present in punctae that move along cytonemes. These observations are consistent with a role for cytonemes in signal transduction. ..
  23. Landsberg K, Farhadifar R, Ranft J, Umetsu D, Widmann T, Bittig T, et al. Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary. Curr Biol. 2009;19:1950-5 pubmed publisher
    ..Our results provide a physical mechanism in which the local increase in Myosin II-dependent cell bond tension directs cell sorting at compartment boundaries. ..
  24. Roy S, Hsiung F, Kornberg T. Specificity of Drosophila cytonemes for distinct signaling pathways. Science. 2011;332:354-8 pubmed publisher
  25. Pauli T, Seimiya M, Blanco J, Gehring W. Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog. Development. 2005;132:2771-82 pubmed
    ..we performed a genome-wide search and have thereby been able to identify eyeless as well as the signalling gene hedgehog as putative targets of so...
  26. Xia R, Jia H, Fan J, Liu Y, Jia J. USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol. 2012;10:e1001238 pubmed publisher
    The seven transmembrane protein Smoothened (Smo) is a critical component of the Hedgehog (Hh) signaling pathway and is regulated by phosphorylation, dimerization, and cell-surface accumulation upon Hh stimulation...
  27. Hime G, Lada H, Fietz M, Gillies S, Passmore A, Wicking C, et al. Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism. Dev Dyn. 2004;229:780-90 pubmed
    ..of a Drosophila patched transgene, carrying the analogous mutation to G509V, causes ectopic activation of Hedgehog target genes and ectopic membrane stabilisation of Smoothened...
  28. Farzan S, Ascano M, Ogden S, Sanial M, Brigui A, Plessis A, et al. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Curr Biol. 2008;18:1215-20 pubmed publisher
    The Hedgehog (Hh) signaling pathway initiates an evolutionarily conserved developmental program required for the proper patterning of many tissues [1]...
  29. Karim M, Moore A. Convergent local identity and topographic projection of sensory neurons. J Neurosci. 2011;31:17017-27 pubmed publisher
    ..Near the ventral midline, both Hedgehog and Epithelial growth factor receptor signaling are required for class IV neurogenesis...
  30. Bergantiños C, Corominas M, Serras F. Cell death-induced regeneration in wing imaginal discs requires JNK signalling. Development. 2010;137:1169-79 pubmed publisher
    ..During cell death-induced regeneration, the JNK pathway is activated at the leading edges of healing tissue and not in the apoptotic cells, and is required for the regulation of healing and regenerative growth. ..
  31. Gonzalez A, Chaouiya C, Thieffry D. Logical modelling of the role of the Hh pathway in the patterning of the Drosophila wing disc. Bioinformatics. 2008;24:i234-40 pubmed publisher
    ..The morphogen Hedgehog (Hh) is the inter-cellular signal coordinating this process...
  32. Tokusumi Y, Tokusumi T, Stoller Conrad J, Schulz R. Serpent, suppressor of hairless and U-shaped are crucial regulators of hedgehog niche expression and prohemocyte maintenance during Drosophila larval hematopoiesis. Development. 2010;137:3561-8 pubmed publisher
    ..Cells of the PSC express the Hedgehog (Hh) signaling molecule, which instructs cells within the neighboring medullary zone to maintain a hematopoietic ..
  33. Albert R, Othmer H. The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster. J Theor Biol. 2003;223:1-18 pubmed
    ..The model gives important insights into the functioning of the segment polarity gene network, such as the crucial role of the wingless and sloppy paired genes, and the network's ability to correct errors in the pre-pattern. ..
  34. Lim C, Santoso B, Boulay T, Dong E, Ohler U, Kadonaga J. The MTE, a new core promoter element for transcription by RNA polymerase II. Genes Dev. 2004;18:1606-17 pubmed
    ..In addition, the MTE exhibits strong synergism with the TATA-box as well as the DPE. These findings indicate that the MTE is a novel downstream core promoter element that is important for transcription by RNA polymerase II. ..
  35. Sprecher S, Reichert H, Hartenstein V. Gene expression patterns in primary neuronal clusters of the Drosophila embryonic brain. Gene Expr Patterns. 2007;7:584-95 pubmed
  36. Sisson B, Ziegenhorn S, Holmgren R. Regulation of Ci and Su(fu) nuclear import in Drosophila. Dev Biol. 2006;294:258-70 pubmed
    The Hedgehog (Hh) signal transduction pathway plays a central role in the development of invertebrates and vertebrates...
  37. Avanesov A, Blair S. The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi. Development. 2013;140:107-16 pubmed publisher
    b>Hedgehog (Hh) family proteins are secreted signaling ligands whose short- and long-range activities transform cellular fates in multiple contexts in organisms ranging from metazoans to humans...
  38. Yao S, Lum L, Beachy P. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell. 2006;125:343-57 pubmed
    The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal...
  39. Zhang W, Zhao Y, Tong C, Wang G, Wang B, Jia J, et al. Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell. 2005;8:267-78 pubmed
    b>Hedgehog (Hh) proteins control animal development by regulating the Gli/Ci family of transcription factors...
  40. Price M, Roberts D, McCartney B, Jezuit E, Peifer M. Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. J Cell Sci. 2006;119:403-15 pubmed
    ..Finally, we define roles for the canonical Wingless and Hedgehog pathways and for core planar cell polarity proteins in denticle polarity.
  41. Eugster C, Panàkovà D, Mahmoud A, Eaton S. Lipoprotein-heparan sulfate interactions in the Hh pathway. Dev Cell. 2007;13:57-71 pubmed
    ..bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens...
  42. Makhijani K, Kalyani C, Srividya T, Shashidhara L. Modulation of Decapentaplegic gradient during haltere specification in Drosophila. Dev Biol. 2007;302:243-55 pubmed
    ..We discuss how this complexity may regulate the final form of the adult haltere in the fly, without compromising features such as cell survival, which is also dependent on Decapentaplegic signaling. ..
  43. Yan D, Wu Y, Yang Y, Belenkaya T, Tang X, Lin X. The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development. 2010;137:2033-44 pubmed publisher
    b>Hedgehog (Hh) acts as a morphogen in various developmental contexts to specify distinct cell fates in a concentration-dependent manner...
  44. Zhao Y, Tong C, Jiang J. Transducing the Hedgehog signal across the plasma membrane. Fly (Austin). 2007;1:333-6 pubmed
    Cell signaling mediated by the Hedgehog (Hh) family of secreted proteins is essential for metazoan development and its malfunction causes congenital disorders and cancer...
  45. Renault A, Ricardo S, Kunwar P, Santos A, Starz Gaiano M, Stein J, et al. Hedgehog does not guide migrating Drosophila germ cells. Dev Biol. 2009;328:355-62 pubmed publisher
    ..of signaling pathways known to affect cell migration of other migratory cells, we failed to find a role for the Hedgehog (Hh) pathway in germ cell migration...
  46. Biehs B, Kechris K, Liu S, Kornberg T. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Development. 2010;137:3887-98 pubmed publisher
    Paracrine Hedgehog (Hh) signaling regulates growth and patterning in many Drosophila organs...
  47. Jekely G, Rørth P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep. 2003;4:1163-8 pubmed
    ..with high levels of ubiquitinated proteins: not only RTKs (EGFR and PVR) but also Notch and receptors for Hedgehog and Dpp (TGF-beta related). Hrs is not required for Dpp signalling...
  48. Urbach R, Technau G. Segment polarity and DV patterning gene expression reveals segmental organization of the Drosophila brain. Development. 2003;130:3607-20 pubmed
    ..we carried out a comprehensive analysis of the expression of segment polarity genes (engrailed, wingless, hedgehog, gooseberry distal, mirror) and DV patterning genes (muscle segment homeobox, intermediate neuroblast defective, ..
  49. Zhang Q, Zhang L, Wang B, Ou C, Chien C, Jiang J. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell. 2006;10:719-29 pubmed
    The Ci/Gli family of transcription factors mediates Hedgehog (Hh) signaling in many key developmental processes. Here we identify a Hh-induced MATH and BTB domain containing protein (HIB) as a negative regulator of the Hh pathway...
  50. Cheng S, Maier D, Neubueser D, Hipfner D. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev Biol. 2010;337:99-109 pubmed publisher
    The Hedgehog (Hh) signaling pathway plays a conserved and essential role in regulating development and homeostasis of numerous tissues...
  51. Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, Tolhuis B, et al. Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol. 2009;7:e13 pubmed publisher
    ..Furthermore, several DNA sequence features discriminate between PcG- and TRX-N-bound regions, indicating that underlying DNA sequence contains critical information to drive PREs and TREs towards silencing or activation. ..
  52. Fan J, Liu Y, Jia J. Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner. Dev Biol. 2012;366:172-84 pubmed publisher
    The activation of Smoothened (Smo) requires phosphorylation at three clusters of Serine residues in Drosophila Hedgehog (Hh) signaling...
  53. Vincent S, Perrimon N, Axelrod J. Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Development. 2008;135:2767-75 pubmed publisher
    A fundamental concept in development is that secreted molecules such as Wingless (Wg) and Hedgehog (Hh) generate pattern by inducing cell fate...
  54. Umemori M, Takemura M, Maeda K, Ohba K, Adachi Yamada T. Drosophila T-box transcription factor Optomotor-blind prevents pathological folding and local overgrowth in wing epithelium through confining Hh signal. Dev Biol. 2007;308:68-81 pubmed
    ..that a negative feedback loop, where omb plays a crucial role, exists between Dpp and its upstream regulator Hedgehog (Hh), a short-range morphogen...
  55. Callejo A, Torroja C, Quijada L, Guerrero I. Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development. 2006;133:471-83 pubmed
    The Hedgehog (Hh) family of morphogenetic proteins has important instructional roles in metazoan development...
  56. Gallet A, Therond P. Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment. Dev Biol. 2005;277:51-62 pubmed
    Morphogenetic gradient of Hh is tightly regulated for correct patterning in Drosophila and vertebrates. The Patched (Ptc) receptor is required for restricting Hh long-range activity in the imaginal discs...
  57. Yang X, Mao F, Lv X, Zhang Z, Fu L, Lu Y, et al. Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. J Cell Sci. 2013;126:4230-8 pubmed publisher
    The hedgehog (Hh) signaling pathway plays a very important role in metazoan development by controlling pattern formation...
  58. Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, et al. Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction. J Biol Chem. 2013;288:12605-14 pubmed publisher
    The Hedgehog (Hh) signaling pathway plays evolutionarily conserved roles in controlling embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and ..
  59. Walters J, Munoz C, Paaby A, Dinardo S. Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation. Dev Biol. 2005;286:415-26 pubmed
    ..During segmental patterning, distinct signaling territories are established that employ either the Hedgehog, Spitz, Serrate or Wingless ligands. How these pathways control segmental pattern is not completely clear...
  60. Fu W, Baker N. Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development. Development. 2003;130:5229-39 pubmed
    ..b>Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contribute...
  61. Dawber R, Hebbes S, Herpers B, Docquier F, van den Heuvel M. Differential range and activity of various forms of the Hedgehog protein. BMC Dev Biol. 2005;5:21 pubmed
    The Hedgehog (Hh) family of secreted proteins act as extracellular messengers to control and coordinate growth and differentiation...
  62. Smelkinson M, Kalderon D. Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr Biol. 2006;16:110-6 pubmed
    Signaling by extracellular Hedgehog (Hh) molecules is crucial for the correct allocation of cell fates and patterns of cell proliferation in humans and other organisms ...
  63. Katanaev V, Solis G, Hausmann G, Buestorf S, Katanayeva N, Schrock Y, et al. Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J. 2008;27:509-21 pubmed publisher
    The lipid-modified morphogens Wnt and Hedgehog diffuse poorly in isolation yet can spread over long distances in vivo, predicting existence of two distinct forms of these morphogens...
  64. Irons D, Wojcinski A, Glise B, Monk N. Robustness of positional specification by the Hedgehog morphogen gradient. Dev Biol. 2010;342:180-93 pubmed publisher
    Spatial gradients of Hedgehog signalling play a central role in many patterning events during animal development, regulating cell fate determination and tissue growth in a variety of tissues and developmental stages...
  65. Cheng S, Maier D, Hipfner D. Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling. Development. 2012;139:85-94 pubmed publisher
    G-protein-coupled receptor kinases (GRKs) play a conserved role in Hedgehog (Hh) signaling. In several systems, GRKs are required for efficient Hh target gene expression...
  66. McLellan J, Zheng X, Hauk G, Ghirlando R, Beachy P, Leahy D. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 2008;455:979-83 pubmed publisher
    b>Hedgehog (Hh) proteins specify tissue pattern in metazoan embryos by forming gradients that emanate from discrete sites of expression and elicit concentration-dependent cellular differentiation or proliferation responses...
  67. Rojas Ríos P, Guerrero I, González Reyes A. Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. PLoS Biol. 2012;10:e1001298 pubmed publisher
    ..b>Hedgehog (Hh) proteins mediate homeostasis in several adult niches, but a detailed understanding of Hh signalling in stem ..
  68. McLellan J, Yao S, Zheng X, Geisbrecht B, Ghirlando R, Beachy P, et al. Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A. 2006;103:17208-13 pubmed
    b>Hedgehog (Hh) signaling molecules mediate key tissue-patterning events during animal development, and inappropriate activation of Hh signaling in adults has been associated with human cancers...
  69. Deshpande G, Godishala A, Schedl P. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. PLoS Genet. 2009;5:e1000333 pubmed publisher
    ..Hmgcr has also been implicated in the release of the signaling molecule Hedgehog (Hh) from hh expressing cells and in the production of an attractant that directs primordial germ cells to ..
  70. Vied C, Kalderon D. Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind. Development. 2009;136:2177-86 pubmed publisher
    Normal self-renewal of follicle stem cells (FSCs) in the Drosophila ovary requires Hedgehog (Hh) signaling. Excess Hh signaling, induced by loss of patched (ptc), causes cell-autonomous duplication of FSCs...
  71. Mahoney M, Parks A, Ruddy D, Tiong S, Esengil H, Phan A, et al. Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics. 2006;172:2309-24 pubmed
    ..The predicted functions of these newly identified genes are consistent with extracellular matrix and vesicular trafficking mechanisms in Presenilin and Notch pathway regulation and suggest a novel role for gamma-tubulin in the pathway. ..
  72. Apionishev S, Katanayeva N, Marks S, Kalderon D, Tomlinson A. Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol. 2005;7:86-92 pubmed
    The Hedgehog (Hh) signalling pathway is crucial for animal development and is aberrantly activated in several types of cancer...
  73. Eldar A, Rosin D, Shilo B, Barkai N. Self-enhanced ligand degradation underlies robustness of morphogen gradients. Dev Cell. 2003;5:635-46 pubmed
    ..The two robust networks are consistent with properties of the Wg and Hh morphogens in the Drosophila wing disc and provide novel insights into their function.
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    G protein-coupled receptor kinase 2 (Gprk2/GRK2) plays a conserved role in modulating Hedgehog (Hh) pathway activity, but its mechanism of action remains unknown...
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    ..The establishment of antero-posterior polarity requires the secreted protein Hedgehog, which is only expressed in P compartments and which is a key effector of the Engrailed transcription factor...
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    ..of neuroblast proliferation requires signaling by the Fibroblast Growth Factor homolog Branchless and by the Hedgehog growth factor...
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    ..Here we show that CySC but not GSC maintenance requires Hedgehog (Hh) signalling in addition to Jak/Stat pathway activation...
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    ..Furthermore, we find that mutations in sotv and ttv impair Hh, Wg and Decapentaplegic (Dpp) signaling...
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    b>Hedgehog (Hh) signaling activates full-length Ci/Gli family transcription factors and prevents Ci/Gli proteolytic processing to repressor forms. In the absence of Hh, Ci/Gli processing is initiated by direct Pka phosphorylation...
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    The Hedgehog (Hh) signaling pathway has conserved roles in development of species ranging from Drosophila to humans...
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    The Hedgehog morphogen is a major developmental regulator that acts at short and long range to direct cell fate decisions in invertebrate and vertebrate tissues...
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    In Drosophila, Hedgehog (Hh) signal transduction has been shown to require a multiprotein complex (Hedgehog signaling complex (HSC)), which includes the Kinesin-related protein Costal2 (Cos2), the serine/threonine protein kinase Fused (Fu)..
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    The signaling molecules Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg) function as morphogens and organize wing patterning in Drosophila...
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    The hedgehog (Hh) family of morphogens plays important instructional roles in the development of numerous metazoan structures...
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    b>Hedgehog (Hh) plays crucial roles in tissue-patterning and activates signaling in Patched (Ptc)-expressing cells...
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    ..We show that the Hedgehog (Hh), Wingless (Wg) and Epidermal Growth Factor Receptor (Egfr) pathways provide specific inputs for posterior ..
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    ..In contrast, Vps35 is not required for Hedgehog secretion, suggesting specificity...
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    The protein kinase Fused (Fu) is an integral member of the Hedgehog (Hh) signaling pathway...
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    The correct interpretation of a gradient of the morphogen Hedgehog (Hh) during development requires phosphorylation of the Hh signaling activator Smoothened (Smo); however, the molecular mechanism by which Smo transduces graded Hh ..
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    The signalling molecule Hedgehog (Hh) functions as a morphogen to pattern a field of cells in animal development...
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    The secreted morphogens of the Hedgehog family have important roles in normal development as well as in associated pathologies, including cancer...
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    ..Thus, Dally-like act as a gatekeeper, ensuring the sharing of Wingless among cells along the dorsoventral axis. Our analysis suggests that the other glypican, Dally, could act as a classical co-receptor. ..