Gene Symbol: H
Description: Hairless
Alias: CG5460, Dmel\CG5460, hairless, CG5460-PA, CG5460-PB, CG5460-PC, CG5460-PD, H-PA, H-PB, H-PC, H-PD
Species: fruit fly

Top Publications

  1. Araújo S, Cela C, Llimargas M. Tramtrack regulates different morphogenetic events during Drosophila tracheal development. Development. 2007;134:3665-76 pubmed
    ..In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development. ..
  2. Marquart J, Alexief Damianof C, Preiss A, Maier D. Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist Hairless. Dev Genes Evol. 1999;209:155-64 pubmed
    b>Hairless is a member of the Notch signalling pathway, where it acts as antagonist by binding to Suppressor of Hairless [Su(H)], thereby inhibiting Notch target gene activation...
  3. Schweisguth F, Gho M, Lecourtois M. Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster. Dev Genet. 1996;18:28-39 pubmed
    ..We also show that Notch, Hairless, and Suppressor of Hairless, three components of this intercellular signaling pathway, exhibit dose-dependent ..
  4. Schweisguth F, Posakony J. Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell. 1992;69:1199-212 pubmed
    Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila...
  5. Barolo S, Stone T, Bang A, Posakony J. Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Genes Dev. 2002;16:1964-76 pubmed
    The DNA-binding transcription factor Suppressor of Hairless [Su(H)] functions as an activator during Notch (N) pathway signaling, but can act as a repressor in the absence of signaling...
  6. Maier D, Stumm G, Kuhn K, Preiss A. Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein. Mech Dev. 1992;38:143-56 pubmed
    b>Hairless is a dominant loss of function mutation in Drosophila affecting the formation of adult sensory organs...
  7. Bang A, Posakony J. The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development. Genes Dev. 1992;6:1752-69 pubmed
    ..Loss-of-function mutations of Hairless (H) confer two distinct mutant phenotypes on adult bristles...
  8. Nagel A, Preiss A. Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila. Hereditas. 2011;148:77-84 pubmed publisher
    ..the Notch receptor is cleaved and the intracellular part ICN assembles an activator complex around Suppressor of Hairless [Su(H)] that activates Notch target genes...
  9. Maier D, Nagel A, Preiss A. Two isoforms of the Notch antagonist Hairless are produced by differential translation initiation. Proc Natl Acad Sci U S A. 2002;99:15480-5 pubmed
    ..Notch signals need to be tightly regulated, and in Drosophila they are antagonized by the Hairless (H) protein...

More Information


  1. Morel V, Schweisguth F. Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev. 2000;14:377-88 pubmed
    ..the ligand-induced intracellular processing of Notch, and the formation of a processed Notch-Suppressor of Hairless complex that binds DNA and activates the transcription of Notch target genes...
  2. Go M, Eastman D, Artavanis Tsakonas S. Cell proliferation control by Notch signaling in Drosophila development. Development. 1998;125:2031-40 pubmed
    ..Vestigial and Wingless, on the contrary, display synergistic effects with Notch signaling, resulting in the stimulation of cell proliferation in imaginal discs. ..
  3. Lyman D, Yedvobnick B. Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development. Genetics. 1995;141:1491-505 pubmed
    ..Genetically, Hairless (H) acts as an antagonist of most neurogenic genes and may insulate neural precursor cells from inhibition...
  4. Llimargas M. The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates. Development. 1999;126:2355-64 pubmed
    ..Both the localised expression and the mutant phenotypes of Delta, a known ligand for Notch, suggest that Delta may activate Notch to specify cell fates at the tips of the developing tracheal branches. ..
  5. Matsuno K, Go M, Sun X, Eastman D, Artavanis Tsakonas S. Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development. 1997;124:4265-73 pubmed
    ..in the interactions between Notch and two intracellular elements of the pathway: Deltex (Dx) and Suppressor of Hairless (Su(H))...
  6. Maier D, Marquart J, Thompson Fontaine A, Beck I, Wurmbach E, Preiss A. In vivo structure-function analysis of Drosophila Hairless. Mech Dev. 1997;67:97-106 pubmed
    b>Hairless plays an important role as the major antagonist in the Notch signalling pathway in Drosophila. It appears to be a direct inhibitor of the signal transducer Su(H)...
  7. Schweisguth F, Lecourtois M. The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction. Dev Genes Evol. 1998;208:19-27 pubmed
    Drosophila Hairless (H) encodes a negative regulator of Notch signalling. H activity antagonizes Notch (N) signalling during bristle development at the pupal stage...
  8. Vässin H, Vielmetter J, Campos Ortega J. Genetic interactions in early neurogenesis of Drosophila melanogaster. J Neurogenet. 1985;2:291-308 pubmed
    ..function we have studied interactions of the loci N, Dl and E(spl) among each other and with another locus (H), by means of increasing and decreasing the number of wild-type copies of one of these genes in the presence of ..
  9. Bang A, Bailey A, Posakony J. Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway. Dev Biol. 1995;172:479-94 pubmed
    In Drosophila imaginal discs, the function of the Hairless (H) gene is required at multiple steps during the development of adult sensory organs...
  10. Muller D, Nagel A, Maier D, Preiss A. A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila. J Cell Sci. 2006;119:250-8 pubmed
    ..4 from Drosophila melanogaster as a molecular interaction partner of Hairless. Hairless plays a major role as antagonist of Notch signalling in Drosophila, prompting our interest in the ..
  11. Eastman D, Slee R, Skoufos E, Bangalore L, Bray S, Delidakis C. Synergy between suppressor of Hairless and Notch in regulation of Enhancer of split m gamma and m delta expression. Mol Cell Biol. 1997;17:5620-8 pubmed
    ..regulatory regions of these two genes led to the identification of a number of target sites for the Suppressor of Hairless [Su(H)] protein, a transcription factor activated by Notch signaling...
  12. Artavanis Tsakonas S, Rand M, Lake R. Notch signaling: cell fate control and signal integration in development. Science. 1999;284:770-6 pubmed
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. ..
  13. Nagel A, Maier D, Preiss A. Su(H)-independent activity of hairless during mechano-sensory organ formation in Drosophila. Mech Dev. 2000;94:3-12 pubmed
    ..In contrast, the Notch antagonist Hairless, thought to act upon Su(H), influences strongly the entire cell lineage demonstrating that it functions through ..
  14. Maier D, Chen A, Preiss A, Ketelhut M. The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster. BMC Evol Biol. 2008;8:175 pubmed publisher
    ..There is one notable exception, Hairless, which acts as a general Notch antagonist in Drosophila...
  15. de Celis J, Barrio R, Del Arco A, Garcia Bellido A. Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. Proc Natl Acad Sci U S A. 1993;90:4037-41 pubmed
    ..The basis for the genetic antimorphism of NM1 seems to reside in the titration of Notch wild-type products into NM1/N+ nonfunctional dimers and/or the titration of Delta products into nonfunctional ligand-receptor complexes. ..
  16. Schreiber S, Preiss A, Nagel A, Wech I, Maier D. Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila. Genesis. 2002;33:141-52 pubmed
    b>Hairless was identified as antagonist in the Notch signaling pathway based on genetic interactions. Molecularly, Hairless inhibits Notch target gene activation by directly binding to the Notch signal transducer Su(H)...
  17. Dai Q, Andreu Agullo C, Insolera R, Wong L, Shi S, Lai E. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Development. 2013;140:1892-902 pubmed publisher
    ..These data reveal a novel mammalian CSL co-repressor in the nervous system, and show that the Notch-inhibitory activity of certain BEN-solo proteins is conserved between flies and mammals. ..
  18. Fortini M, Artavanis Tsakonas S. The suppressor of hairless protein participates in notch receptor signaling. Cell. 1994;79:273-82 pubmed
    ..Notch signaling in the developing Drosophila eye, we isolated rare, gain-of-function alleles of Suppressor of Hairless (Su(H)), the fly homolog of the mammalian C promoter-binding factor 1 (CBF1) gene...
  19. Koelzer S, Klein T. A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development. 2003;130:1973-88 pubmed
    Su(H)/CBF1 is a key component of the evolutionary conserved Notch signalling pathway. It is a transcription factor that acts as a repressor in the absence of the Notch signal...
  20. Castro B, Barolo S, Bailey A, Posakony J. Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Development. 2005;132:3333-44 pubmed publisher
    ..to direct regulation by both the proneural proteins and the N pathway transcription factor Suppressor of Hairless [Su(H)], and their activation is generally highly asymmetric; i.e...
  21. Maier D. Hairless: the ignored antagonist of the Notch signalling pathway. Hereditas. 2006;143:212-21 pubmed
    ..Together with mastermind and CSL (CBF-1, Suppressor of Hairless, lag-2) DNA-binding proteins, Notch forms a complex that mediates transcriptional activation of the respective ..
  22. Bailey A, Posakony J. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 1995;9:2609-22 pubmed
    ..peripheral neurogenesis in Drosophila: Notch (N), which encodes a transmembrane receptor protein, Suppressor of Hairless [Su(H)], which encodes a DNA-binding transcription factor, and the Enhancer of split gene complex [E(spl)-C], ..
  23. Posakony J. Nature versus nurture: asymmetric cell divisions in Drosophila bristle development. Cell. 1994;76:415-8 pubmed
  24. Zhou D, Udpa N, Gersten M, Visk D, Bashir A, Xue J, et al. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011;108:2349-54 pubmed publisher
    ..Unique analytical tools and genetic and bioinformatic strategies allowed us to discover that Notch activation plays a major role in this hypoxia tolerance in Drosophila melanogaster. ..
  25. Protzer C, Wech I, Nagel A. Hairless induces cell death by downregulation of EGFR signalling activity. J Cell Sci. 2008;121:3167-76 pubmed publisher
    Overexpression of the Notch antagonist Hairless (H) during imaginal development in Drosophila is correlated with tissue loss and cell death...
  26. Nagel A, Krejci A, Tenin G, Bravo Patiño A, Bray S, Maier D, et al. Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol Cell Biol. 2005;25:10433-41 pubmed
    Notch signal transduction centers on a conserved DNA-binding protein called Suppressor of Hairless [Su(H)] in Drosophila species...
  27. Furriols M, Bray S. Dissecting the mechanisms of suppressor of hairless function. Dev Biol. 2000;227:520-32 pubmed
    Suppressor of Hairless [Su(H)] is a DNA-binding protein that is the main intracellular transducer of the Notch signaling pathway in Drosophila...
  28. Koelzer S, Klein T. Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev Biol. 2006;289:77-90 pubmed
    The transcription factor Suppressor of Hairless (Su(H)) belongs to the CSL transcription factor family, which are the main transcriptional effectors of the Notch-signaling pathway...
  29. Nagel A, Wech I, Schwinkendorf D, Preiss A. Involvement of co-repressors Groucho and CtBP in the regulation of single-minded in Drosophila. Hereditas. 2007;144:195-205 pubmed
    ..It was shown earlier that sim is restricted in the neuroectoderm with help of Suppressor of Hairless [Su(H)] and Hairless...
  30. Morel V, Lecourtois M, Massiani O, Maier D, Preiss A, Schweisguth F. Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Curr Biol. 2001;11:789-92 pubmed
    ..NICD associates with Suppressor of Hairless [Su(H)], a DNA binding protein, and Mastermind (Mam), a transcriptional coactivator [7-9]...
  31. Lopez Schier H, St Johnston D. Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis. Genes Dev. 2001;15:1393-405 pubmed
    ..The germ line therefore regulates the development of the follicle cells through two complementary signaling pathways: Gurken signals twice to control spatial patterning, whereas Delta signals twice to exert temporal control. ..
  32. Rouault H, Mazouni K, Couturier L, Hakim V, Schweisguth F. Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny. Proc Natl Acad Sci U S A. 2010;107:14615-20 pubmed publisher
    ..The statistics and phylogeny-based tools described here can be more generally applied to identify the cis-regulatory elements of specific gene regulatory networks in any family of related species with sequenced genomes. ..
  33. Maier D, Nagel A, Johannes B, Preiss A. Subcellular localization of Hairless protein shows a major focus of activity within the nucleus. Mech Dev. 1999;89:195-9 pubmed
    b>Hairless, a major antagonist of the Notch signaling-pathway in Drosophila (Bang and Posakony, 1992; Maier et al., 1992), associates with Suppressor of Hairless [Su(H)], thereby inhibiting trans-activation of Notch target genes (Brou et al...
  34. Brou C, Logeat F, Lecourtois M, Vandekerckhove J, Kourilsky P, Schweisguth F, et al. Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. Genes Dev. 1994;8:2491-503 pubmed
    ..is derived from the previously described RBP-J kappa gene, the human homolog of the Drosophila Suppressor of Hairless [Su(H)] gene...
  35. Wech I, Nagel A. Mutations in rugose promote cell type-specific apoptosis in the Drosophila eye. Cell Death Differ. 2005;12:145-52 pubmed
    ..Together, these findings support the idea that rg plays an important role in the integration of different signals required for the exact regulation of cone cell development and survival. ..
  36. Klein T, Seugnet L, Haenlin M, Martinez Arias A. Two different activities of Suppressor of Hairless during wing development in Drosophila. Development. 2000;127:3553-66 pubmed
    ..We also find that the Hairless protein interacts with Notch signalling during wing development and inhibits the activity of Su(H)...
  37. Bang A, Hartenstein V, Posakony J. Hairless is required for the development of adult sensory organ precursor cells in Drosophila. Development. 1991;111:89-104 pubmed
    Reduction of the wild-type activity of the gene Hairless (H) results in two major phenotypic effects on the mechanosensory bristles of adult Drosophila. Bristles are either 'lost' (i.e...
  38. Sun X, Artavanis Tsakonas S. The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development. 1996;122:2465-74 pubmed
    ..Notch, Delta, mastermind, deltex and groucho, but are suppressed by a duplication of Delta or mutations in Hairless, a negative regulator of the pathway...
  39. Maier D, Kurth P, Schulz A, Russell A, Yuan Z, Gruber K, et al. Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster. Mol Biol Cell. 2011;22:3242-52 pubmed publisher
    ..that includes the DNA-binding protein CSL, a composite of human C-promoter binding factor 1, Suppressor of Hairless of Drosophila melanogaster [Su(H)], and lin-12 and Glp-1 phenotype of Caenorhabditis elegans...
  40. Schweisguth F, Posakony J. Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis. Development. 1994;120:1433-41 pubmed
    ..We show here that the activity of Suppressor of Hairless is required for both the sensory organ precursor (SOP) versus epidermal cell fate decision, and for the trichogen ..
  41. Mackay T, Fry J. Polygenic mutation in Drosophila melanogaster: genetic interactions between selection lines and candidate quantitative trait loci. Genetics. 1996;144:671-88 pubmed
    ..It is possible that much of the response to selection was from new mutations at candidate bristle number quantitative trait loci, and that for some of these loci, mutation rates were high. ..
  42. Mahoney M, Parks A, Ruddy D, Tiong S, Esengil H, Phan A, et al. Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics. 2006;172:2309-24 pubmed
    ..The predicted functions of these newly identified genes are consistent with extracellular matrix and vesicular trafficking mechanisms in Presenilin and Notch pathway regulation and suggest a novel role for gamma-tubulin in the pathway. ..
  43. Goodbourn S. Signal transduction. Notch takes a short cut. Nature. 1995;377:288-9 pubmed
  44. Flores G, Duan H, Yan H, Nagaraj R, Fu W, Zou Y, et al. Combinatorial signaling in the specification of unique cell fates. Cell. 2000;103:75-85 pubmed
    ..We expect that similar mechanisms may specify pattern formation in vertebrate developmental systems that involve intercellular communication. ..
  45. Escudero L, Wei S, Chiu W, Modolell J, Hsu J. Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning. Development. 2003;130:6305-16 pubmed
    ..Consistently, we find that Ed also antagonizes the bristle-promoting activity of the Egfr pathway, either by the enhancement of N signalling or, similar to the eye, by a more direct action on the Egfr pathway. ..
  46. House V. The Interaction of Mutants Affecting Venation in Drosophila Melanogaster. I. Interaction of Hairless, Engrailed and Cubitus Interruptus. Genetics. 1953;38:199-215 pubmed
  47. Sotillos S, Roch F, Campuzano S. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development. 1997;124:4769-79 pubmed
    ..kuzbanian and different genes of the Notch pathway indicate that kuzbanian is required upstream of Suppressor of Hairless. Moreover, the requirement of kuzbanian for signalling by a ligand-dependent Abruptex receptor, but not by a ..
  48. Röttgen G, Wagner T, Hinz U. A genetic screen for elements of the network that regulates neurogenesis in Drosophila. Mol Gen Genet. 1998;257:442-51 pubmed
    ..Besides mutations in genes expected to modify the phenotype, we have isolated mutations in six genes not known so far to be involved in neurogenesis. ..
  49. Foronda D, Weng R, Verma P, Chen Y, Cohen S. Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut. Genes Dev. 2014;28:2421-31 pubmed publisher
  50. Thomas G, van Meyel D. The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. Development. 2007;134:591-600 pubmed
  51. Fostier M, Evans D, Artavanis Tsakonas S, Baron M. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics. 1998;150:1477-85 pubmed
    ..b>Hairless, a mutation in a known negative regulator of the Notch pathway, was also enhanced by Su(dx)...
  52. de Celis J, Bray S, Garcia Bellido A. Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development. 1997;124:1919-28 pubmed
  53. Maier D, Praxenthaler H, Schulz A, Preiss A. Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities. PLoS ONE. 2013;8:e81578 pubmed publisher
    ..In Drosophila, this protein is named Suppressor of Hairless [Su(H)]...
  54. Sharp N, Agrawal A. Evidence for elevated mutation rates in low-quality genotypes. Proc Natl Acad Sci U S A. 2012;109:6142-6 pubmed publisher
    ..Positive mutational feedback could affect human health by increasing the rate of germline mutation, and possibly somatic mutation, in individuals of poor health because of genetic or environmental stress. ..
  55. Tekotte H, Berdnik D, Torok T, Buszczak M, Jones L, Cooley L, et al. Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila. Dev Biol. 2002;244:396-406 pubmed
    ..We propose that mutations in house keeping genes often cause specific developmental phenotypes, such as those observed in many human genetic disorders. ..
  56. Stacey S, Muraro N, Peco E, Labbe A, Thomas G, Baines R, et al. Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion. J Neurosci. 2010;30:14446-57 pubmed publisher
  57. Lindsley D, Sandler L, Baker B, Carpenter A, Denell R, Hall J, et al. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics. 1972;71:157-84 pubmed
    ..Moreover, except for the single triplo-lethal locus, the effects of hyperploidy are much less pronounced than those of the corresponding hypoploidy. ..
  58. Mao Y, Freeman M. Fasciclin 2, the Drosophila orthologue of neural cell-adhesion molecule, inhibits EGF receptor signalling. Development. 2009;136:473-81 pubmed publisher
    ..Our results introduce a new regulatory interaction between an adhesion protein and a Drosophila signalling pathway and highlight the extent to which the EGFR pathway must be regulated at multiple levels. ..
  59. Shamloula H, Mbogho M, Pimentel A, Chrzanowska Lightowlers Z, Hyatt V, Okano H, et al. rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics. 2002;161:693-710 pubmed
    ..Our results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. ..
  60. Zimmerman E, Palsson A, Gibson G. Quantitative trait loci affecting components of wing shape in Drosophila melanogaster. Genetics. 2000;155:671-83 pubmed
  61. Ben Yaacov S, Le Borgne R, Abramson I, Schweisguth F, Schejter E. Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling. J Cell Biol. 2001;152:1-13 pubmed
    ..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway. ..
  62. Merdes G, Soba P, Loewer A, Bilic M, Beyreuther K, Paro R. Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 2004;23:4082-95 pubmed
  63. Hall L, Alexander S, Chang M, Woodling N, Yedvobnick B. An EP overexpression screen for genetic modifiers of Notch pathway function in Drosophila melanogaster. Genet Res. 2004;83:71-82 pubmed
    ..Our results suggest that a genetic screen that combines partial loss of function with random gene overexpression might be a useful strategy in the analysis of developmental pathways. ..
  64. Milan M, Cohen S. A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development. 2003;130:553-62 pubmed
    ..We propose that Apterous controls expression of surface proteins that confer an affinity difference in conjunction with activated Notch. Thus, we view Apterous as instructive and Notch activity as essential, but permissive. ..
  65. Iwaki D, Lengyel J. A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut. Mech Dev. 2002;114:71-84 pubmed
    ..This Notch-induced cell specification is distinguished by the fact that it does not appear to utilize the ligand Serrate and the modulator Fringe. ..
  66. Brockmann B, Mastel H, Oswald F, Maier D. Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless. Hereditas. 2014;151:209-19 pubmed publisher
    ..which is effected by the transcription factor CSL, an acronym for vertebrate CBF1/RBP-J, Drosophila Suppressor of Hairless [Su(H)] and C. elegans Lag1...