Genomes and Genes
Gene Symbol: Gycalpha99B
Description: Guanylyl cyclase alpha-subunit at 99B
Alias: CG1912, Dgc1, Dgcalpha1, Dmel\CG1912, GCalpha1, GYCa 99B, Gcalpha1, Gycalpha-99B, Gycalpha63A, SGCalpha, dgc1, dgca1, dgcalpha1, gycalpha, sGC, sGCalpha1, sGCalpha99B, guanylyl cyclase alpha-subunit at 99B, CG1912-PA, Gycalpha99B-PA, guanyl cyclase alpha-subunit at 63A, guanylate cyclase 99B, soluble guanylate cyclase, soluble guanylyl cyclase alpha
Species: fruit fly
- Brenman J, Gao F, Jan L, Jan Y. Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev Cell. 2001;1:667-77 pubmed
- Morton D. Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. J Biol Chem. 2004;279:50651-3 pubmed..This is the first demonstration of a soluble guanylyl cyclase that is activated in response to changing oxygen concentrations. ..
- Morton D, Langlais K, Stewart J, Vermehren A. Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. J Insect Sci. 2005;5:12 pubmed..Two of these genes code for subunits, Gycalpha-99B and Gycbeta-100B, which form a conventional NO-sensitive guanylyl cyclase and the other three code for ..
- Rabinovich D, Yaniv S, Alyagor I, Schuldiner O. Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling. Cell. 2016;164:170-182 pubmed publisher..Taken together, these results suggest that NO signaling provides a switching mechanism between the degenerative and regenerative states of neuronal remodeling. ..
- Yoshikawa S, Miyamoto I, Aruga J, Furuichi T, Okano H, Mikoshiba K. Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. J Neurochem. 1993;60:1570-3 pubmedWe have isolated and characterized a new guanylyl cyclase gene (dgc1) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian soluble-type guanylyl cyclase alpha subunit...
- Kanao T, Sawada T, Davies S, Ichinose H, Hasegawa K, Takahashi R, et al. The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE. 2012;7:e30958 pubmed publisher..Nitric oxide synthase (NOS) and soluble guanylyl cyclase (sGC) also increased FoxO's activity, whereas the administration of a NOS inhibitor L-NAME suppressed the loss of DA ..