Gene Symbol: gus
Alias: A11, CG2944, CG2946, Dmel\CG2944, GUS, Gus, dmSSB4, i25, gustavus, CG2944-PG, CG2944-PH, CG2944-PI, CG2944-PJ, CG2944-PK, CG2944-PL, CG2944-PM, gus-PG, gus-PH, gus-PI, gus-PJ, gus-PK, gus-PL, gus-PM
Species: fruit fly
Styhler S, Nakamura A, Lasko P. VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. Dev Cell. 2002;3:865-76 pubmed
..We identified a gene, gustavus (gus), that encodes a protein that interacts with VAS...
Woo J, Suh H, Park S, Oh B. Structural basis for protein recognition by B30.2/SPRY domains. Mol Cell. 2006;24:967-76 pubmed
..2/SPRY domain of a SPRY domain-containing SOCS box (SSB) protein, GUSTAVUS, complexed with a 20 amino acid peptide derived from the RNA helicase VASA, revealing how these domains recognize ..
Kugler J, Woo J, Oh B, Lasko P. Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. Mol Cell Biol. 2010;30:1769-82 pubmed publisher
..Here, we found that Gustavus (Gus) and Fsn, two ubiquitin Cullin-RING E3 ligase specificity receptors, bind to the same motif on Vasa through ..
Woo J, Imm J, Min C, Kim K, Cha S, Oh B. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 2006;25:1353-63 pubmed
..Here, we report the crystal structure of an SPRY-SOCS box family protein GUSTAVUS in complex with Elongins B and C, revealing a highly distorted two-layered beta-sandwich core structure of its ..
Anne J, Mechler B. Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen. Development. 2005;132:2167-77 pubmed
..As the PMRT5/MEP50 complex is involved in ribonucleoprotein complex assembly, we hypothesize that the Vls complex may play a similar function in assembling the nuage in nurse cells and the polar granules in the oocyte. ..
Kugler J, Chen Y, Weng R, Cohen S. Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster. G3 (Bethesda). 2013;3:1573-6 pubmed publisher
..Our observations are consistent with the hypothesis that miR-969 and miR-9c contribute to stabilizing the processes that control germ number, supporting phenotypic robustness. ..
Kugler J, Lem C, Lasko P. Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis. PLoS ONE. 2010;5:e9048 pubmed publisher
..All of these cul-5 phenotypes are strongly enhanced by reduced activity of gustavus (gus), which encodes a substrate receptor of Cul-5-based ubiquitin E3 ligases...
Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al
. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher