gro

Summary

Gene Symbol: gro
Description: groucho
Alias: BEST:GM01575, BEST:LD15161, BcDNA.LD33829, BcDNA:LD33829, CG8384, DGro, Dmel\CG8384, E(spl)-WD, E(spl)[2], E(spl)gro, E(spl)m9/m10, En-spl, GRO, Grg/TLE, Gro, Groucho, anon-WO0118547.385, dAES1, dAES2, dGro, l(3)gro, m10, m9-m10, m9/10, m9/m10, CG8384-PA, CG8384-PB, CG8384-PC, CG8384-PD, CG8384-PE, CG8384-PF, CG8384-PG, CG8384-PH, CG8384-PI, dgroucho, gro-PA, gro-PB, gro-PC, gro-PD, gro-PE, gro-PF, gro-PG, gro-PH, gro-PI
Species: fruit fly

Top Publications

  1. ncbi Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesis
    J A Campos-Ortega
    Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
    Eur J Biochem 190:1-10. 1990
  2. ncbi The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
    X Sun
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 122:2465-74. 1996
  3. pmc Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
    H Zhang
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 96:535-40. 1999
  4. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  5. pmc Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
    H Zhang
    Department Molecular Cell Biology, Division of Genetics and Development, University of California, Berkeley, California 94720, USA
    Genes Dev 15:261-6. 2001
  6. doi Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho
    Wendy Lee
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Dev Biol 325:263-72. 2009
  7. pmc Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
    G Poortinga
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    EMBO J 17:2067-78. 1998
  8. pmc Conversion of dorsal from an activator to a repressor by the global corepressor Groucho
    T Dubnicoff
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 11:2952-7. 1997
  9. pmc Capicua integrates input from two maternal systems in Drosophila terminal patterning
    Einat Cinnamon
    Department of Biochemistry, Faculty of Medicine, Hadassah Medical School, The Hebrew University, Jerusalem, Israel
    EMBO J 23:4571-82. 2004
  10. pmc Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density
    Clint J Winkler
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10166. 2010

Research Grants

  1. Modulation of Oncogenesis by E1A--Role of CtBP and CtIP
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2005
  2. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2010
  3. APOPTOSIS REGULATION BY VIRAL AND CELLULAR PROTEINS
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2003
  4. ONCOGENIC AND CHEMORESISTANCE BY BCL 2
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2002
  5. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
  6. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
  7. Apoptosis Regulation by Adenovirus and Cellular Genes
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
  8. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
  9. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1990
  10. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1993

Scientific Experts

Detail Information

Publications119 found, 100 shown here

  1. ncbi Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesis
    J A Campos-Ortega
    Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
    Eur J Biochem 190:1-10. 1990
    ....
  2. ncbi The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
    X Sun
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 122:2465-74. 1996
    ..are enhanced by loss-of-function mutations in the Notch pathway elements, Notch, Delta, mastermind, deltex and groucho, but are suppressed by a duplication of Delta or mutations in Hairless, a negative regulator of the pathway...
  3. pmc Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
    H Zhang
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 96:535-40. 1999
    ..In contrast, the two long-range repressors, Hairy and Dorsal, recruit a different corepressor protein, Groucho. Hairy also was shown to interact with dCtBP, thereby raising the possibility that Groucho and dCtBP are ..
  4. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  5. pmc Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
    H Zhang
    Department Molecular Cell Biology, Division of Genetics and Development, University of California, Berkeley, California 94720, USA
    Genes Dev 15:261-6. 2001
    ..It binds the consensus sequence, TGGCGc/tc/t, and interacts with the Groucho corepressor through a conserved sequence motif, FKPY...
  6. doi Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho
    Wendy Lee
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Dev Biol 325:263-72. 2009
    ..been shown in the Drosophila eye that Hipk interferes with the repressive activity of the global co-repressor, Groucho (Gro)...
  7. pmc Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
    G Poortinga
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    EMBO J 17:2067-78. 1998
    ..While Hairy is probably not the only segmentation gene interacting with dCtBP, we show dose-sensitive genetic interactions between dCtBP and hairy mutations...
  8. pmc Conversion of dorsal from an activator to a repressor by the global corepressor Groucho
    T Dubnicoff
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 11:2952-7. 1997
    ..We show here, via the analysis of embryos lacking the maternally encoded Groucho corepressor and via protein-binding assays, that recruitment of Groucho to the template by protein:protein ..
  9. pmc Capicua integrates input from two maternal systems in Drosophila terminal patterning
    Einat Cinnamon
    Department of Biochemistry, Faculty of Medicine, Hadassah Medical School, The Hebrew University, Jerusalem, Israel
    EMBO J 23:4571-82. 2004
    ..Signalling by the Torso pathway relieves repression mediated by the Capicua and Groucho repressors, allowing the restricted expression of the zygotic terminal gap genes tailless and huckebein...
  10. pmc Groucho-mediated repression may result from a histone deacetylase-dependent increase in nucleosome density
    Clint J Winkler
    Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10166. 2010
    b>Groucho (Gro) is a Drosophila melanogaster transcriptional corepressor that directly interacts with the histone deacetylase Rpd3...
  11. ncbi Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch
    Y Apidianakis
    Institute of Molecular Biology and Biotechnology, FO R T H, Heraklion, Greece
    Development 128:4361-70. 2001
    b>Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors...
  12. pmc Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
    D Levanon
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:11590-5. 1998
    ..most mammalian RD proteins terminate in a common pentapeptide, VWRPY, which serves to recruit the corepressor Groucho (Gro)...
  13. pmc Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries
    M Kobayashi
    Kimmel Cancer Institute, Thomas Jefferson Univ, Phila, PA 19107, USA
    Development 128:1805-15. 2001
    b>Groucho acts as a co-repressor for several Drosophila DNA binding transcriptional repressors...
  14. ncbi Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo
    Girish S Ratnaparkhi
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095 1569, USA
    Development 133:4409-14. 2006
    ..Dorsal represses transcription by recruiting the co-repressor Groucho. However, repression occurs only when Dorsal-binding sites are close to binding sites for other factors that also ..
  15. pmc The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells
    H Schrons
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Genetics 132:481-503. 1992
    ..Another gene in the 96F region, namely groucho, is also required for this process...
  16. ncbi The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways
    Alexandre Neves
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Cell 8:867-79. 2005
    ..Our results show that the highly divergent REF-1 proteins are nonetheless HES-like bHLH effectors of Notch signaling...
  17. ncbi Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
    K Matsuno
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 124:4265-73. 1997
    ..These signaling activities are independent of the known effector Su(H) and suggest the existence of yet unidentified Notch pathway components...
  18. ncbi Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression
    Z Paroush
    Imperial Cancer Research Fund, London, UK
    Development 124:3827-34. 1997
    ..In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the embryonic termini...
  19. pmc Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways
    J V Price
    Institute of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Genetics 147:1139-53. 1997
    ..With this screen, we have recovered mutations in Hairless (H), vein, groucho (gro), and three apparently novel loci...
  20. doi Hairless induces cell death by downregulation of EGFR signalling activity
    Cornelia E Protzer
    University of Hohenheim, Institute of Genetics 240, 70599 Stuttgart, Germany
    J Cell Sci 121:3167-76. 2008
    ..Together with the co-repressors Groucho (Gro) and C-terminal binding protein (CtBP), H assembles a repression complex on Notch target genes, thereby ..
  21. ncbi Transcriptional repression: the long and the short of it
    A J Courey
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 15:2786-96. 2001
  22. ncbi Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo
    Luiz P Andrioli
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 276:541-51. 2004
    ..The Slp1 protein contains a protein motif (EH1) which mediates binding to the transcriptional corepressor Groucho (Gro). We show that this domain is required for Slp1-mediated repression in vivo.
  23. pmc Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning
    G Jimenez
    Institut de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 14:224-31. 2000
    ..gene expression by inactivating at the embryonic poles a uniformly distributed repressor activity that involves the Gro corepressor...
  24. ncbi Six3 and Six6 activity is modulated by members of the groucho family
    Javier Lopez-Rios
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Development 130:185-95. 2003
    ..the results of the latter screen that led to the identification of TLE1 (a transcriptional repressor of the groucho family) and AES (a potential dominant negative form of TLE proteins) as cofactors for both SIX6 and SIX3...
  25. ncbi The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts
    E C Lai
    Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla, CA 92093 0349, USA
    Development 125:4077-88. 1998
    ..In support of this, we present sequence analyses that implicate genes of the iroquois Complex (Iro-C) and engrailed as additional targets of K box-mediated regulation...
  26. ncbi Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors
    Changqi C Zhu
    Department of Genetics, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Development 129:2835-49. 2002
    ..Here, we report that Grg4 and Grg5, mouse counterparts of the Drosophila transcriptional co-repressor Groucho, interact with mouse Six3 and its closely related member Six6, which may also be involved in vertebrate eye ..
  27. doi Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila
    Anja C Nagel
    Institut fur Genetik, Universitat Hohenheim, Stuttgart, Germany
    Hereditas 148:77-84. 2011
    ..In the absence of Notch signal, H binds to Su(H) and recruits two general co-repressors, Groucho (Gro) and C-terminal Binding Protein (CtBP); this repression complex downregulates Notch target genes...
  28. ncbi Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:1919-28. 1997
    ....
  29. ncbi Neuronal cell fate specification in Drosophila
    Y N Jan
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco 94143 0724
    Curr Opin Neurobiol 4:8-13. 1994
    ..Selective expression of certain neuronal-type selector genes further specifies the type of neuron(s) that a neural precursor will produce...
  30. ncbi Involvement of co-repressors Groucho and CtBP in the regulation of single-minded in Drosophila
    Anja C Nagel
    Universitat Hohenheim, Institut fur Genetik, Stuttgart, Germany
    Hereditas 144:195-205. 2007
    ..Here, we address the involvement of the two co-repressors CtBP and Groucho (Gro) in repression of sim in the neuroectoderm...
  31. pmc C-terminal-binding protein directly activates and represses Wnt transcriptional targets in Drosophila
    Ming Fang
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    EMBO J 25:2735-45. 2006
    ..CtBP binds to Wnt-regulated enhancers in a TCF-independent manner and represses target genes in parallel with TCF. Our data indicate dual roles for CtBP as a gene-specific activator and repressor of Wnt target gene transcription...
  32. ncbi TCF transcription factors: molecular switches in carcinogenesis
    J Roose
    Department of Immunology, Center for Biomedical Genetics, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands
    Biochim Biophys Acta 1424:M23-37. 1999
    ..In contrast, Tcf proteins mediate repression when bound to members of the Groucho family of transcriptional repressors, CBP and CtBP...
  33. pmc Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression
    S R Dawson
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 15:6923-31. 1995
    ..repression of specific transcriptional activators, such as Scute, through the bHLH and Orange domains and repression of other activators via interaction of the C-terminal WRPW motif with corepressors, such as the Groucho protein.
  34. ncbi Getting a molecular grasp on Hox contextual activity
    Samir Merabet
    Laboratoire de Genetique et Physiologie du Developpement, IBDM, CNRS, Universite de la Mediterranee, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Trends Genet 21:477-80. 2005
    ..A recent study identified novel Hox molecular partners, whose properties set a conceptual framework to understand how Hox proteins use and integrate contextual information...
  35. pmc Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
    G Jimenez
    Imperial Cancer Research Fund ICRF, London WC2A 3PX, England
    Genes Dev 11:3072-82. 1997
    ..Here, we use in vivo functional assays to test whether different repressor activities are mediated by the Groucho (Gro) corepressor in the Drosophila embryo...
  36. pmc Brinker requires two corepressors for maximal and versatile repression in Dpp signalling
    P Hasson
    Department of Biochemistry, The Hebrew University Hadassah Medical School, PO Box 12272, Jerusalem 91120, Israel
    EMBO J 20:5725-36. 2001
    ..that Brk harbours a functional and transferable repression domain, through which it recruits the corepressors Groucho and CtBP...
  37. ncbi The enhancer of split complex of Drosophila includes four Notch-regulated members of the bearded gene family
    E C Lai
    Division of Biology Department of Cell and Developmental Biology and Center for Molecular Genetics, University of California San Diego, La Jolla, CA 92093 0349, USA
    Development 127:3441-55. 2000
    ..Finally, we present our initial studies of the structure, expression and regulation of the newest member of the Brd gene family, Ocho, which is located in the recently identified Bearded Complex...
  38. pmc Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
    Scott Barolo
    Division of Biological Sciences Cell and Developmental Biology, University of California San Diego, La Jolla, California 92093 0349, USA
    Genes Dev 16:1964-76. 2002
    ..Here we show that, in vitro, H directly binds two corepressor proteins, Groucho (Gro) and dCtBP...
  39. pmc Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression
    R D Flores-Saaib
    Department of Chemistry and Biochemistry, 5034 Young Hall, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA
    Nucleic Acids Res 28:4189-96. 2000
    The Drosophila Groucho (Gro) protein is the defining member of a family of metazoan corepressors that have roles in many aspects of development, including segmentation, dorsal/ventral pattern formation, Notch signaling, and Wnt/Wg ..
  40. ncbi A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression
    Hugh N Nuthall
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 277:51049-57. 2002
    Transcriptional corepressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family are involved in a variety of cell differentiation mechanisms in both invertebrates and vertebrates...
  41. ncbi Activation and repression by the C-terminal domain of Dorsal
    R D Flores-Saaib
    Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095 1569, USA
    Development 128:1869-79. 2001
    ..Deletion analysis indicates that this region mediates transcriptional repression and binding to Groucho, a co-repressor known to be required for Dorsal-mediated repression...
  42. ncbi Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube
    J Muhr
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S 171 77 Stockholm, Sweden
    Cell 104:861-73. 2001
    ..We show that most of these homeodomain proteins possess a conserved eh1 motif that mediates the recruitment of Gro/TLE corepressors...
  43. ncbi Two modes of recruitment of E(spl) repressors onto target genes
    Nikolaos Giagtzoglou
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece
    Development 130:259-70. 2003
    ..Irrespective of whether E(spl) are recruited via direct DNA binding or interaction with proneural proteins, the co-repressor Groucho is always needed for target gene repression.
  44. pmc In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein
    Jude Canon
    Department of Biological Chemistry and Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Genes Dev 17:838-43. 2003
    ..This study provides a mechanistic basis for the dual function of Runx proteins that is likely to be conserved in mammalian systems...
  45. pmc Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient
    Li Chin Yao
    Department of Developmental and Cell Biology and the Developmental Biology Center, University of California Irvine, Irvine, CA 92612, USA
    Development 135:2183-92. 2008
    ..This unusual promoter organization may be necessary for brk to respond to the Dpp gradient in a precise and robust fashion...
  46. pmc Spreading of a corepressor linked to action of long-range repressor hairy
    Carlos A Martinez
    Department of Biochemistry and Molecular Biology and Genetics Program, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Cell Biol 28:2792-802. 2008
    ..Several long-range repressors interact with Groucho, a conserved corepressor that is homologous to mammalian TLE proteins...
  47. pmc Differential in vivo requirements for oligomerization during Groucho-mediated repression
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, UK
    EMBO Rep 9:76-83. 2008
    The Groucho (Gro)/transducin-like enhancer of split family of transcriptional corepressors are implicated in many signalling pathways that are important in development and disease, including those mediated by Notch, Wnt and Hedgehog...
  48. pmc A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development
    Amir Orian
    Division of Basic Sciences, Genomic Resource, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:15771-6. 2007
    ..chromatin profiling, we identified a protein-protein interaction between the Drosophila Myc oncogene and the Groucho corepressor that regulates a subset of direct dMyc targets...
  49. ncbi Evolution of the Groucho/Tle gene family: gene organization and duplication events
    Baubak Bajoghli
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria
    Dev Genes Evol 217:613-8. 2007
    The Groucho/Tle family of corepressor proteins has important roles in development and in adult tissue in both Protostomes and Deuterostomes. In Drosophila, a single member of this family has been identified...
  50. doi Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis
    Einat Cinnamon
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    Development 135:829-37. 2008
    ..We have previously shown that the EGFR RTK pathway causes phosphorylation and downregulation of Groucho, a global co-repressor that is widely used by many developmentally important repressors for silencing their ..
  51. ncbi Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 22:645-55. 2006
    The Groucho (Gro)/TLE/Grg family of corepressors operates in many signaling pathways (including Notch and Wnt)...
  52. pmc The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee
    Rebekka Schlatter
    Universitat Hohenheim, Institut fur Genetik, Garbenstr 30, 70599 Stuttgart, Germany
    BMC Evol Biol 5:67. 2005
    ..The question arose how these complexes evolved with regard to gene number in the evolution of insects concentrating on Diptera and the Hymenoptera Apis mellifera...
  53. pmc Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors
    Anja C Nagel
    Anette Preiss, Institut für Genetik 240, Universitat Hohenheim, Garbenstr 30, D 70599 Stuttgart, Germany
    Mol Cell Biol 25:10433-41. 2005
    ..in conjunction with a partner, Hairless, which contains binding motifs for two global corepressors, CtBP and Groucho (Gro)...
  54. pmc DNA-dependent conversion of Oct-1 and Oct-2 into transcriptional repressors by Groucho/TLE
    Stephen Malin
    Department of Microbiology and Tumor biology Box 280, Karolinska Institutet, 171 77 Stockholm, Sweden
    Nucleic Acids Res 33:4618-25. 2005
    ....
  55. ncbi Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless
    Brian Castro
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093 0349, USA
    Development 132:3333-44. 2005
    ..Finally, we define crucial roles for the adaptor protein Hairless and the co-repressors Groucho and CtBP in conferring repressive activity on Su(H) in the SOP...
  56. ncbi Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho
    Cheol Yong Choi
    Laboratory Research Program, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:21427-36. 2005
    b>Groucho function is essential for Drosophila development, acting as a corepressor for specific transcription factors that are downstream targets of various signaling pathways...
  57. ncbi EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output
    Peleg Hasson
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel
    Nat Genet 37:101-5. 2005
    ..The global corepressor Groucho (Gro) and its transducin-like Enhancer-of-split (TLE) mammalian homologs mediate repression by a myriad of ..
  58. pmc Groucho oligomerization is required for repression in vivo
    Haiyun Song
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    Mol Cell Biol 24:4341-50. 2004
    Drosophila Groucho (Gro) is a member of a family of metazoan corepressors with widespread roles in development...
  59. pmc Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor
    Sandhya Payankaulam
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 106:17314-9. 2009
    ..been suggested to stem from the differential recruitment of the CtBP corepressor to short-range repressors and Groucho to long-range repressors...
  60. ncbi Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist Hairless
    J Marquart
    Universitat Hohenheim, Institut für Genetik 240, Garbenstrasse 30, D 70599 Stuttgart, Germany
    Dev Genes Evol 209:155-64. 1999
    ..In summary, this evolutionary study improves the knowledge on functionally significant domains of the Hairless protein, and may be helpful for the future identification of homologues in other animals, especially in vertebrates...
  61. pmc The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
    A L Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, USA
    Mol Cell Biol 16:2670-7. 1996
    ..This motif was previously shown to be necessary for interactions with Groucho, a genetically defined corepressor for Drosophila Hairy-related proteins...
  62. ncbi Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
    Z Paroush
    Laboratory of Developmental Genetics, University of Oxford, England
    Cell 79:805-15. 1994
    ..We find that the groucho (gro) protein binds specifically to hairy and also to hairy-related bHLH proteins encoded by deadpan and the ..
  63. pmc Two distinct types of repression domain in engrailed: one interacts with the groucho corepressor and is preferentially active on integrated target genes
    E N Tolkunova
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Cell Biol 18:2804-14. 1998
    ..eh1) is highly conserved throughout several classes of homeoproteins and interacts specifically with the Groucho corepressor...
  64. pmc A role for Groucho tetramerization in transcriptional repression
    G Chen
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    Mol Cell Biol 18:7259-68. 1998
    The Drosophila Groucho (Gro) protein is a corepressor required by a number of DNA-binding transcriptional repressors...
  65. ncbi Drosophila Tcf and Groucho interact to repress Wingless signalling activity
    R A Cavallo
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Nature 395:604-8. 1998
    ..the absence of Armadillo, dTcf acts as a transcriptional repressor of Wingless-responsive genes, and we show that Groucho acts as a corepressor in this process...
  66. pmc Drosophila evolution challenges postulated redundancy in the E(spl) gene complex
    D Maier
    University of Basel, Department of Cell Biology, Switzerland
    Proc Natl Acad Sci U S A 90:5464-8. 1993
    ..distinct functions, vital and neurogenic, reside within the complex defined by lethal mutations in the l(3) gro gene and by the typical neurogenic phenotype of deletions, respectively...
  67. ncbi Groucho: making its Marx as a transcriptional co-repressor
    S M Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Trends Genet 14:130-2. 1998
  68. ncbi Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
    Development 122:161-71. 1996
    ..Here we show that mutation of either the bHLH-encoding genes of the Enhancer of split complex (E(spl)-C) or groucho, like Notch or Delta mutants, cause an overproduction of sensory organ precursors at the expense of epidermis...
  69. ncbi Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
    A L Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021 USA
    Genes Dev 12:1931-40. 1998
  70. ncbi A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit
    D A Hartley
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Cell 55:785-95. 1988
    ..We demonstrate that expression of the transcripts relates to the developing central nervous system. These data suggest a mechanism of interaction between the gene products of Notch and Enhancer of split...
  71. pmc Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster
    C Delidakis
    Howard Hughes Medical Institute, Department of Cell Biology and Biology, Yale University, New Haven, Connecticut 06511
    Genetics 129:803-23. 1991
    ..Immunocytochemical localization of the E(spl) m9/10 protein has revealed that it is a ubiquitously distributed nuclear component in embryonic, larval and imaginal tissues...
  72. ncbi Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:2719-28. 1996
    ..Transcriptional activation mediated by Suppressor of Hairless and transcriptional repression mediated by Enhancer of split could provide greater diversity in the response of individual genes to Notch activity...
  73. pmc Groucho-dependent and -independent repression activities of Runt domain proteins
    B D Aronson
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 17:5581-7. 1997
    ..an evolutionarily conserved protein-protein interaction between Runt domain proteins and the corepressor Groucho. The interaction, however, is independent of the Runt domain and can be mapped to a 5-amino-acid sequence, VWRPY, ..
  74. pmc Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster
    C Klämbt
    Institut für Entwicklungsphysiologie, Universitat zu Koln, FRG
    EMBO J 8:203-10. 1989
    ..Another lesion is a deletion in the coding region that leads to a shorter protein which, in addition, differs in its carboxy-terminal end from the wild-type protein by the presence of nine amino acids...
  75. pmc A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development
    G Chen
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 USA
    Genes Dev 13:2218-30. 1999
    The Drosophila gene groucho (gro) encodes a transcriptional corepressor that has critical roles in many development processes...
  76. ncbi The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3
    A Palaparti
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 272:26604-10. 1997
    b>Groucho is a transcriptional repressor implicated in Notch signaling and involved in neural development and segmentation in Drosophila...
  77. ncbi CtBP, an unconventional transcriptional corepressor in development and oncogenesis
    G Chinnadurai
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, St Louis, MO 63110, USA
    Mol Cell 9:213-24. 2002
    ..CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed...
  78. pmc The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila
    A Preiss
    Department of Biology, Yale University, New Haven, CT 06511
    EMBO J 7:3917-27. 1988
    ..indicates that this transcription unit includes functions associated with both the dominant E(spl)D mutation and the recessive visible allele groucho, and is necessary for the correct differentiation of the embryonic nervous system.
  79. pmc Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer
    S A Valentine
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    Mol Cell Biol 18:6584-94. 1998
    ..Repression by Dorsal requires the corepressor Groucho (Gro) and is mediated by silencers termed ventral repression regions (VRRs)...
  80. pmc Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions
    J Husain
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada
    Biochem J 317:523-31. 1996
    The Drosophila protein Groucho is involved in embryonic segmentation and neural development, and is implicated in the Notch signal transduction pathway...
  81. ncbi Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo
    John Cowden
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Dev Biol 262:335-49. 2003
    ..The N-terminal domain of Vnd contains a putative eh1 repression domain that binds Groucho in vitro. Mutations in this domain diminish Groucho binding and also attenuate repression in vivo...
  82. pmc The Groucho/TLE/Grg family of transcriptional co-repressors
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, Lincoln s Inn Fields, London, WC2A 3PX, UK
    Genome Biol 9:205. 2008
    The Drosophila Groucho (Gro) protein was the founding member of the family of transcriptional co-repressor proteins that now includes the transducin-like enhancer of split (TLE) and Grorelated gene (Grg) proteins in vertebrates...
  83. doi Position dependent responses to discontinuities in the retinal determination network
    Claire L Salzer
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Dev Biol 326:121-30. 2009
    ..Taken together these results suggest that the complexities of development are best appreciated when spatial and temporal information is incorporated when describing gene regulatory networks...
  84. pmc Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes
    R T Collins
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 14:3140-52. 2000
    ..of Armadillo but is sensitive both to the relative levels of activating Armadillo/Pangolin and repressing Groucho/Pangolin complexes present and to the responsiveness of the promoter to Wingless...
  85. ncbi neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis
    E Pavlopoulos
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
    Dev Cell 1:807-16. 2001
    ..The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups...
  86. ncbi Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development
    Kristy L Kenyon
    Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Dev Dyn 234:497-504. 2005
    ....
  87. pmc An eh1-like motif in odd-skipped mediates recruitment of Groucho and repression in vivo
    Robert E Goldstein
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    Mol Cell Biol 25:10711-20. 2005
    Drosophila Groucho, like its vertebrate Transducin-like Enhancer-of-split homologues, is a corepressor that silences gene expression in numerous developmental settings...
  88. pmc Dysfusion transcriptional control of Drosophila tracheal migration, adhesion, and fusion
    Lan Jiang
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Cell Biol 26:6547-56. 2006
    ..These results indicate that fusion cells undergo dynamic changes in gene expression as they switch from migratory to fusion modes and that dysfusion regulates a discrete, but important, set of these genes...
  89. pmc Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 90:4037-41. 1993
    ..The basis for the genetic antimorphism of NM1 seems to reside in the titration of Notch wild-type products into NM1/N+ nonfunctional dimers and/or the titration of Delta products into nonfunctional ligand-receptor complexes...
  90. ncbi Positive and negative signaling mechanisms in the regulation of photoreceptor induction in the developing Drosophila retina. Review
    D Yamamoto
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Genetica 88:153-64. 1993
    ..Pokkuri-mediated repression represents one such regulatory mechanism. The positive and negative signaling pathways operating in the fate determination of other photoreceptor cells are also discussed...
  91. ncbi The enhancer of split locus and neurogenesis in Drosophila melanogaster
    E Knust
    Dev Biol 122:262-73. 1987
    ..Therefore, E(spl) formally behaves as a gene switching between neural and epidermal pathways...
  92. ncbi The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis
    T Xu
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genes Dev 4:464-75. 1990
    ....
  93. pmc Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein
    K Tietze
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Proc Natl Acad Sci U S A 89:6152-6. 1992
    ..Furthermore, we could show that the dominant enhancement of spl is caused by truncation of the E(SPL)D protein in combination with deletion of a putative regulatory element...
  94. ncbi The HMG-box transcription factor SoxNeuro acts with Tcf to control Wg/Wnt signaling activity
    Anna T Chao
    Department of Biology, Duke University, Durham, NC 27708, USA
    Development 134:989-97. 2007
    ..In both flies and in human cells, SoxN repression is potentiated by adding ectopic Tcf, suggesting that SoxN interacts with the repressor form of Tcf to influence Wg/Wnt target gene transcription...
  95. ncbi Regulatory interactions during early neurogenesis in Drosophila
    B Hassan
    Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
    Dev Genet 18:18-27. 1996
    ..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...
  96. ncbi Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development
    Kristy L Kenyon
    Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Dev Biol 286:158-68. 2005
    ....
  97. ncbi A Drosophila MBD family member is a transcriptional corepressor associated with specific genes
    E Ballestar
    Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Eur J Biochem 268:5397-406. 2001
    ..This banding pattern suggests gene-specific regulatory functions for dMBD-like and the Drosophila Mi-2 complex...
  98. ncbi Transcriptional coregulators in development
    M Mannervik
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Science 284:606-9. 1999
    ..Recent studies suggest that a growing set of coactivators and corepressors mediate communication between diverse upstream regulatory proteins and the core RNA polymerase II transcription complex...
  99. ncbi Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho
    R E Goldstein
    Department of Biochemistry, Hadassah Medical School, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel
    Development 126:3747-55. 1999
    The Groucho corepressor mediates negative transcriptional regulation in association with various DNA-binding proteins in diverse developmental contexts...
  100. ncbi Regeneration in insects
    J L Marsh
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA
    Semin Cell Dev Biol 10:365-75. 1999
    ..Each of the regulatory networks could themselves serve as the subject of a detailed review and that is beyond the scope of this discussion. Here we will focus on the interplay between the regulatory networks in patterning the tissue...

Research Grants62

  1. Modulation of Oncogenesis by E1A--Role of CtBP and CtIP
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2005
    ..Thus, our proposed studies should illuminate how a viral oncoprotein, adenovirus EtA, modulates oncogenesis novel pathways that involve cellular proteins CtBP and CtIP. ..
  2. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2010
    ..Our proposed studies will harness the knowledge gained from the study of the viral oncoprotein E1A to unravel potential new mechanisms governing oncogenesis and suggest strategies to inhibit the process in humans. ..
  3. APOPTOSIS REGULATION BY VIRAL AND CELLULAR PROTEINS
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2003
    ..The proposed studies should illuminate the mechanisms by which E1B-19K and related BCL-2 family proteins control cellular life and death cycles. ..
  4. ONCOGENIC AND CHEMORESISTANCE BY BCL 2
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2002
    ..These studies hope to provide tools and strategies to interfere with Bcl-2 activity in neoplastic diseases. ..
  5. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..Our proposed studies will harness the knowledge gained from the study of the viral oncoprotein E1A to unravel potential new mechanisms governing oncogenesis and suggest strategies to inhibit the process in humans. ..
  6. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  7. Apoptosis Regulation by Adenovirus and Cellular Genes
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..abstract_text> ..
  8. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. ..
  9. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1990
    ..Since 175R T antigen is also localized on the nuclear envelope, we will investigate whether this protein could play a role in the nucleocytoplasmic transport of RNA via enhanced nucleoside triphophatase activity...
  10. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1993
    ..The role of the chimeric receptor in calcium mobilization and ligand-dependent internalization will be determined. The proposed studies should facilitate understanding of the biochemical mechanism of 19K-mediated transformation...
  11. SHORT-TERM TRAINING: STUDENTS IN HEALTH PROFESS. SCHOOLS
    Michael Atchison; Fiscal Year: 2007
    ..Students also participate in a school-wide research day held each Spring. Future goals include further expansion of funded slots and development of additional strategies for recruitment of veterinary students into research careers. ..
  12. DORSOVENTRAL PATTERNING THROUGH TRANSCRIPTIONAL CONTROL
    ALBERT COUREY; Fiscal Year: 2003
    ..Dorsalinteracting protein that plays a key role in regulating dorsal/ventral pattern formation is the corepressor Groucho. This factor, which functions as a homotetramer, may mediate an interaction between Dorsal and histone ..
  13. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2000
    ....
  14. DORSOVENTRAL PATTERNING THROUGH TRANSCRIPTIONAL CONTROL
    ALBERT COUREY; Fiscal Year: 2007
    ..One Dorsal-interacting protein that is essential for Dorsal-mediated repression is the corepressor Groucho. The first specific aim of this proposal is to illuminate the mechanism of Dorsal-mediated activation by ..
  15. Smt3-conjugation in cell biology and development
    ALBERT COUREY; Fiscal Year: 2004
    ..The conjugation of this protein to Smt3 appears to control its localization to discrete nuclear foci termed PML bodies. Recent experiments suggest that Drosophila nuclei may contain similar Smt3-dependent foci. ..
  16. Roles of Oct4 dimers during mouse germline development
    Michael Atchison; Fiscal Year: 2006
    ..The anticipated results will have relevant applicability to stem cell and germline biology and lead to a better understanding of human reproduction. ..