Gene Symbol: HDAC4
Description: Histone deacetylase 4
Alias: CG1770, DHDAC4, Dmel\CG1770, GC1770, HDAC, HDAC4a, dHDAC4, dmHDA405, hdac4, histone deacetylase 4, CG1770-PB, CG1770-PD, CG1770-PE, CG1770-PF, CG1770-PG, CG1770-PH, CG1770-PI, CG1770-PJ, HDAC4-PB, HDAC4-PD, HDAC4-PE, HDAC4-PF, HDAC4-PG, HDAC4-PH, HDAC4-PI, HDAC4-PJ
Species: fruit fly

Top Publications

  1. Zhou D, Udpa N, Gersten M, Visk D, Bashir A, Xue J, et al. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011;108:2349-54 pubmed publisher
    ..Unique analytical tools and genetic and bioinformatic strategies allowed us to discover that Notch activation plays a major role in this hypoxia tolerance in Drosophila melanogaster. ..
  2. Zeremski M, Stricker J, Fischer D, Zusman S, Cohen D. Histone deacetylase dHDAC4 is involved in segmentation of the Drosophila embryo and is regulated by gap and pair-rule genes. Genesis. 2003;35:31-8 pubmed
    ..This study describes the isolation of dHDAC4, a novel, catalytically active class II Drosophila histone deacetylase, and the analysis of its role in embryonic ..
  3. Wang B, Moya N, Niessen S, Hoover H, Mihaylova M, Shaw R, et al. A hormone-dependent module regulating energy balance. Cell. 2011;145:596-606 pubmed publisher
    ..We identified a hormone-dependent module, consisting of the Ser/Thr kinase SIK3 and the class IIa deacetylase HDAC4, which regulates FOXO activity in Drosophila...
  4. Choi S, Lim D, Chung J. Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in Drosophila. PLoS Genet. 2015;11:e1005263 pubmed publisher
    ..Using genetic and biochemical analyses, we identify HDAC4, a class IIa histone deacetylase, as a lipolytic target of the LKB1-SIK3 pathway...
  5. Fogg P, O Neill J, Dobrzycki T, Calvert S, Lord E, McIntosh R, et al. Class IIa histone deacetylases are conserved regulators of circadian function. J Biol Chem. 2014;289:34341-8 pubmed publisher
    ..Mutation of the Drosophila homolog HDAC4 impairs locomotor activity rhythms of flies and decreases period mRNA levels...
  6. Pushpavalli S, Ramaiah M, Lavanya A, Ganesh A, Kumbhare R, Bhadra K, et al. Imidazo-benzothiazoles a potent microRNA modulator involved in cell proliferation. Bioorg Med Chem Lett. 2012;22:6418-24 pubmed publisher
    ..The expression of direct targets of bantam such as Hid and HDAC-6 were affected upon compound treatment...
  7. Milon B, Cheng H, Tselebrovsky M, Lavrov S, Nenasheva V, Mikhaleva E, et al. Role of histone deacetylases in gene regulation at nuclear lamina. PLoS ONE. 2012;7:e49692 pubmed publisher
    ..These findings demonstrate the manifold and central involvement of class I HDACs in regulation of lamina-associated genes, illuminating a mechanism by which these enzymes can orchestrate normal and pathological development...
  8. Baumann A, Benoit J, Michalková V, Mireji P, Attardo G, Moulton J, et al. Juvenile hormone and insulin suppress lipolysis between periods of lactation during tsetse fly pregnancy. Mol Cell Endocrinol. 2013;372:30-41 pubmed publisher
  9. Fitzsimons H, Schwartz S, Given F, Scott M. The histone deacetylase HDAC4 regulates long-term memory in Drosophila. PLoS ONE. 2013;8:e83903 pubmed publisher
    ..Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila...

More Information


  1. Fitzsimons H. The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?. Neurobiol Learn Mem. 2015;123:149-58 pubmed publisher
    ..Recent studies have revealed that Class IIa HDAC family member HDAC4 contributes essential functions to synaptic plasticity and memory as well as other neurological processes...
  2. Barlow A, van Drunen C, Johnson C, Tweedie S, Bird A, Turner B. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp Cell Res. 2001;265:90-103 pubmed
    ..Consistent with this, recombinant dHDAC1 coimmunoprecipitates with components of the Drosophila NuRD complex and dHDAC3 with an as yet unknown 45-kDa protein. ..
  3. Xie L, Ng C, Ali T, Valencia R, Ferreira B, Xue V, et al. Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013;14 Suppl 3:S9 pubmed publisher
    ..network levels allows us to identify driver mutations and their interactions (epistasis) in H, Rad51D, Ulp1, Wnt5, HDAC4, Sol, Dys, GalNAc-T2, and CG33714 genes, all of which are involved in the up-regulation of Notch and Gurken/EGFR ..
  4. Ronen R, Udpa N, Halperin E, Bafna V. Learning natural selection from the site frequency spectrum. Genetics. 2013;195:181-93 pubmed publisher
    ..We further apply our test to human data and identify regions that are in agreement with earlier studies, as well as many novel regions. ..
  5. Lai E. Developmental signaling: shrimp and strawberries help flies make cones. Curr Biol. 2002;12:R722-4 pubmed
    ..A new study has revealed a serial linkage between them, via Ebi and Strawberry Notch, which is important in determining the cone cell fate in the Drosophila eye. ..
  6. Pallos J, Bodai L, Lukacsovich T, Purcell J, Steffan J, Thompson L, et al. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet. 2008;17:3767-75 pubmed publisher
    ..disease (HD) is associated with transcriptional dysregulation, and multiple studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for restoring transcriptional balance and appropriate protein ..
  7. Feller C, Forné I, Imhof A, Becker P. Global and specific responses of the histone acetylome to systematic perturbation. Mol Cell. 2015;57:559-71 pubmed publisher
    ..Conceivably, the acetylation level is adjusted to maintain the global charge neutralization of chromatin and the stability of nuclei. ..
  8. Miotto B, Sagnier T, Bérenger H, Bohmann D, Pradel J, Graba Y. Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev. 2006;20:101-12 pubmed
    ..This study establishes a direct link among JNK signaling, DFos phosphorylation, chromatin modification, and AP-1-dependent transcription and its importance in a developing organism. ..