HDAC1

Summary

Gene Symbol: HDAC1
Description: Histone deacetylase 1
Alias: CG7471, DHDAC1, DRpd3, DmHDAC1, Dmel\CG7471, E(var)3-64BC, HDAC, HDAC-1, Hdac, Hdac1, RPD3, Rpd3, Rpd3/HDAC, Su(var)3-26, Su(var)326, Su(var)328, dHDAC-1, dHDAC1, dRPD3, dRpd3, dmHDA401, drpd3, hdac1, l(3)04556, l(3)64Cc, rpd3, rpd[3], histone deacetylase 1, CG7471-PA, HDAC1-PA, Rpd3, Rpd3 histone deacetylase, histone Deacetylase-1, histone deacetylase, histone deacetylase 1 (HDAC1), reduced potassium dependency 3, suppressor of variegation 326
Species: fruit fly

Top Publications

  1. Mannervik M, Levine M. The Rpd3 histone deacetylase is required for segmentation of the Drosophila embryo. Proc Natl Acad Sci U S A. 1999;96:6797-801 pubmed
    ..A specific histone deacetylase, Rpd3, interacts with a variety of sequence-specific transcriptional repressors, including Mad-Max ..
  2. Wang L, Charroux B, Kerridge S, Tsai C. Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep. 2008;9:555-62 pubmed publisher
  3. Kunert N, Wagner E, Murawska M, Klinker H, Kremmer E, Brehm A. dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression. EMBO J. 2009;28:533-44 pubmed publisher
    ..NuRD) complex, and transcriptional repression by Mi-2 is thought to be dependent on its associated histone deacetylase. Here, we have purified a novel dMi-2 complex from Drosophila that is distinct from dNuRD...
  4. Pallos J, Bodai L, Lukacsovich T, Purcell J, Steffan J, Thompson L, et al. Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet. 2008;17:3767-75 pubmed publisher
    Huntington's disease (HD) is associated with transcriptional dysregulation, and multiple studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for restoring transcriptional balance and appropriate protein ..
  5. Fitzsimons H, Scott M. Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila. PLoS ONE. 2011;6:e29171 pubmed publisher
    ..Furthermore, the importance of histone acetylation in Drosophila memory has not been reported. The histone deacetylase (HDAC) Rpd3 is abundant in the adult fly brain, suggesting a post-mitotic function...
  6. Wheeler J, VanderZwan C, Xu X, Swantek D, Tracey W, Gergen J. Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. Nat Genet. 2002;32:206-10 pubmed
    ..By contrast, the co-repressor proteins Groucho and dCtBP, and the histone deacetylase Rpd3, do not affect establishment but instead maintain repression after the blastoderm stage...
  7. Lee N, Erdjument Bromage H, Tempst P, Jones R, Zhang Y. The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol Cell Biol. 2009;29:1401-10 pubmed publisher
    ..In addition to Lid, the complex contains Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15. Rpd3 is a histone deacetylase, and along with Polycomb group proteins, which antagonize the function of Trithorax group proteins, it ..
  8. Dallman J, Allopenna J, Bassett A, Travers A, Mandel G. A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. J Neurosci. 2004;24:7186-93 pubmed
  9. Ballestar E, Pile L, Wassarman D, Wolffe A, Wade P. A Drosophila MBD family member is a transcriptional corepressor associated with specific genes. Eur J Biochem. 2001;268:5397-406 pubmed
    ..proteins exhibit transcriptional and biochemical properties consistent with roles as components of a histone deacetylase-dependent corepressor complex similar to the vertebrate Mi-2 complex...

More Information

Publications81

  1. Scharf A, Meier K, Seitz V, Kremmer E, Brehm A, Imhof A. Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation. Mol Cell Biol. 2009;29:57-67 pubmed publisher
    ..H4K20 methylation-dependent dl(3)MBT association with chromatin and the identification of a dl(3)MBT-dRPD3 complex suggest that a deacetylase is specifically recruited to the monomethylated substrate through interaction ..
  2. Poux S, Melfi R, Pirrotta V. Establishment of Polycomb silencing requires a transient interaction between PC and ESC. Genes Dev. 2001;15:2509-14 pubmed
    ..embryonic extracts, we find PC transiently associated with ESC in a complex that includes EZ, PHO, PH, GAGA, and RPD3 but not PSC...
  3. Czermin B, Schotta G, Hülsmann B, Brehm A, Becker P, Reuter G, et al. Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila. EMBO Rep. 2001;2:915-9 pubmed
    ..important for chromatin-mediated gene silencing, the histone methyltransferase SU(VAR)3-9 and the histone deacetylase HDAC1, associate in vivo. The two activities cooperate to methylate pre-acetylated histones...
  4. Tie F, Furuyama T, Prasad Sinha J, Jane E, Harte P. The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development. 2001;128:275-86 pubmed
    ..We have purified this ESC complex and show that it also contains the histone deacetylase RPD3 and the histone-binding protein p55, which is also a component of the chromatin remodeling complex ..
  5. Tie F, Banerjee R, Stratton C, Prasad Sinha J, Stepanik V, Zlobin A, et al. CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development. 2009;136:3131-41 pubmed publisher
    ..Here we show that H3K27 is specifically acetylated by Drosophila CBP and its deacetylation involves RPD3. H3K27ac is present at high levels in early embryos and declines after 4 hours as H3K27me3 increases...
  6. Pile L, Wassarman D. Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression. EMBO J. 2000;19:6131-40 pubmed
    ..To examine how the SIN3-RPD3 deacetylase complex contributes to these events in vivo, we examined binding of SIN3 and RPD3 to Drosophila ..
  7. Rogina B, Helfand S. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A. 2004;101:15998-6003 pubmed
    ..extends life span, whereas a decrease in dSir2 blocks the life-span-extending effect of calorie reduction or rpd3 mutations...
  8. Mottus R, Sobel R, Grigliatti T. Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegation. Genetics. 2000;154:657-68 pubmed
    ..One prediction, based on this correlation, is that hypomorphic or null mutations in histone deacetylase genes should lead to increased levels of histone acetylation and result in increased levels of ..
  9. Tweedie S, Ng H, Barlow A, Turner B, Hendrich B, Bird A. Vestiges of a DNA methylation system in Drosophila melanogaster?. Nat Genet. 1999;23:389-90 pubmed
  10. Nakayama T, Shimojima T, Hirose S. The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. Development. 2012;139:4582-90 pubmed publisher
    ..3 replacement to execute boundary functions. Our results provide new insight into the function of the trithorax group during development. ..
  11. Brehm A, Langst G, Kehle J, Clapier C, Imhof A, Eberharter A, et al. dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties. EMBO J. 2000;19:4332-41 pubmed
    ..We have used antibodies to immobilize a complex containing dMi-2 and the dRPD3 histone deacetylase from Drosophila embryo extracts...
  12. Walrad P, Hang S, Joseph G, Salas J, Gergen J. Distinct contributions of conserved modules to Runt transcription factor activity. Mol Biol Cell. 2010;21:2315-26 pubmed publisher
    ..These results provide a foundation for further studies on the molecular interactions that contribute to the context-dependent properties of Runx proteins as developmental regulators. ..
  13. Gepner J, Li M, Ludmann S, Kortas C, Boylan K, Iyadurai S, et al. Cytoplasmic dynein function is essential in Drosophila melanogaster. Genetics. 1996;142:865-78 pubmed
    ..The intragenic complementation of dynein alleles reveals multiple mutant phenotypes including male and/or female sterility, bristle defects, and defects in eye development. ..
  14. Buscaino A, Kocher T, Kind J, Holz H, Taipale M, Wagner K, et al. MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex. Mol Cell. 2003;11:1265-77 pubmed
    ..We find that the acetylation status of MSL-3 determines its interaction with roX2 RNA. Furthermore, we find that RPD3 interacts with MSL-3 and that MSL-3 can be deacetylated by the RPD3 complex...
  15. Murawska M, Kunert N, van Vugt J, L ngst G, Kremmer E, Logie C, et al. dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Mol Cell Biol. 2008;28:2745-57 pubmed publisher
    ..Unlike dMi-2, dCHD3 exists as a monomer. Nevertheless, both proteins colocalize with RNA polymerase II to actively transcribed regions on polytene chromosomes, suggesting that both remodelers participate in the process of transcription...
  16. Spain M, Caruso J, Swaminathan A, Pile L. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. J Biol Chem. 2010;285:27457-67 pubmed publisher
    The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC) complexes. SIN3 and its associated HDAC have been shown to have critical roles in both development and the regulation of cell cycle progression...
  17. Barlow A, van Drunen C, Johnson C, Tweedie S, Bird A, Turner B. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Exp Cell Res. 2001;265:90-103 pubmed
    We have identified new members of the histone deacetylase enzyme family in Drosophila melanogaster. dHDAC6 is a class II deacetylase with two active sites, and dSIR2 is an NAD-dependent histone deacetylase...
  18. Winkler C, Ponce A, Courey A. Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density. PLoS ONE. 2010;5:e10166 pubmed publisher
    Groucho (Gro) is a Drosophila melanogaster transcriptional corepressor that directly interacts with the histone deacetylase Rpd3...
  19. Singh N, Zhu W, Hanes S. Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Dev Biol. 2005;278:242-54 pubmed
    ..Here, we show that retraction requires a Bicoid-interacting protein, Sap18, which is part of the Sin3/Rpd3 histone deacetylase complex. In sensitized-mutant backgrounds (e.g...
  20. Muller J, Hart C, Francis N, Vargas M, Sengupta A, Wild B, et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell. 2002;111:197-208 pubmed
    ..These results identify E(Z) as a PcG protein with enzymatic activity and implicate histone methylation in PcG-mediated silencing. ..
  21. Martinez C, Arnosti D. Spreading of a corepressor linked to action of long-range repressor hairy. Mol Cell Biol. 2008;28:2792-802 pubmed publisher
  22. Qi D, Bergman M, Aihara H, Nibu Y, Mannervik M. Drosophila Ebi mediates Snail-dependent transcriptional repression through HDAC3-induced histone deacetylation. EMBO J. 2008;27:898-909 pubmed publisher
    ..In mammalian cells, the Ebi homologue TBL1 is part of the NCoR/SMRT-HDAC3 (histone deacetylase 3) co-repressor complex...
  23. Swaminathan A, Pile L. Regulation of cell proliferation and wing development by Drosophila SIN3 and String. Mech Dev. 2010;127:96-106 pubmed publisher
    ..A SIN3 knock down phenotype can be suppressed by overexpression either of STG or of Cdk1, the target of STG phosphatase. These data link SIN3 and STG in a genetic pathway that affects cell cycle progression in a developing tissue. ..
  24. Chen G, Fernandez J, Mische S, Courey A. A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev. 1999;13:2218-30 pubmed
    ..One of these proteins was found to be the histone deacetylase Rpd3...
  25. Johnson C, Barlow A, Turner B. Molecular cloning of Drosophila melanogaster cDNAs that encode a novel histone deacetylase dHDAC3. Gene. 1998;221:127-34 pubmed
    ..Here we describe the cloning, sequencing and genetic mapping of two histone deacetylase genes in Drosophila melanogaster: dHDAC1 is essentially identical to the previously cloned D...
  26. Wen Y, Nguyen D, Li Y, Lai Z. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye. Genetics. 2000;156:195-203 pubmed
    ..A dCtBP consensus binding motif in the C terminus appears to contribute to Ttk69 activity, but it cannot be fully responsible for the function of the C terminus. ..
  27. Phippen T, Sweigart A, Moniwa M, Krumm A, Davie J, Parkhurst S. Drosophila C-terminal binding protein functions as a context-dependent transcriptional co-factor and interferes with both mad and groucho transcriptional repression. J Biol Chem. 2000;275:37628-37 pubmed
    ..The regions of dCtBP required for activation and repression are separable. We find that mSin3A-histone deacetylase complexes are altered in the presence of dCtBP and that dCtBP interferes with both Groucho and Mad ..
  28. De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, et al. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature. 1996;384:589-91 pubmed
    ..The gene corresponds to that encoding the transcriptional regulator RPD3 in yeast, and to a human histone deacetylase. In yeast, RRD3-deletion strains show enhanced TPE, suggesting a conserved role of the histone deacetylase ..
  29. Chang Y, Peng Y, Pan I, Sun D, King B, Huang D. Essential role of Drosophila Hdac1 in homeotic gene silencing. Proc Natl Acad Sci U S A. 2001;98:9730-5 pubmed
    ..We show that Drosophila Hdac1, an Rpd3-type gene, interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that ..
  30. Rogina B, Helfand S, Frankel S. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science. 2002;298:1745 pubmed
  31. Flores Saaib R, Courey A. Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression. Nucleic Acids Res. 2000;28:4189-96 pubmed
    ..Deletions that weaken histone binding also weaken repression. These findings, along with our recent report that Gro interacts with the histone deacetylase Rpd3, suggest a mechanism for Gro-mediated repression.
  32. Courey A, Jia S. Transcriptional repression: the long and the short of it. Genes Dev. 2001;15:2786-96 pubmed
  33. Kurzhals R, Tie F, Stratton C, Harte P. Drosophila ESC-like can substitute for ESC and becomes required for Polycomb silencing if ESC is absent. Dev Biol. 2008;313:293-306 pubmed
    ..Thus escl appears to function in a backup capacity during development that becomes important only when normal esc expression is compromised. ..
  34. Peterson K, Davis P, Judd B. The determined state of white expression in the Drosophila eye is modified by zeste1 in the wzm family of mutants. Mol Gen Genet. 1994;242:717-26 pubmed
    ..The unpairing of homologs is proposed to be one of the initial results of conformational change, providing an explanation for the role of zeste in transvection. ..
  35. Zraly C, Marenda D, Dingwall A. SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. Genetics. 2004;168:199-214 pubmed
    ..Thus, in addition to important functions of the Brm complex in G1-S control, the complex also appears to be important for transcription of genes required for cell cycle progression. ..
  36. Iliadi K, Knight D, Boulianne G. Healthy aging - insights from Drosophila. Front Physiol. 2012;3:106 pubmed publisher
  37. Shirangi T, Taylor B, McKeown M. A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Nat Genet. 2006;38:1435-9 pubmed
    ..Thus, we show that fru and dsx together act as a 'switch' system regulating behavior in the context of other developmental genes, such as retn. ..
  38. Kirilly D, Wong J, Lim E, Wang Y, Zhang H, Wang C, et al. Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. Neuron. 2011;72:86-100 pubmed publisher
    ..Thus, specific intrinsic epigenetic factors cooperate with steroid hormones to activate selective transcriptional programs, thereby initiating neuronal remodeling. ..
  39. Anderson A, Karandikar U, Pepple K, Chen Z, Bergmann A, Mardon G. The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development. Development. 2011;138:1957-66 pubmed publisher
    ..More importantly, our mutant phenotypes confirm that Caf1-mediated silencing is vital to Drosophila development. These studies underscore the importance of Caf1 and its mammalian homologs in development and disease. ..
  40. Walrad P, Hang S, Gergen J. Hairless is a cofactor for Runt-dependent transcriptional regulation. Mol Biol Cell. 2011;22:1364-74 pubmed publisher
    ..that H is important for maintenance of engrailed (en) repression as was previously demonstrated for Groucho (Gro), Rpd3, and CtBP...
  41. Huang H, Yu Z, Zhang S, Liang X, Chen J, Li C, et al. Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. J Cell Sci. 2010;123:2853-61 pubmed publisher
    ..Together, these findings suggest that Drosophila CAF-1 p180 is an essential factor in the epigenetic control of heterochromatin formation and/or maintenance. ..
  42. Russell M, Ostafichuk L, Scanga S. Lethal P-lacZ insertion lines expressed during pattern respecification in the imaginal discs of Drosophila. Genome. 1998;41:7-13 pubmed
    ..One is an allele of schnurri, a gene that encodes a component of the decapentaplegic (dpp) signal transduction pathway used for positional signalling in the embryo and in imaginal discs. ..
  43. Messina G, Damia E, Fanti L, Atterrato M, Celauro E, Mariotti F, et al. Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization. J Cell Sci. 2014;127:2577-88 pubmed publisher
    ..V at chromatin sites. Overall, our findings suggest an unanticipated role of YETI protein in chromatin organization and provide, for the first time, mechanistic clues on how BCNT proteins control development in multicellular organisms. ..
  44. Struffi P, Arnosti D. Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase. J Biol Chem. 2005;280:40757-65 pubmed
    ..The protein migrates in a complex of approximately 450 kDa and was found to copurify with the Rpd3 histone deacetylase protein during a double affinity purification procedure...
  45. Fitzsimons H, Schwartz S, Given F, Scott M. The histone deacetylase HDAC4 regulates long-term memory in Drosophila. PLoS ONE. 2013;8:e83903 pubmed publisher
    ..In the same genetic background, we also found that RNAi-mediated knockdown of HDAC4 impairs long-term memory, therefore we demonstrate that HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation. ..
  46. Reenan R, Rogina B. Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila. Aging Cell. 2008;7:179-86 pubmed publisher
    ..Thus, decreased neural transmission, a hallmark of which is ts paralysis, is a biomarker of aging. ..
  47. Chinnadurai G. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell. 2002;9:213-24 pubmed
    ..They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis...
  48. Tie F, Siebold A, Harte P. The N-terminus of Drosophila ESC mediates its phosphorylation and dimerization. Biochem Biophys Res Commun. 2005;332:622-32 pubmed
    ..but eliminates the 1 MDa ESC/E(Z) complex, which is distinguished from the former by the presence of the additional subunits PCL and RPD3. Thus, stability and perhaps assembly of larger ESC complexes may depend on ESC phosphorylation.
  49. Nikalayevich E, Ohkura H. The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J Cell Sci. 2015;128:566-75 pubmed
    ..We further show that NHK-1 is important for chromosome condensation during mitosis as well as in oocytes. ..
  50. Frankel S, Woods J, Ziafazeli T, Rogina B. RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity. Aging (Albany NY). 2015;7:1112-29 pubmed
    ..RPD3 is a conserved histone deacetylase (Class I HDAC). Previously we showed that Drosophila rpd3 mutations increase longevity...
  51. Stielow B, Sapetschnig A, Krüger I, Kunert N, Brehm A, Boutros M, et al. Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen. Mol Cell. 2008;29:742-54 pubmed publisher
    ..Our results suggest that MEP-1, Mi-2, and Sfmbt are part of a common repression complex established by DNA-bound SUMO-modified transcription factors. ..
  52. Ranjini M, Ramachandra N. Rapid evolution of a few members of nasuta-albomicans complex of Drosophila: study on two candidate genes, Sod1 and Rpd3. J Mol Evol. 2013;76:311-23 pubmed publisher
    ..In view of this, we cloned and characterized Sod1 and Rpd3 in the members of nasuta-albomicans complex of Drosophila. The evolution of Sod1 and Rpd3 in D. n. nasuta and D. n...
  53. Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, et al. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. J Cell Biol. 2013;203:575-83 pubmed publisher
    ..Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription ..
  54. Ferres Marco D, Gutierrez Garcia I, Vallejo D, Bolivar J, Gutiérrez Aviñó F, Dominguez M. Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature. 2006;439:430-6 pubmed
    ..This phenotype depends on the histone-modifying enzymes Rpd3 (a histone deacetylase), Su(var)3-9 and E(z), as well as on the chromodomain protein Polycomb...
  55. González I, Aparicio R, Busturia A. Functional characterization of the dRYBP gene in Drosophila. Genetics. 2008;179:1373-88 pubmed publisher
    ..Furthermore, they also indicate that dRYBP participates in the control of cell proliferation and cell differentiation and we propose that its functional requirement may well depend on the robustness of the animal. ..
  56. Jia H, Pallos J, Jacques V, Lau A, Tang B, Cooper A, et al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease. Neurobiol Dis. 2012;46:351-61 pubmed
    ..disease (HD)-related phenotypes in R6/2 transgenic mice in response to treatment with the novel histone deacetylase (HDAC) inhibitor 4b...
  57. Huang X, Kadonaga J. Biochemical analysis of transcriptional repression by Drosophila histone deacetylase 1. J Biol Chem. 2001;276:12497-500 pubmed
    ..by RNA polymerase II, we investigated the biochemical properties of purified recombinant Drosophila histone deacetylase 1 (dHDAC1, also known as dRPD3)...
  58. Eberle A, Jordán Pla A, Gañez Zapater A, Hessle V, Silberberg G, von Euler A, et al. An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster. PLoS Genet. 2015;11:e1005523 pubmed publisher
    ..RRP6 interaction network revealed physical links between RRP6 and the heterochromatin factors HP1a, SU(VAR)3-9 and RPD3. Moreover, genome-wide studies of RRP6 occupancy in cells depleted of SU(VAR)3-9 demonstrated that SU(VAR)3-9 ..
  59. Zhao Y, Lang G, Ito S, Bonnet J, Metzger E, Sawatsubashi S, et al. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell. 2008;29:92-101 pubmed publisher
    ..Thus, the deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo. ..
  60. Canudas S, Perez S, Fanti L, Pimpinelli S, Singh N, Hanes S, et al. dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element. Nucleic Acids Res. 2005;33:4857-64 pubmed
    ..Here, we show that mutant alleles of Trl, dsap18 and drpd3/hdac1 enhance A6-to-A5 transformation indicating a contribution to the regulation of Abd-B expression at A6...
  61. Rimkus S, Katzenberger R, Trinh A, Dodson G, Tibbetts R, Wassarman D. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev. 2008;22:1205-20 pubmed publisher
    ..mutations in a protein deacetylase gene, RPD3, suppressed neurodegeneration, and a human homolog of RPD3, histone deacetylase 2, bound ATM and abrogated ATM activation in cell culture...
  62. Joyce E, Pedersen M, Tiong S, White Brown S, Paul A, Campbell S, et al. Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. J Cell Biol. 2011;195:359-67 pubmed publisher
    ..Thus, we conclude that ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis. ..
  63. Meier K, Mathieu E, Finkernagel F, Reuter L, Scharfe M, Doehlemann G, et al. LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes. PLoS Genet. 2012;8:e1002676 pubmed publisher
    ..Depletion of the LINT core subunits results in derepression of these genes. By contrast, histone deacetylase, histone methylase, and histone demethylase activities are not required to maintain repression...
  64. Thompson E, Travers A. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. PLoS ONE. 2008;3:e3008 pubmed publisher
    ..of dSmyd4 including the MYND domain interacted directly with approximately 150 amino acids at the N-termini of dHDAC1 and dHDAC3. dSmyd4 interacts selectively with Ebi, a component of the dHDAC3/SMRTER co-repressor complex...
  65. Shi S, Calhoun H, Xia F, Li J, Le L, Li W. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet. 2006;38:1071-6 pubmed
    ..These results demonstrate that the JAK/STAT pathway regulates cellular epigenetic status and that globally disrupting heterochromatin-mediated tumor suppression is essential for tumorigenesis induced by JAK overactivation. ..
  66. Tie F, Banerjee R, Fu C, Stratton C, Fang M, Harte P. Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain. Proc Natl Acad Sci U S A. 2016;113:E744-53 pubmed publisher
    ..These results suggest that PC/PRC1 inhibition of CBP HAT activity plays a role in regulating transcription of both repressed and active PC-regulated genes. ..
  67. Tie F, Prasad Sinha J, Birve A, Rasmuson Lestander A, Harte P. A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3. Mol Cell Biol. 2003;23:3352-62 pubmed
    ..is distinguished from the 600-kDa complex by the presence of the PcG protein Polycomblike (PCL) and the histone deacetylase RPD3...
  68. Fiesel F, Voigt A, Weber S, Van den Haute C, Waldenmaier A, Görner K, et al. Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J. 2010;29:209-21 pubmed publisher
    ..To identify relevant targets of TDP-43, we performed expression profiling. Thereby, histone deacetylase 6 (HDAC6) downregulation was discovered on TDP-43 silencing and confirmed at the mRNA and protein level in ..
  69. Ivanov D, Escott Price V, Ziehm M, Magwire M, Mackay T, Partridge L, et al. Longevity GWAS Using the Drosophila Genetic Reference Panel. J Gerontol A Biol Sci Med Sci. 2015;70:1470-8 pubmed publisher
    ..This analysis suggests that our understanding of the genetic basis of natural variation in lifespan from induced mutations is incomplete. ..
  70. Burgio G, Cipressa F, Ingrassia A, Cenci G, Corona D. The histone deacetylase Rpd3 regulates the heterochromatin structure of Drosophila telomeres. J Cell Sci. 2011;124:2041-8 pubmed publisher
    ..Here, we show that the loss of the essential and evolutionarily conserved histone deacetylase Rpd3, the homolog of mammalian HDAC1, causes aberrant telomeric fusions on polytene chromosome ends...
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    ..Here, we report genetic and molecular evidence that the histone acetyltransferase (HAT) Chameau and the histone deacetylase DRpd3 act as antagonistic cofactors of DJun and DFos to modulate JNK-dependent transcription during thorax ..