Gene Symbol: Gr63a
Description: Gustatory receptor 63a
Alias: CG14979, DmGr63a, Dmel\CG14979, GR63a, Gr63F1, gr63a, gustatory receptor 63a, CG14979-PB, Gr63a-PB, gustatory receptor 63F1
Species: fruit fly

Top Publications

  1. Poon P, Kuo T, Linford N, Roman G, Pletcher S. Carbon dioxide sensing modulates lifespan and physiology in Drosophila. PLoS Biol. 2010;8:e1000356 pubmed publisher
    ..We find that a specialized population of olfactory neurons that express receptor Gr63a (a component of the olfactory receptor for gaseous phase CO(2)) affects fly lifespan and physiology...
  2. Jones W, Cayirlioglu P, Kadow I, Vosshall L. Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature. 2007;445:86-90 pubmed
    ..Here we report that CO2-responsive neurons in Drosophila co-express a pair of chemosensory receptors, Gr21a and Gr63a, at both larval and adult life stages...
  3. Wasserman S, Salomon A, Frye M. Drosophila tracks carbon dioxide in flight. Curr Biol. 2013;23:301-6 pubmed publisher
  4. Deng Y, Zhang W, Farhat K, Oberland S, Gisselmann G, Neuhaus E. The stimulatory G?(s) protein is involved in olfactory signal transduction in Drosophila. PLoS ONE. 2011;6:e18605 pubmed publisher OR83b expressing olfactory sensory neurons, but not in neurons expressing CO? responsive proteins GR21a/GR63a. Moreover, signaling of Drosophila ORs involved G?(s) also in a heterologous expression system...
  5. Jiao Y, Moon S, Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 2007;104:14110-5 pubmed
    ..These data demonstrate that multiple Grs are coexpressed with Gr5a and that Drosophila Gr64a is required for the responses to multiple sugars. ..
  6. Yao C, Carlson J. Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila. J Neurosci. 2010;30:4562-72 pubmed publisher
    ..1999, 2000; Vosshall et al., 1999). Ors mediate odor responses, whereas two Grs, Gr21a and Gr63a, mediate CO2 response (Hallem et al., 2004; Jones et al., 2007; Kwon et al., 2007)...
  7. Turner S, Ray A. Modification of CO2 avoidance behaviour in Drosophila by inhibitory odorants. Nature. 2009;461:277-81 pubmed publisher
    ..Using an in vivo expression system we establish that the odorants act on the Gr21a/Gr63a CO(2) receptor...
  8. Kwon J, Dahanukar A, Weiss L, Carlson J. The molecular basis of CO2 reception in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3574-8 pubmed
    ..Here we show that Gr21a and Gr63a, members of a large family of Drosophila seven-transmembrane-domain chemoreceptor genes, are coexpressed in ..
  9. Ai M, Min S, Grosjean Y, Leblanc C, Bell R, Benton R, et al. Acid sensing by the Drosophila olfactory system. Nature. 2010;468:691-5 pubmed publisher
    ..Taken together, these results identify cellular and molecular substrates for acid detection in the Drosophila olfactory system and support a labelled-line mode of acidity coding at the periphery...

More Information


  1. Fischler W, Kong P, Marella S, Scott K. The detection of carbonation by the Drosophila gustatory system. Nature. 2007;448:1054-7 pubmed
    ..This work opens up the possibility that the taste of carbonation may also exist in other organisms...
  2. Robertson H, Kent L. Evolution of the gene lineage encoding the carbon dioxide receptor in insects. J Insect Sci. 2009;9:19 pubmed publisher
    A heterodimer of the insect chemoreceptors Gr21a and Gr63a has been shown to be the carbon dioxide receptor in Drosophila melanogaster (Meigen) (Diptera: Drosophilidae)...
  3. Cayirlioglu P, Kadow I, Zhan X, Okamura K, Suh G, Gunning D, et al. Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science. 2008;319:1256-60 pubmed publisher
    ..We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2...
  4. Sachse S, Rueckert E, Keller A, Okada R, Tanaka N, Ito K, et al. Activity-dependent plasticity in an olfactory circuit. Neuron. 2007;56:838-50 pubmed
    ..Behavioral responses to CO2 were also reduced after such exposure. We suggest that activity-dependent functional plasticity may be a general feature of the Drosophila olfactory system. ..
  5. Partridge L. Some highlights of research on aging with invertebrates, 2010. Aging Cell. 2011;10:5-9 pubmed publisher
    ..The invertebrates continue to be a power house of discovery for future work in mammals. ..
  6. With S, Rice T, Salinas C, Auld V. Fire exit is a potential four transmembrane protein expressed in developing Drosophila glia. Genesis. 2003;35:143-52 pubmed
  7. Sim C, Perry S, Tharadra S, Lipsick J, Ray A. Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex. Genes Dev. 2012;26:2483-98 pubmed publisher
    ..plays an important role in mediating neuron-specific expression of the carbon dioxide (CO(2)) receptor genes (Gr63a/Gr21a) in Drosophila...
  8. Liu Y, Pearce M, Honda T, Johnson T, Charlu S, Sharma K, et al. The Drosophila melanogaster phospholipid flippase dATP8B is required for odorant receptor function. PLoS Genet. 2014;10:e1004209 pubmed publisher
  9. Galizia C. Olfactory coding in the insect brain: data and conjectures. Eur J Neurosci. 2014;39:1784-95 pubmed publisher
    ..A review of experimental data and theoretical conjectures both contribute to this synthesis, creating new hypotheses for future research. ..
  10. Jeong D, Artan M, Seo K, Lee S. Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet. 2012;3:218 pubmed publisher
    ..In this review, we describe findings regarding how sensory nervous system components elicit physiological changes to regulate lifespan in invertebrate models, and discuss their implications in mammalian aging. ..
  11. Helenius I, Krupinski T, Turnbull D, Gruenbaum Y, Silverman N, Johnson E, et al. Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection. Proc Natl Acad Sci U S A. 2009;106:18710-5 pubmed publisher
    ..significantly impairs embryonic morphogenesis, egg laying, and egg hatching even in mutants lacking the Gr63a neuronal CO(2) sensor...
  12. Wilson R. Neurobiology: scent secrets of insects. Nature. 2007;445:30-1 pubmed
  13. Liman E, Zhang Y, Montell C. Peripheral coding of taste. Neuron. 2014;81:984-1000 pubmed publisher
    ..In this Review, we discuss recent advances in taste research, mainly from the fly and mammalian systems, and we highlight principles that are common across species, despite stark differences in receptor types...
  14. French A, Meisner S, Su C, Torkkeli P. Carbon dioxide and fruit odor transduction in Drosophila olfactory neurons. What controls their dynamic properties?. PLoS ONE. 2014;9:e86347 pubmed publisher
    ..In contrast, high frequency dynamics are limited by processes associated with earlier steps in odor transduction, and CO2 is detected more rapidly than fruit odor. ..
  15. Montell C. Gustatory receptors: not just for good taste. Curr Biol. 2013;23:R929-32 pubmed publisher
  16. Gershow M, Berck M, Mathew D, Luo L, Kane E, Carlson J, et al. Controlling airborne cues to study small animal navigation. Nat Methods. 2012;9:290-6 pubmed publisher
  17. Su C, Wang J. Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila. Curr Opin Neurobiol. 2014;29:9-16 pubmed publisher
  18. Freeman E, Wisotsky Z, Dahanukar A. Detection of sweet tastants by a conserved group of insect gustatory receptors. Proc Natl Acad Sci U S A. 2014;111:1598-603 pubmed publisher
    ..Our results provide a molecular basis for tastant detection by the entire repertoire of sweet taste receptors in the fly and lay the foundation for studying Grs in mosquitoes and other insects that transmit deadly diseases. ..
  19. Ziegler A, Berthelot Grosjean M, Grosjean Y. The smell of love in Drosophila. Front Physiol. 2013;4:72 pubmed publisher
    ..PAA enhances male courtship, acting as a food aphrodisiac. Drosophila males have thus developed complementary olfactory strategies to help them to select their mates. ..
  20. Linford N, Chan T, Pletcher S. Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. PLoS Genet. 2012;8:e1002668 pubmed publisher
    ..These results provide evidence that gustatory perception can alter arousal thresholds for sleep behavior in response to dietary cues and provide a mechanism by which organisms tune their behavior and physiology to environmental cues. ..
  21. Bai L, Goldman A, Carlson J. Positive and negative regulation of odor receptor gene choice in Drosophila by acj6. J Neurosci. 2009;29:12940-7 pubmed publisher
    ..Thus, Acj6 acts directly in the process of receptor gene choice; it plays a dual role, positive and negative, in the logic of the process, and acts in partitioning the larval and adult receptor repertoires. ..