Gene Symbol: heix
Alias: 124/1, BG:DS02740.7, CG5876, Dmel\CG5876, ipa-6d, l(2)35Fc, l(2)k12401, heixuedian, CG5876-PA, heix-PA, lethal(2)35Fc
Species: fruit fly
Reese M, Hartzell G, Harris N, Ohler U, Abril J, Lewis S. Genome annotation assessment in Drosophila melanogaster. Genome Res. 2000;10:483-501 pubmed
Dawson I, Roth S, Artavanis Tsakonas S. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J Cell Biol. 1995;129:725-37 pubmed
..Our data suggest that fzy function is required for normal cell cycle-regulated proteolysis that is necessary for successful progress through mitosis. ..
Eberl D, Ren D, Feng G, Lorenz L, Van Vactor D, Hall L. Genetic and developmental characterization of Dmca1D, a calcium channel alpha1 subunit gene in Drosophila melanogaster. Genetics. 1998;148:1159-69 pubmed
..Those that do eclose have difficulty in fluid-filling of the wings. These studies show that this member of the calcium channel alpha1 subunit gene family plays a nonredundant, vital role in larvae and adults. ..
Prokop A, Uhler J, Roote J, Bate M. The kakapo mutation affects terminal arborization and central dendritic sprouting of Drosophila motorneurons. J Cell Biol. 1998;143:1283-94 pubmed
..On the other, a specific type of sensory neuron (scolopidial neurons) shows defects in microtubule organization and detaches from its support cells. ..
Willingham A, Keil T. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. Mech Dev. 2004;121:1289-97 pubmed
Vos M, Esposito G, Edirisinghe J, Vilain S, Haddad D, Slabbaert J, et al
. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 2012;336:1306-10 pubmed publisher
..We identified Drosophila UBIAD1/Heix as a modifier of pink1, a gene mutated in Parkinson's disease that affects mitochondrial function...
Xia Y, Midoun S, Xu Z, Hong L. Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during Drosophila hematopoiesis. Dev Biol. 2015;398:218-30 pubmed publisher
The Drosophila heixuedian (heix) is the ortholog of human UBIAD1 gene (a.k.a TERE1). The protein product of UBIAD1/heix has multiple enzymatic activities, including the vitamin K2 and the non-mitochondrial CoQ10 biosynthesis...