Gene Symbol: halo
Description: halo
Alias: CG7428, Dmel\CG7428, halo, CG7428-PB, halo-PB
Species: fruit fly

Top Publications

  1. Lecuit T, Samanta R, Wieschaus E. slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo. Dev Cell. 2002;2:425-36 pubmed
    ..Our results suggest that developmental induction of Slam organizes the polarized growth of membrane via the recruitment of membrane-targeting proteins at adherens junctions. ..
  2. Gross S, Guo Y, Martinez J, Welte M. A determinant for directionality of organelle transport in Drosophila embryos. Curr Biol. 2003;13:1660-8 pubmed
    ..Using a combination of genetics, molecular biology, and biophysics, we have identified Halo, a novel regulator of lipid droplet transport in early Drosophila embryos...
  3. Guo Y, Jangi S, Welte M. Organelle-specific control of intracellular transport: distinctly targeted isoforms of the regulator Klar. Mol Biol Cell. 2005;16:1406-16 pubmed
    ..Such isoform variation may be a general strategy for adapting a common regulatory mechanism to specifically control motion and positioning of multiple organelles. ..
  4. Welte M, Cermelli S, Griner J, Viera A, Guo Y, Kim D, et al. Regulation of lipid-droplet transport by the perilipin homolog LSD2. Curr Biol. 2005;15:1266-75 pubmed
    ..LSD2 phosphorylation depends on the transacting signal Halo, and LSD2 can physically interact with the lipid-droplet-associated coordinator Klar, identifying LSD2 as a central ..
  5. de Renzis S, Yu J, Zinzen R, Wieschaus E. Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Dev Cell. 2006;10:257-64 pubmed
    ..We propose that Tom antagonizes the activity of Neuralized and thus establishes a sharp mesoderm-mesoectoderm boundary of Notch signaling. ..
  6. Martinez J, Vershinin M, Shubeita G, Gross S. On the use of in vivo cargo velocity as a biophysical marker. Biochem Biophys Res Commun. 2007;353:835-40 pubmed
    ..Studying lipid droplet motion in Drosophila embryos, we compare transport in a mutant, Delta(halo), with that in wild-type embryos...
  7. Welte M. As the fat flies: The dynamic lipid droplets of Drosophila embryos. Biochim Biophys Acta. 2015;1851:1156-85 pubmed publisher
  8. Cohen R. Microtubule motors: LSD2 trips the toggle. Curr Biol. 2005;15:R651-3 pubmed
    ..LSD2 is required for the net directional transport of lipid droplets and the new data support a model in which the protein imparts bias onto a molecular toggle that otherwise randomly engages minus and plus end motors in a paired set. ..
  9. Meyer W, Schreiber S, Guo Y, Volkmann T, Welte M, Müller H. Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. PLoS Genet. 2006;2:e134 pubmed
    ..Our findings argue against a strict separation of Ago1 and Ago2 functions and suggest that these proteins act in concert to control key steps of the midblastula transition and of segmental patterning. ..

More Information


  1. Syed Z, Pelletier J, Flounders E, Chitolina R, Leal W. Generic insect repellent detector from the fruit fly Drosophila melanogaster. PLoS ONE. 2011;6:e17705 pubmed publisher
    ..We have also identified the insect repellent-sensitive receptor, DmOr42a. This generic detector fulfils the requirements for a simplified bioassay for early screening of test insect repellents. ..
  2. Sung H, Spangenberg S, Vogt N, Großhans J. Number of nuclear divisions in the Drosophila blastoderm controlled by onset of zygotic transcription. Curr Biol. 2013;23:133-8 pubmed publisher
    ..We propose that activation of zygotic gene expression is the trigger that determines the timely and concerted cell-cycle pause and cellularization. ..
  3. Arora G, Tran S, Rizzo N, Jain A, Welte M. Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo. J Cell Sci. 2016;129:1416-28 pubmed publisher
    ..and identify the crucial contribution of the previously identified, but poorly characterized, transacting regulator Halo. In particular, we find that Halo is transiently expressed; rising and falling Halo levels control the switches in ..
  4. Bonneaud N, Savare J, Berta P, Girard F. SNCF, a SoxNeuro interacting protein, defines a novel protein family in Drosophila melanogaster. Gene. 2003;319:33-41 pubmed
    ..Finally, data are presented showing the existence in Drosophila of several proteins with a domain of homology to SNCF, which are all expressed early in embryogenesis at the blastoderm stage. ..
  5. Yu Y, Li Z, Rizzo N, Einstein J, Welte M. Targeting the motor regulator Klar to lipid droplets. BMC Cell Biol. 2011;12:9 pubmed publisher
    ..Our analysis demonstrates that droplet targeting of Klar occurs via a cis-acting sequence and generates a new tool for monitoring lipid droplets in living tissues of Drosophila. ..
  6. Fernandez Gonzalez R, Zallen J. Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. Phys Biol. 2011;8:045005 pubmed publisher
    ..We discuss models to explain how the architecture of cytoskeletal networks regulates their contractile behavior and the mechanisms that give rise to oscillatory cell behaviors in intercalating cells...