Gene Symbol: Gycalpha99B
Description: Guanylyl cyclase alpha-subunit at 99B
Alias: CG1912, Dgc1, Dgcalpha1, Dmel\CG1912, GCalpha1, GYCa 99B, Gcalpha1, Gycalpha-99B, Gycalpha63A, SGCalpha, dgc1, dgca1, dgcalpha1, gycalpha, sGC, sGCalpha1, sGCalpha99B, guanylyl cyclase alpha-subunit at 99B, CG1912-PA, Gycalpha99B-PA, guanyl cyclase alpha-subunit at 63A, guanylate cyclase 99B, soluble guanylate cyclase, soluble guanylyl cyclase alpha
Species: fruit fly

Top Publications

  1. Liu W, Yoon J, Burg M, Chen L, Pak W. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system. J Biol Chem. 1995;270:12418-27 pubmed
    ..In situ hybridizations to adult tissue sections showed that drgc mRNA is expressed in a wide range of tissues, including the optic lobe, central brain, thoracic ganglia, digestive tract, and the oocyte. ..
  2. Davies S. Nitric oxide signalling in insects. Insect Biochem Mol Biol. 2000;30:1123-38 pubmed
  3. Gibbs S, Becker A, Hardy R, Truman J. Soluble guanylate cyclase is required during development for visual system function in Drosophila. J Neurosci. 2001;21:7705-14 pubmed
    ..Developing Drosophila photoreceptors express an NO-sensitive soluble guanylate cyclase (sGC), whereas the optic lobe targets express NO synthase...
  4. Zhang L, Tinette S, Robichon A. Drosophila NO-dependent guanylyl cyclase is finely regulated by sequential order of coincidental signaling. J Cell Biochem. 2002;85:392-402 pubmed
    We investigate the mechanism of regulation of Drosophila-soluble guanylate cyclase. Multiple putative sites of phosphorylation for the major kinases are present on both subunits of the heterodimer...
  5. Langlais K, Stewart J, Morton D. Preliminary characterization of two atypical soluble guanylyl cyclases in the central and peripheral nervous system of Drosophila melanogaster. J Exp Biol. 2004;207:2323-38 pubmed
    ..We have also extended our analysis of the NO activation of Gyc-88E and Gyc-89Db, showing that several structurally unrelated NO donors activate Gyc-88E when expressed alone or when co-expressed with Gyc-89Db. ..
  6. Bicker G. STOP and GO with NO: nitric oxide as a regulator of cell motility in simple brains. Bioessays. 2005;27:495-505 pubmed
    ..NO is a membrane permeant molecule, which activates soluble guanylyl cyclase (sGC) and leads to the formation of cyclic GMP (cGMP) in target cells...
  7. Shah S, Hyde D. Two Drosophila genes that encode the alph and beta subunits of the brain soluble guanylyl cyclase. J Biol Chem. 1995;270:15368-76 pubmed
    We identified two Drosophila genes (dgc alpha 1 and dgc beta 1) that encode the soluble guanylyl cyclase alpha and beta subunits, respectively...
  8. Zelhof A, Koundakjian E, Scully A, Hardy R, Pounds L. Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis. Development. 2003;130:4383-92 pubmed
    ..In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression. ..
  9. Tinette S, Zhang L, Garnier A, Engler G, Tares S, Robichon A. Exploratory behaviour in NO-dependent cyclase mutants of Drosophila shows defects in coincident neuronal signalling. BMC Neurosci. 2007;8:65 pubmed
    ..We show that these mutants present errors in integrative and/or coincident processing of signals, which are not reducible to the functions of the peripheral sensory cells. ..

More Information


  1. Brenman J, Gao F, Jan L, Jan Y. Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev Cell. 2001;1:667-77 pubmed
  2. Morton D. Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. J Biol Chem. 2004;279:50651-3 pubmed
    ..This is the first demonstration of a soluble guanylyl cyclase that is activated in response to changing oxygen concentrations. ..
  3. Morton D, Langlais K, Stewart J, Vermehren A. Comparison of the properties of the five soluble guanylyl cyclase subunits in Drosophila melanogaster. J Insect Sci. 2005;5:12 pubmed
    ..Two of these genes code for subunits, Gycalpha-99B and Gycbeta-100B, which form a conventional NO-sensitive guanylyl cyclase and the other three code for ..
  4. Wang L, Hagemann T, Kalwa H, Michel T, Messing A, Feany M. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Nat Commun. 2015;6:8966 pubmed publisher
  5. Rabinovich D, Yaniv S, Alyagor I, Schuldiner O. Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling. Cell. 2016;164:170-182 pubmed publisher
    ..Taken together, these results suggest that NO signaling provides a switching mechanism between the degenerative and regenerative states of neuronal remodeling. ..
  6. Yoshikawa S, Miyamoto I, Aruga J, Furuichi T, Okano H, Mikoshiba K. Isolation of a Drosophila gene encoding a head-specific guanylyl cyclase. J Neurochem. 1993;60:1570-3 pubmed
    We have isolated and characterized a new guanylyl cyclase gene (dgc1) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian soluble-type guanylyl cyclase alpha subunit...
  7. Kanao T, Sawada T, Davies S, Ichinose H, Hasegawa K, Takahashi R, et al. The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE. 2012;7:e30958 pubmed publisher
    ..Nitric oxide synthase (NOS) and soluble guanylyl cyclase (sGC) also increased FoxO's activity, whereas the administration of a NOS inhibitor L-NAME suppressed the loss of DA ..