grau

Summary

Gene Symbol: grau
Description: grauzone
Alias: CG3282, CG33133, Dmel\CG33133, grauzone, CG33133-PA, grau-PA
Species: fruit fly
Products:     grau

Top Publications

  1. Page A, Orr Weaver T. The Drosophila genes grauzone and cortex are necessary for proper female meiosis. J Cell Sci. 1996;109 ( Pt 7):1707-15 pubmed
    ..Here we describe the phenotype of eggs laid by sterile mothers mutant for either grauzone or cortex...
  2. Pesin J, Orr Weaver T. Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. PLoS Genet. 2007;3:e202 pubmed
    ..Our studies reveal the mechanism for developmental regulation of an APC/C activator and suggest it is one strategy for control of the female meiotic cell cycle in a multicellular organism. ..
  3. Chen B, Harms E, Chu T, Henrion G, Strickland S. Completion of meiosis in Drosophila oocytes requires transcriptional control by grauzone, a new zinc finger protein. Development. 2000;127:1243-51 pubmed
    Mutations in grauzone or cortex cause abnormal arrest in Drosophila female meiosis. We cloned grauzone and identified it as a C2H2-type zinc finger transcription factor...
  4. Lieberfarb M, Chu T, Wreden C, Theurkauf W, Gergen J, Strickland S. Mutations that perturb poly(A)-dependent maternal mRNA activation block the initiation of development. Development. 1996;122:579-88 pubmed
    ..This strategy has revealed that maternal-effect mutations in the cortex and grauzone genes impair translational activation and cytoplasmic polyadenylation of bicoid and Toll mRNAs...
  5. Bashirullah A, Halsell S, Cooperstock R, Kloc M, Karaiskakis A, Fisher W, et al. Joint action of two RNA degradation pathways controls the timing of maternal transcript elimination at the midblastula transition in Drosophila melanogaster. EMBO J. 1999;18:2610-20 pubmed
    ..The second pathway is activated 2 h after fertilization and functions together with the maternal pathway to ensure that transcripts are degraded by the MBT. ..
  6. Page A, Orr Weaver T. Activation of the meiotic divisions in Drosophila oocytes. Dev Biol. 1997;183:195-207 pubmed
    ..Also, continued protein synthesis is not required to maintain the metaphase I arrest. New protein synthesis is required, however, for proper chromatin recondensation after meiosis. ..
  7. Harms E, Chu T, Henrion G, Strickland S. The only function of Grauzone required for Drosophila oocyte meiosis is transcriptional activation of the cortex gene. Genetics. 2000;155:1831-9 pubmed
    The grauzone and cortex genes are required for the completion of meiosis in Drosophila oocytes...
  8. Elfring L, Axton J, Fenger D, Page A, Carminati J, Orr Weaver T. Drosophila PLUTONIUM protein is a specialized cell cycle regulator required at the onset of embryogenesis. Mol Biol Cell. 1997;8:583-93 pubmed
    ..Our data suggest that PLU protein is required at the time of egg activation and the completion of meiosis. ..
  9. Weil T, Parton R, Davis I, Gavis E. Changes in bicoid mRNA anchoring highlight conserved mechanisms during the oocyte-to-embryo transition. Curr Biol. 2008;18:1055-61 pubmed publisher
    ..Our results thus highlight a conserved mechanism for regulating mRNA anchoring and redeployment during the oocyte-to-embryo transition. ..

More Information

Publications19

  1. Zolotarev N, Maksimenko O, Shidlovskii Y, Georgiev P, Bonchuk A. [Translation elongation factor EF1?1 interacts with ZAD domains of transcription factors from Drosophila melanogaster]. Mol Biol (Mosk). 2016;50:1014-1019 pubmed publisher
    ..Efficient binding of ZADs from the proteins Grau, ZIPIC, and Zw5 to the translation elongation factor EF1?1 in nuclear and cytoplasmic extracts has been ..
  2. Cook K, Murphy T, Nguyen T, Karpen G. Identification of trans-acting genes necessary for centromere function in Drosophila melanogaster using centromere-defective minichromosomes. Genetics. 1997;145:737-47 pubmed
    ..The results presented in this study strongly suggest that dominant genetic interactions between mutations and centromere-defective minichromosomes could be used effectively to identify novel genes necessary for centromere function. ..
  3. Chung H, Löhr U, Jackle H. Lineage-specific expansion of the zinc finger associated domain ZAD. Mol Biol Evol. 2007;24:1934-43 pubmed
  4. Rivera Pomar R, Jackle H. From gradients to stripes in Drosophila embryogenesis: filling in the gaps. Trends Genet. 1996;12:478-83 pubmed
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva. ..
  5. Thomsen S, Anders S, Janga S, Huber W, Alonso C. Genome-wide analysis of mRNA decay patterns during early Drosophila development. Genome Biol. 2010;11:R93 pubmed publisher
    ..Our data also provide a valuable resource for further experimental and computational studies investigating the process of mRNA decay. ..
  6. Chen B, Chu T, Harms E, Gergen J, Strickland S. Mapping of Drosophila mutations using site-specific male recombination. Genetics. 1998;149:157-63 pubmed
    ..we describe the general method and its application to the mapping of two EMS-induced female-sterile mutations, grauzone and cortex...
  7. Hake L, Richter J. Translational regulation of maternal mRNA. Biochim Biophys Acta. 1997;1332:M31-8 pubmed
  8. Jauch R, Bourenkov G, Chung H, Urlaub H, Reidt U, Jackle H, et al. The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module. Structure. 2003;11:1393-402 pubmed
    ..Here we present the crystal structure of the ZAD of Grauzone (ZAD(Grau)), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit ..
  9. Whitfield Z, Chisholm J, Hawley R, Orr Weaver T. A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. PLoS Biol. 2013;11:e1001648 pubmed publisher
    ..These data indicate APC(Cort) ubiquitylates Mtrm at the oocyte-to-embryo transition, thus preventing excessive inhibition of Polo kinase activity due to Mtrm's presence. ..
  10. Renault A, Zhang X, Alphey L, Frenz L, Glover D, Saunders R, et al. giant nuclei is essential in the cell cycle transition from meiosis to mitosis. Development. 2003;130:2997-3005 pubmed
    ..Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu. ..