Gene Symbol: hangover
Description: hangover
Alias: BcDNA:GM07804, BcDNA:LD22118, CG32575, CG4411, CG4416, Dmel\CG32575, HANG, LD22118, hangover, CG32575-PA, CG32575-PC, CG32575-PD, hang-PA, hang-PC, hang-PD
Species: fruit fly

Top Publications

  1. Scholz H, Franz M, Heberlein U. The hangover gene defines a stress pathway required for ethanol tolerance development. Nature. 2005;436:845-7 pubmed
    ..Here we describe a new gene, hangover, which is required for normal development of ethanol tolerance...
  2. Zhou D, Udpa N, Gersten M, Visk D, Bashir A, Xue J, et al. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011;108:2349-54 pubmed publisher
    ..Unique analytical tools and genetic and bioinformatic strategies allowed us to discover that Notch activation plays a major role in this hypoxia tolerance in Drosophila melanogaster. ..
  3. Ward E, Thaipisuttikul I, Terayama M, French R, Jackson S, Cosand K, et al. GAL4 enhancer trap patterns during Drosophila development. Genesis. 2002;34:46-50 pubmed
  4. Larschan E, Alekseyenko A, Gortchakov A, Peng S, Li B, Yang P, et al. MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell. 2007;28:121-33 pubmed
    ..Our results support a model in which MSL complex uses high-affinity sites to initially recognize the X chromosome and then associates with many of its targets through sequence-independent features of transcribed genes. ..
  5. Morozova T, Goldman D, Mackay T, Anholt R. The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. Genome Biol. 2012;13:239 pubmed publisher
    ..Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms. ..
  6. Ruppert M, Franz M, Saratsis A, Velo Escarcena L, Hendrich O, Gooi L, et al. Hangover Links Nuclear RNA Signaling to cAMP Regulation via the Phosphodiesterase 4d Ortholog dunce. Cell Rep. 2017;18:533-544 pubmed publisher
    The hangover gene defines a cellular stress pathway that is required for rapid ethanol tolerance in Drosophila melanogaster...
  7. Bajpe P, van der Knaap J, Demmers J, Bezstarosti K, Bassett A, van Beusekom H, et al. Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Mol Cell Biol. 2008;28:1606-15 pubmed
    ..We conclude that the balance of TTK ubiquitylation by SINA and deubiquitylation by UBP64 constitutes a specific posttranslational switch controlling cell fate. ..
  8. Li C, Zhao X, Cao X, Chu D, Chen J, Zhou J. The Drosophila homolog of jwa is required for ethanol tolerance. Alcohol Alcohol. 2008;43:529-36 pubmed publisher
    ..JWA is likely a novel molecule playing an important role in ethanol tolerance and drug addiction. Our results present a new direction for research related to alcohol tolerance and addiction. ..
  9. Lindsay H, Baines R, ffrench Constant R, Lilley K, Jacobs H, O Dell K. The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Genetics. 2008;180:873-84 pubmed publisher
    ..13F1-16A2, P-element and SNP mapping reduced the Ocd critical region to <100 kb and to six candidate genes: hangover, CG9947, CG4420, eIF2a, Rbp2, and paralytic (para)...

More Information


  1. Marbach D, Roy S, Ay F, Meyer P, Candeias R, Kahveci T, et al. Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks. Genome Res. 2012;22:1334-49 pubmed publisher
  2. Schwenkert I, Eltrop R, Funk N, Steinert J, Schuster C, Scholz H. The hangover gene negatively regulates bouton addition at the Drosophila neuromuscular junction. Mech Dev. 2008;125:700-11 pubmed publisher
    ..Curr. Opin. Neurobiol. 6, 858-867.]. Here we show a new role for Hangover as a negative regulator of bouton number at the NMJ...
  3. Bhandari P, Kendler K, Bettinger J, Davies A, Grotewiel M. An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance. Alcohol Clin Exp Res. 2009;33:1794-805 pubmed publisher
    ..sensitivity and rapid ethanol tolerance, respectively, were altered in flies with mutations in amnesiac and hangover, genes known to influence these traits...
  4. Ronen R, Udpa N, Halperin E, Bafna V. Learning natural selection from the site frequency spectrum. Genetics. 2013;195:181-93 pubmed publisher
    ..We further apply our test to human data and identify regions that are in agreement with earlier studies, as well as many novel regions. ..
  5. Gersten M, Zhou D, Azad P, Haddad G, Subramaniam S. Wnt pathway activation increases hypoxia tolerance during development. PLoS ONE. 2014;9:e103292 pubmed publisher
    ..Our results indicate that a previously unsuspected major developmental pathway, Wnt, plays a significant role in hypoxia tolerance. ..